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Wyszukujesz frazę "G protein-coupled receptors" wg kryterium: Temat

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    Wyświetlanie 1-6 z 6
    Tytuł:
    Novel approach to computer modeling of seven-helical transmembrane proteins: Current progress in the test case of bacteriorhodopsin.
    Autorzy:
    Nikiforovich, Gregory
    Galaktionov, Stan
    Balodis, Juris
    Marshall, Garland
    Powiązania:
    https://bibliotekanauki.pl/articles/1044163.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    G-protein coupled receptors
    bacteriorhodopsin
    computer modeling
    Opis:
    G-protein coupled receptors (GPCRs) are thought to be proteins with 7-membered transmembrane helical bundles (7TM proteins). Recently, the X-ray structures have been solved for two such proteins, namely for bacteriorhodopsin (BR) and rhodopsin (Rh), the latter being a GPCR. Despite similarities, the structures are different enough to suggest that 3D models for different GPCRs cannot be obtained directly employing 3D structures of BR or Rh as a unique template. The approach to computer modeling of 7TM proteins developed in this work was capable of reproducing the experimental X-ray structure of BR with great accuracy. A combination of helical packing and low-energy conformers for loops most close to the X-ray structure possesses the r.m.s.d. value of 3.13 Å. Such a level of accuracy for the 3D-structure prediction for a 216-residue protein has not been achieved, so far, by any available ab initio procedure of protein folding. The approach may produce also other energetically consistent combinations of helical bundles and loop conformers, creating a variety of possible templates for 3D structures of 7TM proteins, including GPCRs. These templates may provide experimentalists with various plausible options for 3D structure of a given GPCR; in our view, only experiments will determine the final choice of the most reasonable 3D template.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 1; 53-64
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Physiopathological Implications of 7TM Receptors
    Autorzy:
    Cygankiewicz, Adam I.
    Powiązania:
    https://bibliotekanauki.pl/articles/764827.pdf
    Data publikacji:
    2010
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Tematy:
    Seven-transmembrane receptors
    G protein coupled receptors
    pathology
    cancer
    Opis:
    Seven-transmembrane (7TM) receptors are one of the most important proteins involved in perception of extracellular stimuli and regulation of variety of intracellular signaling pathways. Divergence of receptor types, their ligands and signaling pathways makes 7TM receptors important factors in pathology of many diseases. This review focused on the main diseases in which involvement of 7TM receptors was established e.g., retinitis pigmentosa, severe obesity, and dwarfism. Recent findings of aberrant expression of 7TM receptors in development of cancer were also summarized.
    Źródło:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2010, 6; 33-47
    1730-2366
    2083-8484
    Pojawia się w:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    G protein-coupled receptors - recent advances
    Autorzy:
    Latek, Dorota
    Modzelewska, Anna
    Trzaskowski, Bartosz
    Palczewski, Krzysztof
    Filipek, Sławomir
    Powiązania:
    https://bibliotekanauki.pl/articles/1039641.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    G protein-coupled receptors
    chemokine receptors
    β-adrenergic receptors
    rhodopsin
    arrestin.
    G protein
    Opis:
    The years 2000 and 2007 witnessed milestones in current understanding of G protein-coupled receptor (GPCR) structural biology. In 2000 the first GPCR, bovine rhodopsin, was crystallized and the structure was solved, while in 2007 the structure of β2-adrenergic receptor, the first GPCR with diffusible ligands, was determined owing to advances in microcrystallization and an insertion of the fast-folding lysozyme into the receptor. In parallel with those crystallographic studies, the biological and biochemical characterization of GPCRs has advanced considerably because those receptors are molecular targets for many of currently used drugs. Therefore, the mechanisms of activation and signal transduction to the cell interior deduced from known GPCRs structures are of the highest importance for drug discovery. These proteins are the most diversified membrane receptors encoded by hundreds of genes in our genome. They participate in processes responsible for vision, smell, taste and neuronal transmission in response to photons or binding of ions, hormones, peptides, chemokines and other factors. Although the GPCRs share a common seven-transmembrane α-helical bundle structure their binding sites can accommodate thousands of different ligands. The ligands, including agonists, antagonists or inverse agonists change the structure of the receptor. With bound agonists they can form a complex with a suitable G protein, be phosphorylated by kinases or bind arrestin. The discovered signaling cascades invoked by arrestin independently of G proteins makes the GPCR activating scheme more complex such that a ligand acting as an antagonist for G protein signaling can also act as an agonist in arrestin-dependent signaling. Additionally, the existence of multiple ligand-dependent partial activation states as well as dimerization of GPCRs result in a 'microprocessor-like' action of these receptors rather than an 'on-off' switch as was commonly believed only a decade ago.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 4; 515-529
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hypothetical orchestrated cooperation between dopaminergic and kinin receptors for the regulation of common functions
    Autorzy:
    Guevara-Lora, Ibeth
    Niewiarowska-Sendo, Anna
