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    Wyświetlanie 1-6 z 6
    Tytuł:
    Characterization of thiamine uptake and utilization in Candida spp. subjected to oxidative stress
    Autorzy:
    Wolak, Natalia
    Tomasi, Massimo
    Kozik, Andrzej
    Rapala-Kozik, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/1038981.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    vitamin B1
    thiamine diphosphate-dependent enzymes
    antioxidants
    reactive oxygen species
    Candida spp.
    Opis:
    Candida species are associated with an increasing number of life-threatening infections (candidiases), mainly due to the high resistance of these yeast-like fungi to antifungal drugs and oxidative stress. Recently, thiamine (vitamin B1) was found to alleviate stress responses in Saccharomyces cerevisiae; however, thiamine influence on defense systems in pathogenic fungi has never been investigated. The current work was aimed to elucidate the role of thiamine in stress reactions of C. albicans, C. glabrata, C. tropicalis and C. dubliniensis, subjected to hydrogen peroxide treatment. As compared to S. cerevisiae, Candida strains exposed to oxidative stress showed: (i) a much higher dependence on exogenous thiamine; (ii) an increased demand for thiamine diphosphate (TDP) and TDP-dependent enzyme, transketolase; (iii) no changes in gene expression of selected stress markers - superoxide dismutase and catalase - depending on thiamine availability in medium; (iv) a similar decrease of reactive oxygen species (ROS) generation in the presence of thiamine. Moreover, the addition of therapeutic doses of thiamine to yeast culture medium revealed differences in its accumulation between various Candida species. The current findings implicate that the protective action of thiamine observed in S. cerevisiae differs significantly form that in pathogenic Candida strains, both in terms of the cofactor functions of TDP and the effects on fungal defense systems.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 445-455
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Assessment of Candida spp. frequency in the oral cavity ontocenosis of healthy individuals in different age groups
    Autorzy:
    Szymańska, Jolanta
    Wójtowicz, Agnieszka
    Malm, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/972336.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    fungi
    Candida spp
    Candida albicans
    Opis:
    Introduction. Among the microorganisms colonizing the oral cavity ontocenosis, an important role is played by fungi: mainly yeast-like fungi of the Candida genus, and especially by the species C. albicans. Objective. The aim of this study was to evaluate the frequency of oral colonization by Candida species in healthy individuals of different age groups, and to identify the species of the isolates. Materials and method. The fungi were isolated from the oral cavities of 654 healthy individuals of both genders, representing different age groups, and the species of the isolates were determined. Initial identification of the yeast-like fungi was made based on the macroscopic appearance of the colonies on Sabouraud’s medium, and the growth of coloured colonies on ChromAgar Candida medium. API 20 C AUX microtest (bioMerieux) was used to identify the most frequently found species of Candida spp. Results. The frequency of Candida isolation from the oral cavity ontocenosis in healthy individuals of different age groups was assessed as 30.6%. The oral cavity ontocenosis was colonized mainly by the yeast-like fungi of C. albicans species: they were found in 24.5% of the tested population, while the frequency of oral cavity colonization by non-albicans Candida spp. was 6.1%. Seven species of non-albicans Candida spp. were identified: C. glabrata, C. inconspicua, C. famata, C. tropicalis, C. parapsilosis, C. lusitaniae, and C. kefyr. Conclusions. In the Polish population, 30.6% of the oral cavity ontocenosis is colonized by Candida yeast-like fungi, while C. albicans is the fungus that colonizes oral cavity ontocenosis most frequently. The frequency of oral cavity ontocenosis colonization with Candida spp (including C. albicans) increases with age.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2016, 10, 2; 91-94
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Hydrophobic properties of Candida spp. under the influence of selected essential oils
    Autorzy:
    Rajkowska, Katarzyna
    Kunicka-Styczyńska, Alina
    Pęczek, Marlena
    Powiązania:
    https://bibliotekanauki.pl/articles/1038879.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Candida spp.
