Temat: Extracellular matrix - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Evaluation of the Levels of Metalloproteinsase-2 in Patients with Abdominal Aneurysm and Abdominal Hernias
Autorzy:: Antoszewska, Magdalena
Powiązania:: https://bibliotekanauki.pl/articles/1396355.pdf
Data publikacji:: 2013-05-01
Wydawca:: Index Copernicus International
Tematy:: abdominal aortic aneurysm
abdominal hernia
matrix metalloproteinases (MMP-s)
extracellular matrix (ECM)
fascia
Opis:: Abdominal aortic aneurysms and abdominal hernias become an important health problems of our times. Abdominal aortic aneurysm and its rupture is one of the most dangerous fact in vascular surgery. There are some theories pointing to a multifactoral genesis of these kinds of diseases, all of them assume the attenuation of abdominal fascia and abdominal aortic wall. The density and continuity of these structures depend on collagen and elastic fibers structure. Reducing the strengthof the fibersmaybedue to changes in the extracellular matrix (ECM) by the proteolytic enzymes-matrix metalloproteinases (MMPs) that degrade extracellular matrix proteins. These enzymes play an important role in the development of many disease: malignant tumors (colon, breast, lung, pancreas), cardiovascular disease (myocardial infarction, ischemia-reperfusion injury), connective tissue diseases (Ehler-Danlos Syndrome, Marfan’s Syndrome), complications of diabetes (retinopathy, nephropathy). One of the most important is matrix metalloproteinase-2 (MMP-2). The aim of the study was an estimation of the MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia, and in patients with only abdominal aortic aneurysm. Material and methods. The study involved 88 patients aged 42 to 89 years, including 75 men and 13 women. Patients were divided into two groups: patients with abdominal aortic aneurysm and primary abdominal hernia (45 persons, representing 51.1% of all group) and patients with only abdominal aortic aneurysm (43 persons, representing 48,9% of all group). Results. It was a statistically significant increase in MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia compared to patients with only abdominal aortic aneurysm. It was a statistically significant increase in the prevalence of POCHP in patients with only abdominal aortic aneurysm compared to patients with abdominal aortic aneurysm and primary abdominal hernia. Conclusions. Statistically significant higher MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia seems shows that this enzyme plays a role in the pathogenesis of primary abdominal hernias. The observed distribution of MMP-2 blood levels in patients with abdominal aortic aneurysm and primary abdominal hernia may raise the conclusion that this enzyme determines the presence of multi-organ failure of the connective tissue - the patients with only abdominal aortic aneurysm had significantly lower MMP-2 blood levels.
Źródło:: Polish Journal of Surgery; 2013, 85, 5; 271-278
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Rusztowania (scaffolds) stosowane w medycynie regenaracyjnej
Scaffolds for regenerative medicine
Autorzy:: Chaberska, A.
Rosiak, P.
Kamiński, Z. J.
Kolesińska, B.
Powiązania:: https://bibliotekanauki.pl/articles/172308.pdf
Data publikacji:: 2017
Wydawca:: Polskie Towarzystwo Chemiczne
Tematy:: medycyna regeneracyjna
samoorganizacja peptydów
biomimetyczne rusztowania
macierz pozakomórkowa
ECM
składniki funkcjonalne ECM
regenerative medicine
selfassembled peptides
biomimetic scaffolds
extracellular matrix
functional components of ECM
Opis:: The presence of three dimensional support is indispensable condition for successful regeneration of the tissue. In the absence of natural scaffold, or absence of its artificial substitute, regeneration is not possible. The advantage of natural building blocks to create new scaffolds results from the requirements of the materials structures used for tissue regeneration: biocompatibility, biodegradability, lack of cytotoxicity and desirable mechanical properties. Application of these building blocks for the preparation of three dimensional materials should ensure completely biocompatibility of the temporary extracellular matrix equivalent, thus offering construct resembling a natural milieu for the cells and finally regeneration of tissues. These include framework with elements stimulating adhesion of in vitro grown cells, growth factors, hormones and vitamins offered as a completed ingredients in the commercially available culture media. 3D frameworks applied for cell growing should facilitate formation of required tissue shape and size as well as appropriate functioning of the cells. The key factor for the successful regeneration of tissues is the function of the scaffold determining the environment for growing cells, directing proliferation and regulating differentiation processes. The basic feature of the cellular scaffold, determining its functioning is porosity. Pore diameter and their abundance consists a critical factor for penetration of cells into the interior of the implant and finally for successful regeneration of damaged tissue. The progress of tissue regeneration in vitro depends on the presence of cytokines and growth factors, which are controlling cell differentiation process. Nowadays neither of implant material offered on the market has a property comparable to the natural tissue. However, there are many reports presenting preliminary experiments conducted towards attaining novel supports for regenerative medicine derived from peptides and formed by their self-organization. The most advanced of them are known under trade name PuraMatrix, which recently were applied for the regeneration of soft tissues. However, due to tendency of this materials for hydrogels formation, characteristic for them are disadvantageous mechanical properties. The alternative approach based on application of native ECM proteins was also taken into consideration. The weak points of this materials are the susceptibility of proteins towards proteolytic enzymes and theirs immunogenic properties. The diversity of peptide modules give the opportunity to design and synthesize a variety of biomaterials that mimic the structural complexity of the natural ECM.
