- Tytuł:
- Overexpression of human CUTA isoform2 enhances the cytotoxicity of copper to HeLa cells
- Autorzy:
-
Yang, Jingchun
Li, Qiang
Yang, Huirong
Yan, Lichong
Yang, Liu
Yu, Long - Powiązania:
- https://bibliotekanauki.pl/articles/1040764.pdf
- Data publikacji:
- 2008
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
copper toxicity
CUTA isoform2
overexpression
copper-induced apoptosis
cell proliferation - Opis:
- Copper, an essential transient element, can be toxic to cells when present in excess. Altered copper homeostasis is involved in pathological events of many diseases. Human CUTA isoform2 is a member of cation tolerance protein (CutA1) family. In this study, we examined the effect of CUTA isoform2 overexpression on copper toxicity. It was shown that overexpressed CUTA isoform2 sensitized HeLa cells to copper toxicity by promoting copper-induced apoptosis. The inhibition effect of excessive copper on cell proliferation was also enhanced by overexpressed CUTA isoform2. So CUTA isoform2 was implicated to be involved in the cytotoxicity of copper.
- Źródło:
-
Acta Biochimica Polonica; 2008, 55, 2; 411-415
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł