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Tytuł:
Current Perspective About the Effect of a Ketogenic Diet on Oxidative Stress – a Review
Autorzy:
Drabińska, Natalia
Powiązania:
https://bibliotekanauki.pl/articles/28408453.pdf
Data publikacji:
2024-03-07
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
ketogenic diet
oxidative stress
antioxidant
oxidation
lipids
Opis:
Oxidative stress (OS) plays a pivotal role in the development of many diseases. Therefore, many efforts have been undertaken to minimize the consequences of OS or improve antioxidant defence systems. One solution expected to improve redox homeostasis is the ketogenic diet (KD). KD is a low-carbohydrate, high-fat diet leading to a ketosis state. The shift in metabolism occurring in ketosis can affect the reactive oxygen species (ROS)-producing pathways and influence the expression of enzymes involved in redox homeostasis. Therefore, this review summarizes and discusses existing knowledge about KD and ROS homeostasis. The available tools for evaluating OS status are presented, listing their potential and drawbacks. An important aspect is the summary of the current knowledge about the effect of KD on OS conducted in vitro, in vivo, and in clinical trials. Finally, the review addresses future studies needed to understand the connection between KD and OS.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2024, 74, 1; 92-105
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inference of oxidative stress in patients with hypothyroidism
Autorzy:
Rada, Feryal
Powiązania:
https://bibliotekanauki.pl/articles/40555549.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
glutathione
hypothyroidism
malondialdehyde
oxidative stress
paraoxonase-1
Opis:
Introduction and aim. Oxidative stress is one of the complications that accompany defects in thyroid hormone levels. This study was designed to evaluate oxidative stress markers in patients with hypothyroidism. Material and methods. This case control study was comprised of forty-two hypothyroid patients aged 36–46 years and forty age matched (35–43 years) healthy control participants randomly selected from the Endocrine Clinic of Al-Yarmook Hospital in Iraq. Blood levels of thyroid hormones malondialdehyde, glutathione, and paraoxonase-1 were assessed. Body mass index was calculated for each patient and control participant. Results. Regarding the data of oxidative stress markers in hypothyroid patients compared to controls, a significant elevation was reported in blood levels of malondialdehyde and a significant reduction was found in blood levels of glutathione (p=0.031). On the other hand, the blood levels of paraoxonase-1 were significantly different in hypothyroid patients compared with the control. Conclusion. Elevated blood levels of malondialdehyde and declined blood levels of glutathione in hypothyroid patients are a signal of oxidative stress and consequently increase the risk of cardiovascular complications.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 270-274
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Identification and characterisation of mitochondrial proteins isolated from rabbit epididymal spermatozoa – a preliminary study
Autorzy:
Lecewicz, M.
Kordan, W.
Górski, K.
Kondracki, S.
Powiązania:
https://bibliotekanauki.pl/articles/16648003.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
spermatozoa
mitochondria
oxidative stress
proteins profile
Opis:
This is the first study to identify 23 protein spots corresponding to 13 proteins in mitochondria isolated from rabbit epididymal spermatozoa. In the group of protein spots identified in stress-induced samples, the abundance of 20 protein spots increased, whereas the abundance of three protein spots (GSTM3, CUNH9orf172, ODF1) decreased relative to the control. The results of this study provide valuable inputs for future research into the molecular mechanisms implicated in pathological processes during oxidative stress (OS).
