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Wyświetlanie 1-10 z 114
Tytuł:
Cytotoxic surfaces for regional chemotherapy
Autorzy:
Krukiewicz, K.
Cichy, M.
Turczyn, R.
Jarosz, T.
Zak, J. K.
Bednarczyk-Cwynar, B.
Ruszkowski, P.
Powiązania:
https://bibliotekanauki.pl/articles/285824.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
chemotherapy
surfaces
cytotoxicity
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 78
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytotoxicity of hydroxyapatite doped nanoparticles on osteosarcoma
Autorzy:
Espanol, M.
Bonany, M.
Canal, C.
Alcaina, M.
Ginebra, M. P.
Powiązania:
https://bibliotekanauki.pl/articles/285862.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydroxyapatite
cytotoxicity
nanoparticles
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 20
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Design, synthesis and biological evaluation of some novel substituted quinazoline derivatives as antitumor agents.
Autorzy:
Ahmed, Marwa
Magdy, Naja
Powiązania:
https://bibliotekanauki.pl/articles/895417.pdf
Data publikacji:
2018-06-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
cytotoxicity
quinazoline
Tyrosine kinases
Opis:
New series of 6,8-dibromo-2-(4-chlorophenyl)quinazolin-4-yloxy derivatives were synthesized and their cytotoxic activity on MCF7, HEPG2 and HCT116 cell lines were evaluated. Compound XI and XIIIb were two times more active than doxorubicin on MCF7 cancer cell line. Compound VIIIa was 3 times more active than doxorubicin on HEPG2 cancer cell line. While compounds XII, XIIIa and XIIIb were more potent than doxorubicin on HCT116 cancer cell line. IC50 of all newly synthesized compounds were evaluated in vitro for thier inhibition to EGFR tyrosine kinase. All compound show good inhibitory activity on EGFR tyrosine kinase with IC50 range (6.19-19.87) µM.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 3
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
New chitosan wound dressing – first step - the cytotoxicity evaluation
Autorzy:
Karuga, Ewa
Zając, Adam
Rybak, Zbigniew
Hanuza, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/1034845.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
cytotoxicity
wound dressing
Opis:
The cytotoxicity of chitosan with polyvinox (PCH) and crosslinked chitosan (CH) was studied and analyzed. Cell viability was determined by thiazolyl blue formazan (MTT) assay and cell morphology observations were carried out during cell culturing and MTT tests. Crosslinked chitosan was used as a protective foil (scaffold) for skin wounds. Studies in vitro and the other obtained in this work results prove that the studied materials CH and PCH do not cause cytotoxic activity to Balb 3T3 mouse fibroblasts. CH and PCH are promising biomaterials with prospective application as wound healing dressings.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 97-109
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The use of in vitro assays for the assessment of cytotoxicity on the example of MTT test
Autorzy:
Twarużek, Magdalena
Zastempowska, Ewa
Soszczyńska, Ewelina
Ałtyn, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/764848.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
MTT test
SK cells
cytotoxicity
Opis:
Testy biologiczne oparte na hodowlach komórkowych z powodzeniem stosowane są do oceny cytotoksyczności leków, artykułów spożywczych, pasz. Testy in vitro stają się uzupełnieniem konwencjonalnych metod chemicznych, a także alternatywą dla badań przeprowadzanych na zwierzętach. Na podstawie badań własnych można stwierdzić, że test MTT jest czułą metodą diagnostyczną przydatną w ocenie cytotoksyczności nie tylko mikotoksyn, pestycydów, bakterii, pleśni, żywności, pasz, ale także próbek uzyskanych z materiałów budowlanych.
In recent years, biological tests have been developed based on cell cultures and successfully used to the hygienic assess of a variety of samples. In vitro assays become the complement of conventional chemical methods. They do not narrow the results only to the quantitative and qualitative information on toxic substances, but also increase knowledge on the direct impact on the organism. They are also an alternative for animal testing, which are currently given up for ethical reasons. At present, the market is steadily increasing in the number of tests and bio-assay techniques. Based on our own studies we conclude that the MTT test is perfect as a diagnostic method for evaluating the cytotoxicity of materials of different composition such as mycotoxins, pesticides, bacterial cultures, moulds isolates, food, feed, as well as a vast spectrum of other environmental samples.
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2018, 14; 23-32
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Redox properties and prooxidant cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX)
Autorzy:
Šarlauskas, Jonas
Nemeikaitė-Čėnienė, Aušra
Misevičienė, Lina
Krikštopaitis, Kastis
Anusevičius, Žilvinas
Čėnas, Narimantas
Powiązania:
https://bibliotekanauki.pl/articles/1039581.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
flavoenzymes
cytotoxicity
DNQX
oxidative stress
Opis:
In order to characterize the possible mechanism(s) of cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX) we examined the redox properties of DNQX, and its mononitro- (NQX) and denitro- (QX) derivatives. The irreversible electrochemical reduction of the nitro groups of DNQX was characterized by the reduction peak potentials (Ep,7) of -0.43 V and -0.72 V vs. Ag/AgCl at pH 7.0, whereas NQX was reduced at Ep,7 = -0.67 V. The reactivities of DNQX and NQX towards the single-electron transferring enzymes NADPH:cytochrome P-450 reductase and NADPH:adrenodoxin reductase/adrenodoxin complex were similar to those of model nitrobenzenes with the single-electron reduction potential (E17) values of -0.29 V - -0.42 V. DNQX and NQX also acted as substrates for two-electron transferring mammalian NAD(P)H:quinone oxidoreductase (DT-diaphorase). The cytotoxicity of DNQX in bovine leukemia virus-transformed lamb kidney fibroblasts (line FLK) was prevented by antioxidants and an inhibitor of NQO1, dicoumarol, and was enhanced by the prooxidant alkylating agent 1,3-bis(2-chloromethyl)-1-nitrosourea. A comparison with model nitrobenzene compounds shows that the cytotoxicity of DNQX and NQX reasonably agrees with the ease of their electrochemical reduction, and/or their reactivities towards the used enzymatic single-electron reducing systems. Thus, our data imply that the cytotoxicity of DNQX in FLK cells is exerted mainly through oxidative stress.
Źródło:
Acta Biochimica Polonica; 2013, 60, 2; 227-231
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Correlation between mammalian cell cytotoxicity of flavonoids and the redox potential of phenoxyl radical/phenol couple
Autorzy:
Marozienė, Audronė
Nemeikaitė-Čėnienė, Aušra
Vidžiūnaitė, Regina
Čėnas, Narimantas
Powiązania:
https://bibliotekanauki.pl/articles/1039753.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cytotoxicity
antioxidants
flavonoids
oxidative stress
Opis:
Flavonoids exhibit prooxidant cytotoxicity in mammalian cells due to the formation of free radicals and oxidation products possessing quinone or quinomethide structure. However, it is unclear how the cytotoxicity of flavonoids depends on the ease of their single-electron oxidation in aqueous medium, i.e., the redox potential of the phenoxyl radical/phenol couple. We verified the previously calculated redox potentials for several flavonoids according to their rates of reduction of cytochrome c and ferricyanide, and proposed experimentally-based values of redox potentials for myricetin, fisetin, morin, kaempferol, galangin, and naringenin. We found that the cytotoxicity of flavonoids (n=10) in bovine leukemia virus-transformed lamb kidney fibroblasts (line FLK) and murine hepatoma (line MH-22a) increases with a decrease in their redox potential of the phenoxyl radical/phenol couple and an increase in their lipophilicity. Their cytotoxicity was decreased by antioxidants and inhibitors of cytochromes P-450, α-naphthoflavone and isoniazide, and increased by an inhibitor of catechol-O-methyltransferase, 3,5-dinitrocatechol. It shows that although the prooxidant action of flavonoids may be the main factor in their cytotoxicity, the hydroxylation and oxidative demethylation by cytochromes P-450 and O-methylation by catechol-O-methyltransferase can significantly modulate the cytotoxicity of the parent compounds.