Źródło:: Wiadomości Chemiczne; 2017, 71, 3-4; 263-286
0043-5104
2300-0295
Pojawia się w:: Wiadomości Chemiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Endothelial cells on pet vascular prostheses impregnated with polyester-based copolymers and coated with cell-adhesive protein assemblies
Autorzy:: Chlupac, J.
Filova, E.
Riedel, T.
Brynda, E.
Pamuła, E.
Lisa, V.
Bacakova, L.
Powiązania:: https://bibliotekanauki.pl/articles/284406.pdf
Data publikacji:: 2008
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: vascular prostheses
polyethylene terephtalate
poly(glycolide-L-lactide)
poly(glycolide-L-lactide-(ε)caprolactone)
extracellular matrix
surface modification
collagen
laminin
fibronectin
fibrin
endothelial cells
static cell culture
Opis:: Arterial bypass surgery with synthetic vascular prostheses achieves poor patency rates compared to autogenous natural materials, and this is a challenge for tissue engineering research concerning small caliber vascular grafts. Modifications of the prosthetic surface followed by endothelial cell seeding may reduce thrombogenicity and intimal hyperplasia. Planar polyethylene terephthalate (PET) vascular prosthetic samples were impregnated with the copolymer poly(glycolide-L-lactide) (PGL) or with the terpolymer poly(glycolide-L-lactide-(e)caprolactone) (PGLCap) in order to lower the permeability of the knitted fabrics and ensure a less adhesive background. Subsequent modification with adhesive protein assemblies composed of collagen type I (Co) in conjunction with laminin (LM), fibronectin (FN) or fibrin (Fb) gel was performed to enhance cell adhesion. Bovine pulmonary artery endothelial cells (EC) of the CPAE line were seeded on to the coatings and subjected to static tissue culture conditions for 7 days. Impregnation of the PET prostheses decreased the initial adhesion and proliferation of the EC. After coating with the protein assemblies, the impregnated PET provided better substrates for cell culture than the protein-coated PET, on which the EC population started decreasing after 4 days of culture. The cells proliferated better on the CoFN, CoFb and CoFbFN coatings than on the Co and CoLM coatings. Impregnation type and adhesive matrix protein deposition may play an important role in successful endothelialization, healing and clinical performance of vascular grafts.
Źródło:: Engineering of Biomaterials; 2008, 11, no. 81-84; 108-111
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Growth suppression of human breast carcinoma stem cells by lipid peroxidation product 4-hydroxy-2-nonenal and hydroxyl radical-modified collagen
Autorzy:: Cipak, Ana
Mrakovcic, Lidija
Ciz, Milan
Lojek, Antonin
Mihaylova, Boryana
Goshev, Ivan
Jaganjac, Morana
Cindric, Marina
Sitic, Sanda
Margaritoni, Marko
Waeg, Georg
Balic, Marija
Zarkovic, Neven
Powiązania:: https://bibliotekanauki.pl/articles/1040399.pdf
Data publikacji:: 2010
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: collagen
4-hydroxynonenal
breast cancer stem cells
extracellular matrix
oxidative homeostasis
SUM159
Opis:: Breast cancer is a leading cause of mortality and morbidity in women, mostly due to high metastatic capacity of mammary carcinoma cells. It has been revealed recently that metastases of breast cancer comprise a fraction of specific stem-like cells, denoted as cancer stem cells (CSCs). Breast CSCs, expressing specific surface markers CD44+CD24-/lowESA+ usually disseminate in the bone marrow, being able to spread further and cause late metastases. The fundamental factor influencing the growth of CSCs is the microenvironment, especially the interaction of CSCs with extracellular matrix (ECM). The structure and function of ECM proteins, such as the dominating ECM protein collagen, is influenced not only by cancer cells but also by various cancer treatments. Since surgery, radio and chemotherapy are associated with oxidative stress we analyzed the growth of breast cancer CD44+CD24-/lowESA+ cell line SUM159 cultured on collagen matrix in vitro, using either native collagen or the one modified by hydroxyl radical. While native collagen supported the growth of CSCs, oxidatively modified one was not supportive. The SUM159 cell cultures were further exposed to a supraphysiological (35 µM) dose of the major bioactive lipid peroxidation product 4-hydroxynonenal (HNE), a well known as 'second messenger of free radicals', which has a strong affinity to bind to proteins and acts as a cytotoxic or as growth regulating signaling molecule. Native collagen, but not oxidised, abolished cytotoxicity of HNE, while oxidized collagen did not reduce cytotoxicity of HNE at all. These preliminary findings indicate that beside direct cytotoxic effects of anticancer therapies consequential oxidative stress and lipid peroxidation modify the microenvironment of CSCs influencing oxidative homeostasis that could additionally act against cancer.
Źródło:: Acta Biochimica Polonica; 2010, 57, 2; 165-171
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: The role of serum hyaluronic acid determination in the diagnosis of liver fibrosis
Autorzy:: Gudowska, Monika
Cylwik, Bogdan
Chrostek, Lech
Powiązania:: https://bibliotekanauki.pl/articles/1038585.pdf
Data publikacji:: 2017
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: hyaluronic acid
extracellular matrix
non-invasive marker
cirrhosis
fibrosis
hepatitis
Opis:: The common pathway leading to liver fibrosis and cirrhosis is growing deposition of extracellular matrix (ECM). It results from molecular and histological rearrangement of collagens, glycoproteins and hyaluronans. Hyaluronic acid is a chief component of the extracellular matrix of connective tissues and plays the main structural role in the formation of ECM. The most important organ involved in the synthesis of hyaluronic acid is the liver. In this paper the meaning of hyaluronic acid in the diagnostics of liver diseases is discussed. Here, we focus on the described changes of hyaluronic acid concentration in the pathological processes of the liver, including alcoholic and non-alcoholic liver diseases. The results of published clinical studies have shown its high diagnostic sensitivity, which probably enables its application in laboratory diagnosis.
Źródło:: Acta Biochimica Polonica; 2017, 64, 3; 451-457
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Podstawy etiopatogenezy procesu włóknienia wątroby
Basics of pathogenesis of liver firosis
Autorzy:: Gutkowski, Krzysztof
Powiązania:: https://bibliotekanauki.pl/articles/437961.pdf
Data publikacji:: 2012
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:: Włóknienie wątroby
macierz zewnątrzkomórkowa
komórki gwiaździste
metaloproteinazy
Liver firosis
extracellular matrix
stellate cells
metalloproteinases
Opis:: Włóknienie wątroby jest zło- żonym procesem biochemicznym, w którym uszkodzone obszary tkanki wątrobowej zostają otoczone przez macierz zewnątrzkomórkową z wytworzeniem tkanki bliznowatej. Proces ten rozwija się u pacjentów z przewlekłymi chorobami wątroby i jest uzależniony od rodzaju schorzenia i właściwo- ści osobniczych. Najwcześniej ulegają uszkodzeniu obszary, w których czynnik sprawczy uzyskuje największe stężenie, szczególnie u chorych z chorobą alkoholową i wirusowymi zapaleniami wątroby. Do rozwoju włóknienia dochodzi zwykle po wielu miesiącach lub latach działania czynnika uszkadzającego. Dokładny przedział czasowy, w którym włóknienie staje się nieodwracalne nie jest znany, jakkolwiek pojawiają się kolejne badania dowodzące, że nawet zaawansowane jego stadia mogą ulec regresji. Rozwikłanie mechanizmów molekularnych zaangażowanych w proces włóknienia posiada szereg implikacji klinicznych. Jedną z najistotniejszych jest tworzenie leków opóźniają- cych lub odwracających ten proces. W pracy przedstawiono aktualny stan wiedzy na temat kluczowych mechanizmów leżących u podłoża procesu włóknienia wątroby.
