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Wyświetlanie 1-10 z 39
Tytuł:
The effect of hypoxia on exercise tolerance in individuals after acute coronary syndrome treated with angioplasty combined with coronary stent implantation – pilot studies
Autorzy:
Nowak, Agata
Kucio, Cezary
Nowak, Zbigniew
Küpper, Thomas
Powiązania:
https://bibliotekanauki.pl/articles/553042.pdf
Data publikacji:
2019
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
coronary artery disease
hypoxia
angioplasty.
Opis:
Background. Currently, there is little documented research evaluating the effect of a high-mountain environment on patients with ischemic heart disease. Objectives. The main aim of the study was to assess the effect of normobaric hypoxia on exercise tolerance in patients diagnosed with stable coronary disease. Material and methods. 22 men aged 37 to 72 (55.68 ± 9.86 years of age) with coronary disease were qualified. In the pre-study, in a normobaric normoxia environment, each patient underwent: resting ECG, spiroergometric test using a treadmill, laboratory tests (gasometry, lactic acid concentration). The patients stayed in the cabinet for 3 hours at the: 1) normoxia, 2) hypoxia (2000 m a.s.l), 3) hypoxia (3000 m a.s.l.) levels. After the 3-hour period, patients underwent a spiroergometric exercise tolerance test combined with a blood lactic acid concentration test. Venous blood and capillary blood were drawn for gasometry testing purposes. Results. Under 2000 and 3000 m hypoxia noted a significantly shorter duration of the exercise test, distance travelled and MET values. An increase in resting blood pH and a decrease of resting and peak pCO2 and pO2 were observed. Conclusions. As a result of a 3-hour exposure to normobaric hypoxia, the exercise tolerance of patients after acute coronary syndrome treated with angioplasty combined with coronary stent implantation decreases. There is no clear information for patients as to whether high mountain conditions are safe for them. The presented research was a form of introduction to wider and more thorough experiments that can result in practical information for patients.
Źródło:
Family Medicine & Primary Care Review; 2019, 2; 117-123
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis.
Autorzy:
Kimura, Hideo
Esumi, Hiroyasu
Powiązania:
https://bibliotekanauki.pl/articles/1043646.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
angiogenesis
vascular endothelial growth factor
hypoxia inducible factor 1
hypoxia
reciprocal regulation
nitric oxide
Opis:
Physiologically, angiogenesis is tightly regulated, or otherwise it leads to pathological processes, such as tumors, inflammatory diseases, gynecological diseases and diabetic retinopathy. The vascular endothelial growth factor (VEGF) is a potent and critical inducer of angiogenesis. The VEGF gene expression is regulated by a variety of stimuli. Hypoxia is one of the most potent inducers of the VEGF expression. The hypoxia inducible factor 1 (HIF-1) plays as a key transcription factor in hypoxia-mediated VEGF gene upregulation. Nitric oxide (NO) as well as hypoxia is reported to upregulate the VEGF gene by enhancing HIF-1 activity. The Akt/protein kinase B (PKB) pathway may be involved in NO-mediated HIF-1 activation in limited cell lines. There are some reports of negative effects of NO on HIF-1 and VEGF activity. These conflicting data of NO effects may be attributed mainly to the amount of released NO. Indeed, NO can be a positive or negative modulator of the VEGF gene under the same conditions simply by changing its amounts. The VEGF-mediated angiogenesis requires NO production from activated endothelial NO synthase (eNOS). Activation of eNOS by VEGF involves several pathways including Akt/PKB, Ca2+/calmodulin, and protein kinase C. The NO-mediated VEGF expression can be regulated by HIF-1 and heme oxygenase 1 (HO-1) activity, and the VEGF-mediated NO production by eNOS can be also modulated by HIF-1 and HO-1 activity, depending upon the amount of produced NO. These reciprocal relations between NO and VEGF may contribute to regulated angiogenesis in normal tissues.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 49-59
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of prolonged manganese intoxication on memory processes in hypoxic mice
Autorzy:
Lukawski, K.
Sieklucka-Dziuba, M.
Powiązania:
https://bibliotekanauki.pl/articles/3016.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
manganese
intoxication
memory process
hypoxia
mice
mouse
cerebral oligemic hypoxia
passive avoidance
spontaneous alternation
Źródło:
Journal of Pre-Clinical and Clinical Research; 2010, 04, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Imaging of hypoxia in small animals with 18F fluoromisonidasole
Autorzy:
Kilian, K.
Rogulski, Z.
Cheda, Ł.
Drzał, A.
Gerszewska, M.
Cudny, M.
Elas, M.
