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Wyświetlanie 1-15 z 21
Tytuł:
A coumarin-based fluorescent probe for specific and rapid detection of fluoride ions
Autorzy:
Xin, Z.-H.
Meng, Y.-L.
Wu, Y.-H.
Feng, Z.-K.
Kang, Y.-F.
Powiązania:
https://bibliotekanauki.pl/articles/778907.pdf
Data publikacji:
2018
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Fluorion
Fluorescence
Coumarin
Probe
Bioimaging
Opis:
A simple and coumarin-based fluorescence probe has been designed and synthesized with silyl group as recognition group of fluoride ions (F−) in this study. The results showed that the fluorescence intensity of the probe displayed prominent enhancement with addition of F− at 445 nm with incubation of 1 min. There was an excellent linear relationship between fluorescence intensity and fluoride concentration from 0 to 30 μM (0~0.57 ppm), which offered the important condition for the quantitative analysis. In addition, the highly selective response to fluorion, the low detection limit with 28 nM (0.532 ppb), low toxicity and bioimaging afforded an advantage for practical application and detecting fluoride in biological systerms.
Źródło:
Polish Journal of Chemical Technology; 2018, 20, 4; 1-5
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
SYNTHESIS, AND EVALUATION OF COUMARIN HYBRIDS AS ANTIMYCOBACTERIAL AGENTS
Autorzy:
Hassan, Mohd Z.
ALSAYARI, ABDULRHMAN
OSMAN, HASNAH
ALI, MOHAMED A.
MUHSINAH, ABDULLATIF B.
AHSAN, MOHAMED J.
Powiązania:
https://bibliotekanauki.pl/articles/895509.pdf
Data publikacji:
2019-12-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
cytotoxicity
Coumarin
TB
Thiazolopyrimidine
HTS
antimycobacterial
Opis:
A series of twelve hybrid coumarin analogues were synthesized and screened through HTS for their antimycobacterial activity against Mtb H37Rv. The hybrid molecules were efficiently synthesized by the reactions of 3-(bromoacetyl)coumarin with Biginelli products 2-mercapto-6-oxo-4-aryl-1,6-dihydropyrimidine-5-carbonitriles. Of the resulting twelve hybrids, the two compounds 7-(2,4-dichlorophenyl)-5-oxo-3-(2-oxo-2H-chromen-3-yl)-5H-thiazolo[3,2-a] pyrimidine-6-carbonitrile (3d) and 7-(4-nitrophenyl)-5-oxo-3-(2-oxo-2H-chromen-3-yl)-5H-thiazolo[3,2-a]pyrimidine-6-carbonitrile (3f) showed excellent antimycobacterial activity against Mtb (EC50 3.19 & 7.91 µM, respectively) and low cytotoxicity against the VERO cell line (IC50 > 62.5 µg/mL).
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 6; 1029-1036
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin
Autorzy:
Michalska, Marta
Pająk, Wojciech
Kołodziejska, Justyna
Łazarenkow, Andrzej
Nawrot-Modranka, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1040726.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
fibrin
chromone
coumarin
polymerization
viscosity
phosphorohydrazone
Opis:
The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.
Źródło:
Acta Biochimica Polonica; 2008, 55, 3; 613-617
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis of 1,2,3-triazole derivative at 3rd position of coumarin via copper(I) catalyzed click chemistry using ternary solvent system (DMF + t-BuOH + water)
Autorzy:
Safi, Shahrukhkhan
Dhamsaniya, Ashish
Christian, Wilson
Trivedi, Prachi
Chhatbar, Pratiksha
Shah, Anamik
Powiązania:
https://bibliotekanauki.pl/articles/1059512.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Click Chemistry
Coumarin
Triazole
heterocyclic hybrids
Opis:
Coumarin-based triazoles were synthesized from 2-azido-N-phenylacetamide and terminal acetylenic compound by click chemistry. Whereas the CuSO4 used catalyts and sodium ascorbate used as a reducant affords only the favourable 1,4-regioisomer of triazole. Here DMF + t-BuOH + water used as a solvent.
Źródło:
World Scientific News; 2019, 128, 2; 255-301
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A convergent approach for the synthesis of new pyrazolyl bipyridinyl substituted coumarin derivatives as antimicrobials
Autorzy:
Bhila, V. G.
Chovatiya, Y. L.
Patel, C. V.
Giri, R. R.
Brahmbhatt, D. I.
Powiązania:
https://bibliotekanauki.pl/articles/411982.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Coumarin
Bipyridine
Pyrazole
Kröhnke’s reaction
antimicrobial activity
Opis:
Some new 3-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)acryloyl]coumarins 3a-f were synthesized (coumarin chalcones) by the condensation of various 3-acetyl coumarins 1 and appropriate 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehyde 2. These coumarin chalcones 3a-f were then employed for the synthesis of pyrazolyl bipyridinyl substituted coumarins 7a-f, 8a-f, and 9a-f under Krohnke’s reaction condition. The characterization of all the synthesized compounds was carried out by elemental analysis, IR, 1H-NMR, 13C-NMR, DEPT-135 and mass spectral analysis. In addition to that, in vitro antimicrobial competency of the title compounds was assessed against selected pathogens. Compounds 3b, 3e, 7b, 8b, 8c and 9b exhibited excellent antimicrobial activity and said to be the most proficient members of the series.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2015, 40; 1-16
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Design, Efficient Synthesis, Mechanism of Reaction and Antiproliferative Activity Against Cancer And Normal Cell Lines of A Novel Class of Fused Pyrimidine Derivatives
Autorzy:
roaiah, hanaa F.
Rashdan, Huda R.
soliman, abdelmohsen
Muhammed, Zeinab
Wietrzyk, Joanna
Milczarek, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/895705.pdf
Data publikacji:
2018-06-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
anticancer activity
antiproliferative activity
Coumarin
Fused pyrimidines
3-triazole
Opis:
This work concentrated on the utility of hydrazonoyl halides in synthesis of bioactive heterocycles like triazoles, pyrazoles, pyrimidines and their fused derivatives which have a wide spectrum of pharmaceutical value. Herein we discussed the synthesis of new heterocyclic compounds containing fused pyrimidine rings derived from hydrazonoyl halides and their significant pharmaceutical importance as anticancer agents. New fused pyrimidine derivatives bearing 1,2,3-triazole moiety were prepared via reaction of enaminone 2 with and 6-amino-2-thioxo-pyrimidin-4-one and then with hydrazonoyl chlorides 6a-h. In addition 3-amino-6-(2-oxo-2H-chromen-3-yl)pyridine-2-carbonitrile (12) was submitted to react with carbon dioxide to afford 3-(1,2,3,4-tetrahydro-2,4-dithioxopyrido[2,3-d]pyrimidin-7-yl)-2H-chromen-2-one (15), which act as key molecule for synthesis of new series of fused prymidinethione derivatives containing coumarine moiety via its reaction with different selected derivatives of hydrazonoyl halides 6a-h. Structures of the newly synthesized compounds were confirmed using spectral data (IR, H1NMR and Mass spectrometry) and microanalytical methods. Also, they screened for their anticancer activity.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 3
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and antimicrobial activity of coumarinyl Schiff base derivatives
Autorzy:
Mishra, A.
Rathod, J.
Namera, D.
Thakrar, S.
Shah, A.
Powiązania:
https://bibliotekanauki.pl/articles/411623.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
gram positive bacterial
gram negative bacterial
derivatives of coumarin
Opis:
We have reported some novel N’-[(1)-ethylidene]-2-(6-methyl-2-oxo-2H-chromen-4-yl) acetohydrazide synthesized by conventional method. The reaction of 2-(6-methyl-2-oxo-2H-chromen-4-yl)acetohydrazide with substituted benzaldehyde in methanol as a solvent yielded a series of (7a-l). The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1H NMR, 13C NMR and elemental analysis. Moreover, all synthesized compounds were screened for in vitro antimicrobial activity against the gram positive (Staphylococcus aureus, Bacilluas subtilis) and gram negative (Escherichia coli, P. aeruginosa, K. pneunonae, Enterobacter) bacterial strain. In which some the compounds show potential inhibition against the test organisms.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 11, 3; 193-201
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
PEG mediated eco-friendly one pot sunthesis of benzylamine coumarin derivatives using multicomponent reactant
Autorzy:
Viradiya, D. J.
Kotadiya, V. C
Khunt, M. D.
Baria, B. H.
Bhoya, U. C.
Powiązania:
https://bibliotekanauki.pl/articles/412545.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
one pot reaction
benzylamine coumarin derivative
green synthesis
PEG-400
Opis:
A green resourceful, eco-friendly and facile protocol was developed for the synthesis of benzylamine coumarin derivatives by the reaction of 4-hydroxy coumarin, secondary amine and aromatic aldehyde in the presence of PEG400 as a solvent as well as catalyst at room temperature. A wide range of functional groups were tolerated in the developed protocol. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis. The target molecules were obtained in good to excellent yield applying this method.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 11, 2; 177-184
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and anticancer evaluation of some coumarin and azacoumarin derivatives
Autorzy:
Bakare, Safyah B.
Powiązania:
https://bibliotekanauki.pl/articles/1849302.pdf
Data publikacji:
2021
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Coumarin
azacoumarin
1H-NMR spectrum
13C-NMR spectrum
anticancer
Opis:
Coumarin and its nitrogen analogue 1-aza coumarin are a class of lactones and lactams, respectively, which are indispensable heterocyclic units to both chemists and biochemists. 1-Aza coumarin derivatives, which ultimately metabolize as the corresponding 8-hydroxy coumarins in the biological system are therefore found to be very good anti-inflammatory, anti-cancer, and analgesic agents. A series of hybrid substituted coumarin and azacoumarin-3-carboxylic acid derivatives (8-methoxycoumarin-3-carboxylic acid (4a), 8-methoxyazacoumarin-3-carboxylic acid (4b), 5-bromo-8-methoxycoumarin-3-carboxylic acid (5a), 5-bromo-8-methoxyazacoumarin-3-carboxylic acid (5b), 2-acetoxy-5-bromo-8-methoxyquinoline-3-carboxylic acid (6), and 5,7-di(phenylazo)-8-methoxycoumarin-3-carboxylic acid (7) were synthesized and structurally proved using spectral and elemental analysis data. Substituted coumarin-3-carboxylic acid (4a and 5a) and Substituted azacoumarin-3-carboxylic acid (4b, 5b and 6) were tested for their in vitro cytotoxic activity against MCF-7 and HepG-2 cell lines.
Źródło:
Polish Journal of Chemical Technology; 2021, 23, 2; 27-34
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pochodne kumaryny do roli molekularnych sensorów fluorescencyjnych do zastosowań w naukach life science
Coumarin derivatives for the role of molecular fluorescent sensors for the application in life science
Autorzy:
Czarna, M.
Kamińska, I.
Ortyl, J.
Powiązania:
https://bibliotekanauki.pl/articles/134827.pdf
Data publikacji:
2015
Wydawca:
ADVSEO
Tematy:
kumaryna
sensory molekularne
fluoroscencja
coumarin
fluorescence
molecular sensor
molecular probes
fluorophores
Opis:
Fluorescent spectroscopy is an important method in life science which has recently gained popularity. Fluorescent spectroscopy is widely used for example by the researches in the variety of biological structures, intercellular interactions, various kinds of biomolecules and also for understanding of the biochemical processes which take place inside the living organisms. For this purpose, an application of fluorescent sensors and searching for more efficient and more sensitive fluorophore for illustrating, labelling and detection, have become a developing trend in biochemistry, medicine, biology and also in many other chemistry researches. Nowadays, issues which are connected to fluorescence are mainly applied to the newest achievements in the field of fluorescent methods and measurement techniques and also to the development and applications of fluorescent probes, what is closely showed up in this article.
Źródło:
Technical Issues; 2015, 4; 3-10
2392-3954
Pojawia się w:
Technical Issues
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synteza pochodnych hydroksy-2H-1-benzopiran-2-onu w polu promieniowania mikrofalowego oraz w warunkach ogrzewania konwencjonalnego
Synthesis of derivatives of hydroxy-2H-1-benzopyran-2-one using microwave-assisted and conventional heating methods
Autorzy:
Czarna, M.
Ortyl, J.
Powiązania:
https://bibliotekanauki.pl/articles/142463.pdf
Data publikacji:
2015
Wydawca:
Stowarzyszenie Inżynierów i Techników Przemysłu Chemicznego. Zakład Wydawniczy CHEMPRESS-SITPChem
Tematy:
pochodne hydroksykumaryny
kumaryna
promieniowanie mikrofalowe
fluorescencja
hydroxycoumarin derivatives
coumarin
microwave radiation
fluorescence
Opis:
W wyniku przeprowadzonych eksperymentów w polu promieniowania mikrofalowego oraz w warunkach ogrzewania konwencjonalnego, otrzymano szereg pochodnych hydroksy-2H-1-benzopiran- 2-onu o wysokim stopniu czystości. Wykonane badania spektroskopowe oraz analiza związków wykazały, że większość otrzymanych produktów charakteryzuje się interesującymi właściwościami spektroskopowymi, co pozwala na wykorzystanie ich do roli molekularnych sond fluorescencyjnych.
As a result of the conducted experiments under microwave radiation and under conditions of conventional heating, a number of high-purity derivatives of hydroxy-2H-1-benzopyran-2-one were obtained. The conducted spectroscopic measurements and compound analysis showed that the majority of obtained products exhibit interesting spectroscopic properties, which allows their use as a molecular fluorescence probes.
Źródło:
Chemik; 2015, 69, 5; 297-306
0009-2886
Pojawia się w:
Chemik
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Flavonoids and coumarins from Hieracium pilosella L. [Asteraceae]
Autorzy:
Gawronska-Grzywacz, M
Krzaczek, T.