    food-borne and clinical strains
    hydrophobic properties
    essential oils
    Opis:
    Processes of colonization of biotic and abiotic surfaces and biofilm formation depend inter alia on hydrophobic properties of Candida spp. The aim of this research was to determine the effect of tea tree, thyme and clove essential oils on hydrophobic properties of environmental and clinical Candida isolates. The relative cell surface hydrophobicity of strains tested was high, and ranged from 68.7% to 91.2%, with the highest value for a C. rugosa food-borne strain. The effectiveness of essential oils was diversified and depended on the type of essential oil, concentration and yeast strain. Statistically significant decrease of hydrophobicity indexes was observed after application of tea tree oil for C. krusei, clove oil for C. albicans reference strain, and all essential oils tested for C. rugosa. Only in the case of C. famata food-borne strain and C. albicans clinical isolate, solely used essential oils did not affect their hydrophobic properties. To determine the interactions of essential oils, their mixtures (1 MIC:1 MIC, 1 MIC:2 MIC and 2 MIC:1 MIC) were applied. Generally, essential oils used in combinations influenced yeast's hydrophobic properties much more than applied separately. The essential oils' mixtures reduced hydrophobicity of Candida yeasts in the range of 8.2 to 45.1%, depending on combination and strain. The interaction indexes of essential oils used in combinations predominantly indicate their additive effect. The application of tea tree, thyme and clove essential oils, especially in combinations, decreases hydrophobicity of the tested Candida isolates with implications of a probable advantageous limitation of their ability to colonize the food production industry environment.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 4; 663-668
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Therapeutic nail polishes based on ciclopirox
    Autorzy:
    Drabczyk, Anna K.
    Podobińska, Patrycja
    Mamica, Agnieszka
    Jaśkowska, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/35503264.pdf
    Data publikacji:
    2023
    Wydawca:
    Radomskie Towarzystwo Naukowe
    Tematy:
    therapeutic nail polishes
    ciclopirox
    Candida spp
    onychomycosis
    lecznicze lakiery do paznokci
    cyklopiroks
    onychomikoza
    Opis:
    The aim of the research work was to create a nail polish formulation that would carry the therapeutic substance ciclopirox (ciclopiroxolamine), a drug with an exceptionally broad spectrum of activity, exhibiting antifungal, antibacterial, bacteriostatic and anti-inflammatory activity. The experiments conducted proved that ciclopirox can not only be released from the developed formulations when applied directly to the plate, but can also be applied to nails covered with cosmetic varnish. The amount of released active ingredient reaches the minimum inhibitory concentration for cyclopirox in Candida spp. infection. Which suggests that the formulations would be effective for fungal infections. The best results in terms of film formation were obtained for formulations that were based on PVP. The highest released drug concentration occurred with formulation No. 3 and was 4.47 (mg/10ml) after 24 hours.
    Źródło:
    Scientiae Radices; 2023, 2, 4; 347-358
    2956-4808
    Pojawia się w:
    Scientiae Radices
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diagnosis and treatment of invasive Candida infections – a review article
    Autorzy:
    Dąbrowska, Marta
    Sienkiewicz, Monika
    Kwiatkowski, Paweł
    Dąbrowski, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/763841.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
    Tematy:
    Candida spp., candidemia, invasive candidiasis, treatment, recommendation
    Opis:
    Candida albicans is the most common cause of fungal infections worldwide. Invasive candidiasis comprises candidemia and deep-seated candidiasis. Most yeast invasive infections are endogenous with a high mortality. Pathogenesis of candidiasis depends on avoiding host immune responses, as well as the virulence factors of the fungus enabling colonization and invasion of tissues. Adequate source control and antifungal therapy administered within a short time is critical to get a better prognosis. The emergence of drug resistance and the side effects of currently available antifungals are becoming the major problem in the management of Candida spp. infection.
    Źródło:
    Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia; 2018, 73, 1
    2083-3563
    0066-2232
    Pojawia się w:
    Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Diagnosis and treatment of mucosa Candida spp. infections – a review article
    Autorzy:
    Dąbrowska, Marta
    Sienkiewicz, Monika
    Kwiatkowski, Paweł
    Dąbrowski, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/763845.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
    Tematy:
    Candida spp., mucosa, treatment, recommendation
    Opis:
    Candida albicans is the most common cause of fungal infections worldwide. Non-albicans Candida species play an important role in vulvovaginal candidiasis and invasive infections. Most cases of infections are endogenous. In case of patients with immune disorders this opportunistic pathogen causes both surface, systemic infections, and candidemia. Symptoms depend on the area affected. Candidiasis are treated with antimycotics; these include clotrimazole, nystatin, fluconazole, voriconazole, amphotericin B, and echinocandins. The emergence of drug resistance and the side effects of currently available antifungals are becoming a major problem in the management of Candida spp. infection.
    Źródło:
    Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia; 2018, 73, 1
    2083-3563
    0066-2232
    Pojawia się w:
    Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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