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Tytuł:
Synthesis, Characterization and Thermal Decomposition of a New Energetic Salt of 1H,1′H-5,5′-Bistetrazole-1,1′-diol
Autorzy:
Xiao, L.
Jin, B.
Shang, Y.
Liu, Q.
Guo, Z.
Peng, R.
Powiązania:
https://bibliotekanauki.pl/articles/358377.pdf
Data publikacji:
2018
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
1,1-dimethylbiguanidium 1H,1′H-5,5′-bistetrazole-1,1′-diolate (MGBTO)
single crystal
thermal properties
energetic properties
Opis:
1,1-Dimethylbiguanidium 1H,1′H-5,5′-bistetrazole-1,1′-diolate (MGBTO), a novel nitrogen-rich energetic salt, was synthesized by cation exchange. Its structure was characterized by elemental analysis, FTIR, NMR, DTA and TG-DTG. Single crystal X-ray diffraction analysis revealed that MGBTO was crystallized in the monoclinic space group C2/c. Thermal analysis demonstrated that its thermal stability extended up to 531.1 K. The nonisothermal kinetic and apparent thermodynamic parameters of the exothermic decomposition of MGBTO were determined by the Kissinger and Ozawa methods. Its detonation velocity and detonation pressure were calculated on the basis of the Kamlet-Jacobs equation and were 6342 m·s–1 and 15.78 GPa, respectively. The impact and friction sensitivities of MGBTO were quantified using standard BAM (10 kg drop hammer) procedures. The results revealed that the salt has good mechanical sensitivity (FS > 120 N, IS > 40 J), thus indicating its potential applications as an energetic material.
Źródło:
Central European Journal of Energetic Materials; 2018, 15, 3; 405-419
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Greener, facile and ultrasound assisted synthesis of 1,2,3-triazole via CuAAC of 2-(azidomethyl)-1H-benzo[d]imidazole and alkynes and their evaluation of antimicrobial activity
Autorzy:
Kapupara, Vimalkumar H.
Kalavadiya, Prakash L.
Gojiya, Dinesh G.
Parmar, Nilesh D.
Joshi, Hitendra S.
Powiązania:
https://bibliotekanauki.pl/articles/1075696.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
1
1H-benzo[d]imidazole azide
2
3-triazol-1-yl)methyl)-1H-benzo[d]imidazole
3-triazole via CuAAC
4-disubstituted 1H-1
alkynes
antimicrobial
copper(I) catalyst
Opis:
An expeditious room temperature protocol for the synthesis of 1,4-disubstituted 1H-1,2,3-triazol-1-yl)methyl)-1H-benzo[d]imidazole from [3+2] cyclization by using 1H-benzo[d]imidazole azide and various substituted terminal alkynes and copper(I) as a catalyst. This synthetic approach has been various prominent features such as fewer reaction steps, Good Yield, simple reaction condition and no any further purification required. Characterizations of all the synthesized compounds were done by various spectroscopic techniques like FT-IR, NMR and Mass spectrometry. All the synthesized targeted compounds were screened and evaluated for their antimicrobial activities.
Źródło:
World Scientific News; 2019, 119; 139-167
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Syntezy wybranych, nowych pochodnych 2-amino-1H-benzimidazolu i ich mechanizmy działania biologicznego
Synthesis of Selected, New 2-amino-1H-benzimidazole derivatives and Their mechanism of biological activity
Autorzy:
Nowicka, A.
Nawrocka, W. P.
Powiązania:
https://bibliotekanauki.pl/articles/172102.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
pochodne 2-amino-1H-benzimidazolu
syntezy
aktywność biologiczna
2-amino-1H-benzimidazole derivatives
synthesis
biological activity
Opis:
Many 2-amino-1H-benzimidazole drugs such as antihistaminic mizolastine and norastemizole or antiparasitic mebendazole, albendazole and thiabendazole have been used in clinic [1, 2]. Benomyl and its metabolite Carbendazim are both antifungal and anticancer drugs [4]. Recently, a lot of literature has revealed that 2-amino-1H-benzimidazole derivatives could effectively inhibit the growth of various microorganisms, what suggests that 2-aminobenzimidazole compounds should have large potential as a new type of antibacterial [15] and antifungal [18] agents. A number of 2-aminobenzimidazoles have exhibited antiproliferative in vitro properties [11]. Some new compounds, containing in theirs structures 2-aminobenzimidazole, show interesting and diverse cytotoxic mechanism of action, e.g. induce apoptosis of cancer cells [13]. Some of 2-aminobenzimidazole analogues are histamine and serotonin receptors antagonists [32]. 2-Aminobenzimidazoles derivatives have been frequently found to display a variety of biological activities like anti-inflammatory, antioxidant and anticoagulant [32] properties.
Źródło:
Wiadomości Chemiczne; 2013, 67, 3-4; 203-225
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of MRI in the central nervous system
Autorzy:
Leksa, Natalia
Aebisher, David
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454852.pdf
Data publikacji:
2020-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
1H MRI
functional MRI
metabolic brain disfunctions
Opis:
Introduction. Magnetic Resonance Imaging (MRI) has modified the practice of radiology. MRI is base on safe interaction between radiowaves at a particular frequency and hydrogen nuclei in the body. Metabolic encephalophaties are by definition those disorder of the central nervous system that are not due primarily to structural abnormalities. Aim. Here we present the 1H MRI and functional MRI (fMRI) method applied to diagnosis of disorders of the central nervous system. Material and methods. Analysis of literature and self-research. Results.We have discussed the major MRI applications in the characteristic of the central nervous system. The relationship beteen the motion of flowing blood and the representation of the blood on images is complex. This work is an introduction to the basic ideas and techniques of fMRI. Therefore, both, 1H MRI and functional MRI, methods are ued in neuroscience. Conclusion. Nonivasive MRI and functional MRI are daily diagnostics methods in neurology.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 1; 28-31
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wybrane Metody syntezy 2-amino-1H-benzimidazolu
Selected Methods of the Synthesis of 2-amino-1H-benzimidazole
Autorzy:
Nawrocka, W. P.
Nowicka, A.
Powiązania:
https://bibliotekanauki.pl/articles/172251.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
2-amino-1H-benzimidazol
alkilo i arylo pochodne
syntezy
2-amino-1H-benzimidazole
alkyl and aryl derivatives
synthesis
Opis:
2-Amino-1H-benzimidazoles have attracted much attention due to their varied biological activities toward numerous diseases. 2-Amino-1H-benzimidazole core structures can be found in commercial drugs such as astemizole, mizolastine or carbendazime [1, 2]. 2-(N-substituted)-aminobenzimidazoles are widely used chemical substances in medicinal chemistry. Several compounds from this class have been used as anticancer, antihistamine and antiviral agents [3–5]. An efficient practical method for the synthesis of a diverse collection of 2-aminobenzimidazoles would be of great value for drug discovery. Several synthetic methods have been reported in the literature for the synthesis of 2-aminobenzimidazoles [11]. The synthesis of 2-aminobenzimidazole may be carried out in several ways. The most popular and economical method involves the treatment of various 2-substituted anilines with different cyclising agents to yield 2-aminobenzimidazoles. The cyclocondensation of an appropriate o-phenylenediamine with cyanogen bromide affords high yields of 2-aminobenzimidazoles [12]. Hydrogenation of o-cyanaminonitrobenzene over Raney nickel catalyst gives 2-aminobenzimidazole [34, 35]. Substituted 2-aminobenimidazoles have also been prepared by oxidation of the corresponding substituted thioureas with isothiocyanates using desulfurizing agents such as mercury-(II) oxide or methyl iodide [18–21].
Źródło:
Wiadomości Chemiczne; 2013, 67, 7-8; 715-732
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acetylation of methyl 5-amino-1H-[1,2,4]triazole-3-carboxylate
Autorzy:
Dżygiel, Anetta
MAsiukiewicz, Elżbieta
Rzeszotarska, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1044073.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
hetareneamino acid
5-amino-1H-[1,2,4]triazole-3-carboxylate
Opis:
Acetylation with acetic anhydride of methyl 5-amino-1H-[1,2,4]triazole-3-carboxylate, one of the hetareneamino acids, was studied using HPLC,1H NMR, FTIR and GC-MS. The compound has a significantly decreased susceptibility to acetylation compared to 5-amino-1H-[1,2,4]triazole itself. Two isomeric diacetylated products were found.
Źródło:
Acta Biochimica Polonica; 2001, 48, 4; 1169-1173
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of 1H and 31P NMR to topological description of a model of biological membrane fusion Topological description of a model of biological membrane fusion
Autorzy:
Janiak-Osajca, Agnieszka
Timoszyk, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1039735.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
vesicle
topology
fusion
31P-NMR
1H-NMR
Opis:
The process of biological membrane fusion can be analysed by topological methods. Mathematical analysis of the fusion process of vesicles indicated two significant facts: the formation of an inner, transient structure (hexagonal phase - HII) and a translocation of some lipids within the membrane. This shift had a vector character and only occurred from the outer to the inner layer. Model membrane composed of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS) was studied. 31P- and 1H-NMR methods were used to describe the process of fusion. 31P-NMR spectra of multilamellar vesicles (MLV) were taken at various temperatures and concentrations of Ca2+ ions (natural fusiogenic agent). A 31P-NMR spectrum with the characteristic shape of the HII phase was obtained for the molar Ca2+/PS ratio of 2.0. During the study, 1H-NMR and 31P-NMR spectra for small unilamellar vesicle (SUV), which were dependent on time (concentration of Pr3+ ions was constant), were also recorded. The presence of the paramagnetic Pr3+ ions permits observation of separate signals from the hydrophilic part of the inner and outer lipid bilayers. The obtained results suggest that in the process of fusion translocation of phospholipid molecules takes place from the outer to the inner layer of the vesicle and size of the vesicles increase. The NMR study has showed that the intermediate state of the fusion process caused by Ca2+ ions is the HII phase. The experimental results obtained are in agreement with the topological model as well.
Źródło:
Acta Biochimica Polonica; 2012, 59, 2; 219-224
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synteza niektórych azotowych układów hetero cyklicznych oraz ich zastosowanie w komórkach elektroluminescencyjnych
Synthesis of some heterocyclic compounds and application thereof inelectroluminescent cells
Autorzy:
Daniel, A.
Daniel, K.
Powiązania:
https://bibliotekanauki.pl/articles/1287264.pdf
Data publikacji:
2010
Wydawca:
Stowarzyszenie Inżynierów i Techników Przemysłu Chemicznego. Zakład Wydawniczy CHEMPRESS-SITPChem
Tematy:
komórki elektroluminescencyjne
1H-pirazolo[3,4-b]chinoksaliny
1H-pirazolo[3,4-b]chinoliny
bis-pirazolo[3,4-b; 4',3'-e]pirydyny
electroluminescent devices
bis-pyrazolo[3,4-b;4',3'-e]pyridines
1H-pyrazolo[3,4-b]quinolines
1H-pyrazolo[3,4-b]quinoxalines
Opis:
W pracy omówiono syntezę i zastosowanie układów heterocyklicznych, pochodnych 1H-pirazolo[3,4-b]chinolin, 1H-pirazolo[3,4-b]chinoksalin, bis-pirazolo[3,4-b;4',3'-e]pirydyn oraz benzoksazoli w postaci prostych molekuł, oligomerów i polimerów dla urządzeń elektroluminescencyjnych. Zbudowano jedno- lub wielowarstwowe komórki (filmy osadzane próżniowo lub nanoszone za pomocą techniki spin-coating) oraz zbadano ich podstawowe charakterystyki. Uzyskane komórki emitowały światło niebieskie i zielone.
Some nitrogen heterocycles such as 1H-pyrazolo[3,4-b]quinolines, 1H-pyrazolo[3,4-b]quinoxalines, bis-pyrazolo[3,4-b; 4',3'-e]pyridines and benzoxazoles were synthesized. Multilayer devices were fabricated using these dyes. The films were vacuum evaporated or spin-coated from solutions. The devices provided a bright blue, blue-green or green emission.
Źródło:
Chemik; 2010, 64, 7-8; 511-522
0009-2886
Pojawia się w:
Chemik
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the effect of N,N’-bis(1H-benzotriazole) dodecanedioic acid acethydrazide on poly(L-lactic acid)
Badania wpływu N,N-bis(1H-benzotriazolo)acetohydrazydu kwasu dodekanodiowego na właściwości termiczne poli(kwasu L-mlekowego)
Autorzy:
Zhang, Y. H.
Zhao, L.-S.
Cai, Y.-H.
Powiązania:
https://bibliotekanauki.pl/articles/947164.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej
Tematy:
poly(L-lactic acid)
crystallization
melting behavior
thermal stability
1H-benzotriazole
poli(kwas L-mlekowy)
krystalizacja
proces topnienia
stabilność termiczna
1H-benzotriazol
Opis:
A serious disadvantage of poly(L-lactic acid) (PLLA) is its poor crystallization properties. In the present work, a novel type of organic nucleating agent – N,N’-bis(1H-benzotriazole) dodecanedioic acid acethydrazide (DA) – was synthesized and then applied in PLLA crystallization studies. The thermal performance, including non-isothermal crystallization, melting behavior, and thermal stability of the PLLA/DA blend, was evaluated by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). In non-isothermal crystallization, DA exhibited excellent nucleating and accelerating effects for the crystallization of PLLA since the relevant characterization parameters, including the onset crystallization temperature, non-isothermal crystallization enthalpy, etc., increased. Besides, it was found that an increase in the adjusted final melting temperature in the range from 180 °C to 220 °C led to an enhancement of the PLLA crystallization. DSC measurements under different conditions showed that crystallization temperature, crystallization time, rate, and DA content could affect the melting behavior. According to TGA measurements, all PLLA/DA samples revealed a higher thermal decomposition temperature than neat PLLA. Most probably, the observed behavior results from a strong interaction between PLLA and DA.
Poważną wadą poli(kwasu L-mlekowego) (PLLA) w licznych zastosowaniach jest jego mała zdolność do krystalizacji. W niniejszej pracy otrzymano N,N'-bis(1H-benzotriazolo)acetohydrazyd kwasu dodekanodiowego (DA), a następnie zastosowano go do modyfikacji PLLA. Metodą różnicowej kalorymetrii skaningowej (DSC) oraz analizy termograwimetrycznej (TGA) badano przebieg nieizotermicznej krystalizacji, temperaturę topnienia i temperaturę krystalizacji oraz stabilność termiczną kompozytów PLLA/DA z udziałem różnej ilości DA (0,5–3,0 % mas.). Na podstawie oznaczanych: temperatury początku krystalizacji oraz entalpii topnienia w procesie nieizotermicznej krystalizacji otrzymywanych kompozytów stwierdzono wyjątkowy nukleujący i przyspieszający krystalizację PLLA wpływ dodatku DA. Zwiększenie końcowej temperatury topnienia do wartości z przedziału 180–220 °C poprawiło zdolność PLLA do krystalizacji. Metodą pomiarów DSC wykonanych w różnych warunkach wykazano, że temperatura krystalizacji, czas krystalizacji, jej szybkość oraz zawartość dodatku DA w kompozycie wpływa na przebieg procesu jego topnienia. Na podstawie badań TGA stwierdzono, że wszystkie otrzymane próbki PLLA/DA wykazują większą odporność termiczną niż czysty PLLA – ulegają rozkładowi termicznemu w wyższej temperaturze, co prawdopodobnie wynika zsilniejszych oddziaływań pomiędzy makrocząsteczkami PLLA i DA.
Źródło:
Polimery; 2016, 61, 11-12; 773-779
0032-2725
Pojawia się w:
Polimery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in kinesin expression in the CNS of mice with dynein heavy chain 1 mutation
Autorzy:
Kuźma-Kozakiewicz, Magdalena
Kaźmierczak, Beata
Usarek, Ewa
Barańczyk-Kuźma, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1039605.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Dync1h1 mutation
kinesins
Cra1/+ mice
expression
central nervous system
Cra1/SOD1 mice
Opis:
Dysfunction of fast axonal transport, vital for motor neurons, may lead to neurodegeneration. Anterograde transport is mediated by N-kinesins (KIFs), while retrograde transport by dynein 1 and, to a minor extent, by C-kinesins. In our earlier studies we observed changes in expression of N- and C-kinesins (KIF5A, 5C, C2) in G93ASOD1-linked mouse model of motor neuron degeneration. In the present work we analyze the profile of expression of the same kinesins in mice with a dynein 1 heavy chain mutation (Dync1h1, called Cra1), presenting similar clinical symptoms, and in Cra1/SOD1 mice with milder disease progression than SOD1 transgenics. We found significantly higher levels of mRNA for KIF5A and KIF5C but not the KIFC2 in the frontal cortex of symptomatic Cra1/+ mice (aged 365 days) compared to the wild-type controls. No changes in kinesin expression were found in the spinal cord of any age group and only mild changes in the hippocampus. The expression of kinesins in the cerebellum of the presymptomatic and symptomatic mice (aged 140 and 365 days, respectively) was much lower than in age-matched controls. In Cra1/SOD1 mice the changes in KIFs expression were similar or more severe than in the Cra1/+ groups, and they also appeared in the spinal cord. Thus, in mice with the Dync1h1 mutation, which impairs dynein 1-dependent retrograde transport, expression of kinesin mRNA is affected in various structures of the CNS and the changes are similar or milder than in mice with double Dync1h1/hSOD1G93A mutations.
