Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "CAG" wg kryterium: Temat

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-8 z 8
    Tytuł:
    Silencing of genes responsible for polyQ diseases using chemically modified single-stranded siRNAs
    Autorzy:
    Fiszer, Agnieszka
    Ellison-Klimontowicz, Marianna
    Krzyzosiak, Wlodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1038736.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    siRNA
    CAG repeats
    polyglutamine diseases
    Huntington's disease
    Opis:
    Polyglutamine (polyQ) diseases comprise a group of nine genetic disorders that are caused by the expansion of the CAG triplet repeat, which encodes glutamine, in unrelated single genes. Various oligonucleotide (ON)-based therapeutic approaches have been considered for polyQ diseases. The very attractive CAG repeat-targeting strategy offers selective silencing of the mutant allele by directly targeting the mutation site. CAG repeat-targeting miRNA-like siRNAs have been shown to specifically inhibit the mutant gene expression, and their characteristic feature is the formation of mismatches in their interactions with the target site. Here, we designed novel single-stranded siRNAs that contain base substitutions and chemical modifications, in order to develop improved therapeutic tools with universal properties for several polyQ diseases. We tested these ONs in cellular models of Huntington's disease (HD), spinocerebellar ataxia type 3 (SCA3) and dentatorubral-pallidoluysian atrophy (DRPLA). Selected siRNAs caused the efficient and selective downregulation of the mutant huntingtin, ataxin-3 and atrophin-1 levels in cultured human fibroblasts. We also prove the efficiency of novel ONs, with chemical modification pattern mainly containing 2'-fluoro (2'F), in HD mouse striatal cells.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 4; 759-764
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer
    Autorzy:
    Linkowska, Katarzyna
    Jawień, Arkadiusz
    Marszałek, Andrzej
    Skonieczna, Katarzyna
    Grzybowski, Tomasz
    Powiązania:
    https://bibliotekanauki.pl/articles/1039019.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    POLG gene
    CAG repeat
    colorectal cancer
    somatic mutations
    Opis:
    Mitochondrial DNA polymerase gamma (POLG) is the only DNA polymerase involved in maintaining the mitochondrial genome. Recent studies demonstrated an association of CAG repeat polymorphism in the second exon of POLG gene with the risk of cancer. We investigated the CAG repeat variability in the POLG gene in tumor and non-tumor tissues from colorectal cancer patients and in DNA samples isolated from blood obtained from age-matched healthy persons. Somatically occuring CAG-repeat alterations in cancer tissues have been observed in 10% of patients, but no association has been found between the CAG repeat variants in the POLG gene and colorectal cancer risk.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 625-627
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Normy i standardy z zakresu bezpieczeństwa informacyjnego i teleinformatycznego
    Information security and computer safety norms and standards
    Autorzy:
    Liderman, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/273168.pdf
    Data publikacji:
    2009
    Wydawca:
    Wojskowa Akademia Techniczna im. Jarosława Dąbrowskiego
    Tematy:
    NIST
    CAG
    ITIL
    COBIT
    SSE-CMM
    Opis:
    Artykuł zawiera przegląd norm i standardów z zakresu bezpieczenstwa teleinformatycznego nieco mniej znanych niż normy serii ISO/IEC 27000 oraz ISO/IEC 15408.
    This paper contains information security and computer safety norms and standards review, a little less known than ISO/IEC 27000 and ISO/IEC 15408.