Liver firosis is a complicated biochemical process in which damaged regions of the liver tissue are encapsulated by an extracellular matrix with scar formation. It develops in all patients with chronic liver injury at variable rates depending in part upon the cause of liver disease and in part upon the host factors. This process occurs earliest in regions where injury is most severe, particularly in chronic inflmmatory liver diseases due to alcohol or viral infection. The development of firosis usually requires several months to years of ongoing injury. The exact point in which firosis becomes irreversible is unknown however, increasing evidence suggests that even advanced stages of fibrosis may be reversible. An understanding of the molecular mechanisms involved in firogenesis process has a number of clinical implications. One of the most important is development of therapeutic interventions designed to impede or reverse hepatic firosis. This review discusses the current mechanisms underlying liver firosis.
Źródło:: Medical Review; 2012, 4; 402-409
2450-6761
Pojawia się w:: Medical Review
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Numerical experiments with model equations of cancer invasion of tissue
Autorzy:: Kolev, M.
Zubik-Kowal, B.
Powiązania:: https://bibliotekanauki.pl/articles/206179.pdf
Data publikacji:: 2011
Wydawca:: Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:: in vivo tumorigenicity
cancer cells
proliferation
chemotaxis
haptotaxis
extracellular matrix
tumour invasion
mathematical model
animal models
approximations
Opis:: In this paper we investigate a mathematical model of cancer invasion of tissue, which incorporates haptotaxis, chemotaxis, proliferation and degradation rates for cancer cells and the extracellular matrix, kinetics of urokinase receptor, and urokinase plasminogen activator cycle. We solve the model using spectrally accurate approximations and compare its numerical solutions with laboratory data. The spectral accuracy allows to use low-dimensional matrices and vectors, which speeds up the computations of the numerical solutions and thus to estimate the parameter values for the model equations. Our numerical results demonstrate correlations between numerical data computed from the mathematical model and in vivo tumour growth rates from prostate cell lines.
Źródło:: Control and Cybernetics; 2011, 40, 3; 779-791
0324-8569
Pojawia się w:: Control and Cybernetics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Muscle cathepsins of marine fish and invertebrates
Autorzy:: Kolodziejska, I.
Sikorski, Z.E.
Powiązania:: https://bibliotekanauki.pl/articles/1372835.pdf
Data publikacji:: 1995
Wydawca:: Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:: invertebrate
endopeptidase
fish
structure
protease
extracellular matrix
lysosome
exopeptidase
cathepsin C
cathepsin A
muscle protein
myofibrillar protein
lysosomal protease
marine fish
protein
myofibril
muscle cathepsin
food preservation
sarcoplasm
cathepsin L
carboxypeptidase A
cathepsin B
Opis:: Muscle proteases are located mainly in the lysosomes, in the sarcoplasm, and in the extracellular matrix of the connective tissue surrounding each cell. The lysosomal proteases, cathepsins, have optimum activity in the acidic range, although many of them retain high activity also 1 or 2 pH units away from the optimum value. Among the cathepsins there are endopeptidases and exopeptidases. Most cathepsins hydrolyse several proteins of the myofibrils. The major protease of the lysosomes in fish and squid muscles is cathepsin D, an aspartyl endoproteinase. Although it is present in the muscle fibre itself, its generally rather low activity at low temperature limits its significance in tenderization of refrigerated fish of most species. Cathepsin L, a cysteinyl protease, is involved in autolysis and softening in matured chum salmon. Cathepsin B, a cysteinyl carboxypeptidase, is capable to attack also some myofibrillar proteins. Cathepsin A or carboxypeptidase A, and cathepsin C, a dipeptidyl hydrolase and dipeptidyl transferase, contribute to the hydrolysis of muscle proteins in a concerted action with the other cathepsins.