Powiązania:
https://bibliotekanauki.pl/articles/148618.pdf
Data publikacji:
2016
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
18F-fluoromisonidazole
radiopharmaceuticals
hypoxia imaging
Opis:
A method of automated synthesis of [18F]fluoromisonidazole ([18F]FMISO) for application in preclinical studies on small animals was presented. A remote-controlled synthesizer Synthra RNplus was used for nucleophilic substitution of NITTP (1-(2'-nitro-1'-imidazolyl)-2-O-tetrahydropyranyl-3-O-toluenesulfonyl-propanediol) with 18F anion. Labeling of 5 mg of precursor was performed in anhydrous acetonitrile at 100°C for 10 min, and the hydrolysis with HCl was performed at 100°C for 5 min. Final purifi cation was done with high-performance liquid chromatography (HPLC) and the radiochemical purity of radiotracer was higher than 99%. Proposed [18F]FMISO synthesis was used as a reliable tool in studies on hypoxia in Lewis lung carcinoma (LLC) in mouse models.
Źródło:
Nukleonika; 2016, 61, 2; 119-223
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The direction of the changes of rates of the internal and external training load under the influence of high-altitude hypoxia on mountain bikers
Autorzy:
Gabrys, Tomasz
Szmatlan-Gabrys, Urszula
Stanula, Arkadiusz
Powiązania:
https://bibliotekanauki.pl/articles/1922006.pdf
Data publikacji:
2019-02-20
Wydawca:
PPHU Projack Jacek Wąsik
Tematy:
cycling
altitude training
aerobic capacity
hypoxia
Opis:
The aim of the research carried out was to establish the direction, and scope of the changes in internal, and external load indicator values in cyclists, men, and women, in high-altitude hypoxia conditions. The participants of the study were mountain bike cyclists, members of Russian and Polish Nationals Teams (women n=11, men n=9). They have done the graded incremental exercise test at the altitude of 170 m (Lonato del Garda, Italy) and 2250 m (Livignio-Trepale Italy). In the course of effort VO2, VE, VCO2 was measured by means of K4b2 analyser (Cosmed Italy). Effort intensity was determined at ventilators thresholds VT1 (AT), and VT2. Internal and external load indicators undergo changes during physical effort in cyclists under the influence of high altitude hypoxia. In groups of men and women, the changes in indicator values reach VE: 9% and 12%, HR: 0,5% and 15, O2HR: 7% and 15%, VO2: 14% and 20% respectively, as well as a decrease in 5 and 4% of the generated power, respectively. A decrease in the generated power by 5%, higher ventilation, amounting to 10%, a higher VO2max, amounting to 17% in hypoxic conditions, in comparison with the conditions similar to those at sea level, show that it is necessary to modify training loads.
Źródło:
Physical Activity Review; 2019, 7; 40-48
2300-5076
Pojawia się w:
Physical Activity Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Properties of B16-F10 murine melanoma cells subjected to metabolic stress conditions
Autorzy:
Mitrus, Iwona
Bryndza, Ewa
Kazura, Malgorzata
Smagur, Andrzej
Sochanik, Aleksander
Cichon, Tomasz
Szala, Stanislaw
Powiązania:
https://bibliotekanauki.pl/articles/1039711.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
epithelial-mesenchymal transition
Metabolic stress
hypoxia
Opis:
Neoplastic cells which co-form tumors are usually subjected to various stress factors, mainly hypoxia and shortage of nutrient factors. Such cells employ different strategies that permit their survival under such conditions. Experiments in vitro are usually carried out in the presence of 21% oxygen and medium supplemented with 10% FBS. Altering these parameters can approximate the in vivo conditions found within tumor mass. The present paper reports certain properties (especially ability to metastasize) of B16-F10 cells able to grow upon exposure to altered growth conditions (medium supplemented with 0.06% FBS or presence of 1% oxygen for 24 or 72 hours). These properties were compared with those of control cells cultured in the presence of 21% oxygen and in medium supplemented with 10% FBS. Some properties of the cells exposed to medium supplemented with 0.06% FBS differ from those of cells cultured under low oxygenation conditions (ability to form metastases, to migrate, or to express various proteins). Only the partial deprivation of oxygen did increase both the number of migrating cells and the number of metastases formed. Serum deficiency enhanced only the cell ability to metastasize, but not to migrate. It appears that cultured B16-F10 cells employ different adaptation strategies under conditions of oxygen shortage and those of serum deficiency. Under oxygen deprivation, such cells most likely undergo an epithelial-mesenchymal transition, whereas serum deficiency ("starvation"), while increasing the tumorigenicity of B16-F10 cells, does not induce the epithelial-mesenchymal transition.
Źródło:
Acta Biochimica Polonica; 2012, 59, 3; 363-366
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
N-myc downstream regulated 1 gene and its place in the cellular machinery
Autorzy:
Kitowska, Agnieszka
Pawełczyk, Tadeusz
Powiązania:
https://bibliotekanauki.pl/articles/1040413.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
NDRG1
cancer
hypoxia
metastases
nickel
Opis:
The exact function of the protein product of N-myc downstream regulated 1 gene (NDRG1) is unclear. Depending on the tissue type the NDRG1 protein is localized in the cytoplasm, nucleus, mitochondrion or membranes. Moreover, the expression of NDRG1 may be altered by several factors such as hypoxia, heavy metals, DNA damage, hormones, oncogene, and tumor-suppressor genes. A number of studies emphasize the role of NDRG1 in cancerogenesis. Presumably NDRG1 participates in angiogenesis, metastases, and mechanisms leading to anti-cancer drug resistance. This review summarizes current knowledge about the NDRG1 gene and the position of NDRG1 protein in the cellular machinery. The role of NDRG1 in cancer pathogenesis and its possible usefulness as a prognostic factor for patients with cancer is also discussed.
Źródło:
Acta Biochimica Polonica; 2010, 57, 1; 15-21
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Targeting the hypoxia pathway in malignant plasma cells by using 17-allylamino-17-demethoxygeldanamycin
Autorzy:
Kocemba-Pilarczyk, Kinga
Ostrowska, Barbara
Trojan, Sonia
Aslan, Ecce
Kusior, Dorota
Lasota, Małgorzata
Lenouvel, Claire
Dulińska-Litewka, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1038530.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Multiple myeloma
HIF-1
hypoxia
17-AAG
Opis:
Multiple myeloma (MM) is characterized as a clonal expansion of malignant plasma cells in the bone marrow, which is often associated with pancytopenia and osteolytic bone disease. Interestingly, myeloma-infiltrated bone marrow is considered to be hypoxic, providing selection pressure for a developing tumour. Since HSP90 was shown to participate in stabilization of the subunit of the key transcription factor HIF-1, which controls the hypoxic response, the aim of this study was to investigate the influence of a HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG), on MM cells cultured under low oxygenation conditions. We confirmed that 17-AAG inhibits hypoxic induction of the HIF-1 target genes in malignant plasma cells and demonstrate the concentration range of severe hypoxia-specific cytotoxicity. Next, we selected the malignant plasma cells under severe hypoxia/re-oxygenation culture conditions in the presence or absence of 17-AAG and subsequently, the cells which survived were further expanded and analyzed. Interestingly, we have noticed significant changes in the survival and the response to anti-MM drugs between the parental cell lines and those selected in cyclic severe hypoxia in the presence and absence of 17-AAG. Importantly, we also observed that the lack of oxygen itself, irrespectively of HIF-1 inhibition, is the main/pivotal factor driving the selection process in the experiments presented here.
Źródło:
Acta Biochimica Polonica; 2018, 65, 1; 101-109
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antiproliferative activity of new benzimidazole derivatives
Autorzy:
Błaszczak-Świątkiewicz, Katarzyna
Olszewska, Paulina
Mikiciuk-Olasik, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/1039545.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
anticancer activity
ntiproliferation
apoptosis
benzmidazole
hypoxia
nitrobenzimidazole
Opis:
A series of new benzimidazole derivatives were synthesized and tested in vitro for possible anticancer activity. Their effect of proliferation into selected tumor cell lines at normoxia and hypoxia conditions was determined by WST-1 test. Additionally, apoptosis test (caspase 3/7 assay) was used to check the mode caused by the agents of cell death. Four of the examined compounds (7, 8, 13, 11) showed a very good antiproliferative effect and three of them were specific for hypoxia conditions (8, 14, 11). Compound 8 was the most cytotoxic against human lung adenocarcinoma A549 cells at hypoxic conditions. Hypoxia/ normoxia cytotoxic coefficient of compound 14 (4.75) is close to hypoxia/normoxia cytotoxic coefficient of tirapazamine (5.59) - a reference compound in our experiments and this parameter locates it between mitomycin C and 2-nitroimidazole (misonidazole). Screening test of caspase-dependent apoptosis proved that exposure to A549 cells of compounds 7-8 and 13-14 for 48 h promote apoptotic cell death. These results supplement our earlier study of the activity of new potentialy cytotoxic heterocyclic compounds against selected tumor cells.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 427-433
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Uraz ciśnieniowy płuc w przebiegu hipoksji u płetwonurka pod wodą
Pulmonary barotrauma in the course of a divers underwater hypoxia
Autorzy:
Olszański, R.
Siermontowski, P.
Dąbrowiecki, Z.
Powiązania:
https://bibliotekanauki.pl/articles/366195.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej
Tematy:
hipoksja
uraz ciśnieniowy płuc
hypoxia
pulmonary barotrauma
Opis:
W artykule opisano przypadek nieprawidłowego zachowania nurka pod wodą, które doprowadziło do niedotlenienia i hiperkapni z następową utratą przytomności podczas nurkowania powietrznego, płytkowodnego, w skafandrze suchym, powikłanego urazem ciśnieniowym płuc.
The article discusses the case of an improper diver’s underwater behaviour which led to hypoxia and hypercapnia, with a following loss of consciousness during air diving in shallow water and in a dry diving suit, and consequent pulmonary barotrauma.
Źródło:
Polish Hyperbaric Research; 2010, 3(32); 67-70
1734-7009
2084-0535
Pojawia się w:
Polish Hyperbaric Research
Dostawca treści:
Biblioteka Nauki
Artykuł
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