Temat: Caenorhabditis elegans - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Structural and functional relationship of mammalian and nematode ferritins
Autorzy:: Lewandowski, J.
Komur, A.A.
Sobanska, D.
Powiązania:: https://bibliotekanauki.pl/articles/2096865.pdf
Data publikacji:: 2021
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: nematode ferritins
FTH1
Caenorhabditis elegans
Opis:: Ferritin is a unique buffering protein in iron metabolism. By storing or releasing iron in a tightly controlled manner, it prevents the negative effects of free ferrous ions on biomolecules in all domains of life – from bacteria to mammals. This review focuses on the structural features and activity of the ferritin protein family with an emphasis on nematode ferritins and the similarities in their biological roles with mammalian ferritins. The conservative characteristic of the ferritin family across the species originates from the ferroxidase activity against redox-active iron. The antioxidative function of these proteins translates into their involvement in a wide range of important biological processes, e.g., aging, fat metabolism, immunity, anticancer activity, and antipathogenic activity. Moreover, disturbances in ferritin expression lead to severe iron-associated diseases. Research on the Caenorhabditis elegans model organism may allow us to better understand the wide spectrum of mechanisms involving ferritin activity.
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 4; 457-471
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Caenorhabditis elegans as a model organism in obesity research
Autorzy:: Dyczkowska, A.A.
Chabowska-Kita, A.
Powiązania:: https://bibliotekanauki.pl/articles/2096413.pdf
Data publikacji:: 2021
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: obesity
Caenorhabditis elegans
microbiota
dietary restriction
bioactive compounds
temperature
Opis:: Obesity is a global health problem associated with many comorbidities such as type 2 diabetes and cancer. The number of individuals with overweight and obesity have increased dramatically within the past few years. Given the worldwide cost of an obesity pandemic, it is crucial to understand molecular pathways and identify novel factors that regulate fat storage in humans. In recent years, Caenorhabditis elegans has been widely used to investigate metabolic and neuroendocrine mechanisms involved in the regulation of energy metabolism. In this review, we describe similarities in fundamental signalling pathways regulating fat accumulation between nematodes and mammals. Like in humans, fat storage in C. elegans depends on the interaction of genetic and environmental factors such as diet, microbiota and ambient temperature. Despite many challenges, the simplicity of use, relatively short lifespan, genetic conservation and availability of many valuable experimental techniques make C. elegans an attractive and useful model organism in obesity research.
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 3; 337-362
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Interaction of three Caenorhabditis elegans isoforms of translation initiation factor eIF4E with mono- and trimethylated mRNA 5 cap analogues.
Autorzy:: Stachelska, Alicja
Wieczorek, Zbigniew
Ruszczyńska, Katarzyna
Stolarski, Ryszard
Pietrzak, Monika
Lamphear, Barry
Rhoads, Robert
Darżynkiewicz, Edward
Jankowska-Anyszka, Marzena
Powiązania:: https://bibliotekanauki.pl/articles/1043732.pdf
Data publikacji:: 2002
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: fluorescence quenching
eIF4E
Caenorhabditis elegans
mRNA 5' cap
translation initiation
Opis:: Translation initiation factor eIF4E binds the m7G cap of eukaryotic mRNAs and mediates recruitment of mRNA to the ribosome during cap-dependent translation initiation. This event is the rate-limiting step of translation and a major target for translational control. In the nematode Caenorhabditis elegans, about 70% of genes express mRNAs with an unusual cap structure containing m32,2,7G, which is poorly recognized by mammalian eIF4E. C. elegans expresses five isoforms of eIF4E (IFE-1, IFE-2, etc.). Three of these (IFE-3, IFE-4 and IFE-5) were investigated by means of spectroscopy and structural modelling based on mouse eIF4E bound to m7GDP. Intrinsic fluorescence quenching of Trp residues in the IFEs by iodide ions indicated structural differences between the apo and m7G cap bound proteins. Fluorescence quenching by selected cap analogues showed that only IFE-5 forms specific complexes with both m7G- and m32,2,7G-containing caps (Kas 2×106 M-1 to 7×106 M-1) whereas IFE-3 and IFE-4 discriminated strongly in favor of m7G-containing caps. These spectroscopic results quantitatively confirm earlier qualitative data derived from affinity chromatography. The dependence of Kas on pH indicated optimal cap binding of IFE-3, IFE-4 and IFE-5 at pH 7.2, lower by 0.4 pH units than that of eIF4E from human erythrocytes. These results provide insight into the molecular mechanism of recognition of structurally different caps by the highly homologous IFEs.
Źródło:: Acta Biochimica Polonica; 2002, 49, 3; 671-682
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Badania roli receptorow Toll-podobnych [TLR] w odpowiedzi zywiciela na inwazje pasozytnicza na tle wspolczesnej wiedzy o TLR u ssakow i modelowego nicienia Caenorhabditis elegans
The investigations of the role of toll-like receptors [TLR] in host response to parasitic infection of current back-ground regarding TLR in mammals and the model nematode Caenorhabditis elegans
Autorzy:: Wojtkowiak, A.
Powiązania:: https://bibliotekanauki.pl/articles/837784.pdf
Data publikacji:: 2007
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: odpowiedz immunologiczna
receptory toll-podobne
ssaki
parazytologia
organizmy modelowe
Caenorhabditis elegans
nicienie
inwazja pasozytnicza
Źródło:: Annals of Parasitology; 2007, 53, 3; 203-211
0043-5163
Pojawia się w:: Annals of Parasitology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Badania roli receptorów Toll-podobnych [TLR] w odpowiedzi żywiciela na inwazje pasożytnicza na tle współczesnej wiedzy o TLR u ssaków i modelowego nicienia Caenorhabditis elegans
The investigations of the role of toll-like receptors [TLR] in host response to parasitic infection of current back-ground regarding TLR in mammals and the model nematode Caenorhabditis elegans
Autorzy:: Wojtkowiak, A.
Powiązania:: https://bibliotekanauki.pl/articles/2143925.pdf
Data publikacji:: 2007
Wydawca:: Polskie Towarzystwo Parazytologiczne
Tematy:: odpowiedz immunologiczna
receptory toll-podobne
ssaki
parazytologia
organizmy modelowe
Caenorhabditis elegans
nicienie
inwazja pasozytnicza
Opis:: Toll−like receptors (TLRs) are amongst the most highly conserved in the evolution of receptor family, being found in both immune and other cells. TLRs were observed in vascular endothelial cells, epithelial cells, microglia cells, adipocytes, and intestinal and renal cells. TLRs plays a key role in the innate immune response to a variety of pathogens. At present, very little is known about the role of TLRs in host defense against parasitic pathogen infections. The first study shows that TLRs contribute to both innate and adaptive immune responses following infection with protozoan parasite Leishmania major. The TLRs recognizing PAMPs associated with the parasite L. major are essential for the activation of the innate and adaptive immune responses to infection. A study concerning recognition of the role of TLRs in the host−parasite relationship would be an interesting challenge for future study.
Źródło:: Wiadomości Parazytologiczne; 2007, 53, 3; 203-211
0043-5163
Pojawia się w:: Wiadomości Parazytologiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: A simultaneous localization and tracking method for a worm tracking system
Autorzy:: Kowalski, M.
Kaczmarek, P.
Kabaciński, R.
Matuszczak, M.
Tranbowicz, K.
Sobkowiak, R.
Powiązania:: https://bibliotekanauki.pl/articles/330526.pdf
Data publikacji:: 2014
Wydawca:: Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:: Caenorhabditis elegans behavior
worm tracking
computer vision
image processing
feature extraction
wizja komputerowa
przetwarzanie obrazu
ekstrakcja cech
Opis:: The idea of worm tracking refers to the path analysis of Caenorhabditis elegans nematodes and is an important tool in neurobiology which helps to describe their behavior. Knowledge about nematode behavior can be applied as a model to study the physiological addiction process or other nervous system processes in animals and humans. Tracking is performed by using a special manipulator positioning a microscope with a camera over a dish with an observed individual. In the paper, the accuracy of a nematode’s trajectory reconstruction is investigated. Special attention is paid to analyzing errors that occurred during the microscope displacements. Two sources of errors in the trajectory reconstruction are shown. One is due to the difficulty in accurately measuring the microscope shift, the other is due to a nematode displacement during the microscope movement. A new method that increases path reconstruction accuracy based only on the registered sequence of images is proposed. The method Simultaneously Localizes And Tracks (SLAT) the nematodes, and is robust to the positioning system displacement errors. The proposed method predicts the nematode position by using NonParametric Regression (NPR). In addition, two other methods of the SLAT problem are implemented to evaluate the NPR method. The first consists in ignoring the nematode displacement during microscope movement, and the second is based on a Kalman filter. The results suggest that the SLAT method based on nonparametric regression gives the most promising results and decreases the error of trajectory reconstruction by 25% compared with reconstruction based on data from the positioning system.
Źródło:: International Journal of Applied Mathematics and Computer Science; 2014, 24, 3; 599-609
1641-876X
2083-8492
Pojawia się w:: International Journal of Applied Mathematics and Computer Science
Dostawca treści:: Biblioteka Nauki