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Tytuł:
Synthesis, characterization of isoxazole derivatives and evaluation of their antibacterial, antioxidant and anticancer activity
Autorzy:
Vashisht, Ketan
Sethi, Pooja
Bansal, Anshul
Singh, Tejveer
Kumar, Raman
Singh Tuli, Hardeep
Saini, Shallu
Powiązania:
https://bibliotekanauki.pl/articles/40570865.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
antibacterial
antioxidant activity and anticancer potential
isoxazole
pathogenic bacterial
Opis:
Introduction and aim. The synthesis of heterocyclic compounds containing oxygen and nitrogen is profoundly intriguing due to their mechanistic implications in both research and development within organic chemistry and drug discovery. The primary aim of this study is to fabricate a range of pharmacologically active drugs containing the isoxazole moiety. Material and methods. The synthesis of new derivatives of isoxazole was achieved through a one-pot condensation reaction of 2-[(Substituted phenyl)hydrazono]malononitrile (1) and 3-[(Substituted phenyl)azo]-2,4-Pentanedione (2) with sodium acetate and hydroxylamine hydrochloride (1:1) in ethanol. All the compounds were screened for their in vitro antibacterial activity, in vitro antioxidant and anticancer activity. The synthesized compounds underwent characterization through FTIR, 1H NMR, and 13C NMR analyses, supported by mass spectral data and elemental analysis. Results. A set of novel isoxazole derivatives was synthesized with a favorable yield. Among compounds 1d, 1e, 2c, 2d, and 2e exhibited notable antioxidant activities. Compounds 1a, 1b, and 1c demonstrated significant anticancer potential against prostate cancer [PC3] cell lines compared to normal HEK cell lines, while 2a displayed the highest inhibitory zone against Escherichia coli. Conclusion. Novel compounds with multifaceted biological activities have been successfully designed, and a synthetic route to create isoxazole derivatives has been devised and verified.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 376-387
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Formulation and Stability of Cellulose Particles Enriched with Phenolic Acids
Autorzy:
Kopjar, Mirela
Vukoja, Josipa
Buljeta, Ivana
Ćorković, Ina
Pichler, Anita
Šimunović, Josip
Powiązania:
https://bibliotekanauki.pl/articles/24024620.pdf
Data publikacji:
2023-11-06
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
cellulose
gallic acid
caffeic acid
storage stability
antioxidant potential
complexation
Opis:
Dietary fibers and phenolic acids are recognized for their various health benefits; thus, cellulose was selected as a carrier polymer of phenolic acids, including gallic acid and caffeic acid. Dried cellulose particles were prepared through the complexation of different amounts of cellulose (2.5, 5, 7.5 and 10%, w/v) with a constant amount of phenolic acids. Additionally, the complexation time was 15 or 60 min with the goal to determine an impact of the duration of complexation on the adsorption of phenolic acids onto cellulose. The prepared particles were stored at ambient temperature for 12 months to assess their storage stability. Cellulose particles were assessed for the amount of adsorbed phenolic acids and antioxidant activities. For both phenolic acids, the same correlation was established, i.e., reduction of adsorption of phenolic acids occurred with the increase of cellulose amount during complexation. The duration of complexation was not a significant factor in the adsorption of phenolic acids. Antioxidant activity generally followed the trend that was obtained for the amount of adsorbed phenolic acids. Comparing both phenolic acids, cellulose had a higher affinity for caffeic acid (4.665 g/kg) than for gallic acid (3.399 g/kg). However, greater stability of gallic acid/cellulose particles was observed throughout the storage. After storage, the content of gallic acid in cellulose particles slightly decreased (up to 3%), while that of caffeic acid decreased from 10 to 20%. The complexation of phenolic acids with cellulose was proven by recording infrared spectra. Formulated cellulose particles can be a valuable tool for the preparation of plant-based functional additives which can be used for the enrichment of products with phenolic acids in order to improve their antioxidant potential and stability.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2023, 73, 4; 322-331
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Techno-Functional and Bioactive Properties and Chemical Composition of Guava, Mamey Sapote, and Passion Fruit Peels
Autorzy:
López-Martínez, Leticia X.
