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Wyszukujesz frazę "Biginelli reaction" wg kryterium: Temat

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    Wyświetlanie 1-5 z 5
    Tytuł:
    Comparative study of chemical synthesis of dihydropyrimidine (DHPMS) derivatives by Biginelli Reaction using microwave irradiation and conventional method
    Autorzy:
    Sonawane, R.P.
    Powiązania:
    https://bibliotekanauki.pl/articles/411784.pdf
    Data publikacji:
    2013
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    dihydropyrimidine derivatives
    Biginelli reaction
    microwave irradiation
    conventional method
    Opis:
    The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is comparative study of chemically synthesis of two DHPMs derivatives by Biginelli Reaction using microwave irradiation and conventional method. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3-dicarbonyl compounds) in presence of HCl / NH4Cl as a catalyst. Two derivative viz. 3,4-dihydropyrimidin-2-(1H)-ones and 3,4-dihydropyrimidin-2-(1H)-thiones were synthesized and characterized using IR. The melting points were obtained are 203 °C and 211 °C respectively. Microwave irradiation was easy and gave more yield than conventional method. This study will help to develop easy protocol for the synthesis of many more DHPMs derivative with high yield.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2013, 5; 7-11
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparative Study of Chemical Synthesis of Pyrimidine Derivatives by Using Grindstone Chemistry Technique and Conventional Metod
    Autorzy:
    Sonawane, R. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/412505.pdf
    Data publikacji:
    2014
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    dihydropyrimidine derivatives
    Biginelli reaction
    Grindstone chemistry
    Opis:
    The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is comparative study of chemically synthesis of two DHPMs derivatives by Biginelli Reaction using conventional method and grindstone chemistry technique. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3-dicarbonyl compounds) in presence of HCl / NH4Cl as a catalyst. Two derivative viz. 3,4-dihydropyrimidin-2-(1H)-ones and 3,4-dihydropyrimidin-2-(1H)-thiones were synthesized and characterized using IR. The melting points were obtained are 208 °C and 210 °C respectively. “Grindstone Chemistry Technique” catalyzed by CuCl2•2H2O and Conc. HCl. gave more yield, solvent free and ecofriendly. The obtained products have been identified by comparison with spectral data & their melting points. This study will help to develop easy protocol for the synthesis of many more DHPMs derivative with high field.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2014, 14, 1; 22-27
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Green synthesis of pyrimidine derivative
    Autorzy:
    Sonawane, R. P.
    Powiązania:
    https://bibliotekanauki.pl/articles/412470.pdf
    Data publikacji:
    2014
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    dihydropyrimidine derivatives
    Biginelli reaction
    Grindstone chemistry
    Opis:
    The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is study and synthesis of dihydropyrimidinones efficiently and in high yields under mild, solvent free and eco-friendly conditions by using “Grindstone Chemistry Technique” catalyzed by CuCl2•2H2O and Conc. HCl. The obtained products have been identified by comparison with spectral data & their melting points. The synthesis of DHPMs derivative involves a multicomponent reaction (aldehyde derivative, urea /thiourea and 1,3-dicarbonyl compounds) in presence of HCl / NH4Cl as a catalyst. 3,4-dihydropyrimidin-2-(1H)-ones was synthesized and characterized using IR. The melting points was obtained 203 °C.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2014, 2; 64-68
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    One-pot three component (LaCl3•7H2O) catalysed biginelli reaction for the synthesis of 1,2,3,4-tetrahydropyrimidine
    Autorzy:
    Murugesan, C.
    Sihabudeen, M. Mohamed
    Ahamed, A. Asrar
    Powiązania:
    https://bibliotekanauki.pl/articles/1190119.pdf
    Data publikacji:
    2016
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    2
    3
    4-tetrahydropyrimidine; one pot synthesis
    Multicomponent reaction; Biginelli reaction; 1
    Opis:
    A Series of tetrahydropyrimidine has been derived by LaCl3•7H2O catalysed one pot three component biginelli reaction. The compounds have synthesised from an aldehyde, ethyl acetoacetate and urea or thiourea in an ethanolic medium using a catalytic amount of (LaCl3•7H2O). This method provides quantitative yield and the catalysis can be easily recovered from the reaction medium and be re-used.
    Źródło:
    World Scientific News; 2016, 35; 87-99
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and characterization of fully substituted pyrimidines by using ketene dithioacetal as potent antimicrobial agent
    Autorzy:
    Khunt, H. R.
    Pipaliya, P. P.
    Ghelani, S. M.
    Babariya, J. S.
    Naliapara, Y. T.
    Powiązania:
    https://bibliotekanauki.pl/articles/412064.pdf
    Data publikacji:
    2014
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    ketene dithioacetal
    pyrimidines
    guanidine
    biginelli reaction
    Opis:
    Various ketene dithioacetals of acetoacetanilides were reacted with guanidine nitrate in the presence of base to produce the 2-amino-4-isopropyl-6-alkoxy-N-arylpyrimidine-5-carboxamide derivatives with good yields. All the synthesized compounds were characterized by mass, NMR and IR and also evaluated for antimicrobial activity against five different bacterial and fungal strains. The compounds 4i, 4k and 4l has found comparatively good active against all the bacterial strains.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2014, 5; 134-141
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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