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Wyświetlanie 1-22 z 22
Tytuł:
Depressive Disorders in COPD Patients - Economic Aspects
Autorzy:
Rysiak, Edyta
Prokop, Izabela
Zaręba, Ilona
Osińska, Milena
Mróz, Robert
Powiązania:
https://bibliotekanauki.pl/articles/895308.pdf
Data publikacji:
2019-02-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
depression
COPD
pharmacoeconomics
Opis:
Chronic obstructive pulmonary disease is one of the most important health problems and one of the most common chronic diseases. The occurrence of COPD is associated with a particular dimension of physical suffering, the source of which is the difficulty in breathing. A significant percentage of patients experience the mental consequences of illness such as depression and anxiety disorders. The aim of the study was to analyze the prevalence of depressive symptoms in patients with medium-severe and severe forms of COPD and to assess the cost of coexistence of depression in this group of patients. The retrospective study, based on medical records, included two groups of patients: Group 1- 63 persons and Group 2– 60 persons. The study evaluated the following parameters: degree of severity of COPD according to Global Initiative for Chronic Obstructive Lung Disease (GOLD), degree of severity of dyspnea using the mMRC scale of dyspnea developed by the Medical Research Council and occurrence of depressive symptoms and their severity using the Beck Depression Scale questionnaire. Patients were treated at the CENTER for Respiratory Medicine between January 2016 and December 2016. Results of our study showed that in both treatment groups analysis of the answers received from the Beck’s Depression Scale questionnaire revealed that all these patients have depressive symptoms of varying severity.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 167-174
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Validation of the respiratory toxics exposure score (RTES) for chronic obstructive pulmonary disease screening
Autorzy:
Salameh, Pascale
Khayat, Georges
Waked, Mirna
Powiązania:
https://bibliotekanauki.pl/articles/2185372.pdf
Data publikacji:
2011-12-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
carbon monoxide
COPD
biomarker
Opis:
Objective: Our aim is to evaluate the validity of exhaled carbon monoxide (CO) and of a newly-created score as markers of Chronic Obstructive Pulmonary Disease (COPD). Materials and Methods: The CO level was measured in a derivation subsample of a cross-sectional study and linked to COPD diagnosis; its predictors were evaluated, and a scale was constructed. It was evaluated in a validation subsample and in a clinical setting. Results: Individuals with COPD had higher CO levels than healthy individuals. CO level signifi cant predictors were cigarettes per day, waterpipes per week, lower age, male gender, living close to diesel exhaust, heating home with the use of diesel, and having indoor family smokers. A score composed of CO predictors was able to signifi cantly predict COPD (Ora = 4–7.5). Conclusions: Coupled with the clinical judgment of physicians, this scale would be an excellent low-cost tool for screening COPD, in absence of spirometry.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2011, 24, 4; 339-347
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of sex and BMI on the clinical course of COPD and bronchial asthma
Autorzy:
Wytrychowski, Krzysztof
Hans-Wytrychowska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/551681.pdf
Data publikacji:
2016
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
obesity
gender
COPD
bronchial asthma.
Źródło:
Family Medicine & Primary Care Review; 2016, 3; 368-372
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The obstacles encountered by COPD patients about quitting smoking
Autorzy:
Cavusoglu, F.
Beser, A.
Kılınc, O.
Powiązania:
https://bibliotekanauki.pl/articles/1918872.pdf
Data publikacji:
2019-08-26
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Quit Smoking
obstacle
COPD
smoking
Opis:
Purpose: To determine the obstacles encountered by chronic obstructive respiratory disease (COPD) patients when quitting smoking. Materials and methods: Phenomenological research design was used in this study. A total of 20 smoker COPD patients chosen with purposive sampling constituted the universe of this study. Data were collected through the in-depth interview method using semi-structured interview forms. Analysis of the data was performed with inductive analysis using the content analysis method. Results: The challenges encountered by COPD patients when quitting smoking consist of 3 main themes and sub-themes including “İndividual specific challenges, environmental and social challenges and addiction/life with cigarettes”. Conclusions: This study revealed the individual, environmental-social and physical, psychological and social challenges in relation to addiction encountered by COPD patients when quitting smoking. Patients should be informed about the relationship between COPD and smoking through trainings, behaviours of individuals about smoking cessation should be determined and accordingly necessary actions should be taken in line with the motivational interview principles and families be included in these actions.
Źródło:
Progress in Health Sciences; 2019, 1; 28-35
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Favre-Racouchot syndrome and chronic obstructive pulmonary disease – a common link
Autorzy:
Imran Shamsi, Mohd
Dawar, Sachet
Ishtiyaq Shaafie, Harris
Chaudhry, Arun
Powiązania:
https://bibliotekanauki.pl/articles/2216795.pdf
Data publikacji:
2022-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
comedones
COPD
Favre-Racouchot syndrome
Opis:
Introduction and aim. Favre-Racouchot syndrome though mostly reported in Caucasian men (with an estimated prevalence of 6% in adults older than 50 years), cases have been reported in dark-skinned population including Indians, albeit rarely. It is characterized by large open and closed comedones along with epidermal cysts over the nose, cheeks, temples, forehead and periorbital areas. The association of this condition with chronic heavy smoking is what it makes compelling. Description of the case report. We report a case of elderly male, chronic heavy smoker who was diagnosed as a case of chronic obstructive pulmonary disease (COPD) as per standard guidelines. He presented with multiple nodulo-cystic lesions and had undergone a skin biopsy. Histomorphology features were consistent with Favre-Racouchot syndrome. Conclusion. Early identification of this skin condition in mildly symptomatic and asymptomatic smokers may help clinicians to forewarn the patients regarding development of chronic obstructive pulmonary disease (COPD).
