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    Wyświetlanie 1-9 z 9
    Tytuł:
    Synthesis and Biological Evaluation of Some New Hydrazone Derivatives Bearing Pyrimidine Ring as Analgesic and Anti-Inflammatory Agents
    Autorzy:
    Akdağ, Kadriye
    Ünal, Gökhan
    Tok, Fatih
    Arıcıoğlu, Feyza
    Temel, Halide E.
    Kaymakcıoğlu-Koçyiğit, Bedia
    Powiązania:
    https://bibliotekanauki.pl/articles/895455.pdf
    Data publikacji:
    2018-10-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    anti-inflammatory activity
    hydrazones
    analgesic activity
    Opis:
    New hydrazone derivatives were synthesized from 4-chloro-2-(methylthio)pyrimidine-5-carbohydrazide. Synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR, mass spectral data and elemental analysis. All compounds were investigated for analgesic and anti-inflammatory activity with hot plate test and biochemical assay, respectively. The results of anti-inflammatory activity showed that compound 2t had maximal Lipoxygenase (LOX) inhibition (66.30%) whereas inhibitions of 2a, 2c, 2i, 2k, 2l, 2m, 2p, 2s and 2u were observed between approximately 45-15 %. Our results also indicated that 15 compounds of 21 had analgesic effect in hot plate test. Analgesic effect of 2l, 2s, 2t began earlier than others while effect of 2i began at latest time. According to the activity results, compound 2t have significant analgesic and anti-inflammatory effects.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1147-1159
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Analgesic and anti-inflammatory activities of some transition metal schiff base complexes
    Autorzy:
    Jesmin, M.
    Islam, M. K.
    Ali, S. M. M.
    Powiązania:
    https://bibliotekanauki.pl/articles/411762.pdf
    Data publikacji:
    2014
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Analgesic activity
    Anti-inflammatory activity
    Schiff bases complexes
    Writhing test
    Opis:
    Analgesic and anti-inflammatory activities of four transition metal complexes of a Schiff base derived from salicylaldehyde and glycine, viz. [N-salicylideneglycinato diaqua cobalt(II) dimer] (SGCo)2, [N-salicylideneglycinato-di-aqua-nickel(ll)dimer] (SGN)2, [N-salicylideneglycinato-aqua-copper(II)] (SGC) and [N-salicylideneglycinato diaqua zinc(II) dimer] (SGZ)2 were studied in swiss albino mice. 10 mg/kg (p.o) dose for each compound were selected throughout the research work. The analgesic activity was determined by acetic acid induced writhing and tail immersion methods. All such data were compared with standard drugs at the dose of 10 mg/kg (p.o. The anti-inflammatory activity of the test compounds was determined by the carragenan induced mice paw edema inhibition method.). Analgesic and anti-inflammatory activities of the test compounds at 10 mg/kg (p.o.) were quite comparable to those of standard drugs at 10 mg/kg (p.o.). All these compounds can be considered as potent analgesic and anti-inflammatory agents.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2014, 8; 64-72
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Aronia melanocarpa Leaves as a Source of Chlorogenic Acids, Anthocyanins, and Sorbitol, and Their Anti-Inflammatory Activity
    Autorzy:
    Zielińska, Agnieszka
    Bryk, Dorota
    Paradowska, Katarzyna
    Wawer, Iwona
    Powiązania:
    https://bibliotekanauki.pl/articles/1363310.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
    Tematy:
    Aronia melanocarpa leaves
    sorbitol
    chlorogenic acids
    anti-inflammatory activity
    NMR
    HPLC
    Opis:
    Aronia melanocarpa E. berries are a valuable component of the healthy diet. They are extremely high in phenolics exhibiting strong antioxidant properties. However, not much information is available on the chemical composition and bioactive potential of chokeberry leaves. Therefore, the analyses of sugars and phenolics of extracts from chokeberry leaves collected from June to October were performed using spectroscopic (NMR) and chromatographic (HPLC-DAD/RI, GC-MS) methods. The leaf extracts contained a significant amount of sorbitol, especially those made of leaves collected since June to July (avg. 145.2 mg/g d.w.). The average contents of Cya-3-Gal and chlorogenic acids in the extracts were at 0.52 mg g d.w. and up to 13.1 mg/g d.w., respectively. Chokeberry leaf extracts from green and red leaves were subjected to the in vitro study on human umbilical vein endothelial cells (HUVCs). Both extracts suppressed TNF-α-induced surface expression of ICAM-1 and VCAM-1 molecules, and exhibited anti-adhesive and anti-inflammatory properties. Green and red leaves may foster a therapeutic potential in the prevention of atherosclerosis and other pathological events involving leucocyte adhesion. That is why chokeberry leaves can be considered as a promising component of functional foods owing to the high content of chlorogenic acids and sorbitol.
    Źródło:
    Polish Journal of Food and Nutrition Sciences; 2020, 70, 4; 409-418
    1230-0322
    2083-6007
    Pojawia się w:
    Polish Journal of Food and Nutrition Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Recent developments in Neem (Azadirachta indica – A. Juss) derived antimicrobial constituents for control of human and plant diseases – a review
    Autorzy:
    Dohroo, Aradhana
    Karnwal, Arun
    Ghai, Manisha
    Powiązania:
    https://bibliotekanauki.pl/articles/1036421.pdf
    Data publikacji:
    2016
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    antiallergic
    antidermatic
    antifeedent
    antifungal
    anti-inflammatory activity
    azadirachta indica
    bacterial pathogens
    neem
    secondary metabolites
    Opis:
    Neem has immense biocontrol potential against a large number of pathogens causing various diseases in human beings and plants. The plant has maximum useful value in its leaves, bark, flowers and fruits than any other tree species. These values include antiallergic, antidermatic, antifeedent, antifungal and anti-inflammatory properties. Due to the vast activities of neem, it has become extremely valuable in making our ecosystem a green treasure. Neem leaves have been demonstrated to exhibit immuno-modulatory, anti-inflammatory, antiulcer, antimalarial properties. Neem tree plant parts contain a promising pest control substance which has found effective use against economically important agricultural pests. Neem plant products are easy to process by village level industries on the micro scale level and use by resource poor farmers in crop protection resulting thereby in income generation. This plant also has antioxidant properties and free radical scavenging potential in its different extracted solvents. The present review highlights the properties of neem against the pathogens of living organisms for environmental protection.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2016, 70; 220-223
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preliminary assessment of the anti-inflammatory and analgesic effects of methanol leaf extract of Cussonia barteri (Araliaceae) in rodents
    Autorzy:
    Igbe, Ighodaro
    Edosuyi, Osaze
    Okhuarobo, Agbonlahor
    Pongri, Adarki
    Maduako, Nkechi
    Ehimen, Isaac
    Powiązania:
    https://bibliotekanauki.pl/articles/2048743.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Włókien Naturalnych i Roślin Zielarskich
    Tematy:
    Cussonia barteri
    methanol leaf extract
    anti-inflammatory activity
    analgesic activity
    metanolowy wyciąg z liści
    działanie przeciwzapalne
    działanie przeciwbólowe
    Opis:
    Introduction: Potato (Solanum tuberosum L.) is an important vegetable crop in Syria. Potato tuber moth Cussonia barteri is a small tree that grows in the sub-Saharan part of Africa. Various parts of the plant are used for the treatment of a variety of ailments in ethno-medicine. Objective: To evaluate the anti-inflammatory and analgesic effect of the methanol leaf extract of Cussonia barteri. Material and methods: The leaves were air-dried, powdered and repeatedly extracted with methanol using a Soxhlet apparatus. The resulting methanol extract (100, 200 and 400 mg/kg) was evaluated for antiinflammatory activity using carrageenan-induced paw oedema, xylene-induced ear oedema and formalininduced arthritis tests. Analgesic effect was evaluated using acetic acid-induced mouse writhing, hot plate and tail flick tests. Results: All doses of the extract significantly (p<0.05) reduced carrageenan-induced paw oedema, however the 400 mg/kg dose gave a sustained effect. The extract significantly inhibited xylene induced ear oedema at all doses. There were no significant (p>0.05) reductions in paw swellings due to formalin. In the acetic acid induced writhing test, the extract significantly (p<0.05) decreased writhing at 400 mg/kg only. Reaction times were not significantly different from the control in the hot plate and tail flick tests. Conclusion: This study has shown that the methanol extract possesses acute anti-inflammatory and peripherally mediated analgesic effects.
    Źródło:
    Herba Polonica; 2019, 65, 3; 22-31
    0018-0599
    Pojawia się w:
    Herba Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anti-inflammatory activities of garlic sprouts, a source of α-linolenic acid and 5-hydroxy-l-tryptophan, in RAW 264.7 cells
    Autorzy:
    Gdula-Argasińska, Joanna
    Paśko, Paweł
    Sułkowska-Ziaja, Katarzyna
    Kała, Katarzyna
    Muszyńska, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1038621.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Allium sativum sprouts
    indolic and phenolic compounds
    α-linolenic acid
    anti-inflammatory activity
    RAW 264.7 cells
    Opis:
    The purpose of this study was to analyze the indolic, phenolic, and fatty acid content and antioxidant activity of garlic sprouts growing in the dark and in the daylight. The pro- or anti-inflammatory properties of the garlic sprout extract were investigated by evaluating the cyclooxygenase-2 (COX-2), prostaglandin E synthase (cPGES), glutathione S transferase (GSTM1), nuclear factor NF-κB, peroxisome proliferator-activated receptors (PPARs), and aryl hydrocarbon receptor (AhR) protein levels in the RAW 264.7 cells activated with lipopolysaccharide (LPS). The highest amount of total indolic (73.56 mg/100 g f.w.) and phenolic compounds (36.23 mg/100 g f.w.) was detected in garlic sprouts grown in the daylight. Studies on antioxidant activity (the FRAP and DPPH method) of garlic sprouts showed that this activity is significantly higher for sprouts grown in full access to light when compared to those grown in the dark. In garlic sprout extracts, α-linolenic acid (ALA) was found to be in greater amount. COX-2 and cPGES level was lower when compared to LPS alone activated cells. After garlic extract treatment, higher level of GSTM1, PPARΥ, cytosolic p50 and p65 protein, as well as a lower NF-ĸB p50/p65 activity was noted in the RAW 264.7 cells which suggested PPARs and AhR transrepression mechanism of NF-ĸB signalling. The obtained results indicate Allium sativum sprouts are a rich source of n-3 fatty acids, indolic and phenolic compounds characterized by anti-inflammatory and antioxidative activity, which may support their high therapeutic and dietary potential.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 3; 551-559
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pochodne 1,2,3-triazolu. Potencjalne leki?
