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    Wyświetlanie 1-6 z 6
    Tytuł:
    Investigation of fenofibrate solubility in the presence of chitosan
    Autorzy:
    Grimling, Bożena
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035391.pdf
    Data publikacji:
    2012
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    dissolution
    fenofibrate
    solid state
    Opis:
    Fenofibrate is an active substance which is well absorbed from the gastrointestinal tract, but it is characterized by limited solubility. Due to a wide spectrum of its pharmacological activity, it would be beneficial to improve its solubility, and thus increase the drug absorption capability. The aim of the study was to investigate the effect of chitosan on the solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions at the drug to polymer ratio of 3:7,5:5,7:3. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; mean amount of dissolved fenofibrate and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multi-fold increase (from 33 to 50 times) in fenofibrat solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The obtained results may help develop new technologies for fenofibrate preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 79-86
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Low doses of fenofibrate and bezafibrate stimulate renal 2-oxoglutarate dehydrogenase (2-OGDH) in protein-restricted rats
    Autorzy:
    Knapik-Czajka, Malgorzata E.
    Drag, Jagoda M.
    Gawedzka, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/895613.pdf
    Data publikacji:
    2020-04-29
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    2-oxoglutarate dehydrogenase
    Fenofibrate
    Bezafibrate
    kidney
    Opis:
    2-oxoglutarate dehydrogenase (2-OGDH) is the key regulatory enzyme of cell metabolism. It has been previously demonstrated that in rats subjected to protein restriction low, clinically relevant doses of fibrates up-regulate liver 2-OGDH and promote 2-oxoglutarate catabolism. The aim of the present study was to evaluate the effect of low doses of fenofibrate and bezafibrate on renal 2-OGDH complex in rats fed low-protein chow. Fibrates were administrated for 14 days to Wistar male rats at one daily doses of 5, 10 and 20 mg/kg b.wt./day. The 2-OGDH activity was assayed spectrophotometrically. The mRNA levels for 2-OGDH catalytic subunits (E1 and E2) and PPARα were quantified by means of semi-quantitative reverse-transcription-PCR. 2-OGDH activity increased in response to administration of fenofibrate and bezafibrate (by 11, 24, 32% and 9, 12, 21%, respectively). The difference was statistically significant for the doses of 10 and 20 mg/kg b.wt of fenofibrate (p<0.001) and the highest dose of bezafibrate (p<0.05). Stimulation of 2-OGDH was not accompanied by changes in mRNA levels for E1 and E2. In addition, mRNA level for PPARα did not change. It is conceivable that fibrate-induced stimulation of 2-OGDH activity can affect renal metabolism and contribute to changes in kidney functions.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 281-288
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of physicochemical properties of solid dispersions of bcs class ii substances with chitosan
    Autorzy:
    Grimling, Bożena
    Górniak, Agata
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035366.pdf
    Data publikacji:
    2012
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    DSC studies
    chitosan
    dissolution
    fenofibrate
    solid state lyophilisation
    Opis:
    The BCS class II includes drugs with low solubility and high permeability. The substances require modification to increase their solubility in the upper part of the digestive system. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation by means of freeze-drying at the drug to polymer ratio of 3:7,5:5,7:3. The study revealed a multi-fold increase (from 33 to 57 times) in fenofibrat solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. DSC examination revealed a possible physical interaction between the drug and the polymer. The degree of lowering of temperature and increased heat effects is correlated with increased solubility of the drug in all the formulations. DSC studies confirmed that fenofibrate is present in solid dispersions in a crystalline form.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 87-94
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Investigation of fenofibrate dissolution rate incorporated on solid dispersions into chitosan
    Autorzy:
    Grimling, Bożena
    Szcześniak, Maria
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035351.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    dissolution
    fenofibrate
    molecular weight of the chitosan
    solid state
    Opis:
    The aim of the study was to investigate the effect of chitosan on the dissolution of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in physical mixtures at the drug to polymer ratio of 1:9, 3:7, and 5:5. The solubility investigation was performed by means of a dynamic method in a dissolution apparatus; mean amount of dissolved fenofibrate and the drug to polymer quantitative ratio in which the solid dispersion possessed the most beneficial properties improving the drug solubility were calculated. The study revealed a multi-fold increase (from 13 to 70 times) in fenofibrate solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. The dissolution rates of fenofibrate in the presence of chitosan at the weight ratio 1:9 increased with the increment of the molecular weight of the chitosan. The obtained results may help develop new technologies for fenofibrate preparations with chitosan, with better solubility characteristics, and thus increased bioavailability of the drug.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 149-156
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The investigation of physicochemical properties of the solid dispersions in the presence polymeric carrier- chitosan
    Autorzy:
    Grimling, Bożena
    Meler, Jan
    Pluta, Janusz
    Górniak, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1035561.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    DSC
    IR studies
    chitosan
    fenofibrate
    physical mixtures
    saturation solubility
    solid dispersions
    Opis:
    The BCS class II includes drugs with low solubility and high permeability.. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the saturation solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation and physical mixtures at the drug to polymer ratio of 1:9,3:7,5:5.Solid dispersion of fenofibrate containing different ratio of medium and high molecular weight chitosan showed high saturation solubility compared to pure sample of drug. IR spectroscopy reveals that there was no chemical interaction between drug and the polymer. DSC studies showed that there is no change in the crystal structure of drug during the solid dispersion technique. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 167-173
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of the physicochemical factors on dissolution of the substance of class ii bcs from solid dispersions with chitosan
    Autorzy:
    Grimling, Bożena
    Górniak, Agata
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035331.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    different molecular weights of chitosan
    fenofibrate
    solid dispersion prepared solvent evaporation
    solubility
    Opis:
    The BCS class II includes drugs with low solubility and high permeability. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan about average molecular weight in various formulations on the dissolution of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporations at the drug to polymer ratio of 1:9;3:7;5:5. The highest dissolution of fenofibrate, amounting to 72.7%, was observed after 60 minutes from solid dispersions with drug-polymer weight ratio 1:9 in the presence chitosan A and was72 times higher in relation to the amount of added polymer in comparison to the solubility of pure drug. Investigations DSC showed that fenofibrate was remained in crystalline state in solid dispersion.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 157-165
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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