- Tytuł:
-
Aktywność biologiczna pochodnych 2-amino -1H-benzimidazolu. Część II
Biological activity of 2-amino -1Hbenzimidazole derivatives. Part II - Autorzy:
-
Nawrocka, W. P.
Nowicka, A.
Liszkiewicz, H. - Powiązania:
- https://bibliotekanauki.pl/articles/171652.pdf
- Data publikacji:
- 2012
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
pochodne 2-aminobenzimidazolu
aktywność biologiczna
2-aminobenzimidazole derivatives
biological activity - Opis:
- 2-Aminobenzimidazole occur in a broad spectrum of drugs and pharmacological agents with hypotensive [26], antihistaminic, immunotropic [16], antiarrhythmic [25], analgesic [21, 22] or antiaggregatory properties [27]. There are 30 drugs, 2-aminobenzimidazole derivatives, registered in the world which exhibit diverse pharmacological activities. Carbendazim is an antifungal drug, but in 2003 it has been registered as anticancer [1]. They are also voltage sensitive calcium channel blockers [33], inhibitors of vascular endothelial growth factor [12]. The main goal of this article is to present a various biological activity of 2-aminobenzimidazole derivatives. During the past 20 years the biological activity of 2-aminobenzimidazole have been studied. Based on a review of the chemical literature, derivatives of 2-aminobenzimidazole showed a multipharmacological effects such as hypotensive effect [28], antiinflammatory effect [20] or antibacterial activity. Some chemical compounds, which contain in their structure 2-aminobenzimidazole system inhibit neurodegeneration and in the future they may be used in a treatment of Alzheimer’s disease or Parkinson’s disease [32]. Some of described derivatives of 2-aminobenimidazole can be used in a treatment of metabolic syndrome and diabetes [38]. Synthesis of new 2-aminobenzimidazole derivatives with anticancer activity is now one of the most important direction of research conducted on this group of compounds. Present compounds exhibit anticancer, antiproliferate, neuroprotetic and antiinflaminatory activity. Some of them can be used in a treatment of diabetes and hypertension.
- Źródło:
-
Wiadomości Chemiczne; 2012, 66, 9-10; 840-865
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł