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Wyświetlanie 1-15 z 55
Tytuł:
Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76).
Autorzy:
Awasthi, Sanjay
Sharma, Rajendra
Yang, Yusong
Singhal, Sharad
Pikula, Slawomir
Bandorowicz-Pikula, Joanna
Singh, Shivendra
Zimniak, Piotr
Awasthi, Yogesh
Powiązania:
https://bibliotekanauki.pl/articles/1043688.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
RLIP76
RalBP1
glutathione conjugate
multidrug resistance
transport
Opis:
We have recently demonstrated that a previously known Ral-binding GTPase activating protein, RLIP76, can also catalyze ATP-dependent transport of various structurally unrelated xeno- and endobiotics irrespective of their net charge (Awasthi et al., 2000, Biochemistry, 39: 9327). RLIP76 is a non-ATP binding cassette (ABC) protein but it has two ATP-binding sites and shows basal ATPase activity which is stimulated in the presence of its transport substrates (allocrites) such as doxorubicin (DOX) and S-(2,4-dinitrophenyl) glutathione (DNP-SG). Proteoliposomes reconstituted with purified RLIP76 catalyze ATP-dependent, saturable transport of DOX, as well as of glutathione-conjugates including leukotrienes (LTC4) and the GSH-conjugate of 4-hydroxynonenal (GS-HNE). In erythrocytes the majority of transport activity for DOX, GS-HNE, and LTC4 is accounted for by RLIP76. Cells exposed to mild oxidative stress show a rapid and transient induction of RLIP76 resulting in an increased efflux of GS-HNE and acquire resistance to oxidative stress mediated toxicity and apoptosis. Cells transfected with RLIP76 acquire resistance to DOX through increased efflux of the drug suggesting its possible role in the mechanisms of drug-resistance. In this article, we discuss the significance of transport functions of RLIP76 highlighting its role in the defense mechanisms against oxidative injury, and modulation of signaling mechanisms.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 855-867
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of turbulence model, turbulence length scale and wall roughness on the laminar-turbulence transition and temperature distribution of a convectively cooled C3X turbine vane
Autorzy:
Banaś, K.
Badur, J.
Powiązania:
https://bibliotekanauki.pl/articles/175460.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
laminar-turbulent transition
conjugate heat transfer analysis of turbine
C3X turbine vane
roughness correction
Opis:
Our paper demonstrates the ability of Favre-averaged Navier–Stokes (FANS) turbulence models to predict the laminar-turbulent transition and shows the influence of the models on the wall temperature distribution. The investigations were based on conjugate heat transfer analyses of a convectively cooled C3X turbine vane, which were performed using commercial flow simulation software. We compared several eddy-viscosity models: shear stress transport (SST), γ-Reθ SSTtransition, v2-f, k-ε, realizable, k-kl-ω transition, and second-order closure ε-based Reynolds stress model (RSM) with a linear pressure-strain model. The turbulence length scale (TLS) was not measured during the experiment, so its influence on the location of the transition onset and wall temperature distribution is presented. We also examined the influence of the roughness of the airfoil wall on the location of turbulence initialization and the wall temperature distribution.
Źródło:
Transactions of the Institute of Fluid-Flow Machinery; 2017, 138; 13-32
0079-3205
Pojawia się w:
Transactions of the Institute of Fluid-Flow Machinery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
On an approach to the thermo-elasto-plastic failure based on the Burzynski criterion
Autorzy:
Banaś, K.
Badur, J.
Powiązania:
https://bibliotekanauki.pl/articles/175155.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Burzynski stress
thermal-FSI
conjugate heat transfer
thermal stresses
turbine guide vane
Opis:
In this paper the comparison of material eort models: the classic Huber-Mises-Hencky approach and the Burzynski condition was presented. Burzynski yield condition is pressure sensitive and naturally takes into account the strength dierential eect, which has been observed in nickel-base super alloys such as Inconel 718. Investigation was performed during thermal-uidstructure interaction analysis of a power turbine guide vane of turbine helicopter engine PZL- 10W. Firstly, computational uid dynamics conjugate heat transfer analysis was carried out, then stress analysis was performed with boundary conditions obtained via computational uid dynamics analysis. During stress analysis, two mentioned above equivalent stress denitions were applied and dierence in material eort modelling by them was shown.
