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Tytuł:
The role of dopamine D2 receptor in the behavioral effects of imipramine - study with the use of antisense oligonucleotides
Autorzy:
Dziedzicka-Wasylewska, M.
Kolasiewicz, W.
Rogoz, Z.
Margas, W.
Maj, J.
Powiązania:
https://bibliotekanauki.pl/articles/70213.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
antisense oligonucleotide
locomotor activity
drug
mRNA
dopamine D2 receptor
limbic forebrain
antidepressant drug
imipramine
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effects of increased inspired oxygen with and without dopamine on lung and diaphragm hydrogen peroxide and apoptosis following hemorrhagic shock
Autorzy:
Mach, W.J.
Thimmesch, A.R.
Slusser, J.G.
Clancy, R.L.
Pierce, J.D.
Powiązania:
https://bibliotekanauki.pl/articles/3448.pdf
Data publikacji:
2010
Wydawca:
Instytut Medycyny Wsi
Tematy:
reactive oxygen species
dopamine
lung
hydrogen peroxide
apoptosis
hemorrhagic shock
DNA damage
hemodynamics
acid-base balance
hyperoxia
Źródło:
Journal of Pre-Clinical and Clinical Research; 2010, 04, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The circulatory levels of Serotonin and Dopamine and physical fitness factors in active and inactive men addicted to opium during rehabilitation
Autorzy:
Arazi, Hamid
Mollazadeh, Rahim
Dadvand, Seyedeh Shiva
Davaran, Maryam
Powiązania:
https://bibliotekanauki.pl/articles/1031952.pdf
Data publikacji:
2016
Wydawca:
PPHU Projack Jacek Wąsik
Tematy:
Addiction
Dopamine
Exercise
Opium
Serotonin
Opis:
Addiction to drugs is one of the significant problems in many countries. Opium is a kind of drug that its use goes back to many years ago. Dopamine and serotonin are neurotransmitters involved in the process of addiction. As a result, this study aimed to investigate the blood levels of serotonin, dopamine and physical fitness factors in active and inactive men addicted to opium during their rehabilitation period. This study is a descriptive and Causal after the occurrence. A total of 34 men addicted to opium referring to rehabilitation center had been admitted voluntarily as samples were available in the study. According to a questionnaire answered by them, 16 of them did exercise during their rehabilitation period (active group) and 18 of them did not do any physical activity during this period (inactive group). 5 cc of peripheral blood samples were obtained from both groups and were tested their aerobic capacity, muscular endurance, flexibility, body composition, blood pressure and heart rate. Statistical analysis showed that blood levels of serotonin and dopamine in active group were significantly more than inactive group (p<0.05). In addition, the active group compared with the inactive group had low body fat percent, more muscular endurance, more flexibility, and low resting heart rate (p<0.05). According to the findings, we can conclude that low physical activity but as regular walking can affect blood levels of serotonin and dopamine, and health-related fitness factors of addicted men and as a non-drug treatment is helpful.
Źródło:
Physical Activity Review; 2016, 4; 1-8
2300-5076
Pojawia się w:
Physical Activity Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Significant association of DRD2 and ANKK1 genes with rural heroin dependence and relapse in men
Autorzy:
Lachowicz, M.
Chmielowiec, J.
Chmielowiec, K.
Suchanecka, A.
Masiak, J.
Michałowska-Sawczyn, M.
Mroczek, B.
Mierzecki, A.
Ciechanowicz, I.
Gezywacz, A.