    Derivatives of 1,2,3-triazole. Potential drugs?
    Autorzy:
    Bankowska, E.
    Wróblewski, A. E.
    Powiązania:
    https://bibliotekanauki.pl/articles/171634.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    pochodne 1,2,3-triazolu
    aktywność przeciwbakteryjna
    aktywność przeciwgrzybicza
    aktywność przeciwgruźlicza
    aktywność przeciwpsychotyczna
    aktywność przeciwdrgawkowa
    aktywność przeciwzapalna
    aktywność hipoglikemiczna
    aktywność przeciwnowotworowa
    aktywność przeciwwirusowa
    1,2,3-triazole derivatives
    antibacterial activity
    antifungal activity
    antitubercular activity
    antipsychotic activity
    anticonvulsant activity
    anti-inflammatory activity
    hypoglycemic activity
    anticancer activity
    antiviral activity
    Opis:
    Recently, 1,2,3-triazoles have gained an increased attention in the field of drug discovery because several derivatives have already been marketed as medications (e.g. tazobactam, cefatrizine, rufinamide) [1, 2] and many of them appeared to be very active in diverse biological studies including plinambulin 69 currently in the last stage of the clinical trials [60]. In this review very recent investigations of antibacterial, antitubercular, antifungal, antipsychotic, antiepileptic, anti-inflammatory, hypoglycemic, anticancer and antiviral properties of 1,2,3-triazole derivatives are discussed. These studies allowed to select several compounds which were found to be more active in comparison to the already used drugs.
    Źródło:
    Wiadomości Chemiczne; 2012, 66, 11-12; 993-1022
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antibacterial, antifungal, anti-oxidant, anti-inflammatory and anti-hypertensive activities of N-chloropyrazinamide
    Autorzy:
    Vaijayanthi, S. P.
    Mathiyalagan, N.
    Powiązania:
    https://bibliotekanauki.pl/articles/412474.pdf
    Data publikacji:
    2014
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    antibacterial activity
    antifungal activity
    antioxidant activity
    anti-inflammatory
    anti-hypertensive activity
    N-chloropyrazinamide
    Opis:
    N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that N-chloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2014, 7; 1-8
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Scavenging activity, anti-inflammatory and diabetes related enzyme inhibition properties of leaves extract from some varieties of Phoenyx dactylifera l.
    Autorzy:
    Eddine, L. S.
    Segn, L.
    Noureddine, G.
    Mohammed Redha, O.
    Mokni, Sonia
    Powiązania:
    https://bibliotekanauki.pl/articles/412126.pdf
    Data publikacji:
    2013
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Phoenyx dactylifera L
    phenolic content
    leaves extract
    Scavenger activity
    anti-inflammatory
    antidiabetic
    Opis:
    In this study we investigate the antioxidant, anti-inflammatory, and antidiabetic activities of ethanolic leaves extracts of three selected varieties of Phoenyx dactylifera L. namely: “Ghars”, “Deglet Nour” and “Hamraya”. The assessment of the antioxidant potential of crude leaves extracts, using superoxide anions inhibition, DPPH and total antioxidant activity essays, was carried out. Furthermore, the anti-inflammatory properties of the extracts were determined by measuring the inhibition of nitric oxide (NO) production. Moreover, the antidiabetic effect was evaluated by inhibition of α-amylase enzymes. The total phenolic content measured by Folin-ciocalteu method was as well conducted. The raw leaves extracts of the selected varieties was found to contain a high content of total phenolic content (342.45 mg GAE/gDW for GE) and therefore exhibited a higher antioxidant activity and inhibitory effect of radicals scavenging activity against DPPH and superoxide anion (IC50 = 7.44 μg/mL and 39.11 μg/mL respectively). The three varieties exhibited significant inhibition nitric oxide using in-vitro assay (IC50 = 240.28 μg/mL for GE). The extracts also displayed high inhibition actions against α-amylase enzymes. The results suggest that the leaves of the three selected varieties of Phoenyx dactylifera can be considered as a good source of natural antioxidant and anti-inflammation drugs as well as potent antidiabetic medicine.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2013, 9, 2; 125-135
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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