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 2; 311-314
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction
Autorzy:
Omon, Emmanuel Akokhamen
Ajay, Olawale David
Powiązania:
https://bibliotekanauki.pl/articles/29520465.pdf
Data publikacji:
2023-12-31
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
antioxidants
dysfunction
malondialdehyde
oxidative stress
thyroid hormone
Opis:
Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 4; 768-775
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
p-Coumaric acid as a potent additive in blood storage solution
Autorzy:
Rajanand, Magdaline Christina
Hsieh, Carl
Pallavi, Masannagari
Nayak, Ashabaree
John, Maria Shilpa
Malik, Shivangi
Vempati, Vaishnavi
Thacker, Yasmin
Rajashekaraiah, Vani
Powiązania:
https://bibliotekanauki.pl/articles/25102377.pdf
Data publikacji:
2023-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
blood storage
oxidative stress
p-coumaric acid
antioxidants
Opis:
Introduction and aim. Stored erythrocytes develop lesions involving changes in their structure and function reducing their efficacy. Oxidative Stress (OS) being one of the main causes of storage lesion, can be attenuated by antioxidants as additives in the storage solution. This study aims to evaluate the effect of p-Coumaric acid (CA) on erythrocytes during whole blood storage. Material and methods. Blood collected from Male Wistar rats was stored at 4°C in CPDA-1 solution for 21 days. Blood samples were stored with and without 1mM CA (CA 1) and 10 mM CA (CA 10). The erythrocytes were isolated every week during storage and the biomarkers for OS and antioxidant status were analysed. Results. Superoxide dismutase and catalase elevated on day 14. Conjugate dienes decreased in CA 10 on day 14. Thiobarbituric acid reactive substances increased on day 7 and decreased on day 14 in CA groups. Protein sulfhydryls decreased in controls and CA 1 on day 14 whereas, it was maintained in CA 10. Conclusion. Coumaric acid upregulated the antioxidant enzymes and protected the cells from oxidative damage. Thus, coumaric acid can be employed as a potent additive during storage and opens new avenues of employing it in similar OS situations in erythrocytes
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 2; 298-304
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rola stresu oksydacyjnego w cukrzycy ciążowej
The role of oxidative stress in gestational diabetes
Autorzy:
Stopińska, Kamila
Marzec, Adrianna
Powiązania:
https://bibliotekanauki.pl/articles/2170102.pdf
Data publikacji:
2023-02-21
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
stres oksydacyjny
reaktywne formy tlenu
cukrzyca ciążowa
oxidative stress
reactive oxygen species
gestational diabetes mellitus
Opis:
Cukrzyca ciążowa (gestational diabetes mellitus – GDM) jest jedną z najczęstszych chorób prowadzących do powikłań w trakcie ciąży. Zauważono, że GDM towarzyszy nasilenie stresu oksydacyjnego. Celem niniejszej pracy jest podsumowanie stanu wiedzy na temat wpływu stresu oksydacyjnego na występowanie i przebieg GDM oraz jej odległe skutki. Przegląd ma także na celu sprawdzenie potencjalnych implikacji klinicznych związanych z GDM. Przeszukano bazy danych takie jak Pubmed, Scopus i Google Scholar. Artykuły wyszukiwano m.in. z użyciem fraz „gestational diabetes mellitus” i „oxidative stress”. Wykazano istotnie wyższy po-ziom stresu oksydacyjnego u kobiet z GDM, zarówno we krwi, jak i w łożysku. Stres oksydacyjny może być ściśle związany z patogenezą GDM. Ze względu na istotną rolę stresu oksydacyjnego w patofizjologii GDM wiele badań skupia się na poszukiwaniu substancji, które mogą zmniejszyć stężenie prooksydantów i zwiększyć udział antyoksydantów, tym samym poprawiając potencjał oksydacyjny. Stres oksydacyjny odgrywa kluczową rolę w patogenezie i patofizjologii GDM. Ponieważ jest to choroba, która może prowadzić do wielu powikłań zarówno u matki, jak i u płodu, jej wczesne wykrycie i skuteczne leczenie wymaga szczególnej uwagi. Ocena możliwości zastosowania parametrów stresu oksydacyjnego jako biomarkerów do wczesnego wykrywania GDM wymaga dalszych szczegółowych badań.
Gestational diabetes mellitus (GDM) is one of the most common diseases that leads to complications during pregnancy. It has been noticed that GDM is accompanied by an increase in oxidative stress. The aim of this study is to summarize the state of knowledge on the influence of oxidative stress on the occurrence and course of gestational diabetes as well as its long-term effects. This review also aims to examine the potential clinical implications of GDM. Databases such as Pubmed, Scopus, and Google Scholar were searched. Articles were searched for using the phrases “gestational diabetes mellitus” and “oxidative stress”. A significantly higher level of oxidative stress was found in women with GDM, both in the blood and in the placenta. Oxidative stress may be closely related to the pathogenesis of GDM. Due to the important role of oxidative stress in the pathophysiology of GDM, many studies have focused on finding substances that can reduce the concentration of prooxidants and increase the proportion of antioxidants, thereby improving the oxidative potential. Oxidative stress plays a key role in the pathogenesis and pathophysiology of GDM. As it is a disease that can lead to a number of complications for both the mother and the fetus, its early detection and effective treatment require special attention. Further detailed research is required to evaluate the possibility of using the parameters of oxidative stress as biomarkers for the early detection of GDM.
