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Wyszukujesz frazę "Gymnema sylvestre" wg kryterium: Temat

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    Wyświetlanie 1-2 z 2
    Tytuł:
    Zastosowania gurmaru (Gymnema sylvestre) w zapobieganiu i terapii cukrzycy
    Applications of Gymnema sylvestre, in the prevention and treatment of diabetes
    Autorzy:
    Zielińska, Agnieszka
    Krzystyniak, Krzysztof
    Łuszczyna, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/2077891.pdf
    Data publikacji:
    2022-05-27
    Wydawca:
    Wydawnictwo Naukowe Medyk sp. z o.o.
    Tematy:
    Gymnema sylvestre
    gymnemic acid
    diabetes
    obesity
    gurmar
    kwasy gymnemowe
    cukrzyca
    otyłość
    Opis:
    Diabetes mellitus is a major endocrine disorder affecting nearly 10% of the population worldwide and a key issue of concern. There is a lot of interest in plant preparations that will allow to control diabetes with less side effects compared to a conventional antidiabetic drug. Such plants include Gymnema sylvestre, traditionally used in the Ayurvedic medicine system. G. sylvestre supplementation is effective in improving glycemic control and reducing lipid levels in patients with type 2 diabetes. It exhibits a wide range of other therapeutic effects (including anti-arthritis, immunostimulatory, antimicrobial and hepatoprotective effects). The gymnemic acids present in G. sylvestre block the absorption of carbohydrates in the intestine, thus preventing the consumption of "empty calories" that may contribute to obesity. Supplementation with Gymnema sylvestre can be an important part of the diet of people with diabetes as well as those in the high-risk group.
    Źródło:
    Lek w Polsce; 2022, 371, 04; 6-11
    2353-8597
    Pojawia się w:
    Lek w Polsce
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Molecular docking and prediction of ADME/drug-likeness properties of potentially active antidiabetic compounds isolated from aqueous-methanol extracts of Gymnema sylvestre and Combretum micranthum
    Autorzy:
    Ononamadu, C.J.
    Ibrahim, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/2096363.pdf
    Data publikacji:
    2021
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    Gymnema sylvestre
    Combretum micranthum
    antidiabetic compounds
    molecular docking
    pharmacokinetics
    drugs
    Opis:
    Gymnema sylvestre and Combretum micranthum are well known for their ethno-medicinal uses in the northwest of Nigeria. In our recent study, we demonstrated the antidiabetic and antioxidant activities of the aqueous-methanol extracts of the two plants and identified some potentially active compounds. The present study aimed to conduct molecular docking and ADME/drug-likeness screening of the identified potentially active candidate compounds from aqueous-methanol extracts of G. sylvestre and C. micranthum leaves by using in silico techniques. Molecular docking of compounds on target proteins (α-amylase, α-glucosidase, and phosphorylated insulin receptor tyrosine kinase) was performed using Molsoft ICM-pro 3.8-3. The physicochemical, ADME, and drug-likeness parameters were computed using the SwissADME online program. The result corroborated the antidiabetic activities of the plants with significant binding interactions between compounds A (2,2-dimethyl-3-[4-(acetyloxy)phenyl]-4-ethyl2H-1-benzopyran-7-ol acetate), D (9,13-di-cis-retinoic acid), E (4-hydroxycinnamic acid), F ((-)-11-hydroxy-9,10-dihydrojasmonic acid), G (colnelenic acid), H (glyinflanin A), I (6,8a-seco-6,8a-deoxy-5-oxoavermectin “2a” aglycone), and J (3-deshydroxysappanol trimethyl ether) and at least one of the three target proteins. Four compounds, namely A (2,2-dimethyl-3-[4-(acetyloxy)phenyl]-4-ethyl-2H-1-benzopyran-7-ol acetate), E (4-hydroxycinnamic acid), H (glyinflanin A), and J (3-deshydroxysappanol trimethyl ether), yielded the best docking scores with respect to the target proteins, of which three (E (4-hydroxycinnamic acid), H (glyinflanin A), and J (3-deshydroxysappanol trimethyl ether)) were identified to have relatively optimal drug-likeness and medicinal chemistry characteristics. Thus, the present study concluded that these compounds may have contributed to the observed antidiabetic properties of these plants and can be investigated further as drugs or drug-like compound candidates.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 1; 85-99
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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