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Wyświetlanie 1-15 z 25
Tytuł:
Significant association of DRD2 and ANKK1 genes with rural heroin dependence and relapse in men
Autorzy:
Lachowicz, M.
Chmielowiec, J.
Chmielowiec, K.
Suchanecka, A.
Masiak, J.
Michałowska-Sawczyn, M.
Mroczek, B.
Mierzecki, A.
Ciechanowicz, I.
Gezywacz, A.
Powiązania:
https://bibliotekanauki.pl/articles/2085710.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
Addiction
heroin
dopamine
haplotypes
Opis:
Introduction. Substance abuse significantly influences human health and may induce problems with social functioning worldwide. Numerous genetic and environmental risk factors, as well as their interactions, accelerate the development of drug addiction. Etiologically, the dopaminergic mesocorticolimbic reward pathways are related to psychoactive substance addiction, and the reward properties of heroin are connected with changes in the mesolimbic dopaminergic system. Objective. The aim of this study is a haplotypic analysis of subjects addicted to polysubstance. However, with the knowledge that this is not a homogenous subgroup, it was decided to separate and analyze homogenous subgroups of subjects in order to find specific haplotypic variants among them. The subjects in the subgroups were addicted to heroin, and subjects with more than two relapses in the past two years. Materials and method. The study group comprised of 301 polysubstance addicted rural male subjects. From this group, 2 homogenous subgroups of subjects were isolated and additionally analyzed: (1) a group of heroin addicted subjects (n=61), and (2) a group of heroin-addicted subjects with at least two relapses in the last two years (n=21). The group consisting of all polysubstance addicted rural subjects and both homogenous subgroups were analyzed against a control group of non-addicted subjects (n=300), matching gender and age. Five polymorphisms in the DRD2/ANKK1 region were analyzed: rs1076560, rs1800498, rs1079597, rs6276 in the DRD2 gene, and rs1800497 in the ANKK1 gene. Results. A statistically significant haplotype association was found in analysis of the heroin addicted subjects, compared to controls, and two possible trends – when comparing the whole group of addicted subjects to controls, and in relapse subgroups, compared to the controls. Conclusion. The results obtained showed that haplotypes indicate a part of the biological component of addiction.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 2; 269-273
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The circulatory levels of Serotonin and Dopamine and physical fitness factors in active and inactive men addicted to opium during rehabilitation
Autorzy:
Arazi, Hamid
Mollazadeh, Rahim
Dadvand, Seyedeh Shiva
Davaran, Maryam
Powiązania:
https://bibliotekanauki.pl/articles/1031952.pdf
Data publikacji:
2016
Wydawca:
PPHU Projack Jacek Wąsik
Tematy:
Addiction
Dopamine
Exercise
Opium
Serotonin
Opis:
Addiction to drugs is one of the significant problems in many countries. Opium is a kind of drug that its use goes back to many years ago. Dopamine and serotonin are neurotransmitters involved in the process of addiction. As a result, this study aimed to investigate the blood levels of serotonin, dopamine and physical fitness factors in active and inactive men addicted to opium during their rehabilitation period. This study is a descriptive and Causal after the occurrence. A total of 34 men addicted to opium referring to rehabilitation center had been admitted voluntarily as samples were available in the study. According to a questionnaire answered by them, 16 of them did exercise during their rehabilitation period (active group) and 18 of them did not do any physical activity during this period (inactive group). 5 cc of peripheral blood samples were obtained from both groups and were tested their aerobic capacity, muscular endurance, flexibility, body composition, blood pressure and heart rate. Statistical analysis showed that blood levels of serotonin and dopamine in active group were significantly more than inactive group (p<0.05). In addition, the active group compared with the inactive group had low body fat percent, more muscular endurance, more flexibility, and low resting heart rate (p<0.05). According to the findings, we can conclude that low physical activity but as regular walking can affect blood levels of serotonin and dopamine, and health-related fitness factors of addicted men and as a non-drug treatment is helpful.
Źródło:
Physical Activity Review; 2016, 4; 1-8
2300-5076
Pojawia się w:
Physical Activity Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Deuterium isotope effects in oxidation of dopamine and norepinephrine catalyzed by horseradish peroxidase
Autorzy:
Byszewska, W.
Pająk, M.
Kańska, M.
Powiązania:
https://bibliotekanauki.pl/articles/146852.pdf
Data publikacji:
2013
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
deuterium
dopamine (DA)
norepinephrine
isotope effects
oxidation
peroxidase
Opis:
Deuterium kinetic isotope effects (KIE’s) in the reaction of oxidation of dopamine (DA) catalyzed by the enzyme horseradish peroxidase (HRP, EC 1.11.1.7) was determined using a non-competitive spectrophotometric method. For kinetic studies, the deuterium ring labelled isotopomer [2’,5’,6’-2H3]-dopamine was synthesized using acid catalyzed isotopic exchange between authentic dopamine and heavy water. Deuterium solvent isotope effects (SIE’s) for dopamine and norepinephrine were determined separately for the enzymatic oxidation carried out in the presence or absence of hydrogen peroxide. Some mechanistic details of enzymatic oxidation of dopamine and norepinephrine to corresponding catecholchromes catalyzed by HRP were discussed.
Źródło:
Nukleonika; 2013, 58, 4; 475-479
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bradykinin B2 receptor and dopamine D2 receptor cooperatively contribute to the regulation of neutrophil adhesion to endothelial cells
Autorzy:
Niewiarowska-Sendo, Anna
Łabędź-Masłowska, Anna
Kozik, Andrzej
Guevara-Lora, Ibeth
Powiązania:
https://bibliotekanauki.pl/articles/1038361.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bradykinin
bradykinin receptor
dopamine receptor
endothelial cells
neutrophil adhesion
Opis:
Leukocyte adhesion to the vascular endothelium contributes to many immunological and inflammatory disorders. These processes have been shown to be mediated by bradykinin receptor type 2 (B2R) and dopamine receptor type 2 (D2R). In a previous study, we reported the formation of a B2R-D2R heterodimer, possibly altering cellular functions. Hence, in the present study, we examined the effect of co-activation of endothelial cells with B2R and D2R agonists on the interaction of these cells with neutrophils. Bradykinin, the main B2R agonist, significantly increased cell adhesion, and this effect was reversed when the endothelial cells were additionally co-treated with a selective D2R agonist, sumanirole. These results were dependent on the incubation time, showing an opposite tendency after prolonged stimulation. Significant changes in the expression of adhesion proteins, such as E-selectin and intercellular adhesion molecule 1 in endothelial cells were observed. Additionally, the cells preincubated with tumor necrosis factor-α showed decreased cell adhesion and IL-8 release after long incubation with both agonists. The modulation of cell adhesion by D2R and B2R seem to be mediated via STAT3 phosphorylation. In summary, this study demonstrated a protective role of D2R in neutrophil-endothelial cell adhesion induced by bradykinin, especially in cytokine-stimulated endothelial cells.
Źródło:
Acta Biochimica Polonica; 2018, 65, 3; 367-375
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neurotransmitters detection using a fluorescence-based sensor with graphene quantum dots
Autorzy:
Baluta, S.
Cabaj, J.
Malecha, K.
Powiązania:
https://bibliotekanauki.pl/articles/175014.pdf
Data publikacji:
2017
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
sensor
dopamine
fluorescence
Förster resonance energy transfer
quantum dots
Opis:
In the paper, the development and performance of an optical sensor for detection of neurotransmitters (dopamine) is presented. The concentration of dopamine is measured basing on fluorescence quenching of graphene quantum dots. In the sensor, the dopamine molecules coat the graphene quantum dots surface – in result, the quenching of fluorescence occurs due to the Förster resonance energy transfer. The changes in fluorescence correspond to specific concentrations of the neurotransmitter in tested samples, so it is possible to accurately determine the concentration of dopamine in the sample.
Źródło:
Optica Applicata; 2017, 47, 2; 225-231
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Deuterium isotope effects in oxidation of dopamine by tyramine oxidase
Autorzy:
Pająk, M.
Byszewska, W.
Kańska, M.
Powiązania:
https://bibliotekanauki.pl/articles/147724.pdf
Data publikacji:
2013
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
deuterium
dopamine (DA)
isotope effects
oxidation
tyramine oxidase
Opis:
We report the studies on the mechanism of oxidation of dopamine (DA) to 3’,4’-dihydroxyphenylacetaldehyde (DOPAL) by enzyme tyramine oxidase (EC 1.4.3.6) using kinetic isotope effects (KIE) and solvent isotope effects (SIE) methods. For kinetic studies, the selectively deuterium labelled isotopologues of dopamine, i.e., [(1R)-2H]-, and [(1S)- -2H]-DA were used. The numerical values of KIE’s for the (1R)- and (1S)-isotopologues of dopamine in the enzymatic oxidation of DA to DOPAL were determined using the non competitive spectrophotometric method. Also, the SIE’s for this reaction carried out in heavy water were obtained spectrophotometrically. Some mechanistic details of enzymatic oxidation of DA to DOPAL were discussed.
Źródło:
Nukleonika; 2013, 58, 2; 255-259
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
INFLAMMATORY MARKERS AND NEUROPEPTIDES CHARACTERISTIC OF PARKINSON’S DISEASE AND THEIR RESPONSE TO VISUALIZATION AND SUGGESTION BASED MIND-BODY THERAPY
Autorzy:
Ostapiuk-Karolczuk, Joanna
Kasperska, Anna
Botwina, Ryszard
Powiązania:
https://bibliotekanauki.pl/articles/2137791.pdf
Data publikacji:
2017-12-23
Wydawca:
Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
Tematy:
mind-body therapy
visualization
inflammation
dopamine
BDNF Parkinson`s disease
Opis:
Progress in elucidating neuroimmune connections has created new opportunities for improving the treatment of Parkinson’s disease (PD). In recent years, mind-body therapies have been shown to have positive effects on the immune and nervous systems, but interactions at the molecular level have not been tested. Thus, the main aim of the present study was to investigate the effects of therapy based on visualization and suggestion on the concentrations of IL-6, CRP, DA, BDNF, CoQ10, and TAC in patients with advanced PD. Eight patients with PD and 8 elderly healthy men (control group) were enrolled in the study. The therapy lasted 19 days and consisted of three parts: individual sessions with the therapist, mixed (therapist and audio-file), and self-training (audio-file). Blood samples were taken before training and at the end of each part. The expected changes in the investigated markers was observed during therapy: the serum concentration of IL-6 and CRP decreased, whereas DA and BDNF increased, however, this change was observed only after the first part of intervention when the therapy was conducted by the therapist. In the subsequent stages, the levels returned to the baseline. Noteworthy, after the therapy, we observed a significant increase in the motor and intellectual skills of the PD patients. No such changes were observed in the control group. Mind-body therapy based on visualization and suggestions aimed at changing the concentrations of signaling molecules, which are crucial in the development or treatment of PD, may be an effective element in supporting pharmacological therapy.
Źródło:
Acta Neuropsychologica; 2017, 15(4); 443-456
1730-7503
2084-4298
Pojawia się w:
Acta Neuropsychologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Kinetics and specificity of guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase towards substituted benzaldehydes.
Autorzy:
Panoutsopoulos, Georgios
Beedham, Christine
Powiązania:
https://bibliotekanauki.pl/articles/1041542.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
xanthine oxidase
dopamine
benzaldehydes
aldehyde oxidase
protocatechuic aldehyde
isovanillin
Opis:
Molybdenum-containing enzymes, aldehyde oxidase and xanthine oxidase, are important in the oxidation of N-heterocyclic xenobiotics. However, the role of these enzymes in the oxidation of drug-derived aldehydes has not been established. The present investigation describes the interaction of eleven structurally related benzaldehydes with guinea pig liver aldehyde oxidase and bovine milk xanthine oxidase, since they have similar substrate specificity to human molybdenum hydroxylases. The compounds under test included mono-hydroxy and mono-methoxy benzaldehydes as well as 3,4-dihydroxy-, 3-hydroxy-4-methoxy-, 4-hydroxy-3-methoxy-, and 3,4-dimethoxy-benzaldehydes. In addition, various amines and catechols were tested with the molybdenum hydroxylases as inhibitors of benzaldehyde oxidation. The kinetic constants have shown that hydroxy-, and methoxy-benzaldehydes are excellent substrates for aldehyde oxidase (Km values 5×10-6 M to 1×10-5 M) with lower affinities for xanthine oxidase (Km values around 10-4 M). Therefore, aldehyde oxidase activity may be a significant factor in the oxidation of the aromatic aldehydes generated from amines and alkyl benzenes during drug metabolism. Compounds with a 3-methoxy group showed relatively high Vmax values with aldehyde oxidase, whereas the presence of a 3-hydroxy group resulted in minimal Vmax values or no reaction. In addition, amines acted as weak inhibitors, whereas catechols had a more pronounced inhibitory effect on the aldehyde oxidase activity. It is therefore possible that aldehyde oxidase may be critical in the oxidation of the analogous phenylacetaldehydes derived from dopamine and noradrenaline.