Źródło:
Acta Biochimica Polonica; 2013, 60, 1; 51-55
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-tumor agents: Design, Synthesis, and Biological study of N-Substituted-7-hydroxy-1-azacoumarin-3-carboxamide derivatives as potent cytotoxic agents
Autorzy:
Bakare, Safyah B.
Powiązania:
https://bibliotekanauki.pl/articles/1849341.pdf
Data publikacji:
2021
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
azacoumarin-3-carboxamide
cytotoxicity
1H
13C-NMR
spectraMCF-7
Opis:
Synthesis of ethyl 7-hydroxy-1-azacoumarin-3-carboxylate (3) was developed using ethyl-7-hydroxy coumarin-3-carboxylate and ammonium solution as the key synthons. Condensation of ethyl 7-hydroxy-1-azacoumarin-3-carboxylate with ammonium acetate and aniline to give N-substituted-7-hydroxy-1-azacoumarin-3-carboxamides (7-Hydroxy -1-azacoumarin-3-carboxamide (4) and N-phenyl 7-Hydroxy-1-azacoumarin-3-carboxamide (5)). Bromo derivative (N-phenyl 6, 8-dibromo-7-hydroxy-1-azacoumarin-3-carboxamide (6)) was obtained from halogenation of compound N-phenyl 7-Hydroxy-1-azacoumarin-3-carboxamide (5) with bromine in glacial acetic acid. N-phenyl-2,5-diacetoxy-6, 8-disubstituted-Quinoline-3-carboxamides (N-phenyl 2,7-diacetoxy-Quinoline-3-carboxamide (7) and N-phenyl 2,7-diacetoxy-6,8-dibromo-Quinoline-3-carboxamide (8)) were prepared via the acetylation of compounds 5 and 6 with acetic anhydride. Five compounds 4–8 were evaluated in vitro against more than one human tumor cell lines. Among the selected compounds, 6 showed the best in vitro cytotoxicity against the human cancer cell line; MCF-7 (with IC50 = 10.12 μM). In addition, cell cycle analysis of compound 6 demonstrated cell cycle arrest at G2/M phase and Pre-G1 apoptosis.
Źródło:
Polish Journal of Chemical Technology; 2021, 23, 1; 53-59
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detection of acylglycines in urine by 1H and 13C NMR for the diagnosis of inborn metabolic diseases
Autorzy:
Gryff-Keller, Adam
Kraska-Dziadecka, Anna
Kubica, Dominika
Powiązania:
https://bibliotekanauki.pl/articles/1039667.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
13C NMR
urinalysis
inherited metabolic disease
1H NMR
acylglycine
Opis:
A range of inborn metabolic diseases result in abnormal accumulation of acylglycines in body fluids. Therefore, detection of these metabolites is important for diagnostic purposes. 1H and 13C NMR spectroscopies have successfully been applied for both qualitative and quantitative determinations of various acylglycines in urine samples from patients suffering from metabolic diseases connected with excretion of these compounds. Various acylglycines were identified in test urine samples from 15 patients suffering from five different metabolic diseases, providing information which could be crucial for their diagnoses. The paper reports complete 1H and 13C NMR data of 11 acylglycines, which is essential for this type of NMR analysis of body fluids. NMR spectroscopy has been proven effective in determining the presence as well as the levels of acylglycines in urine. The proposed method is rapid, simple and requires minimal sample treatment.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 613-617
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and anticancer evaluation of some coumarin and azacoumarin derivatives
Autorzy:
Bakare, Safyah B.
Powiązania:
https://bibliotekanauki.pl/articles/1849302.pdf
Data publikacji:
2021
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Coumarin
azacoumarin
1H-NMR spectrum
13C-NMR spectrum
anticancer
Opis:
Coumarin and its nitrogen analogue 1-aza coumarin are a class of lactones and lactams, respectively, which are indispensable heterocyclic units to both chemists and biochemists. 1-Aza coumarin derivatives, which ultimately metabolize as the corresponding 8-hydroxy coumarins in the biological system are therefore found to be very good anti-inflammatory, anti-cancer, and analgesic agents. A series of hybrid substituted coumarin and azacoumarin-3-carboxylic acid derivatives (8-methoxycoumarin-3-carboxylic acid (4a), 8-methoxyazacoumarin-3-carboxylic acid (4b), 5-bromo-8-methoxycoumarin-3-carboxylic acid (5a), 5-bromo-8-methoxyazacoumarin-3-carboxylic acid (5b), 2-acetoxy-5-bromo-8-methoxyquinoline-3-carboxylic acid (6), and 5,7-di(phenylazo)-8-methoxycoumarin-3-carboxylic acid (7) were synthesized and structurally proved using spectral and elemental analysis data. Substituted coumarin-3-carboxylic acid (4a and 5a) and Substituted azacoumarin-3-carboxylic acid (4b, 5b and 6) were tested for their in vitro cytotoxic activity against MCF-7 and HepG-2 cell lines.
Źródło:
Polish Journal of Chemical Technology; 2021, 23, 2; 27-34
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modifying the structure of certain steel grades by low-temperature glow discharge assisted nitriding
Kształtowanie struktury wybranych gatunków stali w procesie niskotemperaturowego azotowania jarzeniowego
Autorzy:
Trojanowski, J.
Sitek, R.
Wierzchoń, T.
Powiązania:
https://bibliotekanauki.pl/articles/256670.pdf
Data publikacji:
2006
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Technologii Eksploatacji - Państwowy Instytut Badawczy
Tematy:
wyładowanie jarzeniowe
stal 1H18N9T
stal WCL
warstwa azotowana
glow discharge
steel 1H18N9T
steel WCL
nitriding layer
Opis:
The paper presents the results of studies on the glow discharge assisted nitriding of selected grades of steel (1H18N9T corresponding to EN X6CrNi18-10, and WCL corresponding to EN X37CrMoV51), using the conventional glow discharge nitriding method (the treated parts function as the cathode) and nitriding in the so-called potential of glow discharge plasma. The structure, surface topography, microhardness, phase composition, chemical composition and the residual stress state of the nitrided layers thus produced were examined. The glow discharge nitriding was tested in treating various constructional parts.
W artykule przedstawiono wyniki badań procesów azotowania jarzeniowego wybranych gatunków stali (1H18N9T odpowiednik EN X6CrNi18-10, WCL odpowiednik EN X37CrMoV51) metodą konwencjonalną (obrabiane detale jako katoda) oraz azotowanych na tzw. potencjale plazmy wyładowania jarzeniowego. Omówiono wyniki badań, struktury, topografii powierzchni, pomiary mikrotwardości, skład fazowy i chemiczny wytworzonych warstw azotowanych oraz stan naprężeń własnych. Proces azotowania jarzeniowego w obszarze plazmy zastosowano do obróbki konstrukcyjnych wyrobów.
Źródło:
Problemy Eksploatacji; 2006, 4; 197-204
1232-9312
Pojawia się w:
Problemy Eksploatacji
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy
Autorzy:
Bal, Dominika
Kraska-Dziadecka, Anna
Gradowska, Wanda
Gryff-Keller, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1040823.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
urine
13C NMR
inherited metabolic disease
1H NMR
marker metabolite
Opis:
High-resolution 1H NMR spectroscopy of body fluids has proved to be very useful in diagnostics of inherited metabolic diseases, whereas 13C NMR remains almost unexploited. In this paper the application of 13C NMR spectroscopy of fivefold concentrated urine samples for diagnosis of selected metabolic diseases is reported. Various marker metabolites were identified in test urine samples from 33 patients suffering from 10 different diseases, providing information which could be crucial for their diagnoses. Spectra were accumulated for 2 h or overnight when using spectrometers operating at 9.4 or 4.7 T magnetic fields, respectively. Interpretation of the measurement results was based on a comparison of the peak positions in the measured spectrum with reference data. The paper contains a table with 13C NMR chemical shifts of 73 standard compounds. The method can be applied individually or as an auxiliary technique to 1H NMR or any other analytical method.
Źródło:
Acta Biochimica Polonica; 2008, 55, 1; 107-118
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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