Źródło:
European Journal of Clinical and Experimental Medicine; 2022, 4; 478-481
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impact of education on dimensions of adherence in patients with chronic obstructive pulmonary disease
Autorzy:
Olah, Mate
Kresznerits, Szilvia
Gonda, Xenia
Perczel-Forintos, Dora
Szabo, Miklos
Csanky, Eszter
Meszaros, Agnes
Powiązania:
https://bibliotekanauki.pl/articles/895711.pdf
Data publikacji:
2020-02-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
quality of life
COPD
adherence
patient education
Opis:
Objectives To assess the impact of patient education on medication adherence and quality-of-life (QoL) in Hungarian subjects with chronic obstructive pulmonary disease (COPD). Study Design Longitudinal, non-interventional study conducted at three pulmonology outpatient centers in and around Budapest, Hungary. Experimental Subjects visiting the center with COPD were invited to participate in the study. Data collected at baseline included subject demographics, medical history, and responses to the adherence (Morisky Medication Adherence Scale-8 (MMAS-8)) and QoL (EuroQoL-5D-5L (EQ5D), St. George’s Respiratory Questionnaire (SGRQ), and COPD Assessment Tool (CAT)) scales. Subjects were also provided with patient education designed with standardized content. Subjects were asked to provide responses to adherence and QoL scales again at the 3-month follow-up visit. Medication was left unchanged during the course of study. Statistical analysis included independent and paired-samples t-tests, one-way ANOVA, mixed-measures ANOVA and ANCOVA. Results Mean (± standard deviation (SD)) overall adherence score on MMAS-8 scale increased from 6.72 (± 1.46) at baseline to 7.01 (± 1.15) at follow-up (P = .040). A similar increase in mean (± SD) score was observed for question 4 on the MMAS-8 which deals with remembering to carry COPD medication when leaving house (baseline = 0.81 (± 0.40) versus follow-up = 0.89 (± 0.31); P = 0.018). Conclusions Patient education has a positive outcome on medication adherence in subjects with COPD. Further studies will be required to assess if these benefits are translated to patients’ QoL.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 195-204
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of disease-related knowledge among patients with chronic obstructive pulmonary disease: a cross-sectional study
Autorzy:
Tymruk-Skoropad, Kateryna
Pavlova, Iuliia
Sydoryk, Nadiya
Kulitka, Yuliia
Kruk, Bohdan
Powiązania:
https://bibliotekanauki.pl/articles/1922299.pdf
Data publikacji:
2020-11-04
Wydawca:
PPHU Projack Jacek Wąsik
Tematy:
COPD
BCKQ
knowledge
educational component
pulmonary rehabilitation
Opis:
Introduction. The main task of this study was to study the level of knowledge of the Ukrainian patient about chronic obstructive pulmonary disease (COPD), and the factors that cause and affect this indicator, with the help of a validated instrument. Methods. 41 patients were involved in the study. Socio-demographic data, information on the duration, course of the disease and cooperation with a physical therapist were collected. Anthropometric measurements, spirometry, pulse oximetry, tonometry were performed. Patients were surveyed with Modified Medical Research Council Dyspnea Scale, Hospital Anxiety and Depression Scale, Clinical COPD Questionnaire score, and Bristol COPD Knowledge Questionnaire (BCKQ). Bristol COPD Knowledge Questionnaire was translated, crossculturally adapted and validated. Regression analysis was performed to determine relationships between the level of knowledge about the disease, socio-demographic data, indicators of respiratory system functional status, and survey data. Results. The average total score for BCKQ was 24.71±9.62 points. Patients gave the least number of correct answers to the question related to medical treatment. The level of knowledge depends on the factors such as age (β=-0.557; 95% CI: -1.041-0.086, p=0.086), duration of the disease (β=-0.114; 95% CI: -0.077-0.055, p=0.048), respiratory ratings, functional limitations, and own psychosocial dysfunction according to the CCQ scale (β =-0.506; 95% CI: -0.0070.752, p=0.053), and the HADS depression score (β =-0.655; 95% CI: -4.257- -0.085, p=0.043). Conclusion. The level of knowledge of Ukrainian patients about COPD is low. More experience of the disease did not affect the increase in the level of knowledge. Older patients had a lower level of knowledge about their disease. Impact of body mass index, spirometry results, level of severity of shortness of breath, and symptoms of the disease on the level of knowledge was not revealed.
Źródło:
Physical Activity Review; 2020, 2, 8; 72-85
2300-5076
Pojawia się w:
Physical Activity Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Byssinosis and COPD rates among factory workers manufacturing hemp and jute
Autorzy:
Er, Mukremin
Emri, Salih A.
Demir, Ahmet U.
Thorne, Peter S.
Karakoca, Yalcin
Bilir, Nazmi
Baris, Izzettin Y.
Powiązania:
https://bibliotekanauki.pl/articles/2177088.pdf
Data publikacji:
2015-09-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
byssinosis
endotoxin
COPD
hemp
jute
occupational health
Opis:
Objectives Prior studies have been performed on cotton textile plants throughout the world. This study was planned to identify the rate of byssinosis and chronic obstructive pulmonary disease (COPD) in hemp and jute workers and those who worked with both of them. Material and Methods The study was realized in a factory which consecutively processed hemp and jute. The study enrollment included 266 people, 164 of whom were active workers and 102 were retired. A questionnaire, plain chest X-rays, physical examination and pulmonary function tests were performed. Dust levels were measured in various sections of the factory during 8 h work shifts. Endotoxin levels of various quality hemp fibers and dusts were measured. Results The rate of byssinosis (28.2%) was higher among the workers that who exposed to both jute and hemp dust. The frequency of chronic bronchitis in retired workers who previously smoked was higher (20%) as compared to currently smoking workers (17%). High dust levels were measured in some parts of the factory (mean (M) = 2.69 mg/m³). Working in dense dust areas, active smoking, being older than 40 years of age, being an ex-smoker, and working in the factory for a period exceeding 15 years were significantly associated with bronchitis and emphysema development. High endotoxin levels were determined for fine hemp dust (605 EU/mg), coarse hemp dust (336 EU/mg) and poor quality hemp fibers (114 EU/mg), whereas in fresh hemp stalks the level of endotoxin was determined to be lower (0.27 EU/mg). Conclusions Because of high exposures to jute and hemp dusts that are associated with high byssinosis rates, personal protection and environmental hygiene is crucial to prevention of byssinosis.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 1; 55-68
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of selected fatigue determinants in patients with COPD
Analiza wybranych uwarunkowań poczucia zmęczenia u pacjentów z POChP
Autorzy:
Wiśniewska, Anna E.
Ślusarska, Barbara
Klepacka, Julia
Jędrzejkiewicz, Bernadeta
Nowicki, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1035422.pdf
Data publikacji:
2019
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
fatigue
copd
dyspnoea
determinants
zmęczenie
pochp
duszność
uwarunkowania
Opis:
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a partially irreversible narrowing of the respiratory tract that hinders air flow through the lungs. Airflow impairment in patients with COPD causes fatigue. MATERIAL AND METHODS: The aim of the study was to determine the sense of fatigue in patients diagnosed with COPD on the basis of sociodemographic and biomedical factors. The study was conducted in 2016 in a group of 120 patients with COPD. The method of a diagnostic survey using the Brief Fatigue Inventory scale was used. RESULTS: According to the Brief Fatigue Inventory scale, 1.67% of respondents experienced mild fatigue, while 98.33% moderate. Statistical analysis of the study results indicates that the fatigue intensity was significant in the group of women (p < 0.001), people over 60 and 50 to 60 years old (p < 0.001), overweight and underweight (p < 0.001), patients with secondary and primary education (p < 0,001), living in a city (p < 0.001), in a single-family house or block of flats (p < 0.001), smokers (p < 0.001) or passive smokers (p < 0.001), physical workers (p < 0.001), suffering for 3–5 years (p < 0.001). The reasons for the presence of ailments such as coughing or shortness of breath exacerbating fatigue were physical activity (61.67%), respiratory infections (58.33%), contact with chemical agents (55.83%), and rarely stress (28.33%). CONCLUSIONS: In the group of patients with COPD, fatigue is more pronounced in the over 60 age group, in women, overweight patients and those living in the city. Fatigue is intensified by the duration and severity of the disease, physical activity and physical work, as well as cigarette smoking.
WSTĘP: Przewlekła obturacyjna choroba płuc (POChP) polega na częściowo nieodwracalnym zwężeniu dróg oddechowych, które utrudnia przepływ powietrza przez płuca. Upośledzenie przepływu powietrza u chorych z POChP powoduje zmęczenie. MATERIAŁ I METODY: Celem badawczym pracy było określenie poczucia zmęczenia u pacjentów z rozpoznaniem POChP na podstawie czynników socjodemograficznych oraz biomedycznych. Badania przeprowadzono w 2016 r. w grupie 120 pacjentów z POChP. Wykorzystano metodę sondażu diagnostycznego z zastosowaniem skali Krótkiego Inwentarza Zmęczenia. WYNKI: Według skali Krótki Inwentarz Zmęczenia u 1,67% badanych występowało łagodne zmęczenie, natomiast umiarkowane u 98,33%. Analiza statystyczna wyników badań wskazuje, że nasilenie zmęczenia było istotne w grupie kobiet (p < 0,001), osób powyżej 60 lat i 50–60 lat (p < 0,001), u osób z nadwagą oraz niedowagą (p < 0,001), pacjentów z wykształceniem średnim i podstawowym (p < 0,001), mieszkających w mieście (p < 0,001), w domu jednorodzinnym lub bloku (p < 0,001), u osób palących (p < 0,001) lub palących biernie (p < 0,001), w grupie pracującej fizycznie (p < 0,001), chorujących od 3 do 5 lat (p < 0,001). Przyczyną występowania u chorych dolegliwości, takich jak kaszel lub duszność, nasilających zmęczenie były wysiłek fizyczny (61,67%), infekcje dróg oddechowych (58,33%), kontakt z czynnikami chemicznymi (55,83%), rzadko zaś stres (28,33%). WNIOSKI: W grupie pacjentów z POChP zmęczenie w większym nasileniu występuje w grupie wiekowej powyżej 60 lat, u kobiet, pacjentów z nadwagą oraz mieszkających w mieście. Na nasilenie poczucia zmęczenia wpływa czas trwania choroby i stopień jej zaawansowania, aktywność fizyczna oraz wykonywanie pracy fizycznej, a także palenie papierosów.
Źródło:
Annales Academiae Medicae Silesiensis; 2019, 73; 274-282
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of Acinetobacter baumannii resistance patterns in patients with chronic obstructive pulmonary disease (COPD) in terms of choice of effective empiric antibiotic therapy
Autorzy:
Grochowalska, Aneta
Kozioł-Montewka, Maria
Sobieszczańska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/989765.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
copd
antibiotics
acinetobacter baumannii
multidrug-resistant strains
co-infection
Opis:
Introduction. Multi-resistant Acinetobacter baumannii isolated from patients has become one of the most hazardous pathogens in health care settings. The aim of the study was to analyze pneumonia caused by Acinetobacter baumannii in patients hospitalized because of exacerbation of chronic obstructive pulmonary diseases (COPD), who were admitted to the Pulmonology Ward of the Masovian Specialistic Hospital in Radom (MSS). The incidence and drug sensitivity of these non-fermenting rods were evaluated, and compliance with antimicrobial procedure with the algorithm of the guidelines in applicable recommendations, was estimated. This should result in determining the local patterns of resistance and verifying therapeutic procedures in accordance with the assumptions of hospital antibiotic policy. In addition, the study examined the effectiveness of empiric and targeted therapy according to the clinical condition of the patient, and the eradication of A. baumannii, in comparison with the aggravating factors of the patient. Materials and Method. The retrospective study included 90 patients with exacerbation of COPD whose etiological factor of infection was A. baumannii, hospitalized in the Department of Pulmonology (MSS) in 2012–2016. Results. Studies were conducted on 90 patients with COPD exacerbation from which A. baumannii was isolated. Co-infections with other bacterial species among 41 patients were additionally noted. The majority of A. baumannii strains showed a high resistance (90%) to fluoroquinolones, ceftazidime, piperacillin/tazobactam. For strains causing a co-infection, drug resistance was successively 44–56%, 44%, 44%. All of patients received empirical therapy. The most commonly used drug was amoxicillin with a clavulanic acid, often combined with fluoroquinolone. This type of therapy was effective among 10% of patients. The mortality in this group was determined at 29%. Among 79% of patients with COPD, a targeted therapy was performed which proved to be effective in 58% of treated cases by susceptibility testing. The highest efficacy was observer after the use of colistin and carbapenems. Conclusion. In the performed study, the infections caused by multi-resistant Acinetobacter baumannii, were observed in COPD, which should be taken into consideration in choosing empirical antibiotic therapy. Simultaneously, the local resistance patterns of multi-drug-resistant (MDR) Gram-negative strains co-infecting COPD should be considered in empirical treatment. Moreover, both additional clinical complication and co-infections contribute to a more severe course of diseases. In this study, the mortality percent exceeded 29%.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
POPULARNOŚĆ HALOTERAPII W OPINII OSÓB Z PROBLEMAMI UKŁADU ODDECHOWEGO
HALOTHERAPY’S POPULARITY IN THE OPINION OF PATIENTS WITH RESPIRATORY SYSTEM PROBLEMS
Autorzy:
CICHOCKA, IZABELA
KRUPA, JAN
Powiązania:
https://bibliotekanauki.pl/articles/475769.pdf
Data publikacji:
2018
Wydawca:
Wyższa Szkoła Turystyki i Języków Obcych. Wydawnictwo WSTiJO
Tematy:
haloterapia
turnus rehabilitacyjny
POChP
astma
halotherapy
rehabilitation camp
COPD
asthma
Opis:
Haloterapia to forma leczenia uzdrowiskowego, w której wykorzystywana jest sól. Subterraneoterapia to metoda leczenia mikroklimatem w podziemnych komorach wyrobisk solnych. W Polsce najsłynniejszym podziemnym sanatorium jest uzdrowisko w Wieliczce. Celem opracowania było poznanie opinii pacjentów z problemami układu oddechowego na temat skuteczności haloterapii oraz subterraneoterapii. W badaniu ankietowym wzięły udział 164 osoby. Zdaniem 90% respondentów, metody te mają korzystny wpływ na zdrowie. Osoby cierpiące na POChP wyżej oceniają dobroczynny wpływ grot solnych na zdrowie i w większym stopniu dostrzegały poprawę swojego stanu zdrowia niż cierpiący na astmę.
Halotherapy is a form of spa treatment which makes use of salt. Subterraneotherapy is a treatment method utilized to give treatment in a micro-climate of underground salt chambers. In Poland, the most popular subterranean health resort is Wieliczka Salt Mine sanatorium. The aim of this paper was to find opinion on the effectiveness of halotherapy and subterraneotherapy among patients with respiratory system problems. 164 patients participated in an anonymous questionnaire research. In the view of 90% respondents, these two methods have had positive impact on their health. Patient suffering from Chronic Obstructive Pulmonary Disease (COPD) assessed the beneficial effect of salt chambers on their health more highly and noticed a more considerable improvement of their health than patients suffering from asthma.