Źródło:: Polish Journal of Food and Nutrition Sciences; 1995, 04, 3; 3-10
1230-0322
2083-6007
Pojawia się w:: Polish Journal of Food and Nutrition Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Chemical and physical modifications of electrospun fibers as a method to stimulate tissue regeneration – minireview
Autorzy:: Kurpanik, Roksana
Stodolak-Zych, Ewa
Powiązania:: https://bibliotekanauki.pl/articles/1844869.pdf
Data publikacji:: 2021
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: electrospun fibers
fibrous scaffold
surface modification
extracellular matrix
Opis:: Fibrous scaffolds based on (bio)polymers are ob¬served as mimicking the microstructure of the extracel¬lular matrix. Thus, they are considered as an example of a utilitarian scaffold, useful for the regeneration of various types of tissues. The techniques described in the literature are well known to obtain submicrometric and nanometric fibers that, when randomly arranged, mimic the ECM. The biomimetic scaffold criterion might be even better reflected if the cell adhesion sites are present on the surface of such fibers. They promote the formation of the focal adhesion contact or facilitate the formation of a protein film on the fiber surface. Such a process is enhanced by an appropriate physical or chemical modification that activates the protein adsorption and the subsequent cell adhesion. The aim of this paper is to present different methods of physical and/or chemi¬cal modifications of fibrous materials: which can serve as scaffolds to support the regeneration processes of various tissues. In terms of physical methods, only weak interactions between the surface and the modi¬fier were observed. This technique is simple but not durable. Chemisorption used as a second method of fiber modification is possible if a covalent or ionic bond is formed between the fiber and the modifier. Therefo¬re, the chemical adsorption may not be fully reversible and requires a sequence of chemical actions to form a chemical bond. The most commonly used methods are the combined methods where the first step is the physical activation of the fiber surface, which facilitates the chemical modification step.
Źródło:: Engineering of Biomaterials; 2021, 24, 159; 31-41
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Genetic Variation as a Possible Explanation for the Heterogeneity of Pain in Tendinopathy: What can we learn from other pain syndromes?
Autorzy:: Mkumbuzi, Nonhlanhla S.
Posthumus, Michael
September, Alison V.
Collins, Malcolm
Powiązania:: https://bibliotekanauki.pl/articles/1942934.pdf
Data publikacji:: 2021
Wydawca:: Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:: tendon pain
genetics
extracellular matrix genes
inflammation genes
COMT
Opis:: The mechanisms of pain in tendinopathy are unclear. Current theories implicate tendon structural changes, neovascularisation, inflammation or changes in central pain processing. As with other types of musculoskeletal pain, tendon pain has high interindividual variability and, as with other types of pain, this could be attributed to genetic variation. Notably, the association between certain genetic polymorphisms and susceptibility to tendinopathy is well established in the literature. Therefore, the investigation of the mechanisms of tendon pain should also extend to include genetic variation as a possible explanation for the clinical features of tendon pain. This review summarises the current knowledge on genetic contributors to chronic pain and highlights findings that are relevant to chronic tendon pain. In particular, based on the current hypotheses on the possible sources of tendon pain, it focuses on findings that relate to genes that encode structural connective tissue components, inflammatory markers, ion channels and catecholamines and how they may relate to chronic tendon pain. In the absence of a definitive mechanism of tendon pain, an a priori genetic approach that is guided by these current hypotheses may help elucidate the mechanisms of tendon pain which may allow a more rational approach to research and treatment.
Źródło:: Central European Journal of Sport Sciences and Medicine; 2021, 36; 57-72
2300-9705
2353-2807
Pojawia się w:: Central European Journal of Sport Sciences and Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Matrix metalloproteinases in urinary system tumours. Part I - Matrix metalloproteinases in renal cell carcinoma
Autorzy:: Młynarczyk, G.
Kudelski, J.
Darewicz, B.
Galewska, Z.
Romanowicz, L.
