Temat: Cynarin - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Polyphenolic composition of Spanish cultivars of globe artichoke (Cynara cardunculus L. var. scolymus (L.) Fiori)
Autorzy:: Pérez-Esteve, É.
Sałata, A.
Barat, J.M.
Stępniowska, A.
López-Galarza, S.
Nurzyńska-Wierdak, R.
Powiązania:: https://bibliotekanauki.pl/articles/11897335.pdf
Data publikacji:: 2018
Wydawca:: Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
Tematy:: plant cultivation
cardoon
Cynara cardunculus
polyphenolic composition
Opal cultivar
Concerto cultivar
Symphony cultivar
Madrigal cultivar
Blanca de Tudela cultivar
A-106 cultivar
herbal plant
medicinal plant
phenolics content
chlorogenic acid
apigenin
cynarin
Opis:: Globe artichoke (Cynara cardunculus L. var. scolymus (L.) Fiori) is an edible herbaceous perennial plant that plays an important economic role in Mediterranean agriculture. In recent years, extensive research, which aimed to characterize the phenolic profile of the most important globe artichoke cultivars in Italy, has been conducted. However, very little information is available on the phenolic composition of cultivars traditionally grown in Spain. In this work, six cultivars (‘Opal’, ‘Symphony’, ‘Concerto’, ‘Madrigal’, ‘Blanca de Tudela’ and ‘A-106’) cultured in Spain were characterized according to their phenolic content. The phenolic profile differed between cultivars, and also between flower parts. The major phenolic compound in all the different cultivars was chlorogenic acid. Of the six studied cultivars, ‘Madrigal’ had the highest phenolic content.
Źródło:: Acta Scientiarum Polonorum. Hortorum Cultus; 2018, 17, 2; 177-184
1644-0692
Pojawia się w:: Acta Scientiarum Polonorum. Hortorum Cultus
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Modulation of Doxorubicin Cytotoxicity by Isoliquiritin and Cynarin Combination on Different Cancer Cell Lines
Autorzy:: Al-AdamI, Salat G.
Al-Khateeb, EKBAL H.
NUMAN, NAWFAL A.
ABBAS, Mannal M.
Tawfiq, FATIMA A.
Shakya, Ashok K.
Powiązania:: https://bibliotekanauki.pl/articles/895633.pdf
Data publikacji:: 2020-06-29
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: cytotoxicity
doxorubicin
cancer cells
Modulation
Cynarin
Isoliquiritin
Opis:: Natural polyphenolic compounds produced by plant exhibit many pharmacological effects including antioxidant, chemopreventive as well as anticancer properties. This study was conducted to investigate the effect of cynarin ( from Artichoke, Cynara scolymus) and isoliquiritin (from Licorice, Glycyrrhiza uralensis) on doxorubicin (positive control) cytotoxicity in different cell lines including normal (Fibroblasts MCR-5 and Myoblasts H9c2) and cancer (colorectal HCT-116 and hepatocellular HEP-G2) cell lines. The cytotoxic effect of doxorubicin, isoliquiritin and cynarin alone or in different combination was studied on cancer cell lines as well as normal cell lines. The results obtained indicated that both cynarin and isoliquiritin enhance the cytotoxicity of doxorubicin. Both cynarin and isoliquiritin also reduce the cardiotoxicity of doxorubicin on normal cardiac cell lines. The combination of the three compounds (cynarin, isoliquiritin and doxorubicin) result in decrease the cytotoxicity of doxorubicin, which may indicate the presence of interaction and/or antagonism effect between cynarin and isoliquiritin. Cynarin was found to enhance the growth of (HCT-116 and HEP-G2) this might suggest avoiding use of Artichoke in subjects’ susceptibility for these cancers. All results were evaluated using statistical path and showed significant findings. The mechanism of enhanced doxorubicin’s cytotoxicity by cynarin or isoliquiritin also require further investigation to explain the increasing and/or the decreasing effect of these polyphenolic compounds on cytotoxicity of doxorubicin. The current finding can help to start with safe minimum dose of two or three combination of compounds in the context of clinical trials and practice.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 475-484
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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