    Źródło:
    Biuletyn Instytutu Automatyki i Robotyki; 2009, R. 15, nr 26, 26; 29-43
    1427-3578
    Pojawia się w:
    Biuletyn Instytutu Automatyki i Robotyki
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Expression characteristics of triplet repeat-containing RNAs and triplet repeat-interacting proteins in human tissues
    Autorzy:
    Jasinska, Anna
    Kozlowski, Piotr
    Krzyzosiak, Wlodzimierz
    Powiązania:
    https://bibliotekanauki.pl/articles/1040767.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    CUG-containing transcripts
    RNA pathogenesis
    CAG-containing transcripts
    EST
    Opis:
    Numerous human transcripts contain tandem repeats of trinucleotide motifs, the function of which remains unknown. In this study we used the available gene expression EST data to characterize the abundance of a large group of these transcripts in different tissues and determine the mRNAs which had the highest contribution to the observed levels of transcripts containing different types of the CNG repeats. A more extensive characteristics was performed for transcripts containing the CUG repeats, and those encoding the repeat-binding proteins. The scarcity of double-stranded CUG repeats as well as various proportions of the single-stranded and double-stranded CUG repeat-binding proteins were revealed in the studied transcriptomes. The observed correlated levels of transcripts containing single-stranded CUG repeats and of proteins binding single-stranded CUG repeats may imply that in addition to transcripts which only provide binding sites for these proteins there may be a substantial portion of the transcripts whose metabolism is directly regulated by such proteins. Our results showing a highly variable composition of triplet repeat-containing transcripts and their interacting proteins in different tissues may contribute to a better understanding of the mechanism of RNA-mediated pathogenesis in triplet repeat expansion diseases.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 1; 1-8
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    What is the unique nature of the Huntington’s Disease?
    Autorzy:
    Bartoszek, Adrian
    Szalast, Kamil
    Powiązania:
    https://bibliotekanauki.pl/articles/454842.pdf
    Data publikacji:
    2019
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    CAG repeat,
    chorea, family system
    genetic disease
    HD gene
    Opis:
    Introduction. Huntington’s disease is a rare neurodegenerative disease, inherited in an autosomal dominant manner. Every child in the family whose parent is a carrier of the mutant gene has a 50% risk of inheriting the disease. Genetic tests unambiguously confirm whether a person at risk is ill or not. Symptoms include movement, neuropsychiatric and cognitive disorders. Currently, the disease is incurable and there are no effective methods for its treatment. Aim. The aim is to present information about Huntington’s disease, its inheritance, symptoms and pathologies, as well as to draw attention to its unique impact on patients and their families. Material and methods. A literature review of the following databases has been conducted: PubMed, Science Direct, EBSCO, Springer Link. Results. Huntington’s disease, due to the autosomal dominant inheritance, disturbs the whole family system. Over several generations, a family can struggle with the problems of taking care of several patients at the same time, providing children with information about the risk of falling ill, making decisions about genetic testing, and starting a family or having children. Conclusion. Huntington’s disease is a challenge for healthcare professionals who are not always prepared to solve unique, multi-generational problems in families with Huntington’s disease.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2019, 2; 169-174
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    24. Konferencja Afrykańskiego Towarzystwa Geologicznego Addis Abeba, Etiopia, 6-14.01.2013 : międzynarodowa pomoc dla Afryki czy neokolonializm naukowy?
    24th Conference of the Geological Society of Africa - Addis Ababa, Ethiopia, January 6-14, 2013 : interna¬tional aid vs. scientific neocolonialism”
    Autorzy:
    Wołkowicz, S.
    Powiązania:
    https://bibliotekanauki.pl/articles/2075062.pdf
    Data publikacji:
    2013
    Wydawca:
    Państwowy Instytut Geologiczny – Państwowy Instytut Badawczy
    Tematy:
    Colloquium of African Geology CAG24
    CAG24
    geology of Africa
    Polish Aid
    Konferencja Afrykańskiego Towarzystwa Geologicznego
    geologia Afryki
    polska pomoc zgraniczna
    Opis:
    24th Colloquium of Geological Society of Africa covered a wide range of fields in geology, from basic research and mineral resources geology to hydrogeology and geotourism. Presentations delivered at the colloquium confirmed vast scale of mineral wealth of Africa, showing at the same time that any substantial further progress in identifying new resources is hampered by the lack of good geological maps at appropriate scales. Some major problems in exploitation of mineral resources in Africa are related to artisanal and small scale mining (ASM). On one hand, ASM provides an income that is sufficient to cover basic needs for tens of millions of Africans, and on the other hand-its environmental impact may be very harmful, especially in the case of mining and processing of gold-bearing ores. Geological research in Africa is usually supported scientifically and financially by EU countries, USA, Canada, Australia as well as China. This is due to the lack of local specialists and sufficiently equipped laboratories practically everywhere except for RSA. Also two papers presented by the Author and his team gave results of research carried out in Angola and Zambia mainly thanks to assistance projects financed by the Polish Aid Programme of the Ministry of Foreign Affairs of the Republic of Poland.