Powiązania:: https://bibliotekanauki.pl/articles/1918434.pdf
Data publikacji:: 2017
Wydawca:: Uniwersytet Medyczny w Białymstoku
Tematy:: Extracellular matrix
matrix metalloproteinases
urinary tract tumours
renal clear cell carcinoma
Opis:: Extracellular matrix metalloproteinases - MMPs, also referred to as matrixines, provide a group of proteolytic enzymes. They belong to the family of endopeptidases that break down elements of extracellular matrix, resulting in its continuous remodelling. Their activity is regulated at multiple levels, while tissue inhibitors of metalloproteinases play a major role in this process. Metalloproteinases play a significant part in neoplastic processes due to their contribution to local tumour invasion and formation of distant metastases, as well as to angiogenesis Urinary tract tumours pose a significant diagnostic and therapeutic challenge and their incidence tends to grow every year. The aim of this part of review is to describe extracellular matrix and matrix metalloproteinases and to highlight the contribution of matrix metalloproteinases in the development of renal clear cell carcinoma.
Źródło:: Progress in Health Sciences; 2017, 7(1); 161-168
2083-1617
Pojawia się w:: Progress in Health Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Glycosaminoglycans – types, structure, functions, and the role in wound healing processes
Glikozoaminoglikany – rodzaje, struktura, funkcje i rola w procesach gojenia ran
Autorzy:: Orlińska, Kinga
Komosińska-Vassev, Katarzyna
Olczyk, Krystyna
Kowalczyk, Aleksandra
Olczyk, Paweł
Powiązania:: https://bibliotekanauki.pl/articles/18105091.pdf
Data publikacji:: 2023-11-07
Wydawca:: Śląski Uniwersytet Medyczny w Katowicach
Tematy:: glycosaminoglycans
extracellular matrix
proteoglycans
wound healing
glikozoaminoglikany
macierz pozakomórkowa
proteoglikany
gojenie ran
Opis:: Glycosaminoglycans (GAGs) are a group of heteropolysaccharides, which include: chondroitin sulfates, dermatan sulfates, heparan sulfates, heparin, keratan sulfates, and hyaluronic acid. GAGs are composed of negatively charged polysaccharide chains composed of repeating disaccharide units, which include N-acetylated hexosamine residues – D-glucosamine or D-galactosamine – or N-sulfated D-glucosamine and hexuronic acid residues – D-glucuronic or L-iduronic acid – or galactose. All GAGs, except for hyaluronic acid, have a sulfate group and form proteoglycans (PGs) when attached to the core proteins. GAGs have many important biological functions influencing PGs functions. PGs are present in all types of tissues and participate in cell migration, proliferation, and differentiation. They occur mainly in the extracellular matrix (ECM), where they participate in ECM organization, structure formation and mechanical properties. They play an important role in maintaining homeostasis and also influence metabolic processes, such as bone mineralization and blood coagulation. PGs (due to the strongly negative charge of the glycan chains) are involved in the selective permeability of cell membranes. Components of the ECM, including GAGs, play a structural and functional role during the healing of tissue damage. They regulate the healing process by acting as a reservoir and modulator for cytokines and growth factors and perform structural functions by filling tissue defects during the repair process.
Glikozoaminoglikany (glycosaminoglycans – GAGs) są grupą heteropolisacharydów, w której skład wchodzą: siarczany chondroityny, siarczany dermatanu, siarczany heparanu, heparyny, siarczany keratanu oraz kwas hialuronowy. GAGs zbudowane są z ujemnie naładowanych łańcuchów polisacharydowych, złożonych z powtarzających się jednostek disacharydowych, do których należą reszty N-acetylowanej heksozoaminy – D-glukozoaminy lub D-galaktozoaminy – albo N-siarczanowanej D-glukozoaminy oraz reszty kwasu heksuronowego – D-glukuronowego lub L-iduronowego – albo galaktozy. Wszystkie GAGs, z wyjątkiem kwasu hialuronowego, posiadają grupę siarczanową oraz tworzą, po przyłączeniu do białek rdzeniowych, proteoglikany (proteoglycans – PGs). GAGs pełnią wiele ważnych biologicznych funkcji, determinujących funkcje PGs. Te ostatnie są obecne we wszystkich rodzajach tkanek, uczestniczą w procesach migracji, proliferacji i różnicowania komórek. Występują głównie w macierzy pozakomórkowej (extracellular matrix – ECM), biorąc udział w organizacji ECM, kształtując jej strukturę i właściwości mechaniczne. Pełnią istotną rolę w utrzymaniu homeostazy, a także wywierają wpływ na szereg procesów metabolicznych, takich jak mineralizacja kości i krzepnięcie krwi. PGs (ze względu na silnie ujemny ładunek łańcuchów glikanowych) biorą udział w selektywnej przepuszczalności błon komórkowych. Składniki ECM, w tym GAGs, odgrywają rolę strukturalno-czynnościową podczas gojenia się uszkodzeń tkankowych. Regulują proces gojenia poprzez stanowienie rezerwuaru i modulatora dla cytokin i czynników wzrostu oraz pełnią funkcje strukturalne poprzez wypełnianie ubytków tkankowych podczas procesu naprawczego.