Źródło:
Transactions of the Institute of Fluid-Flow Machinery; 2017, 136; 65-76
0079-3205
Pojawia się w:
Transactions of the Institute of Fluid-Flow Machinery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Training neural networks with a hybrid differential evolution algorithm
Uczenie sieci neuronowych hybrydowym algorytmem opartym na differential evolution
Autorzy:
Bandurski, K.
Kwedlo, W.
Powiązania:
https://bibliotekanauki.pl/articles/341051.pdf
Data publikacji:
2009
Wydawca:
Politechnika Białostocka. Oficyna Wydawnicza Politechniki Białostockiej
Tematy:
sieci neuronowe
differential evolution
gradienty sprzężone
minima lokalne
neural networks
conjugate gradients
local minima
Opis:
A new hybrid method for feed forward neural network training, which combines differential evolution algorithm with a gradient-based approach is proposed. In the method, after each generation of differential evolution, a number of iterations of the conjugate gradient optimization algorithm is applied to each new solution created by the mutation and crossover operators. The experimental results show, that in comparison to the standard differential evolution the hybrid algorithm converges faster. Although this convergence is slower than that of classical gradient based methods, the hybrid algorithm has significantly better capability of avoiding local optima.
W artykule przedstawiono nową, hybrydową metodę uczenia sieci neuronowych, łączącą w sobie algorytm Differential Evolution z podejściem gradientowym. W nowej metodzie po każdej generacji algorytmu Differential Evolution, każde nowe rozwiązanie, powstałe w wyniu działania operatorów krzyżowania i mutacji, poddawane jest kilku iteracjom algorytmu optymalizacji wykorzystującego metodę gradientów sprzężonych.Wyniki eksperymentów wskazują, że nowy, hybrydowy algorytm ma szybszą zbieżność niż standardowy algorytm Differential Evolution. Mimo, iż zbieżność ta jest wolniejsza, niż w przypadku klasycznych metod gradientowych, algorytm hybrydowy potrafi znacznie lepiej unikać minimów lokalnych.
Źródło:
Zeszyty Naukowe Politechniki Białostockiej. Informatyka; 2009, 4; 5-17
1644-0331
Pojawia się w:
Zeszyty Naukowe Politechniki Białostockiej. Informatyka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Protective action of vitamin C against DNA damage induced by selenium-cisplatin conjugate.
Autorzy:
Błasiak, Janusz
Kowalik, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1044192.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
endonuclease III
vitamin C
Se-Pt conjugate [(NH3)2Pt(SeO3)]
genotoxic effects of anticancer drugs
DNA damage
comet assay
DNA repair
Opis:
Genotoxicity of anticancer drugs is of a special interest due to the risk of inducing secondary malignancies. Vitamin C (ascorbic acid) is a recognized antioxidant and, since human diet can be easily supplemented with vitamin C, it seems reasonable to check whether it can protect against DNA-damaging effects of antitumor drugs. In the present work the ability of vitamin C to modulate cytotoxic and genotoxic effects of a cisplatin analog, conjugate (NH3)2Pt(SeO3), in terms of cell viability, DNA damage and repair in human lymphocytes was examined using the trypan blue exclusion test and the alkaline comet assay, respectively. The conjugate evoked a concentration-dependent decrease in the cell viability, reaching nearly 50% at 250 μM. (NH3)2Pt(SeO3) at 1, 10 and 30 μM caused DNA strand breaks, measured as the increase in the comet tail moment of the lymphocytes. The treated cells were able to recover within a 30-min incubation in a drug-free medium at 37°C. Vitamin C at 10 and 50 μM diminished the extent of DNA damage evoked by (NH3)2Pt(SeO3) but had no effect on the kinetics of DNA repair. The vitamin did not directly inactivate the conjugate. Lymphocytes treated with endonuclease III, which recognises oxidised pyrimidines, displayed a greater tail moment than those untreated with the enzyme, suggesting that the damages induced by the drug have, at least in part, an oxidative origin. Vitamin C can be considered a potential protective agent against side effects of antitumor drugs, but further research with both normal and cancer cells are needed to clarify this point.
Źródło:
Acta Biochimica Polonica; 2001, 48, 1; 233-240
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modelling of influence of turbulent transition on heat transfer conditions
Autorzy:
Bochon, K.
Wróblewski, W.
