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Wyświetlanie 1-10 z 55
Tytuł:
Preconditioned Conjugate Gradient Method for Solution of Large Finite Element Problems on CPU and GPU
Autorzy:
Fialko, S. Y.
Zeglen, F.
Powiązania:
https://bibliotekanauki.pl/articles/307602.pdf
Data publikacji:
2016
Wydawca:
Instytut Łączności - Państwowy Instytut Badawczy
Tematy:
conjugate gradient
incomplete Cholesky factorization
iterative solvers
NVIDIA CUDA
preconditioned conjugate gradient
Opis:
In this article the preconditioned conjugate gradient (PCG) method, realized on GPU and intended to solution of large finite element problems of structural mechanics, is considered. The mathematical formulation of problem results in solution of linear equation sets with sparse symmetrical positive definite matrices. The authors use incomplete Cholesky factorization by value approach, based on technique of sparse matrices, for creation of efficient preconditioning, which ensures a stable convergence for weakly conditioned problems mentioned above. The research focuses on realization of PCG solver on GPU with using of CUBLAS and CUSPARSE libraries. Taking into account a restricted amount of GPU core memory, the efficiency and reliability of GPU PCG solver are checked and these factors are compared with data obtained with using of CPU version of this solver, working on large amount of RAM. The real-life large problems, taken from SCAD Soft collection, are considered for such a comparison.
Źródło:
Journal of Telecommunications and Information Technology; 2016, 2; 26-33
1509-4553
1899-8852
Pojawia się w:
Journal of Telecommunications and Information Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Salomons Theorem for polynomials with several parameters
Autorzy:
Frontczak, Maria
Skibiński, Przemysław
Spodzieja, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/965925.pdf
Data publikacji:
1999
Wydawca:
Polska Akademia Nauk. Instytut Matematyczny PAN
Tematy:
conjugate polynomials
decomposition of polynomials
Źródło:
Colloquium Mathematicum; 1999, 80, 1; 107-114
0010-1354
Pojawia się w:
Colloquium Mathematicum
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modelling of a Large Rotary Heat Exchanger
Autorzy:
Tulwin, T.
Powiązania:
https://bibliotekanauki.pl/articles/118115.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Promocji Wiedzy
Tematy:
CFD
Conjugate
Heat
Exchanger
Recuperation
Opis:
The first simulation consists of a partial cut-out of gas flow canal between the heat exchanger fins. The simulation is steady state and mainly provides the information about the heat transfer coefficient and pressure drop across the canal. The second simulation takes into account the complete system of rotary heat exchanger. It is a transient simulation with moving mesh. Then the heat transfer and air flow parameters are presented as a porous volume with a heat transfer model and rotational multi zone interface conditions. This simplification is accurate providing much better performance as the number of mesh nodes is much smaller. The methodology of the model setup is presented.
Źródło:
Applied Computer Science; 2017, 13, 1; 20-28
1895-3735
Pojawia się w:
Applied Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and biological activity of raltitrexed-carrier conjugates
Autorzy:
Jagiello, Monika
Kanska, Urszula
Nevozhay, Dmitry
Boratynski, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1040427.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
raltitrexed
tomudex
carrier
conjugate
thymidylate synthase
Opis:
Drugs used in chemotherapy give undesirable side effects, e.g., cardiotoxicity, leucopenia, hair loss and others. Covalent binding of a drug with a carrier may change its biodistribution, elimination and/or rate of transformation in the organism. The aim of this work was to synthesize conjugates of anticancer drug - raltitrexed (RTX) with lysozyme, bovine serum albumin (BSA), and dextran T40 and to investigate their cytotoxicity and influence on the cell cycle in comparison with the free drug. Before conjugation RTX was transformed into anhydride by treatment with dicyclohexylcarbodiimide in dimethylformamide. Activated RTX was added into aqueous solution of carriers at different pH (from 8.5 to 10.5) for 3 to 15 min. The reaction was stopped by reducing the pH to 7.0. Maximum yield of the reaction was obtained at pH 10 for BSA as well as for dextran. The highest level of substitution was obtained after 5 min of the reaction. In in vitro experiments on three cell lines: SW707, LoVo and A549, all conjugates tested had up to a few hundred times higher IC50 than the free drug. Interestingly, it was noticed that the conjugates based on dextran and albumin were more cytotoxic than the free drug in the highest concentrations tested (1000 and 10000 ng/ml). The influence of RTX and the conjugates on SW707 cell cycle was studied. RTX blocked the cell cycle mostly in the G0-G1 and S phase and increased the percentage of apoptotic cells. Cells in the G2-M phase were not observed. The conjugates blocked the cell cycle in the S phase and decreased the percentage of cells in the G0-G1 phase.
Źródło:
Acta Biochimica Polonica; 2010, 57, 1; 83-87
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Purification and functional reconstitution of intact ral-binding GTPase activating protein, RLIP76, in artificial liposomes.
Autorzy:
Singhal, Sharad
Singhal, Jyotsana
Cheng, JiZhong
Pikuła, Sławomir
Sharma, Rajendra
Zimniak, Piotr
Awasthi, Yogesh
Awasthi, Sanjay
Powiązania:
https://bibliotekanauki.pl/articles/1044153.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
RLIP76
glutathione-conjugate
anthracycline
transport
proteolysis
Opis:
We have recently shown that RLIP76, a ral-binding GTPase activating protein, mediates ATP-dependent transport of glutathione-conjugates (GS-E) and doxorubicin (DOX) (S. Awasthi et al., Biochemistry 39, 9327, 2000). Transport function of RLIP76 was found to be intact despite considerable proteolytic fragmentation in preparations used for those studies, suggesting either that the residual intact RLIP76 was responsible for transport activity, or that the transport activity could be reconstituted by fragments of RLIP76. If the former were true, intact RLIP76 would have a much higher specific activity for ATP-hydrolysis than the fragmented protein. We have addressed this question by comparing transport properties of recombinant RLIP76 and human erythrocyte membrane RLIP76 purified in buffers treated with either 100 or 500 μM serine protease inhibitor, PMSF. The purity and identity of recombinant and human erythrocyte RLIP76 was established by SDS/PAGE and Western-blot analysis. These studies confirmed the origin of the 38 kDa protein, previously referred to as DNP-SG ATPase, from RLIP76. Higher PMSF concentration resulted in lower yield of the 38 kDa band and higher yield of intact RLIP76 from both human and recombinant source. In contrast, the substrate-stimulated ATPase activity in presence of DNP-SG, doxorubicin, daunorubicin, or colchicine were unaffected by increased PMSF; similarly, ATP-dependent transport of doxorubicin in proteoliposomes reconstituted with RLIP76 was unaffected by higher PMSF. These results indicated that limited proteolysis by serine proteases does not abrogate the transport function of RLIP76. Comparison of transport kinetics for daunorubicin between recombinant vs human erythrocyte RLIP76 revealed higher specific activity of transport for tissue purified RLIP76, indicating that additional factors present in tissue purified RLIP76 can modulate its transport activity.
Źródło:
Acta Biochimica Polonica; 2001, 48, 2; 551-562
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Conjugate priors for exponential-type processes with random initial conditions
Autorzy:
Magiera, Ryszard
Powiązania:
https://bibliotekanauki.pl/articles/1340503.pdf
Data publikacji:
1994
Wydawca:
Polska Akademia Nauk. Instytut Matematyczny PAN
Tematy:
conjugate prior
stopping time
exponential-type process
Opis:
The family of proper conjugate priors is characterized in a general exponential model for stochastic processes which may start from a random state and/or time.
Źródło:
Applicationes Mathematicae; 1993-1995, 22, 3; 321-330
1233-7234
Pojawia się w:
Applicationes Mathematicae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Low generation polyamidoamine dendrimers (PAMAM) and biotinPAMAM conjugate – the detailed structural studies by 1 H and 13C nuclear magnetic resonance spectroscopy
Autorzy:
Wróbel, Konrad
Wołowiec, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/2040134.pdf
Data publikacji:
2020-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
biotin conjugate
nuclear magnetic resonance polyamidoamine dendrimer
Opis:
Introduction. The concept of targeted drug delivery is nowadays based on nanoparticle transporters. Such drug delivery systems for cancer cells should follow the requirements like: efficient drug release, selective binding and internalization to cancer cells. The anticancer drug selectivity can be achieved by attachment of cancer cell-recognizing molecules, like biotin. Among nanosized carriers the PAMAM dendrimers are tested intensely, especially they can be modified by covalent attachment of prodrug molecules and biotin as targeting molecule. Aim. We aimed at construction and characterization of a conjugate formed between PAMAM and biotin (Biot). The nuclear magnetic resonances is powerful tool to determine both the structure and stoichiometry of the conjugate. Material and methods. PAMAM G0 has been synthesized and functionalized with biotin by reaction with N-hydroxysuccinimide ester of biotin to obtain G0 double-substituted with biotin. All the compound were thoroughly characterized by the NMR spectroscopy. Results. The conjugate of PAMAM G0 dendrimer with two amide-bonded biotin molecules was obtained and fully characterized by NMR spectroscopy. Conclusion. N-hydroxysuccinimide ester of biotin spontaneously reacts with PAMAM G0 to obtain the conjugate of 2:1 biotin:G0 stoichiometry. The latter was designed as a targeting molecule in formation of megameric multidrug delivery system.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 4; 281-285
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Curvatures of single-input control systems
Autorzy:
Jakubczyk, B.
Powiązania:
https://bibliotekanauki.pl/articles/970753.pdf
Data publikacji:
2009
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
control system
curvature
invariants
variational equation
conjugate point
Opis:
We introduce invariants of control-affine systems which we call curvatures. They are defined by the drift and the control distribution, given by the system. The curvatures allow us to analyse the variational equation along a given trajectory, as well as existence of conjugate points.
Źródło:
Control and Cybernetics; 2009, 38, 4B; 1375-1391
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76).
Autorzy:
Awasthi, Sanjay
Sharma, Rajendra
Yang, Yusong
Singhal, Sharad
Pikula, Slawomir
Bandorowicz-Pikula, Joanna
Singh, Shivendra
Zimniak, Piotr
Awasthi, Yogesh
Powiązania:
https://bibliotekanauki.pl/articles/1043688.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
RLIP76
RalBP1
glutathione conjugate
multidrug resistance
transport
Opis:
We have recently demonstrated that a previously known Ral-binding GTPase activating protein, RLIP76, can also catalyze ATP-dependent transport of various structurally unrelated xeno- and endobiotics irrespective of their net charge (Awasthi et al., 2000, Biochemistry, 39: 9327). RLIP76 is a non-ATP binding cassette (ABC) protein but it has two ATP-binding sites and shows basal ATPase activity which is stimulated in the presence of its transport substrates (allocrites) such as doxorubicin (DOX) and S-(2,4-dinitrophenyl) glutathione (DNP-SG). Proteoliposomes reconstituted with purified RLIP76 catalyze ATP-dependent, saturable transport of DOX, as well as of glutathione-conjugates including leukotrienes (LTC4) and the GSH-conjugate of 4-hydroxynonenal (GS-HNE). In erythrocytes the majority of transport activity for DOX, GS-HNE, and LTC4 is accounted for by RLIP76. Cells exposed to mild oxidative stress show a rapid and transient induction of RLIP76 resulting in an increased efflux of GS-HNE and acquire resistance to oxidative stress mediated toxicity and apoptosis. Cells transfected with RLIP76 acquire resistance to DOX through increased efflux of the drug suggesting its possible role in the mechanisms of drug-resistance. In this article, we discuss the significance of transport functions of RLIP76 highlighting its role in the defense mechanisms against oxidative injury, and modulation of signaling mechanisms.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 855-867
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Geometric optimal control and two-level dissipative quantum systems
Autorzy:
Bonnard, B.
Sugny, D.
Powiązania:
https://bibliotekanauki.pl/articles/970909.pdf
Data publikacji:
2009
Wydawca:
Polska Akademia Nauk. Instytut Badań Systemowych PAN
Tematy:
optimal control theory
conjugate and cut loci
quantum mechanics
Opis:
The objective of this article is to present techniques of geometric time-optimal control developed to analyze the control of two-level dissipative quantum systems. Combined with numerical simulations they allow to compute the time-minimal control using a shooting method. The robustness with respect to initial conditions and dissipative parameters is also analyzed using a continuation method.
Źródło:
Control and Cybernetics; 2009, 38, 4A; 1053-1080
0324-8569
Pojawia się w:
Control and Cybernetics
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 55

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