Źródło:
Zeszyty Naukowe. Turystyka i Rekreacja; 2018, 1(21); 79-98
1899-7228
Pojawia się w:
Zeszyty Naukowe. Turystyka i Rekreacja
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Obesity, smoking status and their relationships in selected population groups
Autorzy:
Lenartova, P.
Gazarova, M.
Mrazova, J.
Kopcekova, J.
Powiązania:
https://bibliotekanauki.pl/articles/2085963.pdf
Data publikacji:
2021
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
obesity
cigarette smoking
non-smoker
smoker
COPD patient
lipid profile
Opis:
Background. Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health. Obesity is associated with many chronic diseases, including cardiovascular disease and diabetes, and recently the role of overweight and obesity in lung disease has received new interest. Chronic obstructive lung disease is the third-leading cause of death globally, and both obesity and diet appear to play roles in its pathophysiology. Cross-sectional studies have demonstrated an inverse association between obesity and the prevalence of chronic obstructive pulmonary disease (COPD). Objective. This study aims to evaluate the relationship between smoking, lipid profile and obesity (body composition changes) in a selected groups of population (30 non-smokers, 30 smokers and 60 COPD patients). Material and Methods. We evaluated fat mass, fat free mass, body mass index and lipid profile in a group of 120 randomly selected probands (60 COPD patients; 30 smokers without COPD; 30 non-smokers without COPD) to identify possible negative relationships of smoking to body composition. To the measurement of fat mass (FM) and fat free mass (FFM) was used a device Bodystat Quadscan 4000 (Bodystat Ltd, British Isles). The device works by using four-frequency bioelectrical impedance analysis. Laboratory parameters as total cholesterol (T-C), high-density cholesterol (HDL-C), low-density cholesterol (LDL-C) and triacylglycerols (TG) were investigated by automated clinical chemistry analyzer LISA 200th. The measured values were statistically processed and evaluated in a statistical program STATISTICA Cz. Version 7.1. (Kruskall-Wallis test). Results. A comparison of the mean fat mass we found statistically highly significant differences between the group of COPD patients and non-smokers (P <0.001) and insignificant differences (P ≥ 0.05) between the other groups of our experiment. A comparison of the mean fat mass values of all three groups of the experiment shows a steady increase in fat from non-smokers (17.66 ± 10.04 kg) to COPD patients with the highest mean value (25.08 ± 10.14 kg). In the group of COPD patients we recorded the lowest average value of FFM (51.76 ± 13.84 kg), in group of smokers the middle (56.06 ± 10.76 kg) and in non-smokers the highest average value of FFM (59.91 ± 9.90 kg) at relatively the same body weight in the groups. Based on calculated body mass index (BMI), we found in group of COPD patients overweight in 15 cases (25%), obesity in 7 patients (11.67%), severe obesity in 14 patients (23.3%) and morbid obesity in 2 patients (3.33%); in the group of smokers overweight in 16 cases (53.33%), obesity in 5 cases (16.6%) and severe obesity in 1 case (3.33%); in non-smokers we recording overweight in 14 cases (46.67%), obesity in 5 cases (16.67%) and severe obesity in 2 cases (6.67%). In the lipid profile of the monitored groups of probands, we observed statistically significant differences only for LDL cholesterol (LDL-C). There was a statistically significant difference (P <0.001) between the group with COPD and smokers, as well as between the group of smokers and non-smokers (P < 0.05). Conclusions. In the vast majority of patients with COPD, the lung damage that leads to COPD is caused by long-term cigarette smoking. The presence and absence of risk factors such as smoking, inappropriate lipid profile and obesity (amount of fat mass) in selected population groups were observed. Additional studies to explore both the quantitative and qualitative changes in body composition with disease process of COPD are required.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2021, 72, 3; 291-299
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The association between air pollutions and emergency hospitalizations due to COPD and asthma across 16 Polish cities: population-based study
Autorzy:
Ścibor, Monika
Leoszkiewicz, Katarzyna
Micek, Agnieszka
Chomoncik, Karol
Dubas-Jakóbczyk, Katarzyna
Kocot, Ewa
Bąk, Agata
Kucińska, Jolanta
Dziurda, Dominik
Topór-Mądry, Roman
Powiązania:
https://bibliotekanauki.pl/articles/28762051.pdf
Data publikacji:
2024-03-05
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
asthma
COPD
environmental health
air pollutions
emergency hospitalizations
PM10
Opis:
Objectives In recent years numerous initiatives aimed at reducing air pollution have been undertaken in Poland. The general objective was to examine the correlation between air pollution measured by the level of particulate matter ≤10 μm in diameter (PM₁₀) and emergency hospitalizations due to chronic obstructive pulmonary disease (COPD) and asthma in 16 Polish cities (capitals of the regions). Material and Methods The authors aimed to diagnose the situation across 16 cities over a 5‑year period (2014–2019). Data on the number of hospitalizations was retrieved from the national public insurance system, the National Health Fund. A total number of 22 600 emergency hospitalizations was analyzed (12 000 and 10 600 in 2014 and 2019, respectively). The data on air pollution was accessed via the public register of the Chief Inspectorate for Environmental Protection air quality database. The authors of this article have used the data on PM₁₀ daily exposure in each of the 16 cities in 2014 and 2019. Statistical methods included: non-parametric tests, a 2-stage modelling approach for time-series data, and multivariate meta-analysis of the results. Results The results indicated that there was a statistically significant decrease in PM₁₀ concentration in 2019 in comparison to 2014 in all cities, mainly in the autumn and winter season. However, the correlation between the improvement in the air quality and a decrease in emergency hospitalizations due to asthma and COPD turned out to not be as strong as expected. The authors observed a strong correlation between PM₁₀ concentrations and hospitalizations due to asthma and COPD, but only when air quality norms were significantly above acceptable levels. Conclusions Air pollution measured by PM₁₀ concentration might be used as one of the predictors of the asthma and COPD emergency hospitalization risk, yet other factors like respiratory tract infection, health care organizational aspect, patient self-control, compliance and comorbidities should also be taken into consideration.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2024, 37, 1; 110-127
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The quality of life of farmers with chronic obstructive pulmonary disease (COPD)
Autorzy:
Milanowska, Joanna
Mackiewicz, Barbara
Węgorowski, Paweł
Milanowski, Janusz
Milanowski, Piotr
Makara-Studzińska, Marta
Powiązania:
https://bibliotekanauki.pl/articles/989814.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
chronic obstructive pulmonary disease (copd)
life quality
emotional and behavioural difficulties
farmers
Opis:
Introduction and objective. COPD is a medical state characterized by chronically poor airflow, and typically worsens over time. Farmers have an increased risk of COPD because of being exposed to ammonia, hydrogen sulfide, inorganic dust, and organic dust. The quality of life of the ill depends on biomedical as well as psychosocial factors, the impact of which has not been a frequent subject of studies among COPD patients. The aim of the study was to indicate the factors that have negative and positive influence on the quality of life of farmers suffering from COPD. Materials and method. The study was conducted among 84 farmers treated for COPD in the Department of Pneumology, Oncology and Allergology of the Medical University in Lublin, Poland. The differences between the farmers concerned: severity of the disease, level of education and income, frequency of smoking tobacco and drinking alcohol, kinds of support they receive from their families, and the level of depression and anxiety experienced by the patients. Results. The study revealed that most patients suffered from depressive and anxiety disorders, and the level of depression higher among the patients who smoked more. Lack of family support had significant influence on exacerbation of the patient’s depressive and anxiety symptoms. Patients who had recently experienced a critical situation presented with more severe COPD symptoms, lower quality of life and a higher level of depression. Higher income of the patients had positive influence on their quality of life. Farmers addicted to alcohol suffered from a higher level of anxiety.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of Diesel Particulate Matter Exposure of Underground Miners in Indonesia
Autorzy:
Susanto, A.
Purwanto, P.
Sunoko, H. R.
Setiani, O.
Powiązania:
https://bibliotekanauki.pl/articles/123151.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:
airflow obstruction
COPD
DPM
geostatistics
PEL
spatial interpolation
severity measurement
underground miners
Opis:
In Indonesia, there are underground mines for mineral metal such copper (Cu) and gold (Au), built by tunneling towards the mineral location. The purpose of this study was to determine the mapping a concentration of diesel particulate matter (DPM) and assess the impact on health by severity measurement of airflow obstruction of the miners experiencing chronic obstructive pulmonary disease (COPD). The data of DPM were measured with NIOSH method no. 5040 and applied a geostatistical method in mapping concentration at the area of underground mining. A spirometric measurement was conducted to diagnose COPD that is done to the 314 miners. The results showed that the concentrations exceeding the permissible exposure limit (PEL) and spirometric measurement were found for 26 miners (8.3%) who experience COPD (post bronchodilator <0.70). The severity measurement of airflow obstruction of the miners experiencing COPD, severity of airflow limitation for moderate (GOLD 2) was obtained for 14 miners (54%); severe (GOLD 3) for 10 miners (38%) and very severe (GOLD 4) for 2 miners (8%). It can be concluded that the amount of DPM exposure against the severity of airflow limitation with COPD by 0.03, in which the other factors also affect the severity.
Źródło:
Journal of Ecological Engineering; 2018, 19, 4; 34-42
2299-8993
Pojawia się w:
Journal of Ecological Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spirometric and hygienic criteria in recognition of occupational COPD in Poland – A retrospective analysis of medical records
Autorzy:
Kleniewska, Aneta
Walusiak-Skorupa, Jolanta
Lipińska-Ojrzanowska, Agnieszka
Szcześniak, Kamila
Wiszniewska, Marta
Powiązania:
https://bibliotekanauki.pl/articles/2161758.pdf
Data publikacji:
2017-11-03
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
compensation
acknowledgement of occupational disease
VGDF
occupational
COPD
chronic obstructive pulmonary disease
Opis:
Objectives: Chronic obstructive pulmonary disease (COPD) may be work-related. It has been estimated that 15% of the population burden of COPD is attributable to occupational exposure. However, in Poland COPD is rarely recognized as an occupational disease. The aim of the study has been to analyze the causes of the low prevalence of work-related COPD in the context of the existing criteria as well as to analyze which part of the assessment – clinical or hygienic one – is responsible for such a low rate of occupational COPD recognitions. Material and Methods: The study group included 150 patients hospitalized with a suspicion of occupational COPD. Each patient underwent a clinical examination, spirometry and reversibility test using bronchodilator. Moreover, hygienic evaluation of work conditions was performed in all the considered cases. Results: In the case of the patients who fulfilled the criteria for COPD diagnosis in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) occupational origins of the disease, the disease was not recognized because 24.1% of the individuals did not meet spirometric criteria included in a definition of COPD in the Polish list of occupational diseases, while 27.8% of the individuals did not fulfill the criterion of a documented exposure to dusts and irritant gases. None of these criteria was fulfilled by 42.6% of the patients. Conclusions: In our country, both clinical and hygienic criteria result in limitations in recognition of occupational COPD. There is the need to establish new guidelines for the recognition of COPD as a compensable disease in Poland. Int J Occup Med Environ Health 2018;31(2):139–150
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 2; 139-150
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Całościowa ocena przewlekłej obturacyjnej choroby płuc według raportu GOLD 2011
Combined assessment of chronic obstructive pulmonary disease according to GOLD report 2011
Autorzy:
Grzelewska-Rzymowska, Iwona
Górski, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/1032874.pdf
Data publikacji:
2013
Wydawca:
Medical Communications
Tematy:
B
C
C and D of COPD
GOLD report 2011
categories A
chronic obstructive pulmonary disease (COPD)
cigarette smoking
combined assessment of COPD
raport GOLD 2011
raport gold 2011
przewlekła obturacyjna choroba płuc (pochp)
palenie tytoniu
kategorie a
b
c
d pochp
całościowa ocena POCHP
Opis:
In this paper authors present a new approach to chronic obstructive pulmonary disease patients according to GOLD report 2011. Chronic obstructive pulmonary disease is a global health problem. The BOLD study proved that prevalence of it vary across countries and this disease will be the fourth leading cause of death in 2030. The main cause of chronic obstructive pulmonary disease is tobacco smoking. GOLD report 2011 recommends that a clinical diagnosis of a disease should be considered in patients presenting such symptoms as dyspnoea, cough, sputum expectoration as well as relevant exposure to risk factors with the presence of persistent airflow limitation confirmed by post-bronchodilat or FEV1/FVC < 0.70. The FEV1 is an inadequate descriptor of the impact of chronic obstructive pulmonary disease on patients. It is a complex and heterogeneous disease and that is why the validated tests are proposed – i.e. BODE index, ADO and DOSE – to examine the impact of chronic obstructive pulmonary disease on patients. GOLD report 2011 recommends the use of two validated tests: mMRC questionnaire and COPD Assessment Test (CAT). Spirometric values are classified as GOLD 1 and 2 (mild and moderate) and GOLD 3 and 4 (severe and very severe). Exacerbations of chronic obstructive pulmonary disease are based on the individual patient’s history or FEV1. Finally, the chronic obstructive pulmonary disease patients are classified to category A, B, C or D. Pharmacological treatment should be based on an individualized assessment.
Autorzy omawiają nowe podejście do przewlekłej obturacyjnej choroby płuc, przedstawione w raporcie GOLD 2011. Przewlekła obturacyjna choroba płuc jest ogólnoświatowym problemem zdrowotnym. Badanie BOLD ujawniło, że rozpowszechnienie choroby jest różne w poszczególnych krajach i będzie czwartą przyczyną zgonów w 2030 roku. Główną przyczyną przewlekłej obturacyjnej choroby płuc jest nałóg palenia tytoniu. Raport GOLD 2011 zaleca, aby postawienie diagnozy rozważyć, jeśli pacjent prezentuje takie objawy, jak: duszność, kaszel i odkrztuszanie wydzieliny z ekspozycją na czynniki ryzyka oraz z obecnością obturacji potwierdzonej wartością FEV1/ FVC < 0,70. Wskaźnik FEV1 okazał się niedostatecznym deskryptorem wpływu przewlekłej obturacyjnej choroby płuc na pacjenta. Jest to choroba złożona i różnorodna, zbadanie jej wpływu na zdrowie pacjenta wymaga walidowanych testów, takich jak BODE, ADO, DOSE. Raport GOLD 2011 zaleca stosowanie dwóch walidowanych testów: mMRC i CAT. Wskaźniki wentylacyjne są sklasyfikowane jako GOLD 1 i 2 (zaburzenia łagodne i umiarkowane) oraz GOLD 3 i 4 (zaburzenia ciężkie i bardzo ciężkie). Zaostrzenia przewlekłej obturacyjnej choroby płuc są ustalane na podstawie wywiadu lub wartości FEV1. Ostatecznie pacjentów można zakwalifikować do kategorii A, B, C lub D. Leczenie farmakologiczne powinno być ustalane po dokonaniu zindywidualizowanej oceny.
Źródło:
Pediatria i Medycyna Rodzinna; 2013, 9, 2; 135-143
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tests of the functional performance of patients with COPD: A proposal for the application of the Expanded Timed ‘Get Up and Go Test’ (ETGUG)
Testy sprawności czynnościowej chorych z POChP – propozycja zastosowania Wydłużonego Testu „Wstań i Idź” (ETGUG)
Autorzy:
Bromboszcz, Janusz
Włoch, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1956558.pdf
Data publikacji:
2010
Wydawca:
Akademia Wychowania Fizycznego im. Bronisława Czecha w Krakowie
Tematy:
COPD
functional performance
Physical activity
functional test
Diagnosis
Rehabilitation
POChP
sprawność czynnościowa
aktywność fizyczna
test czynnościowy
diagnostyka
rehabilitacja
Opis:
The testing of physical performance is not a common practice in the treatment of patients with COPD. Only a 6-minute walking test (6MWT) is more often used in the diagnosis and evaluation of the results of rehabilitation conducted in specialist pulmonary clinics. The use of other tests either directly or indirectly assessing physical performance is generally limited to research units. The state of knowledge about the conditioning and consequences of COPD point to the necessity of evaluating physical performance, while in the case of conducting pulmonary rehabilitation it should constitute a routine procedure. Without doubt the 6MWT and other tests presented in the paper should be widely used, though there exists the need to find other activity tests easier to conduct amongst patients with an advanced form of COPD, who have difficulty with effectively carrying out the 6MWT. An interesting proposition appears to be in this case Expanded Timed ‘Get Up and Go Test’ (ETGUG) which has previously not been used with COPD patients. The possibility of relating the results to the strength and endurance of the muscles of the lower limbs, to the ability of maintaining balance as well as physical activity typical for everyday life, corresponds to the pathological changes and limitations encountered in COPD. Research into the TUG test shows that it may be used in patients with COPD, however the extremely short walking distance in this test limits the possibility for result interpretation to an evaluation of the ability to stand from a seated position and to sit as well as the ability to maintain balance. It appears that a 20 metre walking distance for the ETGUG test would be sufficient to assess the walking abilities of patients with COPD, particularly for groups with advanced stages III and IV of the disease according to GOLD. Hence it is necessary to examine the ETGUG test in relation to its validity, reliability and responsiveness for patients with COPD.
Badanie sprawności czynnościowej nie jest częstą praktyką w postępowaniu z chorymi na przewlekłą obturacyjną chorobę płuc (POChP). Test marszu 6-minutowego (6MWT) znajduje zastosowanie w diagnostyce i ewaluacji wyników rehabilitacji jedynie w wyspecjalizowanych ośrodkach pulmonologicznych. Zastosowanie innych badań, bezpośrednio lub pośrednio oceniających sprawność czynnościową, jest na ogół ograniczone do placówek badawczych. Stan wiedzy o uwarunkowaniach i konsekwencjach POChP wskazuje na konieczność oceniania sprawności czynnościowej, a w przypadku prowadzenia rehabilitacji pulmonologicznej powinno to być rutynowe postępowanie. Upowszechnione powinno być stosowanie testu 6MWT i innych testów przedstawianych w artykule, jednak potrzebne jest takŜe poszukiwanie nowych testów czynnościowych. Potrzebne są zwłaszcza testy do badania chorych z zaawansowaną postacią POChP, którzy mają trudności ze skutecznym wykonaniem testu 6MWT. Interesującą propozycją wydaje się w tym względzie Wydłużony Test Wstań i Idź (ang. Expanded Timed ‘Up and Go Test’, ETGUG), którego jak dotąd nie stosowano w grupie chorych z POChP. MoŜliwość odniesienia wyników testu do siły i wytrzymałości mięśni kończyn dolnych, do zdolności utrzymywania równowagi oraz aktywności ruchowej typowej dla Ŝycia codziennego, odpowiada zmianom patologicznym i ograniczeniom spotykanym w POChP. Badania dotyczące Testu „Wstań i Idź” (ang. Timed ‘Up and Go Test’, TUG) pokazują, że może on być stosowany u chorych z POChP, jednak bardzo krótki dystans marszu zastosowany w tym teście ogranicza możliwość interpretacji jego wyników tylko do oceny sprawności wstawania z pozycji siedzącej i siadania oraz zdolności utrzymywania równowagi. Wydaje się, Ŝe 20- metrowy dystans marszu w teście ETGUG może być wystarczający do ocenienia zdolności chodzenia chorych z POChP, szczególnie z grup zaawansowania choroby III i IV wg GOLD. Niezbędne są zatem badania testu ETGUG dotyczące trafności, rzetelności i zdolności reagowania na zmiany stanu chorych z POChP
Źródło:
Medical Rehabilitation; 2010, 14(1); 30-42
1427-9622
1896-3250
Pojawia się w:
Medical Rehabilitation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Czynniki ryzyka przewlekłej obturacyjnej choroby płuc u pacjentów leczonych szpitalnie
Risk factors of chronic obstructive pulmonary disease in hospitalised patients
Autorzy:
Iwanicka-Michałowicz, Małgorzata
Grzelewska-Rzymowska, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1030691.pdf
Data publikacji:
2009
Wydawca:
Medical Communications
Tematy:
copd
risk factors
cigarette smoking
occupational exposure
anti-smoking education
pochp
czynniki ryzyka
palenie tytoniu
narażenie zawodowe
edukacja antytytoniowa
Opis:
COPD is currently one of the most important health problems all over the world. The most frequent factor responsible for COPD development is smoking of cigarettes, both active and passive. Other reasons influencing COPD development are occupational exposure to dust, chemical substances, irritant gases. The risk factor is congenital deficiency of α1-antitrypsin (genetic factor). The aim of the paper was to analyse any risk factors influencing development of COPD. The study was performed in 200 people with diagnosed COPD treated between 2005 and 2007. A patient medical history based on a questionnaire prepared for the study was performed in all patients. The study results then underwent statistical analysis. Of the subjects 124 (62%) were males and 76 (38%) were females. Mean age of the males – 66.1 years and of the females – 66.4 years. The main risk factor of the disease in the group studied was cigarette smoking – found in 170 patients (85%), from them 37.5% were current smokers, 47.5% were former smokers. Smoking history of current and former smokers averaged 42 pack-years (range 1-160). COPD was also found in 30 lifelong non-smokers (15%). Exposure to passive smoking at work and/or at home was observed in 175 people (87.5%). The inhalation of hazardous substances in the work environment was reported in 150 of the people studied (75%). Due to the fact that the smoking habit is very frequently found among COPD patients, it seems necessary to intensify actions taken to spread knowledge regarding COPD’s causes and effects, increase anti-smoking education and implement cheap and effective test screening methods.
POChP należy obecnie do najpoważniejszych problemów zdrowotnych na świecie. Najczęstszym czynnikiem, który odpowiada za rozwój POChP, jest palenie tytoniu, zarówno czynne, jak i bierne. Kolejnymi przyczynami warunkującymi rozwój POChP są narażenie zawodowe na pyły, substancje chemiczne, gazy drażniące. Czynnikiem ryzyka jest także wrodzony niedobór α1-antytrypsyny (czynnik genetyczny). Celem pracy była analiza czynników ryzyka warunkujących rozwój POChP. W badaniu wzięło udział 200 osób z rozpoznaniem POChP leczonych szpitalnie w latach 2005-2007. U wszystkich chorych przeprowadzono wywiad według kwestionariusza przygotowanego na potrzeby badania. Wyniki badania poddano analizie statystycznej. W badanej grupie było 76 kobiet (38%) i 124 mężczyzn (62%). Średnia wieku mężczyzn wynosiła 66,1 roku, kobiet – 66,4 roku. Głównym czynnikiem ryzyka rozwoju choroby w badanej grupie było palenie tytoniu – stwierdzono je u 170 badanych (85%), przy czym 37,5% chorych było aktualnymi palaczami, a 47,5% byłymi palaczami. Średni czas trwania nałogu w grupie obecnych i byłych palaczy wyniósł 42 paczkolata (rozpiętość 1-160). POChP rozpoznano również u 30 osób nigdy niepalących papierosów (15%). Narażenie na bierne palenie w pracy i/lub w domu podawało 175 chorych (87,5%). Narażenie na wdychanie szkodliwych substancji w środowisku pracy zgłaszało 150 badanych (75%). W związku z faktem, że nałóg palenia tytoniu jest zjawiskiem bardzo częstym wśród chorych na POChP, konieczne wydaje się zintensyfikowanie działań mających na celu upowszechnianie wiedzy na temat przyczyn i skutków POChP, realizację edukacji antytytoniowej oraz wdrożenie taniej i skutecznej metody badań przesiewowych.
Źródło:
Pediatria i Medycyna Rodzinna; 2009, 5, 1; 27-32
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena lokalnego i systemowego stanu zapalnego u chorych na przewlekły obturacyjną chorobę płuc w okresie stabilnym i w zaostrzeniu
Local and systemic inflammatory process inpatients with stable and exacerbation phase of chronic obstructive pulmonary disease
Autorzy:
Kwiatkowska, Sylwia
Urbaniak, Agnieszka
Szkudlarek, Urszula
Zięba, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1031064.pdf
Data publikacji:
2008
Wydawca:
Medical Communications
Tematy:
COPD
IL -6
TNF-α
expired breath condensate
hydrogen peroxide
pochp
kondensat powietrza wydechowego
nadtlenek wodoru
tnf-a
il-6
Opis:
Introduction: Chronic obstructive pulmonary disease (COPD) is characterised by the airflow limitation as a consequence of progressive inflammatory response to inhaled noxious particles and gases, particularly cigarette smoke. Three factors play a main role in pathogenesis of the disease: inflammatory process, oxidative stress and imbalance between proteases and antiproteases. Recently there are some evidences that also extrapulmonary changes like cachexia, osteoporosis or depression are associated with COPD. The aim of the study was to access local and systemic inflammation in patients with COPD. Material and methods: The study group consisted of 23 patients with COPD during stable and exacerbation phase of the disease. As a control served 16 asymptomatic smokers. We investigated: 1) concentration of hydrogen peroxide (H2O2) and proinflammatory cytokines like TNF-a and IL-6 in expired breath condensate (EBC); 2) serum levels of TNF-a and IL-6. Results: It was showed that the level of H2O2 in EBC of patients with stable COPD was significantly higher as compared with healthy smokers. Additional significant enhanced in H2O2 exhalation was demonstrated during exacerbation of COPD. There was no difference in IL-6 concentration between the study groups (p>0,05). Discernible level of TNF-a in exhaled air was measured only in those with COPD exacerbation. Exhaled H2O2 correlated with FEV1% predicted value in patients with stable as well as with exacerbation phase of COPD. Also serum levels of TNF-a and IL-6 of patients with stable disease were higher compared to the values of healthy smokers. The serum concentrations of studied cytokines did not change significantly during exacerbation of COPD. Conclusions:Our results demonstrated the occurrence of local oxidative stress in patients with stable COPD. This process significantly increased during exacerbation of the disease. Besides of local reaction in respiratory compartment of patients with stable COPD we revealed systemic inflammatory process measured by serum levels of TNF-a and IL-6. Exhaled H2O2 correlated with lung function (FEV1% pred).
Wstęp: Przewlekłą obturacyjną chorobę płuc (POChP) charakteryzuje ograniczenie przepływu powietrza przez drogi oddechowe będące wynikiem nadmiernej reakcji zapalnej na wdychane pyły i gazy, głównie dym tytoniowy. W patogenezie tej choroby odgrywają rolę trzy czynniki: proces zapalny, stres oksydacyjny oraz zaburzenia równowagi pomiędzy proteinazami i antyproteinazami. W ostatnich latach coraz więcej danych wskazuje na obecność u chorych na POChP zmian pozapłucnych, takich jak wyniszczenie, osteoporoza czy depresja. Celem pracy była ocena stanu zapalnego lokalnego oraz systemowego u chorych na POChP. Materiał i metody: Badania przeprowadzono u 23 chorych na POChP dwukrotnie - w stabilnym okresie choroby oraz w zaostrzeniu. Grupę kontrolną stanowiło 16 asymptomatycznych palaczy papierosów. Analizie poddano: 1) w kondensacie powietrza wydechowego (kpw) stężenie nadtlenku wodoru (H2O2) oraz proza-palnych cytokin TNF-α i IL-6; 2) w surowicy poziom TNF-a i IL-6. Wyniki: Stwierdzono, że u chorych na POChP w okresie stabilnym w kpw poziom H2O2 był znamiennie wyższy niż w grupie kontrolnej osób zdrowych. W trakcie zaostrzenia choroby ulegał on dalszemu wzrostowi (p<0,05). Natomiast stężenie IL-6 w powietrzu wydechowym było w badanych grupach podobne (p>0,05). Mierzalny poziom TNF-α zanotowano jedynie u chorych z zaostrzeniem POChP. Zarówno w okresie stabilnym, jak i w zaostrzeniu choroby poziom H2O2 w kpw korelował z FEV1% wartości należnej. Chorych na stabilną POChP charakteryzowało podwyższone w surowicy zarówno stężenie TNF-α, jak i IL-6 w porównaniu z grupą asymptomatycznych palaczy. W okresie zaostrzenia badane cytokiny nie ulegały istotnym zmianom (p>0,05). Wnioski: U chorych na POChP wykazano obecność lokalnego stresu oksydacyjnego, który w trakcie zaostrzenia choroby ulegał dalszemu znamiennemu nasileniu. Obok reakcji w kompartmencie oddechowym chorzy ze stabilną postacią POChP charakteryzowali się obecnością systemowej reakcji zapalnej mierzonej poziomem TNF-α i IL-6 w surowicy. Poziom nadtlenku wodoru w powietrzu wydechowym korelował z wartościami spirometrycznymi (FEV1% wartości należnej).
Źródło:
Pediatria i Medycyna Rodzinna; 2008, 4, 3; 183-188
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena wiedzy lekarzy na temat przewlekłej obturacyjnej choroby płuc pochodzenia zawodowego
Physicians’ knowledge on the work-related chronic obstructive pulmonary disease
Autorzy:
Kleniewska, Aneta
Walusiak-Skorupa, Jolanta
Piotrowski, Wojciech
Marcinkiewicz, Andrzej
Szcześniak, Kamila
Wiszniewska, Marta
Powiązania:
https://bibliotekanauki.pl/articles/2164393.pdf
Data publikacji:
2016-05-25
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
choroba zawodowa
POChP
przewlekła obturacyjna choroba płuc
orzecznictwo
pyły
gazy drażniące
occupational disease
COPD
chronic obstructive pulmonary disease
medical certification
dusts
irritant gases
Opis:
Wstęp Przewlekła obturacyjna choroba płuc (POChP) może być wywołana warunkami środowiska pracy. Według szacunkowych danych 10–20% wszystkich przypadków POChP ma związek z zawodowym narażeniem na pyły i gazy drażniące. Jednocześnie w 2014 r. w Polsce rozpoznano jedynie 11 przypadków POChP pochodzenia zawodowego. Celem pracy była analiza zależności między niewielką liczbą rozpoznawanej POChP o etiologii zawodowej a wiedzą lekarzy na temat czynników etiologicznych choroby związanych z narażeniem zawodowym oraz znajomości procedur związanych ze zgłaszaniem podejrzenia choroby zawodowej. Materiał i metody Badaniem ankietowym objęto 94 lekarzy pulmonologów losowo wybranych spośród 225 specjalistów chorób płuc zarejestrowanych w Okręgowej Izbie Lekarskiej w Łodzi. Metodą badawczą była autorska anonimowa ankieta. Wyniki Większość ankietowanych pulmonologów prawidłowo określiło środowiskowe czynniki mogące wywoływać POChP, jednocześnie tylko 23,4% wskazało prawidłowo podstawowe czynniki pochodzenia zawodowego jako przyczynę POChP. Jedynie 58,5% pulmonologów zawsze pyta pacjentów z POChP o wykonywany zawód, a 60,6% z nich nie miało wiedzy na temat procedur związanych ze zgłaszaniem podejrzenia choroby zawodowej. Wnioski Lekarze mają niepełną znajomość czynników zawodowych mogących wywoływać POChP, nie zawsze pytają chorych na POChP o wykonywany zawód i związek dolegliwości z wykonywaną pracą, a także nie znają regulacji prawnych dotyczących prawidłowego skierowania pacjenta z podejrzeniem choroby zawodowej do jednostki orzeczniczej. Wyniki przeprowadzonych badań wskazują na potrzebę zwiększania wiedzy lekarzy w zakresie zagadnień związanych z przewlekłą obturacyjną chorobą płuc pochodzenia zawodowego. Med. Pr. 2016;67(3):375–384
Background Chronic obstructive pulmonary disease (COPD) may be induced by the work environment conditions. According to the estimates, 10–20% of all COPD cases are associated with occupational exposure to dusts and irritant gases. However, in 2014, only 11 cases of work-related COPD were recognized in Poland. The aim of the study was to analyze the reasons for the low incidence of work-related COPD in the context of pulmonologists’ knowledge about occupational risk factors and procedures on reporting suspected occupational diseases. Material and Methods A survey included 94 pulmonologists randomly selected out of 225 specialists registered at the Local Physicians Chamber in Łódź. The study was performed anonymously with the use of original questionnaire. Results More than a half of the surveyed pulmonologists identified environmental risk factors for COPD correctly, while only 23.4% properly identified the main occupational risk factors as the cause of COPD. Only 58.5% of the pulmonologists always asked their patients suffering from COPD about their job/profession and 60.6% of them did not have any knowledge about procedures on reporting suspected occupational diseases. Conclusions The physicians rarely ask patients suffering from COPD about their job/profession and the relationship between their ailments and occupational exposure. What is more, they do not know legal regulations on proper referral of a patient with a suspected case of occupational disease. The results of the study clearly indicate that there is an urgent need for increasing pulmonologists’ knowledge on work-related COPD. Med Pr 2016;67(3):375–384
Źródło:
Medycyna Pracy; 2016, 67, 3; 375-384
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cathelicidin LL-37, granzymes, TGF-beta1 and cytokines levels in induced sputum from farmers with and without COPD
Autorzy:
Golec, M
Reichel, C.
Mackiewicz, B.
Skorska, C.
Curzytek, K.
Lemieszek, M.
Dutkiewicz, J.
Gora, A.
Ziesche, R.
Boltuc, J.
Sodolska, K.
Milanowski, J.
Spiewak, R.
Powiązania:
https://bibliotekanauki.pl/articles/49729.pdf
Data publikacji:
2009
Wydawca:
Instytut Medycyny Wsi
Tematy:
cathelicidin LL-37
peptide
chronic obstructive pulmonary disease
COPD zob.chronic obstructive pulmonary disease
sputum
farmer
human disease
organic dust
ELISA test
spirometric value
sputum sample
dust exposure
cytokine
lipopolysaccharide
Źródło:
Annals of Agricultural and Environmental Medicine; 2009, 16, 2; 289-297
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
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