Dykas, S.
Powiązania:
https://bibliotekanauki.pl/articles/1943251.pdf
Data publikacji:
2008
Wydawca:
Politechnika Gdańska
Tematy:
laminar-turbulent transition
Conjugate Heat Transfer (CHT)
computational fluid dynamics CFD
Opis:
This article deals with the turbulent transition phenomenon modelling and its influence on heat transfer. The purpose of the analyses was to verify the transition modelling implemented in the ANSYS CFX 11 commercial code for popular test cases (low flow speed) described in literature, and then use it for verification of the in-house CFD code (created for compressible flows). The inhouse CFD code has been extended lately for the Conjugate Heat Transfer modelling (CHT) as well, taking into account important flow effects, especially the turbulent transition. A Wilcox k-omega turbulence model with the Low-Reynolds modification was used in the in-house code. The calculations in ANSYS CFX were made using an SST turbulence model and a gamma-theta transition model. A fully turbulent flow was modelled by means of both codes, and the results were compared with the available experimental data. Then, the turbulent transition for several test cases was analysed with ANSYS CFX. Afterwards, the in-house CFD code was verified by means of ANSYS CFX for a higher flow speed (Mach numbers). The CHT modelling was analysed by means of both codes and the results were compared and discussed. The conducted analyses show that the results obtained by means of both codes are comparable, but the turbulence model used in the in-house CFD code is simpler and requires less computation time. A modification of two equations turbulence models can be an alternative for design problems in more developed laminar/turbulent flows.
Źródło:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2008, 12, 3-4; 173-184
1428-6394
Pojawia się w:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Geometric optimal control and two-level dissipative quantum systems
Autorzy:
Bonnard, B.
Sugny, D.
Powiązania:
https://bibliotekanauki.pl/articles/970909.pdf
Data publikacji:
2009
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
optimal control theory
conjugate and cut loci
quantum mechanics
Opis:
The objective of this article is to present techniques of geometric time-optimal control developed to analyze the control of two-level dissipative quantum systems. Combined with numerical simulations they allow to compute the time-minimal control using a shooting method. The robustness with respect to initial conditions and dissipative parameters is also analyzed using a continuation method.
Źródło:
Control and Cybernetics; 2009, 38, 4A; 1053-1080
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Operator-splitting and Lagrange multiplier domain decomposition methods for numerical simulation of two coupled Navier-Stokes fluids
Autorzy:
Bresch, D.
Koko, J.
Powiązania:
https://bibliotekanauki.pl/articles/908383.pdf
Data publikacji:
2006
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
dwoistość
gradient sprzężony
przepływ Naviera-Stokesa
domain decomposition
duality
conjugate gradient
Navier-Stokes flows
Opis:
We present a numerical simulation of two coupled Navier-Stokes flows, using operator-splitting and optimization-based nonoverlapping domain decomposition methods. The model problem consists of two Navier-Stokes fluids coupled, through a common interface, by a nonlinear transmission condition. Numerical experiments are carried out with two coupled fluids; one with an initial linear profile and the other in rest. As expected, the transmission condition generates a recirculation within the fluid in rest.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2006, 16, 4; 419-429
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zastosowanie metody gradientów sprzężonych w algorytmie sterowania optymalnego wysokością lotu czterowirnikowego bezzałogowego statku powietrznego
Conjugate gradient method for flight altitude optimal control algorithm of a quadrator unmanned aerial vehicle
Autorzy:
Brzozowski, B.
Kowaleczko, G.
Powiązania:
https://bibliotekanauki.pl/articles/213626.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Lotnictwa
Tematy:
sterowanie optymalne
metoda gradientów sprzężonych
quadrotor
BSP
optimal control
conjugate gradient method
UAV
Opis:
Artykuł przedstawia wyniki przeprowadzonych badań teoretycznych dotyczących zastosowania metody gradientów sprzężonych do rozwiązywania problemu sterowania optymalnego wysokością lotu czterowirnikowego bezzałogowego statku powietrznego (BSP). Ze względu na różnice w strategii sterowania mające wpływ na postać minimalizowanego funkcjonału jakości, problem rozdzielono na dwa zagadnienia – zmianę wysokości oraz stabilizację wysokości. Przeprowadzone analizy pozwoliły na określenie wpływu zmian postaci funkcjonału jakości, jego parametrów czasowych oraz współczynników wagowych na wyznaczoną za pomocą metody gradientów sprzężonych optymalną trajektorię stanu i sterowanie czterowirnikowego BSP podczas zmiany wysokości lotu oraz jej stabilizacji.
This paper presents results of studies on the usage of conjugate gradient method for solving optimal control problem of flight altitude control of a quadrotor unmanned aerial vehicle (UAV). Due to the differences in the control strategy affecting the character of minimized quality functional, the problem was resolved on two issues: changing the flight altitude and altitude stabilization. Conducted researches allowed to determine the impact of changes in the form of a quality functional as well as of its timing and weighting factors on the designated optimal control and state trajectory of a quadrotor UAV using conjugate gradient method during changing and stabilizing flight altitude.
Źródło:
Prace Instytutu Lotnictwa; 2015, 4 (241); 7-18
0509-6669
2300-5408
Pojawia się w:
Prace Instytutu Lotnictwa
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
On the Choice of Subspace for Iterative Methods for Linear Discrete Ill-Posed Problems
Autorzy:
Calvetti, D.
Lewis, B.
Reichel, L.
Powiązania:
https://bibliotekanauki.pl/articles/908057.pdf
Data publikacji:
2001
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
metoda sprzężonych gradientów
problem niewłaściwie postawiony
minimal residual method
conjugate gradient method
ill-posed problems
Opis:
Many iterative methods for the solution of linear discrete ill-posed problems with a large matrix require the computed approximate solutions to be orthogonal to the null space of the matrix. We show that when the desired solution is not smooth, it may be possible to determine meaningful approximate solutions with less computational work by not imposing this orthogonality condition.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2001, 11, 5; 1069-1092
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Two implementations of the preconditioned conjugate gradient method on heterogeneous computing grids
Autorzy:
Collignon, T. P.
Van Gijzen, M. B.
Powiązania:
https://bibliotekanauki.pl/articles/907778.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
przetwarzanie siatkowe
system liniowy
metoda iteracyjna
gradient sprzężony
przepływ pęcherzykowy
grid computing
large sparse linear systems
iterative methods
conjugate gradient method
Chronopoulos/Gear CG
GridSolve middleware
bubbly flows
Opis:
Efficient iterative solution of large linear systems on grid computers is a complex problem. The induced heterogeneity and volatile nature of the aggregated computational resources present numerous algorithmic challenges. This paper describes a case study regarding iterative solution of large sparse linear systems on grid computers within the software constraints of the grid middleware GridSolve and within the algorithmic constraints of preconditioned Conjugate Gradient (CG) type methods. We identify the various bottlenecks induced by the middleware and the iterative algorithm. We consider the standard CG algorithm of Hestenes and Stiefel, and as an alternative the Chronopoulos/Gear variant, a formulation that is potentially better suited for grid computing since it requires only one synchronisation point per iteration, instead of two for standard CG. In addition, we improve the computation-to-communication ratio by maximising the work in the preconditioner. In addition to these algorithmic improvements, we also try to minimise the communication overhead within the communication model currently used by the GridSolve middleware. We present numerical experiments on 3D bubbly flow problems using heterogeneous computing hardware that show lower computing times and better speed-up for the Chronopoulos/Gear variant of conjugate gradients. Finally, we suggest extensions to both the iterative algorithm and the middleware for improving granularity.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2010, 20, 1; 109-121
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Can conjugate prior probability explain the illusion of control?
Autorzy:
Czupryna, Marcin
Kubińska, Elżbieta
Markiewicz, Łukasz
Powiązania:
https://bibliotekanauki.pl/articles/1198684.pdf
Data publikacji:
2018
Wydawca:
Akademia Leona Koźmińskiego w Warszawie
Tematy:
overconfidence
illusion of control
emotional and rational model
Bayesian updating
conjugate prior probability.
Opis:
In this paper, we consider the illusion of control by using Bayesian updating as the rationality model. Our paper contributes twofold. First, we empirically verify that the illusion of control may have two concurrent sources, “emotional” and “rational”. The fi rst one produces biased Bayesian processing due to emotional engagement and the second one yields biases due to prior assumptions on the level of control. Second, we propose a method for identifying these two sources. Moreover we verified two hypotheses H1: The emotional factor causes overestimation of the actual level of control. and H2: The rational factor is responsible for the reverse relationship between observed levels of the illusion of control in three separate situations, when subjects have significant control, moderate or no control. Only the hypothesis H2 received partial empirical support.