Villegas-Ochoa, Mónica A.
Domínguez-Avila, J. Abraham
Yahia, Elhadi M.
Gonzalez-Aguilar, Gustavo A.
Powiązania:
https://bibliotekanauki.pl/articles/24024619.pdf
Data publikacji:
2023-11-02
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
tropical fruits
phenolic profile
antioxidant potential
enzyme inhibition
glucose adsorption capacity
fat/oil binding capacity
sodium cholate binding capacity
Opis:
Due to their nutritional and sensorial characteristics, tropical fruits like guava, mamey sapote, and passion fruit are regularly incorporated into daily diets. Their by-products, especially peels, are approximately 10 to 35% of their weight and possess an important content of bioactive compounds, such as dietary fiber and phenolics. The nutritional, technological, physio-functional properties and phenolic compound compositions of guava, mamey sapote, and passion fruit peels were studied. Peels had promising techno- and physio-functional characteristics, good dietary fiber contents (45.18-61.42 g/100 g), and phenolic profiles with ferulic acid, gallic acid, p-coumaric, and catechin as the main compounds. Peel powders also showed excellent DPPH radical scavenging activity (125.3–252.4 µmol TE/100 g) and Trolox equivalent antioxidant capacity, TEAC (369.2–656.8 µmol TE/100 g). The α-amylase and lipase inhibitory activity varied from 28.15 to 51.4% and 30.89 to 57.15%, respectively. Higher values of α-glucosidase inhibition capacity were found, ranging from 51.64 to 70.32%. The chemical composition and properties reported in the present work suggest that peel powders of these guava, mamey sapote, and passion fruit could be used as constituents in different foods, such as bakery and meat goods, with beneficial health effects like control of hyperglycemia, improved intestinal function, and control of overweight; however, more studies are necessary for animal models and humans to confirm these bioactivities conclusively.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2023, 73, 4; 311-321
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of different drying processes on an antioxidant potential of three species of the Lamiaceae family
Autorzy:
Kwaśniewska-Karolak, I.
Mostowski, R.
Powiązania:
https://bibliotekanauki.pl/articles/2049315.pdf
Data publikacji:
2021
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
drying process
herb
thyme
Thymus vulgaris
sage
Salvia officinalis
rosemary
Rosmarinus officinalis
antioxidant potential
Lamiaceae
spice plant
ascorbic acid
suszenie
zioła
działanie antyoksydacyjne
kwas askorbinowy
chlorofil
Opis:
Introduction: Spice plants are a rich source of biologically active compounds. Processes of drying, limits the development of microorganisms and biochemical reactions in raw herbs, at the same time modifies their chemical composition. Objective: The aim of this work was to evaluate the effect of drying process of selected plants on their antioxidant potential and the content of biologically active compounds. Methods: The herbal materials thyme herb (Thymus vulgaris L.), sage leaves (Salvia officinalis L.) and rosemary leaves (Rosmarinus officinalis) were dried using two methods: convective (at 30° C), and freeze-drying. In both, fresh and subjected to drying processes herbs, changes in total polyphenol and antioxidant potential (with the DPPH radical), vitamin C (in the form of ascorbic acid) and chlorophyll pigments contents, were studied. Results: The highest content of polyphenols and vitamin C was recorded in rosemary, while sage was characterized by the highest content of chlorophylls. It was found that the drying processes caused large losses of vitamin C (ascorbic acid) and dyes in comparison to the fresh material. The highest losses of vitamin C occurred in convection dried sage (95%), while most was preserved in lyophilised thyme (losses 74%). Drying had also influenced the reduction of the content of chlorophylls with the largest loss of these compounds, at 94% observed in the freeze-dried rosemary. However, the content of polyphenols increased, underscoring a large impact on the antioxidant activity of herbs. Conclusions: Drying processes resulted in the release of phenolic compounds, so their content increased three to four times in the case of rosemary and sage. The largest increase was observed in the case of lyophilised thyme. Simultaneously, the antioxidant potential was significantly increased. Herbal droughts proved to be a rich source of antioxidant compounds with promising applications as a food additive.
Źródło:
Herba Polonica; 2021, 67, 1; 8-17
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Phytochemical analysis, antioxidant and anticancer activity of Aerva javanica growing in district Karak, Khyber Pakhtunkhwa Pakistan
Autorzy:
Afzal, Sajida
Khan, Siraj
Iqbal, Majid
Akhtar, Anam
Powiązania:
https://bibliotekanauki.pl/articles/2087348.pdf
Data publikacji:
2021
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
phytochemistry
antioxidant potential
anticancer potential
GC-MS analysis
Aerva javanica
fitochemia
potencjał antyoksydacyjny
potencjał przeciwnowotworowy
analiza GC-MS
Opis:
The purpose of this study was to evaluate the photochemical, antioxidants and anticancer activity of the medicinal plant Aerva javanica. This plant belongs to the Amaranthaceae family. Locally it is called “bui”. It is a shrub with a long tap root that grows all over India in the wild. The plant extracts were prepared using ethanol, methanol and distilled water as solvents. The antioxidant activity was determined using DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free radical scavenging activity and IC50 was determined. The total flavonoids compounds found in Aerva javanica ethanolic extract were (0.90 ±0.16) while the total phenolic contents found in ethanolic extract were (0.78 ±0.16), followed by the methanolic and aqueous extract. The antioxidant results of methanolic extract of Aerva javanica showed 0.78 ±0.18 percent inhibition and SCV 49.10% at concentration of 1.5 mg/ml, ethanolic extract showed 0.54 ±0.12 percent inhibition with 64.28% SCV. Phytochemical analysis of best result oriented Aerva javanica extract was done with Gas Chromatography-Mass Spectrometry (GC-MS) technique. The results revealed the presence of different compounds predominantly Acetone (1.18%), Ethyl Acetate (38.95%), (20.77%), n-Propyl acetate (4.09%), Isobutyl acetate (2.71%), (3.84%), isoquinoline,1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy- (3.36%), Cyclohexanone (1.43%), 1,1-Diisobutoxy-isobutane (2.02%), n-Hexadecanoic acid (5.61%), Phytol (3.57%), 9-Octadecenoic acid, 1,2,3-propanetriyl ester (10.72%), Octadecanoic acid (1.78%), Bis(2-ethylhexyl) phthalate (3.48%), Squalene (1.40%), 2,2-Dimethyl-3-(3,7,16,20-tetramethyl (1.12%) and 1,6,10,14,18,22-Tetracosahexaen-3-ol (1.195%). The study concludes that extensive research is required to detect more novel compounds in order to develop effective management approaches that significantly reduce the impact of the pathogens on human health as well as on environment.
Celem pracy była ocena fotochemicznej, antyoksydacyjnej i przeciwnowotworowej aktywności rośliny leczniczej Aerva javanica. Ta roślina należy do rodziny Amaranthaceae. Lokalnie nazywa się „bui”. Jest to krzew o długim korzeniu palowym, który dziko rośnie w całych Indiach. Ekstrakty roślinne przygotowano przy użyciu etanolu, metanolu i wody destylowanej jako rozpuszczalników. Aktywność przeciwutleniającą oznaczono za pomocą DPPH (2,2-difenylo-1-pikrylohydrazyl-hydrat) neutralizując wolne rodniki i wyznaczając IC50. Całkowita zawartość związków flawonoidowych znaleziona w ekstrakcie etanolowym Aerva javanica wynosiła (0,90 ±0,16), podczas gdy całkowita zawartość fenoli znaleziona w ekstrakcie etanolowym wynosiła (0,78 ±0,16), a następnie w ekstrakcie metanolowym i wodnym. Wyniki antyoksydacyjne ekstraktu metanolowego z Aerva javanica wykazały 0,78 ±0,18 procent inhibicji, a SCV 49,10% przy stężeniu 1,5 mg/ml, ekstrakt etanolowy wykazał 0,54 ±0,12 procent inhibicji z 64,28% SCV. Analizę fitochemiczną ekstraktu Aerva javanica przeprowadzono techniką chromatografii gazowej ze spektrometrią mas (GC-MS). Wyniki wykazały obecność różnych związków, głównie acetonu (1,18%), octanu etylu (38,95%), (20,77%), octanu n-propylu (4,09%), octanu izobutylu (2,71%), (3,84%), izochinoliny, 1-[(3,4-dietoksyfenylo) metylo]-6,7-dietoksy- (3,36%), cykloheksanon (1,43%), 1,1-diizobutoksy-izobutan (2,02%), kwas n-heksadekanowy (5,61%), fitol (3,57%), kwas 9-oktadecenowy, ester 1,2,3-propanotriylowy (10,72%), kwas oktadekanowy (1,78%), ftalan bis(2-etyloheksylu) (3,48%), skwalen (1,40%), 2,2-dimetylo-3-3,7,16,20-tetrametyl (1,12%) i 1,6,10,14,18,22-tetrakozaheksaen-3-ol (1,195%). Potrzebne są badania mające na celu wykrycie większej liczby nowych związków w celu opracowania skutecznych metod zarządzania, które znacznie zmniejszą wpływ patogenów na zdrowie człowieka, a także na środowisko.
Źródło:
Acta Biologica; 2021, 28; 91-107
2450-8330
2353-3013
Pojawia się w:
Acta Biologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential
Autorzy:
Drvenica, Ivana
Blazević, Ivica
Bosković, Perica
Bratanić, Andre
Bugarski, Branko
Bilusić, Tea
Powiązania:
https://bibliotekanauki.pl/articles/2019142.pdf
Data publikacji:
2021-12-01
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
sinigrin
liposomes
oxidative stability
gastric digestion
duodenal digestion
antioxidant potential
Opis:
Encapsulation of sinigrin in liposomes with the proliposomal method was performed in order to evaluate the effect of this process on in vitro simulated digestion and antioxidant potential of sinigrin. The recovery of sinigrin after simulated gastric and duodenal digestion of its free and liposomal forms was determined with HPLC-UV using human digestive juices. The antioxidant potential of sinigrin and sinigrin-loaded liposomes was determined with the Rancimat test as their ability to prolong oxidative stability of edible oil . The efficiency of 62% was obtained by encapsulating sinigrin in liposomes. The values of mean diameter, polydispersity index and zeta potential showed satisfactory size uniformity and physical stability of the liposomes containing sinigrin. Liposomes were shown to inhibit the digestion of sinigrin in both human gastric and intestinal juices, clearly enabling its prolonged release. Moreover, sinigrin in the liposomal form significantly prolonged the induction time of edible oil oxidation compared to its free form. The results obtained are encouraging from the point of view of a possible incorporation of the sinigrin-loaded liposomes in real functional food systems or their use as nutraceuticals.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2021, 71, 4; 441-449
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rye (Secale cereale L.) arabinoxylans: molecular structure, physicochemicals properties and the resulting pro-health effects
Autorzy:
Dynkowska, Wioletta
Powiązania:
https://bibliotekanauki.pl/articles/2199941.pdf
Data publikacji:
2020-12-07
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
Rye (Secale cereale L) arabinoxylans
dietary fiber
water extract viscosity
antioxidant activity
health potential
short-chain fatty acids
Opis:
Arabinoxylans are an essential component of dietary fiber, and their health-promoting properties are determined mainly by the content and structural features their biopolymers. Rye bread is particularly rich in these compounds; their unique features in the context of content and chemical structure of rye arabinoxylans make it a valuable component od daily diet. Long-term studies have shown the positive effect of these compounds in the aspect of prevention of civilization diseases such as type 2 diabetes, obesity, and cardiovascular diseases. Among the description of the physicochemical properties and diversity of arabinoxylans, the article contains a collection of the most important reports regarding the health-promoting effects of these polymers, as well as their metabolism in the human body.
Arabinoksylany są niezbędnym składnikiem błonnika pokarmowego, a ich właściwości prozdrowotne są determinowane głównie przez zawartość i cechy strukturalne tych biopolimerów. Chleb żytni jest szczególnie bogaty w te związki; ich unikalne cechy w kontekście zawartości i struktury chemicznej arabinoksylanów żyta sprawiają, że jest cennym składnikiem codziennej diety. Długoterminowe badania wykazały pozytywny wpływ tych związków w aspekcie zapobiegania chorobom cywilizacyjnym, takim jak cukrzyca typu 2, otyłość i choroby sercowo-naczyniowe. Wśród opisu właściwości fizykochemicznych i różnorodności arabinoksylanów w artykule zawarto zbiór najważniejszych raportów dotyczących zdrowotnych efektów działania tych polimerów, a także ich metabolizmu w organizmie człowieka.
Źródło:
Plant Breeding and Seed Science; 2020, 81; 19-38
1429-3862
2083-599X
Pojawia się w:
Plant Breeding and Seed Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A systematic review of the characteristics, phytonutritive, and therapeutic potential of the date palm fruit (Phoenix dactylifera)
Autorzy:
Sharma, G.
Sharma, V.
Mishra, T.
Powiązania:
https://bibliotekanauki.pl/articles/80323.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
date palm
Phoenix dactylifera
therapeutic potential
phytochemical composition
bioactive compound
dietary fibre
antioxidant
nutritional value
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative evaluation of the antioxidant potential of Hericium erinaceus, Hericium americanum and Hericium coralloides
Autorzy:
Atila, F.
Powiązania:
https://bibliotekanauki.pl/articles/12692670.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
Tematy:
mushroom
Hericium erinaceus
Hericium americanum
Hericium coralloides
edible mushroom
rare species
endangered species
antioxidant potential
comparative evaluation
Opis:
The aim of this work was to determine the total phenolic content (TPC) and the antioxidant activity of methanol extracts of Hericium erinaceus, Hericium americanum and Hericium coralloides, including free radical scavenging method (DPPH), ferric reducing antioxidant power (FRAP) and radical cation scavenging method (ABTS). Hericium spp exhibited moderate to high antioxidant activity. The highest TPC (3.27 ±0.01 mg GAE g–1) and antioxidant activity values (17.0 ±0.68 mmol TE g–1 in FRAP; EC 50 = 4.12 ±0.12 mg mL –1 in DPPH •; EC 50= 2.83 ± 0.10 mg mL–1in ABTS•+ ) were found for methanol extracts of H. coralloides. The TPC and antioxidant activity of H. erinaceus isolates varied from strain to strain. H. americanum possessed considerably lower total phenolic content (2.31 ±0.01 mg GAE g–1) and antioxidant activity (10.5 ±0.59 mmol TE g–1 in FRAP; EC 50 = 7.82 ±0.09 mg mL –1 in DPPH•; EC 50 = 6.36 ± 0.12 mg mL–1 in ABTS •+) than H. coralloides and H. erinaceus. A high correlation was determined between TPC and ABTS •+( r2= 0.855), DPPH•(r2= 0.969) and FRAP (r2 = 0.942). According to results obtained in the present study, Hericium spp., especially H. coralloides and some of H. erinaceus isolates, might be promising natural source of antioxidants for food and pharmaceutical industry.
Źródło:
Acta Scientiarum Polonorum. Hortorum Cultus; 2019, 18, 6; 97-106
1644-0692
Pojawia się w:
Acta Scientiarum Polonorum. Hortorum Cultus
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
HPLC and ESI-MS analysis of vanillin analogue 2-hydroxy-4-methoxy benzaldehydein swallow root - the influence of habitat heterogeneity on antioxidant potential
Autorzy:
Pradeep, M.