Źródło:: Annales Academiae Medicae Silesiensis; 2023, 77, 1; 204-216
1734-025X
Pojawia się w:: Annales Academiae Medicae Silesiensis
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Inflammatory bowel disease: the function of metalloproteinases
Autorzy:: Pasternak, Grzegorz
Aebisher, David
Filip, Rafał
Bartusik-Aebisher, Dorota
Powiązania:: https://bibliotekanauki.pl/articles/454718.pdf
Data publikacji:: 2018
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:: inflammatory bowel disease
matrix metalloproteinases extracellular matrix
Opis:: Introduction. Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Aim. The aim of this work was to review the current literature regarding matrix metalloproteinases. The databases such as PubMed, ScienceDirect and Springer were utilized to search the literature for relevant articles. Materials and methods. An analysis of literature. We collected information, data, and examples of the function of metalloproteinases. Results. Herein we show that metalloproteinases play a role in such processes as the immune response, angiogenesis, the epithelial barrier function, fibrosis induced by the inflammatory process, and in the process of carcinogenesis. Conclusions. Further studies on the role of metalloproteinases in the process of carcinogenesis associated with inflammatory bowel diseases are required.
Źródło:: European Journal of Clinical and Experimental Medicine; 2018, 4; 346-349
2544-2406
2544-1361
Pojawia się w:: European Journal of Clinical and Experimental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Extracellular matrix surface network is associated with non-morphogenic calli of Helianthus tuberosus cv. Albik produced from various explants
Autorzy:: Pilarska, M.
Popielarska-Konieczna, M.
Slesak, H.
Kozieradzka-Kiszkurno, M.
Goralski, G.
Konieczny, R.
Bohdanowicz, J.
Kuta, E.
Powiązania:: https://bibliotekanauki.pl/articles/58028.pdf
Data publikacji:: 2014
Wydawca:: Polskie Towarzystwo Botaniczne
Tematy:: callogenesis
extracellular matrix
surface network
in vitro culture
non-morphogenic callus
Helianthus tuberosus
Albik cultivar
explant
transmission electron microscopy
Opis:: Helianthus tuberosus is economically important species. To improve characters of this energetic plant via genetic modification, production of callus tissue and plant regeneration are the first steps. A new, potentially energetic cultivar Albik was used in this study to test callus induction and regeneration. Callus was produced on leaves, petioles, apical meristems and stems from field-harvested plants but was totally non-morphogenic. Its induction started in the cortex and vascular bundles as confirmed by histological analysis. The surface of heterogeneous callus was partially covered with a membranous extracellular matrix surface network visible in scanning and transmission electron microscopies. The results clearly indicate that: (i) the morphogenic capacity of callus in topinambur is genotype dependent, (ii) cv. Albik of H. tuberosus proved recalcitrant in in vitro regeneration, and (iii) extracellular matrix surface network is not a morphogenic marker in this cultivar.
Źródło:: Acta Societatis Botanicorum Poloniae; 2014, 83, 1
0001-6977
2083-9480
Pojawia się w:: Acta Societatis Botanicorum Poloniae
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Measuring the mechanics of morphogenesis
Autorzy:: Routier-Kierzkowska, A.-L.
Weber, A.
Kierzkowski, D.
Nakayama, N.
Mosca, G.
Huflejt, M.
Barbierde Reuille, P.
Felekis, D.
Nelson, B.
Kuhlemeier, C.
Smith, R.S.
Powiązania:: https://bibliotekanauki.pl/articles/80791.pdf
Data publikacji:: 2013
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: conference
cellular level
plant cell
osmotic potential
extracellular matrix
polysaccharide
plant morphogenesis
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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