- Tytuł:
- 5',8-Cyclo-2'-deoxyadenosine (cdA) formation by γ-radiation. Theoretical quantum mechanics study
- Autorzy:
-
Karwowski, Boleslaw
Grand, Andre
Cadet, Jean - Powiązania:
- https://bibliotekanauki.pl/articles/1040482.pdf
- Data publikacji:
- 2009
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
5',8-cyclo-2'-deoxyadenosine
DNA damage
ionizing radiation
density functional theory (DFT) - Opis:
- Reactions of reactive oxygen species and more specifically - of hydroxyl radical (•OH) - with nucleosides may lead to the generation of radicals in the base and 2-deoxyribose moieties. In the present study emphasis was put on the possible reaction modes of 2'-deoxyadenosine (dA) radicals, leading to the formation of related 5',8-cyclonucleosides. It appears that the prerequisite for the formation of 5',8-cyclo-2'-deoxyadenosine (cdA) is the adoption of O4'-exo conformation by 2-deoxyribose; however, this is the least energetically favored conformer among the different puckered forms adopted by the furanose ring. The O4'-exo conformation was found to be present in each of the discussed mechanisms.
- Źródło:
-
Acta Biochimica Polonica; 2009, 56, 4; 655-662
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł