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Tytuł:
Modulation of Doxorubicin Cytotoxicity by Isoliquiritin and Cynarin Combination on Different Cancer Cell Lines
Autorzy:
Al-AdamI, Salat G.
Al-Khateeb, EKBAL H.
NUMAN, NAWFAL A.
ABBAS, Mannal M.
Tawfiq, FATIMA A.
Shakya, Ashok K.
Powiązania:
https://bibliotekanauki.pl/articles/895633.pdf
Data publikacji:
2020-06-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
cytotoxicity
doxorubicin
cancer cells
Modulation
Cynarin
Isoliquiritin
Opis:
Natural polyphenolic compounds produced by plant exhibit many pharmacological effects including antioxidant, chemopreventive as well as anticancer properties. This study was conducted to investigate the effect of cynarin ( from Artichoke, Cynara scolymus) and isoliquiritin (from Licorice, Glycyrrhiza uralensis) on doxorubicin (positive control) cytotoxicity in different cell lines including normal (Fibroblasts MCR-5 and Myoblasts H9c2) and cancer (colorectal HCT-116 and hepatocellular HEP-G2) cell lines. The cytotoxic effect of doxorubicin, isoliquiritin and cynarin alone or in different combination was studied on cancer cell lines as well as normal cell lines. The results obtained indicated that both cynarin and isoliquiritin enhance the cytotoxicity of doxorubicin. Both cynarin and isoliquiritin also reduce the cardiotoxicity of doxorubicin on normal cardiac cell lines. The combination of the three compounds (cynarin, isoliquiritin and doxorubicin) result in decrease the cytotoxicity of doxorubicin, which may indicate the presence of interaction and/or antagonism effect between cynarin and isoliquiritin. Cynarin was found to enhance the growth of (HCT-116 and HEP-G2) this might suggest avoiding use of Artichoke in subjects’ susceptibility for these cancers. All results were evaluated using statistical path and showed significant findings. The mechanism of enhanced doxorubicin’s cytotoxicity by cynarin or isoliquiritin also require further investigation to explain the increasing and/or the decreasing effect of these polyphenolic compounds on cytotoxicity of doxorubicin. The current finding can help to start with safe minimum dose of two or three combination of compounds in the context of clinical trials and practice.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 475-484
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anticancer activity of some new series of 2-(substituted)amino-1,3-thiazole derivatives
Autorzy:
Bakare, Safyah B.
Powiązania:
https://bibliotekanauki.pl/articles/780055.pdf
Data publikacji:
2019
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Thiazole
Anticancer
Cell Cycle Analysis
Annexin V
FITC
Doxorubicin
Opis:
A series of thiazole derivatives were synthesized and structurally elucidated by IR, 1H NMR, 13C NMR, mass and elemental analyses. The prepared compounds were screened for their cytotoxic activity against Leukemia HL-60 cell line. Compound 4b was considered as the most promising antitumor candidate among the tested compounds. Mechanism of action of compound 4b evaluated by flow cytometric assay revealed cell cycle arrest at G2/M phase and pre-G1 apoptosis. The ratio of apoptosis was also determined. Moreover, compound 4b increased the concentration of caspase 3 by 4 fold more than untreated control.
Źródło:
Polish Journal of Chemical Technology; 2019, 21, 3; 19-25
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Administration of liposomal doxorubicin in patients with metastatic breast cancer and significant concomitant cardiovascular conditions
Autorzy:
Bryjak, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/773565.pdf
Data publikacji:
2014
Wydawca:
Medical Education
Tematy:
NLPD
cardiotoxicity
conventional anthracyclines
liposomal doxorubicin
metastatic breast cancer
Opis:
A frequent dilemma faced by an oncologist about to take decision on a chemotherapeutic regime for patients with metastatic breast cancer is how to maintain balance between the expected treatment efficacy and predictable adverse events. In the case of anthracyclines what is problematic is their significant cardiotoxicity, in particular with reference to patients previously treated with them as part of adjuvant therapy. A relatively new method is replacement of conventional doxorubicin with its non-pegylated form, encapsulated in liposomes, which is capable of minimizing the side effects without compromising its therapeutic index. The present article discusses three cases of patients treated with non-pegylated liposomal doxorubicin (NPLD) as first-line chemotherapy administered for metastatic breast cancer. In all three cases considerable clinical improvement was observed, involving remission of pathological lesions and good quality of life.
Źródło:
OncoReview; 2014, 4, 4; A148-A154
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Liposomal doxorubicin in first line metastatic HER-2-positive breast cancer for prevention the cardiotoxicity
Autorzy:
Chmielowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1065040.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
HER-2 overexpression
cardiotoxicity
liposomal doxorubicin
Opis:
We describe a 62 year old female with metastatic HER-2-positive breast cancer, and with independent cardiovascular comorbidities. She was earlier treated with J131 therapy due to thyroid toxicity. She developed grade 2 mitral and tricuspid valvular insufficiency as a result of uncontrolled hypertension. In 2013, the patient was diagnosed with luminal B2 breast cancer with liver and bone metastases, and a large infiltration of the left breast together with the surrounding soft tissue. She was treated with liposomal doxorubicin and cyclophosphamide, with the dose of anthracycline slightly reduced to 50 mg/m2 because of the elevated liver enzymes. She was in complete remission during treatment, without any cardiac or hematologic toxicity. The treatment was prolonged to eight cycles until the liver tests returned to normal. The cumulative dose of liposomal doxorubicin amounted to 400 mg/m2 (with the maximum recommended dose of 600 mg/m2). We decided to administer the liposomal form of doxorubicin, which is less cardiotoxic than conventional doxorubicin, as first-line treatment in order to prevent cardiotoxicity in a patient who is a candidate for another cardiotoxic therapy involving trastuzumab in the future. The patient’s disease progressed 10 months following the completion of first-line therapy. There are no cardiologic contraindications to trastuzumab and there are no signs of liposomal doxorubicin-related cardiotoxicity or deterioration of the valvular insufficiency.
Źródło:
OncoReview; 2015, 5, 1; A11-A15
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Badanie wpływu Selolu na ekspresję genów kodujących transportery błonowe i enzymy metabolizujące leki w komórkach nowotworowych wrażliwych i opornych
A study of the effect of Selol on the expression of genes encoding membrane transporters and drugs metabolism enzymes in sensitive and resistant tumour cells
Autorzy:
Dudkiewicz Wilczyńska, Jadwiga
Grabowska, Agnieszka
Książek, Iza
Nowak, Karolina
Anuszewska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/1035141.pdf
Data publikacji:
2011
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
ekspresja genów
selol 5%
doksorubicyna
hela
kb-v1
gene expression
doxorubicin
hela cells
kb-v1 cells
Opis:
The objective of this study was to demonstrate diff erences in the gene expression of human cervical cancer cells (HeLa) and vinblastine-resistant KB-V1 subline treated with doxorubicin alone and combination of Selol 5% and doxorubicin. Ongoing studies seek to clarify the mechanism of action of Selol in diff erent types of cancer cells, including those which show multidrug resistance. Cells treatment with the tested compounds in the group of genes tested in HeLa cells causes other changes than in KB-V1 cells. In the resistant cells, exposure to Selol 5% and doxorubicin, released the cytotoxic eff ects by changing the expression of ABCC2 and BCL2L1 genes. The observed dependence also allows better understanding the molecular mechanisms of resistance in the KB-V1 cell line.
Celem pracy było wykazanie różnic w ekspresji genów komórek ludzkiego nowotworu szyjki macicy (HeLa) i opornej na winblastynę podlinii KB-V1, poddanych działaniu samej doksorubicyny oraz po łącznym podaniu Selolu 5% i doksorubicy. Prowadzone badania zmierzają do wyjaśnienia mechanizmu działania Selolu w różnych typach komórek nowotworowych, w tym opornych wielolekowo. Poddanie komórek działaniu testowanych związków powoduje inne zmiany w grupie badanych genów w komórkach HeLa niż w komórkach KB-V1. Łączne podanie Selolu 5% i doksorubicyny wyzwala efekt cytotoksyczny w komórkach opornych KB-V1, co przypuszczalnie jest związane ze zmianą ekspresji genów ABCC2 i BCL2L1. Zaobserwowana zależność pozwala także lepiej zrozumieć molekularne podłoże oporności komórek linii KB-V1.
Źródło:
Annales Academiae Medicae Silesiensis; 2011, 65, 5-6; 7-13
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sarcomatoid renal-cell carcinoma: treatment strategy, review of the literature and a case report
Autorzy:
Gębara-Puchniarz, Agnieszka
Hryciuk, Beata
Stec, Rafał
Szczylik, Cezary
Grala, Bartłomiej
Kozłowski, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1064804.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
chemotherapy
doxorubicin
gemcitabine
sarcomatoid renal-cell carcinoma
surgical treatment
Opis:
Introduction: Sarcomatoid renal-cell carcinoma is a very rare cancer characterised with aggressive course of disease and poor prognosis. At present there are no standards of care for this histologic subtype of renal cell carcinoma resistant to various forms of systemic treatment. Methods: The study describes a case of 58 year old woman after left nephrectomy for clear cell carcinoma with sarcomatoid component and after resection of right-kidney tumour for synchronous clear cell carcinoma who received first-line bevacizumab and temsirolimus under the clinical trial, and then second-line chemotherapy based on gemcitabine and doxorubicin and ifosfamide-based third-line chemotherapy. The patient underwent pulmonary metastasectomy twice, and once a metastasectomy for liver metastases. Conclusions: Surgery (including metastases treatment) followed by the systemic chemotherapy seems to be correct option of treatment in patients with renal cell carcinoma with sarcomatoid features. The development of optimum method of systemic treatment requires further prospective randomised trials.
Źródło:
OncoReview; 2016, 6, 4; A184-187
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of genes involved in response to doxorubicin and a GD2 ganglioside-specific 14G2a monoclonal antibody in IMR-32 human neuroblastoma cells
Autorzy:
Horwacik, Irena
Durbas, Małgorzata
Boratyn, Elżbieta
Sawicka, Anna
Węgrzyn, Paulina
Krzanik, Sylwia
Górka, Anna
Drożniak, Joanna
Augustyniak, Ewa
Kowalczyk, Aleksandra
Rokita, Hanna
Powiązania:
https://bibliotekanauki.pl/articles/1038977.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
doxorubicin
GD2 ganglioside
microarray
14G2a
neuroblastoma
mimitin
Opis:
Neuroblastoma is the most common extra-cranial solid tumor of childhood and it is characterized by the presence of a glycosphingolipid, GD2 ganglioside. Monoclonal antibodies targeting the antigen are currently tested in clinical trials. Additionally, several research groups reported results revealing that ganglioside-specific antibodies can affect cellular signaling and cause direct cytotoxicity against tumor cells. To shed more light on gene expression signatures of tumor cells, we used microarrays to analyze changes of transcriptome in IMR-32 human neuroblastoma cell cultures treated with doxorubicin (DOX) or a mouse monoclonal antibody binding to GD2 ganglioside 14G2a (mAb) for 24 h. The obtained results highlight that disparate cellular pathways are regulated by doxorubicin and 14G2a. Next, we used RT-PCR to verify mRNA levels of selected DOX-responsive genes such as RPS27L, PPM1D, SESN1, CDKN1A, TNFSF10B, and 14G2a-responsive genes such as SVIL, JUN, RASSF6, TLX2, ID1. Then, we applied western blot and analyzed levels of RPS27L, PPM1D, sestrin 1 proteins after DOX-treatment. Additionally, we aimed to measure effects of doxorubicin and topotecan (TPT) and 14G2a on expression of a novel human NDUFAF2 gene encoding for mimitin protein (MYC-induced mitochondrial protein) and correlate it with expression of the MYCN gene. We showed that expression of both genes was concomitantly decreased in the 14G2a-treated IMR-32 cells after 24 h and 48 h. Our results extend knowledge on gene expression profiles after application of DOX and 14G2a in our model and reveal promising candidates for further research aimed at finding novel anti-neuroblastoma targets.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 423-433
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aqueous leafextracts of Chromolaena odorata and Tridax procumbens attenuated doxorubicin-induced pulmonary toxicity in Wistar rats
Autorzy:
Ikewuchi, C.C.
Ikewuchi, J.C.
Ifeanacho, M.O.
Powiązania:
https://bibliotekanauki.pl/articles/2096805.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Chromolaena odorata
doxorubicin
pulmonary lipids
electrolyte profiles
pulmonary oxidative stress
Tridax procumbens
Opis:
This study investigated the potential protective role of aqueous leafextracts of Chromolaena odorata and Tridax procumbens against pulmonary toxicity induced by doxorubicin. To this end, the effects of these extracts on the profiles of pulmonary biomarkers, lipids and electrolytes were monitored in doxorubicin-treated rats. Doxorubicin was intraperitoneally administered at 15 mg/kg body weight (48 h prior to sacrifice); metformin was orally administered daily at 250 mg/kg body weight (for 14 days); and both extracts were orally administered daily at 50, 75 and 100 mg/kg body weight (for 14 days).The concentrations of pulmonary malondialdehyde, cholesterol, triglyceride, calcium, chloride and sodium of Test control were significantly higher (P < 0.05) than those of the other groups. However, the concentrations of pulmonary ascorbic acid, reduced glutathione, magnesium and potassium as well as pulmonary catalase, glutathione peroxidase and superoxide dismutase activities of Test control were significantly lower (P < 0.05) than those of the other groups.The administration of the extracts prevented doxorubicin-induced adverse alterations in the profiles of pulmonary biomarkers of oxidative stress, cholesterol and electrolytes and maintained them within the normal ranges .Therefore, these herbal preparations from C. odorata and T. procumbens are promising candidates for the prevention/alleviation of doxorubicin-induced pulmonary toxicity.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 4; 387-398
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Restoration of plasma kidney and liver biomarkers in doxorubicin-treated Wistar rats by aqueous extracts of Pleurotus tuberregium sclerotia and Cnidoscolus aconitifolius leaves
Autorzy:
Ikewuchi, C.C.
Ikewuchi, J.C.
Ifeanacho, M.O.
Powiązania:
https://bibliotekanauki.pl/articles/2096610.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
albumin/globulin ratio
alkaline phosphatase
blood urea nitrogen
creatinine
doxorubicin
transaminases
Opis:
The ability of aqueous extracts of sclerotia of Pleurotus tuberregium and leaves of Cnidoscolus aconitifolius to regulate plasma markers of kidney and liver function/integrity was investigated in doxorubicin-treated Wistar rats. Doxorubicin (dissolved in normal saline) was injected intraperitoneally (15 mg/kg body weight) into the rats; metformin was daily administered orally at 250 mg/kg, while the extracts were daily administered orally at doses of 50, 75, and 100 mg/kg. Compared to the test control, in both the doxorubicin pre-treatment (or ameliorative) study and the extract pre-treatment (protective) studies, the extracts and metformin-treated groups had significantly lower (P < 0.05) plasma levels of alkaline phosphatase, alanine transaminase and aspartate transaminase, and concentrations of creatinine, urea, and blood urea nitrogen. However, the plasma globulin, albumin, and total protein concentrations and the albumin/globulin ratio of the extract and metformin-treated groups were significantly higher (P < 0.05). The extracts prevented (in the protective study) or attenuated (in the ameliorative study) doxorubicin-induced increase in the levels of plasma markers of kidney and liver function/integrity, and afforded protection or recovery towards near-normal values.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 3; 297-306
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Combined effects of doxorubicin and STI571 on growth, differentiation and apoptosis of CML cell line K562
Autorzy:
Jakubowska, Justyna
Stasiak, Marta
Szulawska, Agata
Bednarek, Andrzej
Czyz, Malgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1040880.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
STI571
doxorubicin
anticancer drugs
K562 cells
apoptosis
differentiation
Opis:
STI571 (imatinib mesylate; Gleevec®) is an inhibitor that targets the tyrosine kinase activity of Bcr-Abl present in chronic myelogenous leukemia (CML) cells. Some preclinical studies have demonstrated that the combination of STI571 with chemotherapeutic drugs results in enhanced toxicity in Bcr-Abl-positive leukemias. We investigated the potential benefit of using STI571 to down-regulate Bcr-Abl activity for the enhancement of doxorubicin anti-proliferative action in K562 cell line derived from blast crisis of CML. At low concentrations of both drugs (40 nM doxorubicin combined with STI571 in the range of 100-150 nM), the antiproliferative effects were mainly due to cellular differentiation as assessed by benzidine staining for hemoglobin synthesis level and real-time PCR for γ-globin expression. Higher concentrations of STI571 used in combinations with doxorubicin caused mainly apoptosis as shown by DNA degradation and nuclear fragmentation visualized by fluorescence microscopy after DAPI staining, changes in cell morphology observed after Giemza-May Grünwald staining and cellular membrane organization estimated by flow cytometry after Annexin V staining. As compared with either drug alone, cotreatment with STI571 and DOX induced stronger cellular responses. A low concentration of STI571 in combination with a low concentration of DOX might be tested as an alternative approach to increasing the efficacy of chemotherapy against CML.
Źródło:
Acta Biochimica Polonica; 2007, 54, 4; 839-846
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Off-label drug use in breast cancer therapy
Autorzy:
Jankowski, Tomasz
Urbaniak, Monika
Powiązania:
https://bibliotekanauki.pl/articles/773466.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
breast cancer
capecitabine
chemotherapy
liposomal doxorubicin
metronomic vinorelbine
off-label
Opis:
Breast cancer is one of the most common malignancies across the world, including Poland. Chemotherapy plays an important part in the treatment of the disease. Most of the available chemotherapy drugs and regimens have undergone randomized clinical studies and have been registered for that specific indication. However, a number of drugs are used in an off-label manner, i.e. outside the officially approved product specifications. The paper discusses the use of several off-label therapies in breast cancer in order to demonstrate that such treatment may be well-grounded and indeed turns out beneficial in many cases. It describes the use of liposomal doxorubicin in pre- and post-operative treatment, capecitabine for incomplete efficacy of preoperative treatment, and the administration of metronomic vinorelbine. Moreover, the paper is aimed at demonstrating the legal basis and the principles of marketing authorization of off-label drug use.
Źródło:
OncoReview; 2017, 7, 2; 83-87
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytotoxicity and inhibitory properties against topoisomerase II of doxorubicin and its formamidine derivatives
Autorzy:
Kik, Krzysztof
Studzian, Kazimierz
Wąsowska-Łukawska, Małgorzata
Oszczapowicz, Irena
Szmigiero, Leszek
Powiązania:
https://bibliotekanauki.pl/articles/1040646.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
formamidinodoxorubicins
doxorubicin
topoisomerase II
Opis:
This work was undertaken to compare cytotoxicity, DNA damaging properties and effect on DNA cleavage by topoisomerase II of the anthracycline drug doxorubicin (DOX) and its two derivatives with a formamidino group containing a cyclic amine moiety such as morpholine (DOXM) or hexamethyleneimine (DOXH). The tetrazolium dye colorimetric assay was used to determine the cytotoxic activity of anthracyclines toward L1210 leukemia cells. DNA damage was measured by alkaline elution technique. The effect of anthracyclines on DNA cleavage was studied in a cell-free system containing supercoiled pBR322 DNA and purified human topoisomerase II. The cytotoxicity data and the results of studies on the mechanism of DNA break formation by anthracyclines at the cellular level and in the cell-free system showed that the presence of the formamidino group in the doxorubicin molecule reduced its ability to stimulate DNA cleavage by DNA topoisomerase II. Conclusion: DNA topoisomerase II is not a primary cellular target for DOXM or DOXH. An advantageous feature of formamidinoanthracyclines is their mechanism of cytotoxic action which is not related to the inhibition of DNA topoisomerase II. Therefore this class of anthracyclines seems to be a good source for selection of an anticancer drug directed toward cancer cells with the developed multidrug resistance attributed to the presence of altered DNA topoisomerase II.
Źródło:
Acta Biochimica Polonica; 2009, 56, 1; 135-142
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Resistance of gloves and protective clothing materials to permeation of cytostatic solutions
Autorzy:
Krzemińska, Sylwia
Pośniak, Małgorzata
Szewczyńska, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/2159915.pdf
Data publikacji:
2017-12-21
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
permeation
cytostatic
protective materials
docetaxel
fluorouracil
Doxorubicin
Opis:
Objectives The objective of the work was to determine the resistance of selected protective clothing and glove materials to permeation of cytostatics such as docetaxel, fluorouracil, and doxorubicin. Material and Methods The following glove materials were used: natural rubber latex (code A), acrylonitrile-butadiene rubber (code B) and chloroprene rubber (code C). In addition, we tested a layered material composed of a non-woven polyester (PES), a polypropylene (PP) film, and a non-woven PP used for protective coats (code D). The cytostatics were analyzed by liquid chromatography with diode array detection. The tested samples were placed in a purpose-built permeation cell modified to be different from that specified in the standard EN 6529:2001. Results The tested materials were characterized by good resistance to solutions containing 2 out of the 3 selected cytostatics: doxorubicin and 5-fluorouracil, as indicated by a breakthrough time of over 480 min. Equally high resistance to permeation of the third cytostatic (docetaxel) was exhibited by natural rubber latex, acrylonitrile-butadiene rubber, and chloroprene rubber. However, docetaxel permeated much more readily through the clothing layered material, compromising its barrier properties. Conclusions It was found that the presence of additional components in cytostatic preparations accelerated permeation through material samples, thus deteriorating their barrier properties. Int J Occup Med Environ Health 2018;31(3):341–350
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 3; 341-350
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Therapy with liposomal doxorubicin in patients with advanced breast cancer after treatment with classical doxorubicin
Autorzy:
Kufel-Grabowska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1065267.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
breast cancer
complications of oncological therapy
non-pegylated liposomal doxorubicin
Opis:
Breast cancer is the most common female cancer in the world and in Poland. The improvement of diagnostic and therapeutic methods has led to patients’ longer life expectancy. It has also made breast cancer a chronic disease, increasing the risk of late side effects of oncological therapy. More cardiovascular diseases are diagnose in patients over 65 with an oncological history than in those without it and therefore much effort must be made to maximise effectiveness of the therapy with as few side effects as possible. The article presents two breast cancer patients treated with big doses of liposomal doxorubicin with a good response and almost no side effects.
Źródło:
OncoReview; 2015, 5, 3; A103-108
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Aromatic indolinic aminoxyls as antioxidants in cardiac sarcoplasmic reticulum lipid and protein oxidation.
Autorzy:
Kulawiak-Gałąska, Dorota
Woźniak, Michał
Greci, Lucedio
Powiązania:
https://bibliotekanauki.pl/articles/1043805.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
doxorubicin
protein and lipid oxidation
indolinic aminoxyl
Opis:
The results presented demonstrate the influence of aromatic indolinic aminoxyls: 1,2-dihydro-2-ethyl-2-phenyl-3H-indole-3-phenylimino-1-oxyl (IA-C2) and 1,2-dihydro-2-octadecyl-2-phenyl-3H-indole-3-phenylimino-1-oxyl (IA-C18) on oxidation of lipids and proteins of cardiac sarcoplasmic reticulum membranes. We have used doxorubicin and t-butyl hydroperoxide as agents inducing oxidative stress in isolated rat cardiac sarcoplasmic reticulum membrane system. Carbonyl groups were measured as the end product of membrane protein oxidation, and thiobarbituric acid reactive substances were assessed as a marker of lipid peroxidation. Inhibition of peroxidation of certain membrane components depends on the length of acyl chain. Aminoxyl IA-C2 inhibits the lipid peroxidation process while IA-C18 is an efficient protector against protein oxidation.
Źródło:
Acta Biochimica Polonica; 2002, 49, 1; 43-49
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 29

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