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    Wyświetlanie 1-8 z 8
    Tytuł:
    Sulphur XANES Analysis of Cultured Human Prostate Cancer Cells
    Autorzy:
    Kwiatek, W.
    Podgórczyk, M.
    Paluszkiewicz, Cz.
    Balerna, A.
    Kisiel, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/1812260.pdf
    Data publikacji:
    2008-08
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.64.kd
    87.19.xj
    Opis:
    Prostate cancer is one of the most commonly diagnosed cancers in men throughout the world. It is believed that changes to the structure of protein binding sites, altering its metabolism, may play an important role in carcinogenesis. Sulphur, often present in binding sites, can influence such changes through its chemical speciation. Hence there is a need for precise investigation of coordination environment of sulphur. X-ray absorption near edge structure spectroscopy offers such possibility. Cell culture samples offer histologically well defined areas of good homogeneity, suitable for successful and reliable X-ray absorption near edge structure analysis. This paper presents sulphur speciation data collected from three different human prostate cancer cell lines (PC-3, LNCaP and DU-145). Sulphur X-ray absorption near edge structure analysis was performed on K-edge structure. The spectra of cells were compared with those of cancerous tissue and with organic substances as well as inorganic compounds.
    Źródło:
    Acta Physica Polonica A; 2008, 114, 2; 463-470
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Determination of Changes in Sulphur Oxidation States in Prostate Cancer Cells
    Autorzy:
    Czapla, J.
    Kwiatek, W.
    Lekki, J.
    Steininger, R.
    Göttlicher, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/1490177.pdf
    Data publikacji:
    2012-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.64.kd
    87.19.xj
    Opis:
    Prostate cancer cell lines along with selected organic and inorganic compounds used as references were studied with sulphur K-edge X-ray absorption near edge structure spectroscopy. The experiment was performed at the SUL-X beamline of the synchrotron radiation source ANKA, Karlsruhe (Germany). The sulphur was chosen for the studies because it is an essential biological element and out of many relevant factors, it is believed that it can take an important part in cancer transformations. The main goal was to determine which sulphur forms occur in prostate cancer cells and to compare these results with the ones obtained for non-cancerous cells. Therefore oxidation state of this element was analysed with S K-edge X-ray absorption near edge structure spectroscopy. The analysis of K-edge structure was done in order to investigate also the chemical structure of the elements neighbouring the central atom. The preliminary results from sulphur X-ray absorption near edge structure in prostate cancer cell line PC-3 and prostatic epithelial cell line PZ-HPV-7 (which was used as a control) show that there are various oxidation states of sulphur occurring in cells. The set of reference compounds with various sulphur oxidation states was used to establish the relation between the energy of the white line maximum and the oxidation state of sulphur. The equation of linear fit was used to compute the unknown oxidation state. In order to obtain a more detailed information the method of deconvolution of X-ray absorption near edge structure spectra was used. Experimental spectra were fitted with two Gaussian peaks and one arctangent step function. Fitting procedure was performed in Athena code and the deconvolution was used to assign the fraction of each sulphur form. The next step was to compare the results calculated for cancerous and non-cancerous cells. In this work, the first results of these studies are presented.
    Źródło:
    Acta Physica Polonica A; 2012, 121, 2; 497-501
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytotoxic Effects of Different ICG Concentrations and Laser Parameters on Neuroblastoma
    Autorzy:
    Ak, A.
    Kaya, Ö.
    Coşan, D.
    Gülsoy, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1402428.pdf
    Data publikacji:
    2015-08
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    42.62.-B
    87.19.XJ
    Opis:
    Photodynamic therapy (PDT) is a minimally invasive treatment for cancer therapy. It can be administered in combination with other treatments such as chemotherapy, radiotherapy, and surgical excision. PDT involves a photosensitizing agent that is activated by exposure to a specific wavelength of light. PDT is a cold photochemical process, there is no tissue heating. In our study, we investigated whether different laser parameters with different concentrations of indocyanine green (ICG) have cytotoxic and anti-proliferative effects on neuroblastoma. Plates were divided groups as control, only ICG concentrations (25 and 50 μg/ml), only laser treatment I (50 J/cm²), only laser treatment II (100 J/cm²), 25 μg/ml ICG + laser treatment I and 25 μg/ml ICG + laser treatment II, 50 μg/ml ICG + laser treatment I and 50 μg/ml ICG + laser treatment II. Neuroblastoma cell lines were irradiated with an in-house developed diode laser system (λ=809 nm, 70 mW/cm², 50 & 100 J/cm²) in continuous wave operation mode after ICG application. Cell proliferation was measured by XTT assay after light irradiation. Cell proliferation was decreased in a dose-dependent manner in 25 and 50 μg/ml ICG concentrations when compared with control. The applied ICG concentrations (especially 50 μg/ml) had cytotoxic effects for neuroblastoma cell lines, SH-SY5Y. There was no difference between laser treatment groups (L 50 & 100 J/cm²). However, PDT groups (laser exposure with ICG) showed significant inhibition of cell viability (p<0.05). Additionally, laser exposure did not increase the well temperature above the incubation parameter. In conclusion, PDT has cytotoxic effects in neuroblastoma cell lines. Appropriate ICG dose - laser parameter combinations must be determined for each cell type. Different energy densities may cause different effects of PDT on inhibition of cell viability.
    Źródło:
    Acta Physica Polonica A; 2015, 128, 2B; B-381-B-383
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Development of Low-Cost Photodynamic Therapy Device
    Autorzy:
    Momchilov, N.
    Bliznakova, I.
    Borisova, E.
    Troyanova, P.
    Avramov, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/2047897.pdf
    Data publikacji:
    2007-11
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    42.72.Bj
    87.64.kv
    87.19.xj
    Opis:
    Photodiagnosis and photodynamic therapy of non-melanoma skin cancers using delta-aminolevulinic acid/protoporphyrin IX (5-ALA/PpIX) give a combined application with broadest dissemination in the current clinical practice. The problems with using of lasers as light sources are the expenses associated with the operation of these types of installations. This is why we test the capability of cheaper sources - light-emitting diodes at 405 nm for fluorescence excitation of PpIX and 635 nm for photodynamic action initiation. A LED matrix is developed in our laboratory using two types of LEDs and a combined photodiagnosis/photodynamic theory device applicable for clinical practice is built. Geometrically matrix is formed in such way that power density at 635 nm is about 40 mW/cm$\text{}^{2}$, which allow to reach treatment doses for a 15-20 min irradiation depending of the lesion size in the focus of the system. The therapeutic mode of system developed can be used also with some other photosensitizers from the porphyrins derivatives family.
    Źródło:
    Acta Physica Polonica A; 2007, 112, 5; 1125-1130
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Optical Biopsy Method for Breast Cancer Diagnosis Based on Artificial Neural Network Classification οf Fluorescence Landscape Data
    Autorzy:
    Dramićanin, T.
    Zeković, I.
    Dimitrijević, B.
    Ribar, S.
    Dramićanin, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1795706.pdf
    Data publikacji:
    2009-10
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.64.kv
    84.35.+i
    87.19.xj
    33.50.-j
    Opis:
    Supervised self-organizing map, a type of artificial neural network, is applied for classification of human breast tissue samples utilizing data obtained from fluorescence landscape measurements. Female breast tissue samples were taken soon after the surgical resection, identified and stored at -80°C until fluorescence measurements. From fluorescence landscapes obtained in UV-VIS region spectral features showing statistically significant differences between malignant and normal samples are identified and further quantified to serve as a training input to neural network. Additional set of samples was used as a test group input to trained network in order to evaluate performance of proposed optical biopsy method. Classification sensitivity of 83.9% and specificity of 88.9% are found.
    Źródło:
    Acta Physica Polonica A; 2009, 116, 4; 690-692
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Point Investigation Method for Cancer Changed Tissues
    Autorzy:
    Kłonowski, Ł.
    Kulas, Z.
    Bereś-Pawlik, E.
    Rząca, M.
    Czarnecki, R.
    Grzebieniak, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/1506797.pdf
    Data publikacji:
    2010-12
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.57.-s
    87.57.R-
    87.57.nm
    87.19.xu
    87.19.xj
    Opis:
    In this paper we describe the method of point investigation for cancer changed tissues with application of fluorescence phenomenon. The measurements have been made using a specially constructed scanning setup and fiber sensors. The experiment with investigation of endogenous fluorescence has been made on different types of slide tissues (e.g. breast and intestine tumor or precancerous and pathological skin tissues). The obtained spectral characteristics of fluorescence, with typical intensity peaks in 480-520 nm range, have explicitly outlined healthy and pathologically changed areas. The intensity of detected fluorescence determines the evaluation of disease advancement. Moreover, the ability to scan the surface of a tissue sample with constantly moving step of scanning setup in X-Y axis allows us to present the results in a spatial distribution of fluorescence intensity.
    Źródło:
    Acta Physica Polonica A; 2010, 118, 6; 1174-1176
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Feed Forward Neural Network for Autofluorescence Imaging Classification
    Autorzy:
    Kulas, Z.
    Bereś-Pawlik, E.
    Wierzbicki, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/1506801.pdf
    Data publikacji:
    2010-12
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.57.-s
    87.57.R-
    87.57.nm
    87.19.xu
    87.19.xj
    Opis:
    The key elements in cancer diagnostics are the early identification and estimation of the tumor growth and its spread in order to determine the area to be operated on. The aim of our study was to develop new methods of analyzing autofluorescence images which will allow us an objective and accurate assessment of the location of a tumor and will also be helpful in determining the advancement of the disease. The proposed classification methods are based on neural network algorithms. An Olympus company endoscopic system was used for an autofluorescence intestine imaging study. The autofluorescence imaging analysis process can be divided into several main stages. The first step is preparation of a training data set. The second one involves selection of feature space, namely the selection of those features which enable distinguishing the pathologically altered areas from the healthy ones. Final stages of the analysis include pathologically changed tissue classification and diagnosis.
    Źródło:
    Acta Physica Polonica A; 2010, 118, 6; 1189-1193
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Challenges in Biology and Medicine with Synchrotron Infrared Light
    Autorzy:
    Dumas, P.
    Miller, L.
    Tobin, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1808306.pdf
    Data publikacji:
    2009-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.80.Dj
    87.80.-y
    87.64.km
    87.56.B-
    87.19.xj
    87.16.-b
    87.15.bd
    78.30.-j
    Opis:
    The brightness (or brilliance) of synchrotron radiation was exploited in infrared microspectrosocopy. Among application of this synchrotron-based microanalytical technique, biological and biomedical investigations, at the diffraction-limited spot size, are exhibit of an increasing interest among almost all the existing infrared beamline worldwide. This paper is presenting the main properties of such a source, coupled with an infrared microscope. Several important applications in biomedical field are reported: cancer cells studies and drug effects, human substantia nigra in Parkinson's disease, β-amyloids deposits in Alzheimer's disease.
    Źródło:
    Acta Physica Polonica A; 2009, 115, 2; 446-454
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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