Źródło:
Decyzje; 2018, 29; 87-113
1733-0092
2391-761X
Pojawia się w:
Decyzje
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nd-solid varieties
Autorzy:
Denecke, Klaus
Glubudom, Prisana
Powiązania:
https://bibliotekanauki.pl/articles/728884.pdf
Data publikacji:
2007
Wydawca:
Uniwersytet Zielonogórski. Wydział Matematyki, Informatyki i Ekonometrii
Tematy:
Non-deterministic hypersubstitution
conjugate pair of additive closure operators
M-solid non-deterministic variety
Opis:
A non-deterministic hypersubstitution maps any operation symbol of a tree language of type τ to a set of trees of the same type, i.e. to a tree language. Non-deterministic hypersubstitutions can be extended to mappings which map tree languages to tree languages preserving the arities. We define the application of a non-deterministic hypersubstitution to an algebra of type τ and obtain a class of derived algebras. Non-deterministic hypersubstitutions can also be applied to equations of type τ. Formally, we obtain two closure operators which turn out to form a conjugate pair of completely additive closure operators. This allows us to use the theory of conjugate pairs of additive closure operators for a characterization of M-solid non-deterministic varieties of algebras. As an application we consider M-solid non-deterministic varieties of semigroups.
Źródło:
Discussiones Mathematicae - General Algebra and Applications; 2007, 27, 2; 245-262
1509-9415
Pojawia się w:
Discussiones Mathematicae - General Algebra and Applications
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Jacobi type conditions for singular extremals
Autorzy:
Dmitruk, A. V.
Powiązania:
https://bibliotekanauki.pl/articles/969606.pdf
Data publikacji:
2008
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
singular extremal
Goh transformation
Legendre quadratic form
Euler-Jacobi equation
conjugate point
Opis:
We consider the class of optimal control problems linear in the control, and study a singular extremal. If the Lagrange multipliers are unique, the quadratic order optimality conditions have the form of sign definiteness of a quadratic functional (the second variation of Lagrange function) with totally zero Legendre coefficient. Using the Goh transformation, we convert it to a functional possibly satisfying the strengthened Legendre condition, involving also an additional parameter, and by applying the Hestenes approach, determine its sign definiteness in terms of the conjugate point, i.e. give Jacobi type conditions.
Źródło:
Control and Cybernetics; 2008, 37, 2; 285-306
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Computational and Statistical Aspects of Determining Ships Position
Autorzy:
Drapella, A.
Morgaś, W.
Powiązania:
https://bibliotekanauki.pl/articles/320950.pdf
Data publikacji:
2017
Wydawca:
Polskie Forum Nawigacyjne
Tematy:
determining ship’s position
Least Square method
conjugate gradient
Monte Carlo method
Opis:
In its mathematical essence, the task of determining ship’s position coordinates, is to minimize appropriately defined goal function. This paper proposes to use the method of conjugate gradient for this purpose. The reason is that calculations may be performed in some seconds time because Microsoft and Apache implemented the conjugate gradient method as a tool called the Solver and embedded this tool in their widely offered and popular spreadsheets, namely Excel and the Open Office Calc, respectively. Further in this paper it is shown how to precisely assess errors of ship’s position coordinates with the Monte Carlo method that employs the Solver.
Matematyczna istota wyznaczania współrzędnych pozycji okrętu to minimalizacja odpowiednio zdefiniowanej funkcji celu. Artykuł proponuje wykorzystanie do tego metody gradientu sprzężonego. Dzięki niej obliczenia mogą być wykonane w kilka sekund, ponieważ Microsoft i Apache zaimplementowały metodę gradientu sprzężonego jako narzędzie nazwane Solver i umieściły je w swych szeroko oferowanych i popularnych arkuszach kalkulacyjnych: Excelu i Open Office Calc. W artykule pokazano także, jak precyzyjnie określić błędy oszacowania współrzędnych pozycji okrętu metodą Monte Carlo.
Źródło:
Annual of Navigation; 2017, 24; 5-18
1640-8632
Pojawia się w:
Annual of Navigation
Dostawca treści:
Biblioteka Nauki
Artykuł
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