    Źródło:
    Przegląd Geologiczny; 2013, 61, 5; 290--293
    0033-2151
    Pojawia się w:
    Przegląd Geologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Association between knowledge and anxiety level among patients undergoing coronary angiography in tertiary care hospitals of Peshawar.
    Autorzy:
    Shaheen, Nazia
    Muhammad, Dildar
    Habibullah, Gulzar
    Khattak, Irfan Ullah
    Powiązania:
    https://bibliotekanauki.pl/articles/2026031.pdf
    Data publikacji:
    2022-03-31
    Wydawca:
    Towarzystwo Pomocy Doraźnej
    Tematy:
    Coronary artery disease (CAD)
    coronary angiography (CAG)
    anxiety
    knowledge
    Opis:
    INTRODUCTION: : Coronary artery disease (CAD) leads to mortality and morbidity globally. Approximately, 18 million deaths occurred due to cardiovascular diseases. Objective: To determine the association between knowledge about coronary angiography and anxiety level among patients undergoing coronary angiography. MATERIAL AND METHODS: Analytical cross-sectional study was conducted in two major public-sector hospitals between September 2017 to March 2018. A total of 264 patients were recruited in the study Rusing a non-probability convenience sampling technique. A modified questionnaire about coronary angiography was distributed among participants and the HADS scale was used to assess the anxiety level of the participants. SPSS version 22 was used for data analysis. RESULTS: The mean knowledge score of the participants about angiography was 17.88 ± 4.047. The total knowledge score of both hospitals was good knowledge (6%), fair knowledge (42%) and had poor knowledge (52%). Regarding anxiety level, the participants of both hospitals experienced a high level of anxiety i.e. mild (20%), moderate (34%) & sever (10%). A significant association was found between knowledge and anxiety levels among the participants of both hospitals with a p-value of <0.001. CONCLUSIONS:This study found a significant association between patient’s knowledge about coronary angiography and anxiety level among patients undergoing coronary angiography. The study puts forwards that nurses shall assess the patient’s knowledge before coronary angiography procedure. The provision of accurate knowledge renders categorical purpose to this procedure for salubrious patients’ outcomes.
    Źródło:
    Critical Care Innovations; 2022, 5, 1; 15-23
    2545-2533
    Pojawia się w:
    Critical Care Innovations
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Methods of minimalization of coolant flow rate in the grinding processes - the review
    Autorzy:
    Czapiewski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/95313.pdf
    Data publikacji:
    2017
    Wydawca:
    Politechnika Koszalińska. Wydawnictwo Uczelniane
    Tematy:
    grinding process
    grinding wheel
    minimum quantity lubrication
    MQL
    minimal quantity cooling
    MQC
    cold air guns
    CAG
    szlifowanie
    ściernica
    smarowanie
    chłodzenie
    dysze chłodzące
    Opis:
    The article describes the role and types of cooling lubricants used in grinding processes. Conventional methods of coolants delivery into the grinding zone were described, such as: flood method, high-pressure jet method, centrifugal coolant provision method as well as methods method to minimize coolant flow rate: minimum quantity lubrication (MQL), minimum quantity cooling (MQC) and minimum quantity cooling lubrication (MQCL). Against this background, a methods were presented to completely eliminate grinding fluid from the grinding process (dry grinding) like: impregnated grinding wheels and cold air guns (CAG).
    Źródło:
    Journal of Mechanical and Energy Engineering; 2017, 1, 2; 117-122
    2544-0780
    2544-1671
    Pojawia się w:
    Journal of Mechanical and Energy Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies