Temat: 8-oxo-2'-deoxyguanosine - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Cellular level of 8-oxo-2-deoxyguanosine in DNA does not correlate with urinary excretion of the modified base/nucleoside.
Autorzy:: Foksinski, Marek
Gackowski, Daniel
Rozalski, Rafał
Olinski, Ryszard
Powiązania:: https://bibliotekanauki.pl/articles/1043637.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: 8-oxoguanine
oxidative DNA damage
8-oxo-2'-deoxyguanosine
Opis:: We assessed a relationship between the level of 8-oxodG in leukocyte DNA measured with the high performance liquid chromatography with electrochemical detection (HPLC/EC) technique and urinary excretion of the modified nucleoside/base analysed with a recently developed methodology involving HPLC prepurification followed by gas chromatography with isotope dilution mass spectrometric detection. No correlation was found between these markers of oxidative DNA damage commonly used in epidemiological studies. Several possible explanations of this finding are discussed.
Źródło:: Acta Biochimica Polonica; 2003, 50, 2; 549-553
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Background level of 8-oxo-2-deoxyguanosine in lymphocyte DNA does not correlate with the concentration of antioxidant vitamins in blood plasma.
Autorzy:: Gackowski, Daniel
Ciecierski, Marek
Jawień, Arkadiusz
Oliński, Ryszard
Powiązania:: https://bibliotekanauki.pl/articles/1044149.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: α-tocopherol
ascorbic acid
retinol
8-oxo-2'-deoxyguanosine
Opis:: Antioxidant vitamins, being effective free radical scavengers, can protect cellular DNA from oxidative damage. Therefore, in the present study we report on the relationship between basal level of 8-oxo-2'-deoxyguanosine in human lymphocyte DNA and the concentration of antioxidant vitamins (A, C and E). The average level of 8-oxo-2'-deoxyguanosine in lymphocytes of the studied group (15 males and 20 females) was 9.57 per 106 dG molecules. The endogenous level of ascorbic acid (vitamin C) in the plasma was, on average, 56.78 μM, while the mean concentrations of retinol (vitamin A) and α-tocopherol (vitamin E) were 1.24 μM and 25.74 μM, respectively. No correlations were found between individual 8-oxo-2'-deoxyguanosine levels in lymphocyte DNA and endogenous concentration of the vitamins.
Źródło:: Acta Biochimica Polonica; 2001, 48, 2; 535-539
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Assessment of 8-oxo-7,8-dihydro-2′-deoxyguanosine as a marker of oxidative DNA damage in gasoline filling station attendants
Autorzy:: Beerappa, Ravichandran
Venugopal, Dhananjayan
Sen, Somnath
Ambikapathy, Mala
Rao, Rajmohan H.
Powiązania:: https://bibliotekanauki.pl/articles/2179055.pdf
Data publikacji:: 2013-10-01
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: DNA damage
ELISA
petrol filling attendants
urinary 8-oxo-7
8-dihydro-2’-deoxyguanosine
Opis:: Objectives: The urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) was used as a biomarker of oxidative DNA damage. The urinary 8-oxodG levels in petrol filling station attendants (exposed) at various petrol bunks were estimated as well as in the unexposed (cashier) population. Materials and Methods: A total of 100 workers (79 petrol fillers and 21 cashiers) aged from 20 to 41 years participated in the study. An informed consent was taken from each participant. Information on personal habits and health was obtained through a questionnaire. After shifts, urine samples were collected analyzed for 8-oxodG using enzyme-linked immunosorbent assay (ELISA). Results: Fifty-three percent of workers were in the 21-30 years age group. The maximum level of 8-oxodG was observed in the age group ≥ 41 years and the minimum in the age group of 31-40 years. The maximum level of 8-oxodG was observed among those workers who had ≥ 21 years of experience. The concentrations of 8-oxodG were significantly higher in petrol fillers than those in cashiers (p < 0.05). Conclusions: Despite the conflicting results obtained in our study it was shown that 8-oxodG is related to chemical exposure. Further research is needed embracing a bigger number of participants to highlight the correlations between the exposure and the effects.
Źródło:: International Journal of Occupational Medicine and Environmental Health; 2013, 26, 5; 780-789
1232-1087
1896-494X
Pojawia się w:: International Journal of Occupational Medicine and Environmental Health
Dostawca treści:: Biblioteka Nauki

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