Powiązania:
https://bibliotekanauki.pl/articles/59337.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
weed
flavonoids
invasive weed
mouse-ear hawkweed
coumarin
herb
Compositae
Hieracium pilosella
Opis:
Typical chromatographic methods were successfully applied to isolate nine flavonoid compounds and two coumarin glycosides from the inflorescences and the herb of Hieracium pilosella L. Repeated column chromatography, occasionally paper chromatography and recrystallization made the separation of three flavonoid aglycones and six glycosides - possible. Coumarin glycosides were isolated by preparative thin layer chromatography. Subsequent UV, NMR and MS analyses have led to identification of the following flavonoid derivatives: known for the species - apigenin, luteolin, luteolin 7-O- ß-glucopyranoside, luteolin 4’-O-ß-glucopyranoside, isoetin 7-O-ß- -glucopyranoside, isoetin 4’-O-ß-glucuronide and new for the species – kaempferol 3-methyl ether and apigenin 7-O-ß-glucopyranoside. Third isoetin glycoside contained two different sugar moieties: xylose and glucose, probably attached to the hydroxyl groups at C-4’ or C-4’ and C-2’(or 5’) of an aglycone. Umbelliferone 7-O-ß-glucopyranoside (skimmin) and new for the genus Hieracium esculetin 7-O-ß-glucopyranoside (cichoriin) were determined by NMR and MS methods.
Źródło:
Acta Societatis Botanicorum Poloniae; 2009, 78, 3; 189-195
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterization of novel 2-oxo-4-((4-(3-oxomorpholino)phenyl)amino)-2H-chromene-3-carbonitrile derivatives
Autorzy:
Jilariya, Krushnakumar J.
Chodvadiya, Vijay D.
Patel, P. K.
Babariya, Jayesh
Powiązania:
https://bibliotekanauki.pl/articles/1075711.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
3-cyano-4chlor coumarin
4-(4-aminophenyl)morpholin-3-one
antimicrobial activity
Opis:
A highly functionalized heterocyclic library were synthesized, and characterized by common spectroscopic methods. This novel synthetic rout involves nucleophilic substitution reaction of 3-cyano-4chloro coumarin with 4-(4-aminophenyl)morpholin-3-one in the presence of base and methanol as a solvent in good yield and high purity. Key starting material 4-(4-aminophenyl)morpholin-3-one synthesized from aniline. The reaction of aniline with ethylene oxide gives INT-1 which on reaction with Chloroacetyl chloride yield INT-b. Nitration of INT-b gives INT-c, which on reduction with Sn/HCl gives int-D. Further INT-3 was synthesized from 4-hydroxy coumarin. The Vilsmeier-haack reaction of 4-hydroxy coumarin gives INT-01 which on reaction with hydroxylamine hydrochloride and sodium acetate furnished INT-03. All the synthesized compound of libraries characterized using 1H NMR, Mass, and IR spectroscopic technique.
Źródło:
World Scientific News; 2019, 119; 231-237
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gene-to-metabolite network for coumarins biosynthesis in natural accessions of Arabidopsis thaliana
Autorzy:
Siwinska, J.
Olry, A.
Hehn, A.
Bourgaud, F.
Lojkowska, E.
Ihnatowicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/80417.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
coumarin
secondary metabolite
biosynthesis
antimicrobial activity
antioxidative activity
biotic stress
abiotic stress
Arabidopsis thaliana
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pochodne kumaryny jako molekularne sensory fluorescencyjne stosowane do monitorowania procesów fotopolimeryzacji
Coumarin derivatives as molecular fluorescence probes applied for monitoring photopolymerization processes
Autorzy:
Pudo, A.
Kamińska, I.
Ortyl, J.
Powiązania:
https://bibliotekanauki.pl/articles/134684.pdf
Data publikacji:
2015
Wydawca:
ADVSEO
Tematy:
pochodne kumaryny
fotopolimeryzacja
sensory fluorescencyjne
FPT
fluorescence probes
cationic photopolymerization
radical photopolymerization
coumarin derivatives
polymerization processes monitoring
Opis:
This paper presents research on the use of coumarin derivatives as fluorescent molecular probes for monitoring cationic and free radical photopolymerization processes, using for that purpose modern FPT method (Fluorescence Probe Technology). Literature review on the main trends of applications and spectroscopic properties of coumarin derivatives was described. In the following part of publication, relations between change of fluorescence characteristic and physicochemical changes occurring in the polymerizable composition, (both microviscosity and polarity) were explained. This article also presented the basic methodology of studies on the control of the photopolymerization reaction on-line and off-line, using fluorescence spectroscopy and parameters such as: fluorescence intensity ratio R, number of progress of the reaction β and molecular probe sensitivity S.
Źródło:
Technical Issues; 2015, 1; 47-53
2392-3954
Pojawia się w:
Technical Issues
Dostawca treści:
Biblioteka Nauki
Artykuł
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