Źródło:
Acta Biochimica Polonica; 2012, 59, 2; 299-306
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of a new production method of foam-like wound dressings for skin regeneration
Autorzy:
Vivcharenko, Vladyslav
Kazimierczak, Paulina
Wójcik, Michał
Przekora, Agata
Powiązania:
https://bibliotekanauki.pl/articles/284152.pdf
Data publikacji:
2019
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
chitosan
agarose
biomaterials
fibroblasts
cytotoxicity
Opis:
Chitosan is widely used to prepare films, hydro-gels, cryogels, sponges, fibers and other various biomaterials used in the tissue engineering field. It is one of the best processable polysaccharides used in biomedicine. However, its stability is generally lower as compared with others, due to its pH sensitivity and hydrophilic character. Using chitosan in combination with agarose may not only improve chemical and mechanical properties of the resultant material (by the formation of a biocomposite), but also lead to the formation of a gel imitating physical attributes of the extracellular matrix. Moreover, the combination of these two polysaccharides has a promising ability to improve the stability of chitosan and to increase fibroblasts’ affinity to agarose. Characteristic advan-tageous features of these natural polymers raise a wide interest in tissue engineering. The aim of this study was to develop and optimize a new method to produce a highly biocompatible foam-like chitosan/agarose wound dressing for skin healing applications. The production process optimization helped to obtain the absorbent foam-like biomaterial which is non-toxic to skin fibroblasts and does not conduce their adhesion. Employing sodium bicarbonate as the main agent in the foaming reaction not only led to obtaining the foam-like structure but also neutralized the acidic pH, making the material non-toxic and non-irritating to the skin. In conclusion, the new foam-like biomaterial has great potential for biomedical applications as the wound dressing accelerating the healing process of the damaged tissues.
Źródło:
Engineering of Biomaterials; 2019, 22, 152; 16-20
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The cytotoxicity verification of the VOCs removal by means of photocatalysis
Autorzy:
Czarny, A.
Zaczyńska, E.
Hirszfeld, L.
Górniak, A.
Janicka, A.
Zawiślak, M.
Powiązania:
https://bibliotekanauki.pl/articles/2073650.pdf
Data publikacji:
2015
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
cytotoxicity
photocatalysis
volatile organic compounds
Opis:
This paper constitutes the approach to correlate the results of gas purification properties performed with aid of photocatalysis with the cytotoxicity test results. The gas purification by means of photocatalysis is a subject well known a profusely described in literature. Easiness and continence of application causes the photocatalysis to be used in variety of industries, however this paper considers only automotive industry application. The effectiveness of photocatalysis have been proven experimentally by vast number of researchers. However, the literature contains only the information about the level of volatile organic compounds identification and reduction. The toxicity measure in terms of living cells was not yet fully tested and described in literature. Therefore, the standard chromatography test which enables quantitative identification of volatile organic compounds was confronted with a cytotoxicity tests revealing the virtual toxicity of gases before and after photocatalysis.
Źródło:
Journal of Polish CIMEEAC; 2015, 10, 1; 37--44
1231-3998
Pojawia się w:
Journal of Polish CIMEEAC
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Effects of Niobium on the Bioactivity of Ni-Ti-Al-Nb Shape Memory Alloys
Autorzy:
Teixeira, Ricardo Luiz Perez
de Lacerda, José Carlos
Conceição, Isabella Carolina
da Silva, Sidney Nicodemos
Siqueira, Guilherme O.
Moura, Francisco
Powiązania:
https://bibliotekanauki.pl/articles/2049692.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
nitinol
niobium
aluminum
bioactivity
cytotoxicity
Opis:
This work aims to analyze the effects of niobium on the bioactivity of a titanium, nickel, aluminum, and niobium alloy obtained by the Plasma Skull Push Pull process (PSPP). Titanium alloys, such as NiTinol (NiTi), are metallic biomaterials that have wide application in health and surgical prostheses. In this work the microstructural and bioactivity characteristics of the alloys are evaluated. The addition of aluminum improves alloy ductility and reduces its cost. The addition of niobium favors the hydroxyapatite nucleation. Therefore, the addition of the combination of the two elements contributes to lower cost and better alloy bioactivity.
Źródło:
Archives of Metallurgy and Materials; 2021, 66, 2; 437-442
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 114

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