Źródło:
Acta Biochimica Polonica; 2004, 51, 3; 649-663
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Affording Our Culture: “Smart” Technology and the Prospects for Creative Democracy
Autorzy:
Solymosi, Tibor
Powiązania:
https://bibliotekanauki.pl/articles/451283.pdf
Data publikacji:
2018-12-28
Wydawca:
Uniwersytet Warszawski. Wydział Filozofii
Tematy:
digital devices
social media
democracy
neuropragmatism
dopamine
affordances
neuroscience
Opis:
John Dewey, as Sidney Hook characterized him, was the philosopher of science and freedom. Dewey, as Larry Hickman has demonstrated, was also a philosopher of technology. And, as most people familiar with Dewey know, he was a philosopher of education and democracy. The complex of technology, science, freedom, education and democracy requires re-examination, not only because of our contemporary cultural political situation but also because of our growing insights into the human condition thanks to the technosciences of life, especially human life. Dewey’s philosophical method of reconstruction, equipped with insights from evolutionary neuroscience and ecological psychology, offers means of reconceiving and thus reevaluating our conception of tools and technology within our cultural context. I begin to take up Mark Tschaepe’s challenge to neuropragmatism to counter what he calls “dopamine democracy” – Plato’s critique of democracy resurrected in neural garb coupled with a critical examination of how social media and other so-called “smart” technologies undermine healthy democratic life. Central to this neuropragmatist approach are cultural affordances – opportunities for action humans have created initially for specific purposes and later retrofitted for other ends-in-view. Dewey’s reconstruction – as method as well as the reconstruction of technology, science, freedom, education and democracy as an entangled complex – is thus imagined as our best strategy for achieving the culture of creative democracy.
Źródło:
Eidos. A Journal for Philosophy of Culture; 2018, 2, 4(6); 46-69
2544-302X
Pojawia się w:
Eidos. A Journal for Philosophy of Culture
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hypothetical orchestrated cooperation between dopaminergic and kinin receptors for the regulation of common functions
Autorzy:
Guevara-Lora, Ibeth
Niewiarowska-Sendo, Anna
Polit, Agnieszka
Kozik, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1038753.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
kinin receptors
dopamine receptors
G protein-coupled receptors
oligomerization
signaling pathways
Opis:
The G protein-coupled receptors (GPCRs), one of the largest protein families, are essential components of the most commonly used signal-transduction systems in cells. These receptors, often using common pathways, may cooperate in the regulation of signal transmission to the cell nucleus. Recent scientific interests increasingly focus on the cooperation between these receptors, particularly in a context of their oligomerization, e.g. the formation of dimers that are able to change characteristic signaling of each receptor. Numerous studies on kinin and dopamine receptors which belong to this family of receptors have shown new facts demonstrating their direct interactions with other GPCRs. In this review, current knowledge on signaling pathways and oligomerization of these receptors has been summarized. Owing to the fact that kinin and dopamine receptors are widely expressed in cell membranes where they act as mediators of numerous common physiological processes, the information presented here sheds new light on a putative crosstalk of these receptors and provides more comprehensive understanding of possible direct interactions that may change their functions. The determination of such interactions may be useful for the development of new targeted therapeutic strategies against many disorders in which kinin and dopamine receptors are involved.
Źródło:
Acta Biochimica Polonica; 2016, 63, 3; 387-396
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
How to Handle Humility? Audaciously: A Response to Mark Tschaepe
Autorzy:
Solymosi, Tibor
Bywater, Bill
Powiązania:
https://bibliotekanauki.pl/articles/451557.pdf
Data publikacji:
2019-10-31
Wydawca:
Uniwersytet Warszawski. Wydział Filozofii
Tematy:
neuropragmatism
dopamine democracy
digital devices
social media
information and news
education
Opis:
We address Mark Tschaepe’s response to Tibor Solymosi, in which Tschaepe argues that neuropragmatism needs to be coupled with humility in order to redress “dopamine democracy,” Tschaepe’s term for our contemporary situation of smartphone addiction that undermines democracy. We reject Tschaepe’s distinction between humility and fallibility, arguing that audacious fallibility is all we need. We take the opportunity presented by Tschaepe’s constructive criticism of neuropragmatism to reassert some central themes of neuropragmatism. We close with discussion of Bywater’s method of apprenticeship, as an imaginative education for creative democracy, thereby rejecting Tschaepe’s claim that neuropragmatism lacks a pedagogical method.
