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    Wyświetlanie 1-6 z 6
    Tytuł:
    Possibilities of nanodiamonds application – biological and medical aspects
    Autorzy:
    Solarska-Ściuk, Katarzyna
    Kleszczyńska, Halina
    Powiązania:
    https://bibliotekanauki.pl/articles/895695.pdf
    Data publikacji:
    2019-10-30
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    biocompatibility
    Endocytosis
    drug transporters
    diamond nanoparticles
    surface functionalization
    Opis:
    This topical review briefly discusses selected highlights of research on diamond nanoparticles obtained by different methods and their potential applications in biology and medicine. In recent years nanotechnology has aroused interest of large number of scientists who endeavor to obtain nanoparticles (which differ in size and structure of surface) using different methods, in order to determine their physical, chemical and biological properties that are in relation to the methods used in the process of their production. The knowledge developed in this way will be beneficial in an attempt to use nanoparticles more reasonably in various branches of science. The distinguishing features of carbon nanoparticles are their biocompatibility, photostability and easily chemically modified surface that result in high usefulness for intarcellular studies. What is more, low toxicity of nanoparticles with many cell lines is at the center of scientific interest. This, in turn, leads to a large number of biomedical applications. The property that nanodiamonds are able to penetrate into cells through endocytosis, allows to deliver the drug connected with nanoparticles into cancer cells. These features of nanoparticles have given many promising leads in nanooncology, in particular in drug delivery, diagnosis, imaging and therapy. This paper presents a summary of different classes of nanodiamond particles, the ways of their uptake into cells, an overview of the possible application of nanoparticles as nanocarriers and as a clinical theranostic platform, as well as advantages and disadvantages of using nanodiamonds in biomedicine.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 779-796
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Saccharomyces cerevisiae - a model organism for the studies on vacuolar transport.
    Autorzy:
    Kucharczyk, Róża
    Rytka, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1044044.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    vacuole
    vesicles
    intracellular transport
    phagocytosis
    endocytosis
    yeast
    Opis:
    The role of the yeast vacuole, a functional analogue of the mammalian lysosome, in the turnover of proteins and organelles has been well documented. This review provides an overview of the current knowledge of vesicle mediated vacuolar transport in the yeast Saccharomyces cerevisiae cells. Due to the conservation of the molecular transport machinery S. cerevisiae has become an important model system of vacuolar trafficking because of the facile application of genetics, molecular biology and biochemistry.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 4; 1025-1042
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mechanosensitivity of cell membrane may govern creep-strain recovery, osmotic expansion and lysis
    Autorzy:
    Pawłowski, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1040543.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    mechanosensitivity
    caveolae
    exocytosis
    surface tension
    endocytosis
    cell membrane
    Opis:
    A simple theoretical model considering cell membrane mechanosensitivity can accurately describe published experimental data on membrane area creeping and recovery, and on osmotic expansion and rupture. The model to data fit reveals real values of membrane tension and elasticity modulus, and the parameters describing membrane organization and kinetics of mechanosensitive membrane traffic, including small solute transport, water permeability, endocytosis, exocytosis, and caveolae formation. This estimation allows for separation and quantitative analysis of the participation of different processes constituting the response of plasmalemma to short time-scale membrane load. The predicted properties of the model were verified for membrane stretching at different osmotic pressures. Finally, a simple hypothesis concerning stressed cell membrane breakdown is postulated.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 3; 471-480
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Distinct role of clathrin-mediated endocytosis in the functional uptake of cholera toxin
    Autorzy:
    Broeck, Davy
    Lagrou, Albert
    De Wolf, Marc
    Powiązania:
    https://bibliotekanauki.pl/articles/1040864.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    clathrin-mediated endocytosis
    internalization
    chlorpromazine
    Cholera toxin
    siRNA
    Opis:
    The involvement of the clathrin-mediated endocytic internalization route in the uptake of cholera toxin (CT) was investigated using different cell lines, including the human intestinal Caco-2 and T84 cell lines, green monkey Vero cells, SH-SY5Y neuroblastoma cells and Madin-Darby canine kidney cells. Suppression of the clathrin-mediated endocytic pathway by classical biochemical procedures, like intracellular acidification and potassium depletion, inhibited cholera toxin uptake by up to about 50% as well as its ability to raise intracellular levels of cAMP. Also prior exposure of these cell types to the cationic amphiphilic drug chlorpromazine reduced the functional uptake of cholera toxin, even to a greater extent. These effects were dose- and cell type-dependent, suggesting an involvement of clathrin-mediated endocytosis in the functional uptake of cholera toxin. For a more straightforward approach to study the role of the clathrin-mediated uptake in the internalization of cholera toxin, a Caco-2eps- cell line was exploited. These Caco-2eps- cells constitutively suppress the expression of epsin, an essential accessory protein of clathrin-mediated endocytosis, thereby selectively blocking this internalization route. CT uptake was found to be reduced by over 60% in Caco-2eps- paralleled by a diminished ability of CT to raise the level of cAMP. The data presented suggest that the clathrin-mediated uptake route fulfils an important role in the functional internalization of cholera toxin in several cell types.
    Źródło:
    Acta Biochimica Polonica; 2007, 54, 4; 757-767
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Contrasting patterns in the evolution of the Rab GTPase family in Archaeplastida
    Autorzy:
    Petrzelkova, R.
    Elias, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/59340.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Botaniczne
    Tematy:
    evolution
    Archaeplastida
    Rab GTPase
    endocytosis
    Glaucophyta
    Rhodophyta
    primary plastid
    Opis:
    Rab GTPases are a vast group of proteins serving a role of master regulators in membrane trafficking in eukaryotes. Previous studies delineated some 23 Rab and Rab-like paralogs ancestral for eukaryotes and mapped their current phylogenetic distribution, but the analyses relied on a limited sampling of the eukaryotic diversity. Taking advantage of the recent growth of genome and transcriptome resources for phylogenetically diverse plants and algae, we reanalyzed the evolution of the Rab family in eukaryotes with the primary plastid, collectively constituting the presumably monophyletic supergroup Archaeplastida. Our most important novel findings are as follows: (i) the ancestral set of Rabs in Archaeplastida included not only the paralogs Rab1, Rab2, Rab5, Rab6, Rab7, Rab8, Rab11, Rab18, Rab23, Rab24, Rab28, IFT27, and RTW (=Rabl2), as suggested previously, but also Rab14 and Rab34, because Rab14 exists in glaucophytes and Rab34 is present in glaucophytes and some green algae; (ii) except in embryophytes, Rab gene duplications have been rare in Archaeplastida. Most notable is the independent emergence of divergent, possibly functionally novel, in-paralogs of Rab1 and Rab11 in several archaeplastidial lineages; (iii) recurrent gene losses have been a significant factor shaping Rab gene complements in archaeplastidial species; for example, the Rab21 paralog was lost at least six times independently within Archaeplastida, once in the lineage leading to the “core” eudicots; (iv) while the glaucophyte Cyanophora paradoxa has retained the highest number of ancestral Rab paralogs among all archaeplastidial species studied so far, rhodophytes underwent an extreme reduction of the Rab gene set along their stem lineage, resulting in only six paralogs (Rab1, Rab2, Rab6, Rab7, Rab11, and Rab18) present in modern red algae. Especially notable is the absence of Rab5, a virtually universal paralog essential for the endocytic pathway, suggesting that endocytosis has been highly reduced or rewired in rhodophytes.
    Źródło:
    Acta Societatis Botanicorum Poloniae; 2014, 83, 4
    0001-6977
    2083-9480
    Pojawia się w:
    Acta Societatis Botanicorum Poloniae
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Peptydy penetrujące : rodzaje i mechanizmy przenikania przez błony komórkowe
    Cell-penetrating peptides : types and mechanisms of penetration
    Autorzy:
    Kawczyński, M. T.
    Kreczko-Kurzawa, J.
    Maćkiewicz, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/172725.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    peptydy penetrujące
    penetratyna
    endocytoza
    amfipatyczność
    CPP
    cell-penetrating peptides
    penetratin
    endocytosis
    amphipaticity
    Opis:
    Before discovery of the Tat peptide over twenty years ago, it was assumed that large peptides and proteins do not penetrate cell membranes. After discovery of Tat, Penetratin [1, 2] and several other peptides of natural origin, able to cross the cell membranes in an energy-independent manner, the structural determinants of their cell-penetrating potency were established, including polycationic character, amphipaticity and presence of proline-rich motifs [3, 4]. Currently known cell-penetrating peptides of natural or synthetic origin are composed of 5 to 40 amino acid residues and belong to one of the three families: oligocationic, amphipatic or proline-rich and penetrate the biological membranes by endocytosis or other ways of direct translocation. Most of these translocation mechanisms are not exclusive and may occur simultaneously, and their contribution may be different for each peptide depending on the conditions (e.g. CPP concentration, pH, etc.). Most CPPs demonstrate little or no mammalian cell toxicity what makes them promising vectors for drug delivery. Such vectors might be useful for efficient internalization of compounds otherways poorly penetrating biological membranes. Novel CPP-effector conjugates may become effective anticancer or antimicrobial agents of a great potential for chemotherapy [3, 5]. In this short review we present a glimpse at the current state of knowledge concerning sub‑families, types and mechanisms of action of most prominent members of CPP family.
    Źródło:
    Wiadomości Chemiczne; 2015, 69, 1-2; 9-33
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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