Shetty, N.P.
Giridhar, P.
Powiązania:
https://bibliotekanauki.pl/articles/12298366.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie
Tematy:
Decalepis hamiltonii
endemic plant
root tuber
high performance liquid chromatography
electrospray ionization mass spectrometry
2-hydroxy-4-methoxybenzaldehyde
habitat heterogeneity
antioxidant potential
phenolic compound
flavonoids
vanillin
isomer
Opis:
Decalepis hamiltonii Wight & Arn., is a plant species that is endemic to southern parts of India. The aim of this study is to explore the influence of habitat heterogeneity on total phenolics, flavonoids, flavor compound 2-hydroxy-4-methoxy benzaldehyde (2H4MB) and antioxidant potential of tubers. The flavor metabolite 2H4MB was quantified by HPLC using isocratic solvent system (methanol : acetonitrile : water : acetic acid 47 : 10 : 42 : 1) that indicates obvious difference in 2H4MB content of tubers with a maximum of 96.4 ±2.6 and 92.6 ±1.2 mg 100 g–1 dry weight basis (DW) in samples from B.R. Hills and Mysore area of Karnataka, followed by samples from Tirumalai Hills and Kurnool from Andhra Pradesh (89.02 ±0.9 mg 100 g–1 DW), Tamil Nadu (81.6 ±2.4 mg 100 g–1 DW) and Kerala (80.18 ±1.1 mg 100 g–1 DW) of tubers. There was variation in total phenolics, total flavonoids and 2H4MB content of root samples collected from different habitats. Also significant variation in free radical scavenging potential of methanol root extracts was noticed, which is directly proportional to the phenolics, and flavonoids content. Overall, there was 10–16% difference in content of 2H4MB in D. hamiltonii tubers that were collected from different natural habitats, and this habitat heterogeneity has to be considered vital, while using such tubers for edible purposes and food formulations.
Źródło:
Acta Scientiarum Polonorum. Hortorum Cultus; 2019, 18, 2; 21-28
1644-0692
Pojawia się w:
Acta Scientiarum Polonorum. Hortorum Cultus
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In vivo and ex vivo impact of nutritional xenobiotics – acrylamide and sodium nitrates – on plasma antioxidant properties
Wpływ wybranych ksenobiotyków pokarmowych – akrylamidu i azotanów – na właściwości antyoksydacyjne osocza w warunkach in vivo oraz ex vivo
Autorzy:
Rorbach-Dolata, Anna
Żurawska-Płaksej, Ewa
Marchewka, Zofia
Piwowar, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1035369.pdf
Data publikacji:
2019
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
acrylamide
sodium nitrate (iii) and (v)
daily intake
thiol groups
antioxidant potential
akrylamid
azotan (iii) i (v) sodu
dzienne spożycie
grupy tiolowe
potencjał antyoksydacyjny
Opis:
INTRODUCTION: The thiol (SH) groups present in human blood plasma play an important role in the oxidative/antioxidative homeostasis of the organism. They are susceptible to the adverse actions of different exo- and endogenous factors. Chronic exposure to different xenobiotics, e.g. nitrogen-containing compounds commonly occurring in food, is especially important. The aim of this study was to investigate the effect of acrylamide (ACR) and sodium nitrates (SN) – (V) and (III) – on the plasma antioxidant properties, as reflected by changes in the SH group levels. MATERIAL AND METHODS: The concentration of SH groups was measured by Ellman’s method in blood plasma derived from 62 young people (in vivo model; time t0), and after 1 hour of blood plasma incubation with appropriate ACR and SN (III) concentrations (ex vivo model; time t1). The concentrations used corresponded with their daily intake (DIA – daily intake of acrylamide, and DIN – daily intake of sodium nitrates (V) and (III), respectively), estimated on the basis of a nutritional questionnaire. RESULTS: In both models, acrylamide and nitrates caused a significant decrease in SH group concentrations, but ACR induced stronger changes. The women consumed a greater amount of these nitrogen-containing compounds compared to the men, probably due to their different dietary habits. CONCLUSIONS: The obtained results indicate that these nitrogen-containing xenobiotics are important agents lowering antioxidative plasma potential, hence their intake should be controlled.