Powiązania:
https://bibliotekanauki.pl/articles/2085710.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
Addiction
heroin
dopamine
haplotypes
Opis:
Introduction. Substance abuse significantly influences human health and may induce problems with social functioning worldwide. Numerous genetic and environmental risk factors, as well as their interactions, accelerate the development of drug addiction. Etiologically, the dopaminergic mesocorticolimbic reward pathways are related to psychoactive substance addiction, and the reward properties of heroin are connected with changes in the mesolimbic dopaminergic system. Objective. The aim of this study is a haplotypic analysis of subjects addicted to polysubstance. However, with the knowledge that this is not a homogenous subgroup, it was decided to separate and analyze homogenous subgroups of subjects in order to find specific haplotypic variants among them. The subjects in the subgroups were addicted to heroin, and subjects with more than two relapses in the past two years. Materials and method. The study group comprised of 301 polysubstance addicted rural male subjects. From this group, 2 homogenous subgroups of subjects were isolated and additionally analyzed: (1) a group of heroin addicted subjects (n=61), and (2) a group of heroin-addicted subjects with at least two relapses in the last two years (n=21). The group consisting of all polysubstance addicted rural subjects and both homogenous subgroups were analyzed against a control group of non-addicted subjects (n=300), matching gender and age. Five polymorphisms in the DRD2/ANKK1 region were analyzed: rs1076560, rs1800498, rs1079597, rs6276 in the DRD2 gene, and rs1800497 in the ANKK1 gene. Results. A statistically significant haplotype association was found in analysis of the heroin addicted subjects, compared to controls, and two possible trends – when comparing the whole group of addicted subjects to controls, and in relapse subgroups, compared to the controls. Conclusion. The results obtained showed that haplotypes indicate a part of the biological component of addiction.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 269-273
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of 5-hydroxytryptamine 1B receptors and 5-hydroxytryptamine uptake inhibition in the cocaine-evoked discriminative stimulus effects in rats
Autorzy:
Filip, M.
Nowak, E.
Papla, I.
Przegalinski, E.
Powiązania:
https://bibliotekanauki.pl/articles/70612.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
discriminative stimulus effect
dopamine
5-hydroxy tryptamine 1B receptor
cocaine
rodent
neurotransmission
rat
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polypharmacology – a challenge for current drug design approaches
Autorzy:
Podlewska, Sabina
Kurczab, Rafał
Powiązania:
https://bibliotekanauki.pl/articles/93192.pdf
Data publikacji:
2019
Wydawca:
Państwowa Wyższa Szkoła Zawodowa w Tarnowie
Tematy:
G protein-coupled receptor
polypharmacology
serotonin receptor
dopamine receptor
antipsychotic profile
ligand
receptor sprzężony z białkiem G
polifarmakologia
receptor serotoninowy
receptor dopaminowy
profil przeciwpsychotyczny
Opis:
Drug design process faces many challenges, and the most important ones are connected with side effects. Finding compounds that possess affinity towards target of interest is relatively simple; however, an approach one disease-one target is now making space for the search of polypharmacological ligands, where activity towards several proteins is considered at one time. Such proteins are not always the target ones, but very often such panels include also anti-targets, interaction with which is not desired, due to the side effects that may occur upon such contact. In the study, we examined ligands of four G protein-coupled receptors, forming antipsychotic profile: dopamine receptor D2, serotonin receptors 5-HT2A, 5-HT2C (anti-target), and 5-HT6. Number of ligands belonging to particular activity groups, as well as the selected compound structures are examined in detail. Also compound similarity between sets of different activity groups is analysed, giving a picture of difficulty of constructing molecular modeling methodologies that can help in the search of compounds with desired activity profile.
Źródło:
Science, Technology and Innovation; 2019, 6, 3; 19-23
2544-9125
Pojawia się w:
Science, Technology and Innovation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pattern classification by spiking neural networks combining self-organized and reward-related spike-timing-dependent plasticity
Autorzy:
Nobukawa, Sou
Nishimura, Haruhiko
Yamanishi, Teruya
Powiązania:
https://bibliotekanauki.pl/articles/91886.pdf
Data publikacji:
2019
Wydawca:
Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
Tematy:
spiking neural network
spike timing-dependent plasticity
dopamine-modulated spike timing-dependent plasticity
pattern classification
Opis:
Many recent studies have applied to spike neural networks with spike-timing-dependent plasticity (STDP) to machine learning problems. The learning abilities of dopaminemodulated STDP (DA-STDP) for reward-related synaptic plasticity have also been gathering attention. Following these studies, we hypothesize that a network structure combining self-organized STDP and reward-related DA-STDP can solve the machine learning problem of pattern classification. Therefore, we studied the ability of a network in which recurrent spiking neural networks are combined with STDP for non-supervised learning, with an output layer joined by DA-STDP for supervised learning, to perform pattern classification. We confirmed that this network could perform pattern classification using the STDP effect for emphasizing features of the input spike pattern and DA-STDP supervised learning. Therefore, our proposed spiking neural network may prove to be a useful approach for machine learning problems.
Źródło:
Journal of Artificial Intelligence and Soft Computing Research; 2019, 9, 4; 283-291
2083-2567
2449-6499
Pojawia się w:
Journal of Artificial Intelligence and Soft Computing Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
On the role of serotonin2A-2C receptors in the sensitization to cocaine
Autorzy:
Filip, M.
Nowak, E.
Papla, I.
Powiązania:
https://bibliotekanauki.pl/articles/69954.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
sensitization
prazosin
receptor
serotonin
locomotor activity
dopamine
ketanserin
cocaine
rodent
rat
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neurotransmitters detection using a fluorescence-based sensor with graphene quantum dots
Autorzy:
Baluta, S.
Cabaj, J.
Malecha, K.
Powiązania:
https://bibliotekanauki.pl/articles/175014.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
sensor
dopamine
fluorescence
Förster resonance energy transfer
quantum dots
Opis:
In the paper, the development and performance of an optical sensor for detection of neurotransmitters (dopamine) is presented. The concentration of dopamine is measured basing on fluorescence quenching of graphene quantum dots. In the sensor, the dopamine molecules coat the graphene quantum dots surface – in result, the quenching of fluorescence occurs due to the Förster resonance energy transfer. The changes in fluorescence correspond to specific concentrations of the neurotransmitter in tested samples, so it is possible to accurately determine the concentration of dopamine in the sample.
Źródło:
Optica Applicata; 2017, 47, 2; 225-231
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Klinicznie nieczynne hormonalnie guzy przysadki
NFPAs-non-functioning pituitary adenomas
Autorzy:
Zawada, Natalia Bożena
Kunert-Radek, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1032601.pdf
Data publikacji:
2012
Wydawca:
Łódzkie Towarzystwo Naukowe
Tematy:
klinicznie nieczynne gruczolaki przysadki
guzy przysadki
immunohistochemia guzów przysadki
scyntygrafia receptorowa
receptory
dopaminergiczne
receptory somatostatynowe
leczenie operacyjne
radioterapia
nóż gamma
analogi somatostatyny
agoniści dopaminy
clinically non-functioning pituitary adenomas
pituitary tumours
immunohistochemistry of pituitary tumours
receptor scintigraphy
dopamine
receptors
somatostatin receptors
surgery
radiotherapy
gamma knife
somatostatin analogues
dopamine agonists
Opis:
The significant progress made in recent years, especially in the field of imaging techniques and immunohistochemistry, enables an earlier diagnosis and the treatment of clinically non-functioning pituitary adenomas (NFPAs). In spite of this, these tumours still remain an important medical issue for a large number of specialities. The aim of this article is to provide an overview of the etiopathogenesis, diagnosis and treatment of clinically non-functioning pituitary adenomas with special reference to the development of highly advanced methods in surgery as well as radiotherapy and, especially, in pharmacotherapy.
Istotny postęp, jaki dokonał się w ostatnich latach, zwłaszcza w zakresie rozwoju diagnostyki obrazowej i badań immunohistochemicznych, umożliwia wcześniejsze rozpoznawanie, a następnie leczenie nieczynnych hormonalnie gruczolaków przysadki (NFPAs). Mimo to guzy te dalej pozostają istotnym problemem klinicznym dla lekarzy wielu specjalności. Celem pracy jest szczegółowe przedstawienie poglądów na temat etiopatogenezy, obrazu klinicznego, diagnostyki i metod leczenia klinicznie nieczynnych hormonalnie gruczolaków przysadki ze szczególnym uwzględnieniem postępów w technikach chirurgicznych oraz rozszerzających się możliwości radioterapii, a szczególnie farmakoterapii.