Źródło:
Eidos. A Journal for Philosophy of Culture; 2019, 3, 3(9); 145-159
2544-302X
Pojawia się w:
Eidos. A Journal for Philosophy of Culture
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Enhancing the Safety of Medical Personel Through the Use of Modern Technology
Autorzy:
Ratusiński, Tadeusz
Szczeblowska, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/1832572.pdf
Data publikacji:
2017
Wydawca:
Wyższa Szkoła Bezpieczeństwa Publicznego i Indywidualnego Apeiron w Krakowie
Tematy:
security
health
modern technologies
teaching process
education
dopamine
GeoGebra
infusion pump
Opis:
Security of a society is related to the level of its health which largely depends on the level of professional education of medical staff whose task is to help a person in life-threatening situations. Life-threatening situations include among others acute cardiac failure or renal failure. One of the methods to improve health condition of patients with these medical problems is intravenous treatment with dopamine administered by an infusion pump. Medical staff is responsible for proper programming of a pump so that it gives a patient the appropriate dose. Introduction of modern technology to training programme can facilitate the process of learning how to programme an automatic infusion pump. The article describes an example of a simple computer programme created on the basis of free software which is GeoGebra and shared as HTML pages. The prepared learning resource does not require from its receivers any programming skills or special software.
Źródło:
Security Dimensions; 2017, 24(24); 150-162
2353-7000
Pojawia się w:
Security Dimensions
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
On the role of serotonin2A-2C receptors in the sensitization to cocaine
Autorzy:
Filip, M.
Nowak, E.
Papla, I.
Powiązania:
https://bibliotekanauki.pl/articles/69954.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
sensitization
prazosin
receptor
serotonin
locomotor activity
dopamine
ketanserin
cocaine
rodent
rat
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bulbospinal catecholamine neurones and sympathetic pattern generation
Autorzy:
Coote, J H
Lewis, D.I.
Powiązania:
https://bibliotekanauki.pl/articles/70075.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
catecholamine neuron
sympathetic pattern generation
brain tissue
preganglionic neuron
dopamine
noradrenaline
cardiovascular system
rat
Źródło:
Journal of Physiology and Pharmacology; 1995, 46, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of Fragment Molecular Orbital Method to investigate dopamine receptors
Autorzy:
Preikša, Jokūbas
Śliwa, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/93092.pdf
Data publikacji:
2019
Wydawca:
Państwowa Wyższa Szkoła Zawodowa w Tarnowie
Tematy:
Fragment Molecular Orbital
molecular dynamic
dopamine receptor
Fragment Molecular Orbital (FMO)
dynamika molekularna
receptor dopaminowy
Opis:
GPCRs are a vast family of seven-domain transmembrane proteins. This family includes dopamine receptors (D1, D2, D3, D4, and D5), which mediate the variety of dopamine-controlled physiological functions in the brain and periphery. Ligands of dopamine receptors are used for managing several neuropsychiatric disorders, including bipolar disorder, schizophrenia, anxiety, and Parkinson’s disease. Recent studies have revealed that dopamine receptors could be part of multiple signaling cascades, rather than of a single signaling pathway. For these targets, a variety of experimental and computational drug design techniques are utilized. In this work, dopamine receptors D2, D3, and D4 were investigated using molecular dynamic method as well as computational ab initio Fragment Molecular Orbital method (FMO), which can reveal atomistic details about ligand binding. The results provided useful insights into the significances of amino acid residues in ligand binding sites. Moreover, similarities and differences between active-sites of three studied types of receptors were examined.
Źródło:
Science, Technology and Innovation; 2019, 6, 3; 24-32
2544-9125
Pojawia się w:
Science, Technology and Innovation
Dostawca treści:
Biblioteka Nauki
Artykuł
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