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Wyświetlanie 1-4 z 4
Tytuł:
Let’s discuss the Criteria of Bradford Hill (1965)
Autorzy:
Ulmer, Hans-Volkhart
Powiązania:
https://bibliotekanauki.pl/articles/13108041.pdf
Data publikacji:
2021-06-18
Wydawca:
Akademia Tarnowska
Tematy:
epidemiology
Bradford-Hill-criteria
health
Opis:
On 10th October 2020, the German Federal Ministry for the Environment had responded to an inquiry concerning causality, as follows: The nine criteria of Hill [1] are a “central pillar for the determination of causality in epidemiology.” The reason of the inquiry was the dramatic press release: “Air pollution is responsible for more than 400,000 premature deaths/year in Europe.” Among others, the “central pillar” agrees e. g. with reference [2]. Applying to expert discussions, a colleague had commented on this matter: “All our environmental epidemiologists refer to the Bradford Hill criteria”. Is this also the case in publications?Whilst reading through numerous epidemiological publications on sport & health respectively environment & health, the author had never come across these criteria – the reason for this letter to the editor.In 1965, HILL had given detailed considerations to the conditions that would have to be fulfilled in the case of epidemiological associations found before they could be used as a reason to “cry causation”.Extensive annually published reports of the EEA (European Environment Agency) deal with air pollution and human health. In 2019 as key message ([3] p. 63): “Air pollution is the single largest environmental health risk in Europe, with around 400 000 premature deaths attributed to air pollution¼ in 2018” ([3] p. 63) and again in 2020: “Air pollution is a major cause of premature death ¼, responsible for around 400 000 premature deaths per year” ([4] p. 10).The corresponding EEA studies are based on epidemiological surveys, collected in the categories urban – suburban – rural ([4] p. 11). The results, often calculated using the DPSEEAModel ([5] to Healthcare Waste Management), are correctly described from a statistical point of view as: “Deaths attributed to” ([2] p. 63), “associated with” ([1] p. 10), “relationship (between exposure to ambient pollutant concentrations and health outcome” [1] p. 106), “Estimates are produced” or: “the impacts attributable to exposure” ([4] p. 106). But then there is a mind jump to causality by complaining: “Air pollution is a major cause of premature death” ([4] p.10) and implicite with “air pollution is currently the most important environmental risk to human health” ([4] p.9): A typical case of “cry causation”, but without prior examination of the Bradford-Hill-criteria. These are neither mentioned in the text nor in the reference list, nor are alternative criteria (e.g. [6]). However, the published conclusions claiming causality led to serious environmental policy consequences. Yet the question of causality should be decisive for avoiding a so-called stork statistic.Therefore: Let’s discuss the Bradford-Hill-criteria! I am interested to find environmental epidemiological studies in which all of the 9 criteria have been thoroughly discussed rather than having to endure serious environmental policy consequences triggered as “cry causation”. An orienting PubMed analysis did not reveal any reference to environmental epidemiology among 79 hits, but in other research fields associations were often evaluated using all 9 Bradford-Hill-criteria, in two cases even resulting in the rejection of a hypothesis.Therefore, if anyone knows of an environmental health epidemiological study in which the 9 Bradford-Hill criteria were discussed individually prior to “cry causation”: Please provide the author with the bibliographical details: ulmer@uni-mainz.de.The Editor in Chief has agreed to publish a corresponding list of entries in issue 3/2021.
Źródło:
Health Promotion & Physical Activity; 2021, 15, 2; 56-57
2544-9117
Pojawia się w:
Health Promotion & Physical Activity
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Causation in different scientific disciplines: A comparison of standards in occupational medicine and particle physics
Autorzy:
Dale, Jack R.
Powiązania:
https://bibliotekanauki.pl/articles/23388841.pdf
Data publikacji:
2023-11-14
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational medicine
evidence-based medicine
causation
particle physics
levels of evidence
Bradford Hill criteria
Opis:
Occupational medical research involves the collection and analysis of data to draw conclusions about the causes and prevention of workplace injuries and diseases. However, there has been criticism that some studies lack rigour in determining causation. This article examines the similarities and differences between occupational medical research and particle physics in terms of their approach to hypothesis testing, statistical methods, and confounder control. The article also explores the use of criteria such as the Bradford Hill criteria to determine causation in occupational medical research. While particle physics is often viewed as a highly rigorous science, occupational medical research also employs rigorous scientific methods to ensure findings are accurate and reliable. However, there is room for improvement in determining causation in occupational medical research, particularly in the use of criteria such as the Bradford Hill criteria to guide the development of more robust studies. It is essential for occupational medical research to adhere to rigorous scientific methods to deliver findings that can help reduce workplace injuries and diseases. The use of criteria such as the Bradford Hill criteria can ensure that the conclusions drawn.
Źródło:
Medycyna Pracy. Workers’ Health and Safety; 2023, 74, 4; 333-339
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy. Workers’ Health and Safety
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The determination of potentially allergenicity of selected herbs
Autorzy:
Aninowski, Mateusz
Leszczyńska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/410475.pdf
Data publikacji:
2019
Wydawca:
Politechnika Łódzka. Wydawnictwo Politechniki Łódzkiej
Tematy:
profilins
Bet v I
Bet v II
ELISA test
Total Extractable Protein
Bradford
Pierce
profiliny
test ELISA
białko całkowicie ekstrahowalne
Opis:
The aim of the research was to compare the content of allergens in herbs from the Lamiaceae (basil, oregano) and Apiaceae (cumin, fennel, parsley, anise, coriander) family. Herbal plants from conventional and organic crops were subjected to research. In the extracts of herbs, the content of protein as well as the content of Bet v I analogs and profilin were determined using the immunoenzymatic indirect method. Protein content in conventional crops determined by the Bradford method ranges between 160-204 mg/g, and Pierce determined between 105-394 mg/g. In samples of organic herbs the results are as follows: Bradford method 149-196 mg/g, and Pierce method 109-333 mg/g. In the case of plants grown using conventional methods, the content of Bet v I analogues, based on a commercial test, ranged from 0.5 to 1.15 μg/g in method I, whereas in the method developed by us from 0.22 to 0.68 μg/g. In herbs from organic farming, the range of results according to the commercial test is 0.86-1.54 mg/g, and use by the test we developed 0.5-0.63 mg/g. The results of profilin content were as follows: in samples grown with conventional methods, they ranged from 1.00 to 18.13 ng/g, while organics - from 3.27 to 12.62 ng/g. The calculated p-value is less than the assumed α = 0.05, – this result is statistically significant. The correlation between the results of the method I and II in both crops is strongly statistically significant.
Źródło:
Biotechnology and Food Science; 2019, 83, 1; 3-11
2084-0136
2299-6818
Pojawia się w:
Biotechnology and Food Science
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-4 z 4

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