Źródło:
Folia Medica Lodziensia; 2012, 39, 1; 85-136
0071-6731
Pojawia się w:
Folia Medica Lodziensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Kinetics and specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase towards substituted benzaldehydes.
Autorzy:
Panoutsopoulos, Georgios
Beedham, Christine
Powiązania:
https://bibliotekanauki.pl/articles/1041542.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
xanthine oxidase
dopamine
benzaldehydes
aldehyde oxidase
protocatechuic aldehyde
isovanillin
Opis:
Molybdenum-containing enzymes, aldehyde oxidase and xanthine oxidase, are important in the oxidation of N-heterocyclic xenobiotics. However, the role of these enzymes in the oxidation of drug-derived aldehydes has not been established. The present investigation describes the interaction of eleven structurally related benzaldehydes with guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase, since they have similar substrate specificity to human molybdenum hydroxylases. The compounds under test included mono-hydroxy and mono-methoxy benzaldehydes as well as 3,4-dihydroxy-, 3-hydroxy-4-methoxy-, 4-hydroxy-3-methoxy-, and 3,4-dimethoxy-benzaldehydes. In addition, various amines and catechols were tested with the molybdenum hydroxylases as inhibitors of benzaldehyde oxidation. The kinetic constants have shown that hydroxy-, and methoxy-benzaldehydes are excellent substrates for aldehyde oxidase (Km values 5×10-6 M to 1×10-5 M) with lower affinities for xanthine oxidase (Km values around 10-4 M). Therefore, aldehyde oxidase activity may be a significant factor in the oxidation of the aromatic aldehydes generated from amines and alkyl benzenes during drug metabolism. Compounds with a 3-methoxy group showed relatively high Vmax values with aldehyde oxidase, whereas the presence of a 3-hydroxy group resulted in minimal Vmax values or no reaction. In addition, amines acted as weak inhibitors, whereas catechols had a more pronounced inhibitory effect on the aldehyde oxidase activity. It is therefore possible that aldehyde oxidase may be critical in the oxidation of the analogous phenylacetaldehydes derived from dopamine and noradrenaline.
Źródło:
Acta Biochimica Polonica; 2004, 51, 3; 649-663
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of the central histaminergic systems on the pituitary-adrenocortical response to met-enkephalinamide
Autorzy:
Bugajski, J
Turon, M.
Gadek-Michalska, A.
Olowska, A.
Powiązania:
https://bibliotekanauki.pl/articles/70580.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
hypothalamic histamine
central histaminergic system
brain
endorphin
dopamine
noradrenaline
endogenous enkephalin
histamine receptor
met-enkephalinamide
pituitary-adrenocortical response
opioid receptor
corticosterone
alpha-Fluoromethylhistidine
Źródło:
Journal of Physiology and Pharmacology; 1995, 46, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
INFLAMMATORY MARKERS AND NEUROPEPTIDES CHARACTERISTIC OF PARKINSON’S DISEASE AND THEIR RESPONSE TO VISUALIZATION AND SUGGESTION BASED MIND-BODY THERAPY
Autorzy:
Ostapiuk-Karolczuk, Joanna
Kasperska, Anna
Botwina, Ryszard
Powiązania:
https://bibliotekanauki.pl/articles/2137791.pdf
Data publikacji:
2017-12-23
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
mind-body therapy
visualization
inflammation
dopamine
BDNF Parkinson`s disease
Opis:
Progress in elucidating neuroimmune connections has created new opportunities for improving the treatment of Parkinson’s disease (PD). In recent years, mind-body therapies have been shown to have positive effects on the immune and nervous systems, but interactions at the molecular level have not been tested. Thus, the main aim of the present study was to investigate the effects of therapy based on visualization and suggestion on the concentrations of IL-6, CRP, DA, BDNF, CoQ10, and TAC in patients with advanced PD. Eight patients with PD and 8 elderly healthy men (control group) were enrolled in the study. The therapy lasted 19 days and consisted of three parts: individual sessions with the therapist, mixed (therapist and audio-file), and self-training (audio-file). Blood samples were taken before training and at the end of each part. The expected changes in the investigated markers was observed during therapy: the serum concentration of IL-6 and CRP decreased, whereas DA and BDNF increased, however, this change was observed only after the first part of intervention when the therapy was conducted by the therapist. In the subsequent stages, the levels returned to the baseline. Noteworthy, after the therapy, we observed a significant increase in the motor and intellectual skills of the PD patients. No such changes were observed in the control group. Mind-body therapy based on visualization and suggestions aimed at changing the concentrations of signaling molecules, which are crucial in the development or treatment of PD, may be an effective element in supporting pharmacological therapy.
Źródło:
Acta Neuropsychologica; 2017, 15(4); 443-456
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hypothetical orchestrated cooperation between dopaminergic and kinin receptors for the regulation of common functions
Autorzy:
Guevara-Lora, Ibeth
Niewiarowska-Sendo, Anna
Polit, Agnieszka
Kozik, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1038753.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
kinin receptors
dopamine receptors
G protein-coupled receptors
oligomerization
signaling pathways
Opis:
The G protein-coupled receptors (GPCRs), one of the largest protein families, are essential components of the most commonly used signal-transduction systems in cells. These receptors, often using common pathways, may cooperate in the regulation of signal transmission to the cell nucleus. Recent scientific interests increasingly focus on the cooperation between these receptors, particularly in a context of their oligomerization, e.g. the formation of dimers that are able to change characteristic signaling of each receptor. Numerous studies on kinin and dopamine receptors which belong to this family of receptors have shown new facts demonstrating their direct interactions with other GPCRs. In this review, current knowledge on signaling pathways and oligomerization of these receptors has been summarized. Owing to the fact that kinin and dopamine receptors are widely expressed in cell membranes where they act as mediators of numerous common physiological processes, the information presented here sheds new light on a putative crosstalk of these receptors and provides more comprehensive understanding of possible direct interactions that may change their functions. The determination of such interactions may be useful for the development of new targeted therapeutic strategies against many disorders in which kinin and dopamine receptors are involved.
Źródło:
Acta Biochimica Polonica; 2016, 63, 3; 387-396
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
How to Handle Humility? Audaciously: A Response to Mark Tschaepe
Autorzy:
Solymosi, Tibor
Bywater, Bill
Powiązania:
https://bibliotekanauki.pl/articles/451557.pdf
Data publikacji:
2019-10-31
Wydawca:
Uniwersytet Warszawski. Wydział Filozofii
Tematy:
neuropragmatism
dopamine democracy
digital devices
social media
information and news
education
Opis:
We address Mark Tschaepe’s response to Tibor Solymosi, in which Tschaepe argues that neuropragmatism needs to be coupled with humility in order to redress “dopamine democracy,” Tschaepe’s term for our contemporary situation of smartphone addiction that undermines democracy. We reject Tschaepe’s distinction between humility and fallibility, arguing that audacious fallibility is all we need. We take the opportunity presented by Tschaepe’s constructive criticism of neuropragmatism to reassert some central themes of neuropragmatism. We close with discussion of Bywater’s method of apprenticeship, as an imaginative education for creative democracy, thereby rejecting Tschaepe’s claim that neuropragmatism lacks a pedagogical method.
Źródło:
Eidos. A Journal for Philosophy of Culture; 2019, 3, 3(9); 145-159
2544-302X
Pojawia się w:
Eidos. A Journal for Philosophy of Culture
Dostawca treści:
Biblioteka Nauki
Artykuł
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