WSTĘP: Grupy tiolowe (SH) obecne w osoczu krwi odgrywają ważną rolę w oksydacyjno-antyoksydacyjnej homeostazie organizmu. Są one podatne na niekorzystne działanie różnych czynników egzo- i endogennych. Szczególnie istotnym problemem jest długotrwałe narażenie na różne ksenobiotyki, np. związki zawierające azot, powszechnie występujące w żywności. Celem naszych badań była ocena wpływu akrylamidu (acrylamide – ACR) i azotanu sodu (sodium nitrate – SN) – (V) i (III) – na właściwości przeciwutleniające osocza poprzez pomiar stężenia grup SH. MATERIAŁ I METODY: Stężenie grup SH w osoczu uzyskanym od 62 młodych osób (model in vivo; czas t 0) oraz w próbkach poddanych godzinnej inkubacji z odpowiednim stężeniem ACR i SN (III) (model ex vivo; czas t1) mierzono metodą Ellmana. Stężenia ACR i SN (III) w modelu ex vivo odpowiadały ich dziennemu spożyciu (odpowiednio DIA – daily intake of acrylamide – i DIN – daily intake of sodium nitrates (V) i (III)), oszacowanemu na podstawie kwestionariusza żywieniowego. WYNIKI: W obu modelach akrylamid i azotany spowodowały znaczny spadek stężenia grup SH, ale ACR spowodował silniejsze zmiany. Kobiety spożywały większą ilość związków zawierających azot w porównaniu z mężczyznami, prawdopodobnie z powodu odmiennych nawyków żywieniowych. WNIOSKI: Uzyskane wyniki wskazują, że ksenobiotyki zawierające azot są ważnymi czynnikami obniżającymi potencjał antyoksydacyjny osocza, a ich spożycie powinno być kontrolowane.
Źródło:
Annales Academiae Medicae Silesiensis; 2019, 73; 154-162
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rye (Secale Cereale L.) Phenolic Compounds as Health-related Factors
Autorzy:
Dynkowska, Wioletta M.
Powiązania:
https://bibliotekanauki.pl/articles/2199731.pdf
Data publikacji:
2019-12-30
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
(Secale cereale L)
Rye
phenolic compounds
antioxidant activity
health potential
rye bread
Opis:
The diversity of phenolic compounds found in rye grain makes this cereal the valuable source of these substances in everyday food. Simple phenolic compounds, as well as their metabolites, show a pro-health effect. Phenolic acids and ferulic acid dehydrodimers are included in the group of cereal antioxidants. The antioxidant activity of phenolic compounds is an essential factor in the prevention of cancer and cardiovascular diseases.
