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    Wyświetlanie 1-9 z 9
    Tytuł:
    Effect of amyloid beta peptide on poly(ADP-ribose) polymerase activity in adult and aged rat hippocampus.
    Autorzy:
    Strosznajder, Joanna
    Jęśko, Henryk
    Strosznajder, Robert
    Powiązania:
    https://bibliotekanauki.pl/articles/1044342.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    aging
    amyloid
    poly(ADP-ribose) polymerase
    hippocampus
    neurotoxicity
    Opis:
    It is suggested that the fibrillar amyloid beta peptide (Aβ) in brain plays a direct role in neurodegeneration in Alzheimer's disease, probably through activation of reactive oxygen species formation. Free radicals and numerous neurotoxins elicit DNA damage that subsequently activates poly(ADP-ribose) polymerase (PARP, EC 2.4.2.30). In this study the effect of neurotoxic fragment (25-35) of full length Aβ peptide on PARP activity in adult and aged rat hippocampus was investigated. In adult (4 month old) rat hippocampus the Aβ 25-35 peptide significantly enhanced PARP activity by about 80% but had no effect on PARP activity in cerebral cortex and in hippocampus from aged (24-27 month old) rats. The effect of Aβ peptide was reduced by half by the nitric oxide synthase inhibitor N-nitro-L-arginine. Stimulation of glutamate receptor(s) itself enhanced PARP activity by about 80% in adult hippocampus. However, Aβ 25-35 did not exert any additional stimulatory effect. These results indicate that Aβ, through NO and probably other free radicals, induces activation of DNA bound PARP activity exclusively in adult but not in aged hippocampus.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 3; 847-854
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cross-talk between the ATP and ADP nucleotide receptor signalling pathways in glioma C6 cells.
    Autorzy:
    Czajkowski, Rafał
    Barańska, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1043690.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ATP
    cross-talk
    glioma C6 cells
    ADP
    phospholipase C
    nucleotide receptors
    adenylyl cyclase
    signalling pathways
    adenosine
    Opis:
    In this review we summarize the present status of our knowledge on the enzymes involved in the extracellular metabolism of nucleotides and the receptors involved in nucleotide signalling. We focus on the mechanism of the ATP and ADP signalling pathways in glioma C6, representative of the type of nonexcitable cells. In these cells, ATP acts on the P2Y2 receptor coupled to phospholipase C, whereas ADP on two distinct P2Y receptors: P2Y1 and P2Y12. The former is linked to phospholipase C and the latter is negatively coupled to adenylyl cyclase. The possible cross-talk between the ATP-, ADP- and adenosine-induced pathways, leading to simultaneous regulation of inositol 1,4,5-trisphosphate and cAMP mediated signalling, is discussed.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 4; 877-889
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Adenosine diphosphate receptors on blood platelets - potential new targets for antiplatelet therapy
    Autorzy:
    Rozalski, Marcin
    Nocun, Marek
    Watala, Cezary
    Powiązania:
    https://bibliotekanauki.pl/articles/1041421.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    P2Y12
    ADP antagonists
    ADP receptors
    P2Y1
    platelet
    antiplatelet therapy
    Opis:
    Platelets play a key role not only in physiological haemostasis, but also under pathological conditions such as thrombosis. Platelet activation may be initiated by a variety of agonists including thrombin, collagen, thromboxane or adenosine diphosphate (ADP). Although ADP is regarded as a weak agonist of blood platelets, it remains an important mediator of platelet activation evoked by other agonists, which induce massive ADP release from dense granules, where it occurs in molar concentrations. Thus, ADP action underlies a positive feedback that facilitates further platelet aggregation and leads to platelet plug formation. Additionally, ADP acts synergistically to other, even weak, agonists such as serotonin, adrenaline or chemokines. Blood platelets express two types of P2Y ADP receptors: P2Y_1 and P2Y_12. ADP-dependent platelet aggregation is initiated by the P2Y1 receptor, whereas P2Y_12 receptor augments the activating signal and promotes platelet release reaction. Stimulation of P2Y_12 is also essential for ADP-mediated complete activation of GPIIb-IIIa and GPIa-IIa, and further stabilization of platelet aggregates. The crucial role in blood platelet biology makes P2_Y12 an ideal candidate for pharmacological approaches for anti-platelet therapy.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 411-415
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of aging and oxidative/genotoxic stress on poly(ADP-ribose) polymerase-1 activity in rat brain
    Autorzy:
    Strosznajder, Robert
    Jesko, Henryk
    Adamczyk, Agata
    Powiązania:
    https://bibliotekanauki.pl/articles/1041342.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    aging
    poly(ADP-ribosyl)ation
    brain
    p53 protein
    PARP-1
    genotoxic stress
    oxidative stress
    Opis:
    Poly(ADP-ribose) polymerase-1 (PARP-1, EC 2.4.2.30), a DNA-bound enzyme, plays a key role in genome stability, but after overactivation can also be responsible for cell death. The aim of the present study was to investigate PARP-1 activity in the hippocampus, brain cortex, striatum and cerebellum in adult (4 months) and aged (24 months) specific pathogen free Wistar rats and to correlate it with PARP-1 protein level and p53 expression. Moreover, the response of PARP-1 in adult and aged hippocampus to oxidative/genotoxic stress was evaluated. Our data indicated a statistically significant enhancement of PARP-1 activity in aged hippocampus and cerebral cortex comparing to adults without statistically significant changes in PARP-1 protein level. The expression of p53 mRNA was elevated in all aged brain parts with the exception of the cerebral cortex. Our data suggest that enhancement of PARP-1 activity and p53 expression in aged brain may indicate higher DNA damage. Our data also indicate that during excessive oxidative/genotoxic stress there is no response of PARP-1 activity in aged hippocampus in contrast to a significant enhancement of PARP-1 activity in adults which may have important consequences for the physiology and pathology of the brain.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 4; 909-914
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inhibition of poly(ADP-ribose) polymerase activity affects its subcellular localization and DNA strand break rejoining
    Autorzy:
    Ryabokon, Nadezhda
    Cieślar-Pobuda, Artur
    Rzeszowska-Wolny, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1040571.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    DNA strand break rejoining
    efficiency of PARP inhibition
    PARP foci
    poly(ADP-ribose) polymerase (PARP)
    PARP inhibitors
    Opis:
    Poly(ADP-ribose) polymerase (PARP) plays a crucial role in DNA repair. Modulation of its activity by stimulation or inhibition is considered as a potentially important strategy in clinical practice, especially to sensitize tumor cells to chemo- and radiotherapy through inhibition of DNA repair. Here we studied the effect of the three PARP inhibitors, 5-iodo-6-amino-benzopyrone (INH2BP), 1,5-isoquinolinediol (1,5-dihydroxyisoquinolinediol (1,5-IQD) and 8-hydroxy-2-methylquinazolin-4-[3H]one (NU1025), and for two of them the efficiency in slowing the rejoining of DNA strand breaks induced by H2O2 was compared. Inhibition of PARP changed its intranuclear localization markedly; cells exposed to the inhibitor NU1025 showed a significant tendency to accumulate PARP in large foci, whereas in untreated cells its distribution was more uniform. The speed and efficiency of rejoining of H2O2-induced DNA strand breaks were lower in cells incubated with a PARP inhibitor, and the kinetics of rejoining were modulated in a different manner by each inhibitor. At a concentration of 100 µM the efficiency of the inhibitors could be ranked in the order NU1025 > IQD > INH2BP. The two first compounds were able to decrease the overall PARP activity below the level detected in control cells, while INH2BP showed up to 40% PARP activity after exposure to H2O2.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 2; 243-248
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Design of a Hold-off Time Control Circuit for Geiger-mode Avalanche Photodiodes
    Autorzy:
    Deng, S.
    Morrison A., P.
    Powiązania:
    https://bibliotekanauki.pl/articles/397973.pdf
    Data publikacji:
    2012
    Wydawca:
    Politechnika Łódzka. Wydział Mikroelektroniki i Informatyki
    Tematy:
    fotodioda lawinowa
    GM-ADP
    impuls wtórny
    obwód gaszący
    Geiger-mode avalanche photodiodes
    GM-APD
    afterpulsing
    quench circuit
    hold-off time
    Opis:
    A high-resolution hold-off time control circuit for Geiger-mode avalanche photodiodes (GM-APDs) that enables linear changes to the hold-off time from several nanoseconds to microseconds is presented. The resolution of the hold-off time can be varied from nanoseconds to tens of nanoseconds with a range up to microseconds to cater for a variety of GM-APDs. This circuit allows setting of the optimal 'afterpulse-free' hold-off time for any GM-APD through digital inputs or additional signal processing circuitry. With this circuit, the APD is automatically reset following the end of the hold-off period that further simplifies the end-user's control. A layout of this circuit is designed using a conventional 0.15 μm complementary metal oxide semiconductor (CMOS) process, resulting a area of 95 μm x 55 μm which makes it suitable for use with APD arrays.
    Źródło:
    International Journal of Microelectronics and Computer Science; 2012, 3, 2; 53-59
    2080-8755
    2353-9607
    Pojawia się w:
    International Journal of Microelectronics and Computer Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    RCD1 regulation and recognition of poly(ADP-ribosyl)ation in Arabidopsis
    Autorzy:
    Vainonen, J.
    Shapiguzov, A.
    Wrzaczek, M.
    Kangasjarvi, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/80058.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    abiotic stress
    biotic stress
    plant stress
    stress response
    reactive oxygen species
    poly[ADP ribose] polymerase
    Arabidopsis
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antidiabetic and antiplatelet aggregation study of various methanol fractions of Nymphaea stellata Willd. leaves
    Studium działania przeciwcukrzycowego i antyagregacyjnego różnych frakcji wyciągu metanolowego z liści Nymphaea stellata Willd
    Autorzy:
    Raja, M.M.
    Mishra, S.H.
    Tamboli, R.S.
    Agilandeswari, D.
    Powiązania:
    https://bibliotekanauki.pl/articles/950585.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Włókien Naturalnych i Roślin Zielarskich
    Tematy:
    stz-nad
    ptp1b inhibition
    adp induced
    co-tlc
    histopathology
    Opis:
    Introduction: Nymphaea stellata Willd. (Nymphaeaceae) is traditionally used for the treatment of diabetes. Alcohol extract of N. stellata leaves has been reported for hypoglycaemic activity. Objective: The aim of this study was to further investigate the different methanol fractions of N. stellata leaves for anti-diabetic activity and anti-platelet aggregation activity. Methods: Methanol extract was fractioned in to unsaponified petroleum ether fraction of methanol extract (UPFME), chloroform fraction of methanol extract (CFME) and residual fraction of methanol extract (RFME). All fractions were evaluated for in vivo anti-diabetic activity (STZ-NAD-induced rat model), in vitro anti-diabetic activity (PTP1B inhibition study) and anti-platelet aggregation activity. Results: UPFME showed significant changes in all studied parameters, compared to the diabetic control. UPFME also showed an IC50 value of 19.30±1.1 mg/ml and 13.11±0.7 μg/ml in PTP1B inhibition study and anti-platelet aggregation study, respectively. Conclusion: The study indicates that UPFME of N. stellata leaves exhibit anti-diabetic and anti-platelet aggregation activity.
    Wstęp: Nymphaea stellata Willd. (Nymphaceae) jest tradycyjnie stosowana w leczeniu cukrzycy. Istnieją doniesienia o działaniu hipoglikemicznym wyciągu alkoholowego z liści tej rośliny. Cel: Celem pracy były dalsze badania właściwości przeciwcukrzycowych i antyagregacyjnych różnych frakcji metanolowego wyciągu z liści N. stellata. Metodyka: Ekstrakt metanolowy frakcjonowano na niezmydloną frakcję otrzymaną za pomocą eteru naftowego (UMFME), frakcję otrzymaną za pomocą chloroformu (CFME) oraz pozostałość ekstraktu metanolowego (RFME). Wszystkie frakcję były badane w kierunku działania przeciwcukrzycowego in vivo (w modelu szczurzym cukrzycy wywołanej przy pomocy STZ-NAD), w kierunku aktywności przeciwcukrzycowej w badaniach in vitro (badania hamowania PTP1B) oraz w celu określenia aktywności antyagregacyjnej. Wyniki: Stosowanie frakcji UMFME powodowało znaczące zmiany we wszystkich badanych parametrach zwierząt doświadczalnych (w porównaniu do grupy kontrolnej z wywołaną cukrzycą). Wartość IC50 dla frakcji UMFME wynosiła 19,30±1,1 μg/ml w badaniu hamowania PTP1B oraz 13,11±0,7 μg/ml w badaniu działania antyagregacyjnego. Wnioski: Otrzymane wyniki badań wskazują, że frakcja UMFME z liści N. stellata wykazuje aktywność przeciwcukrzycową i antyagregacyjną.
    Źródło:
    Herba Polonica; 2017, 63, 3
    0018-0599
    Pojawia się w:
    Herba Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Poly(adP-ribose) polymerase inhibitor olaparib in the treatment of ovarian cancer: a comprehensive review of current literature
    Autorzy:
    Poboży, Kamil
    Domańska, Julia
    Domański, Paweł
    Powiązania:
    https://bibliotekanauki.pl/articles/22792529.pdf
    Data publikacji:
    2023-07-02
    Wydawca:
    Medical Education
    Tematy:
    Olaparib
    PARP inhibitor
    ovarian cancer
    targeted therapy
    poly(ADP-ribose) polymerase
    cancer therapy
    Opis:
    Purpose of the review: This comprehensive review aims to provide a summary of current research on the utilization of olaparib, a poly(ADP-ribose) polymerase (PArP) inhibitor, in the treatment of ovarian cancer. The review aims to highlight the key findings from recent clinical trials and assess the potential of olaparib as a targeted therapy for improving the prognosis of ovarian cancer patients. recent findings: Ovarian cancer remains a significant global health concern with high mortality rates. While optimal debulking surgery and platinum-based chemotherapy are the standard treatments, the recurrence rates remain substantial. The emergence of PArP inhibitors, particularly olaparib, has intro duced a novel therapeutic approach that targets the genomic instability and DnA repair mechanisms in cancer cells. notable clinical trials, such as SOl O1, SOl O2, and PAOlA-1, have demonstrated the effectiveness of olaparib in significantly improving progression-free survival, particularly in patients with Br CA mutations or homologous recombination deficiency. Additionally, combination therapies involving olaparib, such as those with bevacizumab or entinostat, have shown promising results. Summary: The utilization of olaparib has brought about a paradigm shift in the treatment of ovarian cancer. notably, it has shown significant improvements in progression-free survival and overall survival, particularly in patients with Br CA mutations or homologous recombination deficiency. The exploration of olaparib through various clinical trials and combination therapies continues to provide valuable insights and offer new prospects for ovarian cancer patients. Moreover, the growing understanding of PArP inhibitors holds the potential for further advancements in the prognosis of patients with this formidable condition.
    Źródło:
    OncoReview; 2023, 13, 2; 39-47
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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