- Tytuł:
- NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme.
- Autorzy:
-
Borowski, Peter
Niebuhr, Andreas
Schmitz, Herbert
Hosmane, Ramachandra
Bretner, Maria
Siwecka, Maria
Kulikowski, Tadeusz - Powiązania:
- https://bibliotekanauki.pl/articles/1043721.pdf
- Data publikacji:
- 2002
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
NTPase/helicase inhibitors
Flaviviridae - Opis:
- RNA nucleoside triphosphatases (NTPase)/helicases represent a large family of proteins that are ubiquitously distributed over a wide range of organisms. The enzymes play essential role in cell development and differentiation, and some of them are involved in transcription and replication of viral single-stranded RNA genomes. The enzymatic activities of a NTPase/helicase were also detected in the carboxyl-terminal non-structural protein 3 (NS3) of members of the Flaviviridae family. The crucial role of the enzyme for the virus life cycle was demonstrated in knock out experiments and by using NTPase/helicase specific inhibitors. This makes the enzyme an attractive target for development of Flaviviridae-specific antiviral therapies. This review will summarize our knowledge about the function and structure of the enzyme, update the spectrum of inhibitors of the enzymatic activities of the NTPase/helicase and describe the different mechanisms by which the compounds act. Some of the compounds reviewed herein could show potential utility as antiviral agents against Flaviviridae viruses.
- Źródło:
-
Acta Biochimica Polonica; 2002, 49, 3; 597-614
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł