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Wyszukujesz frazę "4-oxadiazole" wg kryterium: Temat

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    Wyświetlanie 1-6 z 6
    Tytuł:
    Synthesis and antimicrobial activity of oxadiazole nucleus containing 2,5-substituted 1,3,4-oxadiazole derivatives
    Autorzy:
    Gajera, Jayesh L
    Sutariya, Jignesh K.
    Rakesh Gothwal, Rakesh
    Sharma, Vinay S.
    Ram, Haresh
    Godhaviya, Pankaj K.
    Powiązania:
    https://bibliotekanauki.pl/articles/1839273.pdf
    Data publikacji:
    2021
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    cyclohexanecarbohydrazide
    antibacterial
    antifungal
    1,3,4-oxadiazole
    Opis:
    In this study, we report the synthesis of 2,5-substituted 1,3,4-oxadiazole derivatives using condensation of cyclohexanecarbohydrazide derivatives and carbon disulfide. In present study, we have prepared total seven derivatives based on 1,3,4-oxadiazole core further functionalized with thiol moieties. The structures of synthesized compounds (C1-C9) were confirmed by the 1H NMR, and Mass spectrometry. These synthesized molecules were subjected to antibacterial and fungal activity against selected microbial and fungal strains. Some of derivatives showed good biological behaviour against gram positive and gram negative bacteria.
    Źródło:
    World Scientific News; 2021, 162; 75-86
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Solid phase synthesis of novel 1,3,4-oxadiazole derivatives and evaluation of their antimicrobial activity
    Autorzy:
    Gadara, Shobhana A.
    Ladva, Kartik D.
    Powiązania:
    https://bibliotekanauki.pl/articles/1031813.pdf
    Data publikacji:
    2020
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    4-oxadiazole
    Aminoazole
    in vitro antimicrobial assay
    s-methylthioamide
    Opis:
    A series of 5-(N-Aryl/Arylalkyl)-2-(3-Chclorophenyl)-1,3,4-oxadiazole have been synthesized. The constitution of the products has been delineated by elemental analysis and spectral analyses. All the synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus MTCC-96, Escherichia coli MTCC-443, B. subtilis MTCC-441, P. aeruginosa MTCC-1688, and antifungal activity against Aspergillus niger MTCC-282 and Penicillium SP.at different concentration and compared with standards drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro broth dilution method.
    Źródło:
    World Scientific News; 2020, 147; 35-44
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cyclization and antimicrobial evolution of 1,3,4-oxadiazoles by carbohydrazide
    Autorzy:
    Godhani, Dinesh R.
    Mulani, Vishal B.
    Mehta, Jignasu P.
    Powiązania:
    https://bibliotekanauki.pl/articles/1063054.pdf
    Data publikacji:
    2019
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    1
    3
    4-oxadiazole
    antimicrobial activity
    cytotoxicity
    dihydropyrimidine
    haemolysis
    Opis:
    A series of dihydropyrimidine substituted 1,3,4-oxadiazole derivatives was synthesized by cyclization of carbohydrazide by phosphoryl chloride and benzoic acid in acidic condition. The structures were perceived on the establishment of spectral tools and their purity by elemental analysis. Every compound was primary assessed for their in vitro antimicrobial activities against 5 bacterial strains viz [Staphylococcus aureus (MRSA; ATCC 43300), Klebsiella pneumoniae (ATCC 700603), Escherichia coli (ATCC 25922), Acinetobacter baumannii (ATCC 19606), Pseudomonas aeruginosa (ATCC 27853)] and 2 fungi Strains viz. [Candida albicans (ATCC 90028), Cryptococcus neoformans var. grubii (H99; ATCC 208821)]. Some compounds displayed significant antimicrobial activity, out of 15 compounds, 11 compounds indicated promising antifungal activities without any indications of human cells cytotoxic [Hk: Human Embryonic Kidney cells (ATCC CRL-1573)] and haemolytic activity [RBC (ARCBS 5400 00150)].
    Źródło:
    World Scientific News; 2019, 124, 2; 304-311
    2392-2192
    Pojawia się w:
    World Scientific News
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis, characterization and evaluation of mosquito larvicidal effect of 1,3,4-oxadiazole derivatives against Culex quinquefasciatus
    Autorzy:
    Santhanalakshmi, K.
    Kalyanasundharam, S.
    Muthukumar, S.
    Rosy, P. Jacquline
    Powiązania:
    https://bibliotekanauki.pl/articles/1112036.pdf
    Data publikacji:
    2018
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    1
    3
    4-oxadiazole
    Culex quinquefasciatus
    Larvicidal bioassay
    ultrasonic irradiation
    Opis:
    A new series of 1,3,4-oxadiazole derivatives were prepared from the condensation of acid hydrazide,5-bromo-2-(trifluoromethoxy)benzoic acid in POCl3 by ultrasonic irradiation method. The new synthetic method furnished the desired products in shorter time and good yields. The chemical structures of compounds 4a-h were confirmed by Fourier transform infrared spectroscopy (IR), proton nuclear magnetic resonance (1H-NMR), carbon nuclear magnetic resonance (13C-NMR) and elemental analyses. Larvicidal bioassay tests were performed using several 2-(5-bromo-2-(trifluoromethoxy) phenyl)-5-aryl-1,3,4-oxadiazole. These synthesized compounds presented strong larvicidal activity against urban mosquitoes Culex quinquefasciatus. The results suggest that larvicidal activity might be correlated with the presence of electron-withdrawing substituents in the para position of the phenyl ring. The alterations observed in the larvae spiracular valves of the siphon and anal papillae by 1,3,4-oxadiazoles in the larvicidal bioassay are responsible for larvae’s death.
    Źródło:
    World News of Natural Sciences; 2018, 19; 58-64
    2543-5426
    Pojawia się w:
    World News of Natural Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis, Characterization and Biological evaluation of some newer 5-[6-chloro/fluoro/nitro-2-(p-chloro/ fluoro/ methyl phenyl)-quinolin-4-yl]-1,3,4-oxadiazole-2-thiols
    Autorzy:
    Faldu, V. J.
    Talpara, P. K.
    Bhuva, N. H.
    Vachharajani, P. R.
    Shah, V. H.
    Powiązania:
    https://bibliotekanauki.pl/articles/412197.pdf
    Data publikacji:
    2014
    Wydawca:
    Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
    Tematy:
    Quinolines
    1,3,4-oxadiazole-2-thiols
    therapeutic agents
    antimicrobial assai
    Opis:
    Recent study shows that quinolines represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In present research work, 5-[6-chloro/fluoro/nitro-2-(p-chloro/fluoro/methyl phenyl)-quinolin-4-yl]-1,3,4-oxadiazole-2-thiols have been synthesized by condensation of substituted quinoline-4-carbohydrazides and mixture of carbon disulphide and potassium hydroxide. All of these compounds were screened for their in vitroanti microbial assay against gram (+ve), gram (-ve) bacteria and fungi activity compared with standard drugs viz., Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Griseofulvin and Nystatin at different concentrations.
    Źródło:
    International Letters of Chemistry, Physics and Astronomy; 2014, 6; 26-32
    2299-3843
    Pojawia się w:
    International Letters of Chemistry, Physics and Astronomy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    3,4-Bis(4'-nitrofurazan-3'-yl)furoxan: a Melt Cast Powerful Explosive and a Valuable Building Block in 1,2,5-Oxadiazole Chemistry
    Autorzy:
    Stepanov, A. I.
    Dashko, D. V.
    Astrat'ev, A. A.
    Powiązania:
    https://bibliotekanauki.pl/articles/358174.pdf
    Data publikacji:
    2012
    Wydawca:
    Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
    Tematy:
    3,4-bis(4'-nitrofurazan-3'-yl)furoxan
    furazan
    furoxan
    1,2,5-oxadiazole
    azepine
    Opis:
    The results of our studies on the reactivity of 3,4-bis(4'-nitrofurazan-3'- yl)furoxan (BNFF), with some O- and N-nucleophiles are presented. It is shown that both nitro groups of BNFF can be easily replaced by nucleophiles. Depending on the identity of the nucleophile, BNFF may be transformed into two types of 1,2,5-oxadiazole derivatives, notably 4-R substituted bis(4-R-furazan-3-yl) furoxanes or 7-R substituted 7H(7R)-tris[1,2,5]oxadiazolo[3,4-b:3',4-d:3",4"-f]]azepine-1-oxides - a new heterocyclic system comprised of an azepine ring annelated with three 1,2,5-oxadiazole rings.
    Źródło:
    Central European Journal of Energetic Materials; 2012, 9, 4; 329-342
    1733-7178
    Pojawia się w:
    Central European Journal of Energetic Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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