Źródło:
Plant Breeding and Seed Science; 2019, 79; 9-24
1429-3862
2083-599X
Pojawia się w:
Plant Breeding and Seed Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of Viburnum opulus polyphenolic compounds on metabolic activity and migration of HeLa and MCF cells
Autorzy:
Zakłos-Szyda, Małgorzata
Pawlik, Nina
Powiązania:
https://bibliotekanauki.pl/articles/105848.pdf
Data publikacji:
2019
Wydawca:
Centrum Badań i Innowacji Pro-Akademia
Tematy:
Viburnum opulus
polyphenols
cancer cells migration
mitochondrial potential
antioxidant effect
polifenole
migracja komórek rakowych
potencjał mitochondrialny
działanie przeciwutleniające
Opis:
In recent years, research of antitumor activity of natural compounds isolated from plant material has increased. Polyphenols have gained significant attention due to their proapoptotic abilities and their involvement in migration and inhibition of metastasis processes. The anticancer effects of polyphenolic extracts of Viburnum opulus fruit against human breast (MCF-7) and cervical (HeLa) cancer cell lines have been confirmed in this study. It was demonstrated that the tested preparations (methanol – M and acetone – A from pomace, juice – J and juice after extraction to the solid phase SPE – PF) show cytotoxic activity and regulate the migration process of cancer cells. The degree of inhibition of cell migration was measured at two times - 24 h and 48 h after addition of the tested preparations. The highest toxicity towards both cell lines was demonstrated by the polyphenol fraction obtained after juice purification SPE (IC50 values at concentration of 63,541 and 19,380 μg/mL for HeLa and MCF cell lines, respectively). At the same time, the same preparation inhibited cell migration the most (nearly 70% compared to controls at both times at the concertation of 15 and 30 μg/mL). All preparations showed the antioxidant ability, but the Viburnum opulus juice (200 and 350 μg/mL) and the preparation after its purification (15 and 30 μg/mL) have larger ability to inhibit the intracellular oxidative stress (30-40%) than preparation obtained from pomace (nearly by 20% at concentration of 20 and 50 μg/mL of M and A). Despite the antioxidative capacity of the preparations, they simultaneously decreased cellular mitochondrial potential. The results obtained indicate the high potential of components of Viburnum opulus polyphenolic compounds can be used in the production of innovative dietary supplements or pharmacological preparations for people with an increased risk or inclination towards developing breast or cervical cancer.
Źródło:
Acta Innovations; 2019, 31; 33-42
2300-5599
Pojawia się w:
Acta Innovations
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Badanie właściwości antyoksydacyjnych za pomocą DPPH stosując chromatograficzne rozdzielanie różnych jego form
The research of antioxidant properties using DPPH with chromatographic separation of its various forms
Autorzy:
Piszcz, P.
Obrycka, J.
Głód, B. K.
Powiązania:
https://bibliotekanauki.pl/articles/92350.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Przyrodniczo-Humanistyczny w Siedlcach
Tematy:
antyoksydanty
całkowity potencjał antyoksydacyjny
DPPH
HPLC
antioxidants
total antioxidant potential
Opis:
W pracy przedstawiono wyniki badań nad możliwością zastosowania rodnika DPPH do oznaczania właściwości antyoksydacyjnych, stosując chromatograficzne rozdzielanie różnych jego form. Pomiary wykonywane były w układzie faz odwróconych HPLC z detekcją UV-DAD. Zbadano CPA związków o właściwościach przeciwutleniających – flawonoidów, jak również całkowity potencjał antyoksydacyjny wybranych naparów z ziół. Wyniki otrzymane za pomocą RP-HPLC-UV skorelowane zostały z wynikami otrzymanymi w pomiarze fotometrycznym.
The paper presents the results of the possibility of using the DPPH radical to determine antioxidant properties using chromatographic separation of its various forms. The measurements were performed in the RP-HPLC with UVDAD detection. The TAP values were tested for antioxidants - flavonoids, as well as the total antioxidant potential of selected herbs. The results obtained with RP-HPLC-UV were correlated with the results obtained using photometric measurement.
Źródło:
Camera Separatoria; 2018, 10, 1; 5-16
2083-6392
2299-6265
Pojawia się w:
Camera Separatoria
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Distribution of phytochemicals in stems and leaves of Cichorium intybus and Matricaria chamomilla: assessment of their antioxidant and antimicrobial potential
Autorzy:
Peerzada, T.
Gupta, J.
Powiązania:
https://bibliotekanauki.pl/articles/80745.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Cichorium intybus
chicory
Matricaria chamomilla
chamomile
medicinal herb
medical value
distribution
phytochemical
stem
leaf
antioxidant potential
antimicrobial property
flavonoids
free radical scavenging activity
Folin-Ciocalteu method
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2018, 99, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
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