    Polit, Agnieszka
    Kozik, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1038753.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    kinin receptors
    dopamine receptors
    G protein-coupled receptors
    oligomerization
    signaling pathways
    Opis:
    The G protein-coupled receptors (GPCRs), one of the largest protein families, are essential components of the most commonly used signal-transduction systems in cells. These receptors, often using common pathways, may cooperate in the regulation of signal transmission to the cell nucleus. Recent scientific interests increasingly focus on the cooperation between these receptors, particularly in a context of their oligomerization, e.g. the formation of dimers that are able to change characteristic signaling of each receptor. Numerous studies on kinin and dopamine receptors which belong to this family of receptors have shown new facts demonstrating their direct interactions with other GPCRs. In this review, current knowledge on signaling pathways and oligomerization of these receptors has been summarized. Owing to the fact that kinin and dopamine receptors are widely expressed in cell membranes where they act as mediators of numerous common physiological processes, the information presented here sheds new light on a putative crosstalk of these receptors and provides more comprehensive understanding of possible direct interactions that may change their functions. The determination of such interactions may be useful for the development of new targeted therapeutic strategies against many disorders in which kinin and dopamine receptors are involved.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 387-396
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lysophosphatidic acids, cyclic phosphatidic acids and autotaxin as promissing targets in therapies of cancer and other diseases
    Autorzy:
    Gendaszewska-Darmach, Edyta
    Powiązania:
    https://bibliotekanauki.pl/articles/1040734.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    autotaxin/NPP2
    lysophosphatidic acid
    cyclic phosphatidic acid
    G protein-coupled receptors
    Opis:
    Lysophospholipids have long been recognized as membrane phospholipid metabolites, but only recently lysophosphatidic acids (LPA) have been demonstrated to act on specific G protein-coupled receptors. The widespread expression of LPA receptors and coupling to several classes of G proteins allow LPA-dependent regulation of numerous processes, such as vascular development, neurogenesis, wound healing, immunity, and cancerogenesis. Lysophosphatidic acids have been found to induce many of the hallmarks of cancer including cellular processes such as proliferation, survival, migration, invasion, and neovascularization. Furthermore, autotaxin (ATX), the main enzyme converting lysophosphatidylcholine into LPA was identified as a tumor cell autocrine motility factor. On the other hand, cyclic phosphatidic acids (naturally occurring analogs of LPA generated by ATX) have anti-proliferative activity and inhibit tumor cell invasion and metastasis. Research achievements of the past decade suggest implementation of preclinical and clinical evaluation of LPA and its analogs, LPA receptors, as well as autotaxin as potential therapeutic targets.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 2; 227-240
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Receptory związane z białkami G w odporności wrodzonej bezkręgowców
    G-protein-coupled receptors in invertebrate innate immunity
    Autorzy:
    Andrejko, Mariola
    Mizerska-Kowalska, Magdalena
    Zdzisińska, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1033991.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Przyrodników im. Kopernika
    Tematy:
    G-protein-coupled receptors (GPCRs)
    innate immunity
    invertebrate
    bezkręgowce
    odporność wrodzona
    receptory związane z białkami G (GPCRs)
    Opis:
    Receptory związane z białkami G (GPCRs) stanowią najliczniejszą i bardzo zróżnicowaną grupę receptorów błonowych odpowiedzialnych za przekazywanie sygnałów ze środowiska zewnętrznego do wnętrza komórki. GPCRs uczestniczą niemal w każdym aspekcie życia organizmów, regulując m. in. mechanizmy związane z odpowiedzią immunologiczną, zarówno u kręgowców, jak i bezkręgowców. W pracy opisano ogólną budowę i klasyfikację GPCRs, mechanizmy aktywacji i przekazywania sygnału przez te receptory oraz sposoby regulacji ich aktywności. Ponadto zamieszczono podstawowe informacje na temat mechanizmów rozpoznawania patogenów przez bezkręgowce. W zasadniczej części pracy zaprezentowano wyniki najnowszych badań dotyczące zaangażowania GPCRs w reakcje obronne bezkręgowców, na przykładzie wybranych organizmów modelowych, tj. skrzypłocza atlantyckiego (Limulus polyphemus), muszki owocowej (Drosophila melanogaster) oraz nicienia (Caenorhabditis elegans).
    The G-protein-coupled receptors (GPCRs) form the largest and most diverse group of membrane receptors engaged in extracellular signals transduction. GPCRs are involved in almost all aspects of vertebrates and invertebrates' life, including regulation of the immune response mechanisms. The paper describes the general structure and classification of GPCRs. Moreover, it presents the mechanisms of GPCR activation and signal transduction as well as the regulation of GPCR activity. Furthermore, basic information about the mechanisms of pathogen recognition by invertebrates is included. The main part of this review shows the most recent data about the involvement of GPCRs in defense mechanisms of invertebrates such as the horseshoe crab (Limulus polyphemus), fruit fly (Drosophila melanogaster), and nematode (Caenorhabditis elegans).
    Źródło:
    Kosmos; 2017, 66, 4; 553-562
    0023-4249
    Pojawia się w:
    Kosmos
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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