Źródło:
Annales Academiae Medicae Silesiensis; 2023, 77, 1; 30-36
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Technika LC-MS/MS jako metoda oznaczania izoprostanów: krótki przegląd literatury
LC-MS/MS as a method for the determination of isoprostanes: a brief review
Autorzy:
Król, Magdalena B.
Brzeźnicki, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/2188852.pdf
Data publikacji:
2023-05-19
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
markery stresu oksydacyjnego
izoprostany
peroksydacja lipidów
zastosowanie izoprostanów
LC-MS/MS
izomery prostaglandyn
oxidative stress markers
isoprostanes
lipid peroxidation
application of isoprostanes
prostaglandin isomers
Opis:
Izoprostany to duża grupa związków, które budową przypominają prostaglandyny. Powstają jako produkty wolnorodnikowej reakcji utleniania wielonienasyconych kwasów tłuszczowych i występują powszechnie we wszystkich tkankach oraz płynach biologicznych ciała w możliwym do oznaczenia stężeniu. Od 2018 r. oznaczanie izoprostanów techniką wysokosprawnej chromatografii cieczowej lub gazowej sprzężonej ze spektrometrią mas jest uznawane za złoty standard wśród oznaczeń markerów stresu oksydacyjnego w kontekście oksydacyjnych uszkodzeń lipidów. Publikacja jest syntetycznym przeglądem najnowszej literatury dotyczącej wykorzystania izoprostanów jako markera peroksydacji lipidów z użyciem techniki wysokosprawnej chromatografii cieczowej sprzężonej z tandemową spektrometrią mas. Przedstawiono w niej wyniki badań wykorzystujące oznaczanie izoprostanów w pracy klinicystów i wskazano potencjał zastosowania tych oznaczeń do monitoringu osób pracujących w narażeniu na szkodliwe substancje oraz ich przydatność w badaniach dotyczących stylu życia. Med. Pr. 2023;74(2)
Isoprostanes are a large group of compounds formed as products of free radical oxidation of polyunsaturated fatty acids, which are isomers of prostaglandin. They are present in all body tissues and biological fluids in quantifiable concentrations. Since 2018, the determination of isoprostanes by chromatographic technique with mass spectrometry is the golden standard of the oxidative stress markers determination in relation to oxidative damage to lipids. The publication is a synthetic review of recently published articles on the use of isoprostanes as a marker of lipid peroxidation determined with the liquid chromatography with tandem mass spectrometry technique. It presents the results of research using isoprostanes as a marker in medicine, in monitoring people working in exposure to harmful substances and in lifestyle research. Med Pr. 2023;74(2)
Źródło:
Medycyna Pracy; 2023, 74, 2; 119-125
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Effect of Combined Action of Types of Lead Nanoparticles and Stearates on Indicators of the Oxidative Stress in the Body of Experimental Animals
Wpływ skojarzonego działania rodzajów nanocząstek ołowiu i stearynianów na wskaźniki stresu oksydacyjnego w organizmach zwierząt doświadczalnych
Autorzy:
Fedoriv, Olha
Melnyk, Nataliia
Kopach, Oleksandra
Powiązania:
https://bibliotekanauki.pl/articles/9269562.pdf
Data publikacji:
2023-06-28
Wydawca:
Akademia Bialska im. Jana Pawła II
Tematy:
lead nanoparticles
potassium stearate
sodium stearate
oxidative stress
water pollution
nanocząstki ołowiu
stearynian potasu
stearynian sodu
stres oksydacyjny
zanieczyszczenie wody
Opis:
Background. The aim of this work was to determine the effect of the combined action of nanoparticles of stearates and lead on the state of lipid peroxidation, antioxidant defense, and the level of circulating immune complexes in experimental rats. Material and methods. Experiments were conducted on four groups of white rats. The first (control) and second groups of animals consumed dechlorinated water from the city water supply. The third and fourth groups of animals consumed water, respectively, with the content of sodium stearate and potassium stearate in a dose of 1/250 LD50. After 40 days of drinking the indicated waters, the animals of the second, third, and fourth groups were orally injected with lead nanoparticles at a dose of 1/250 of the LD50. Results. The combined effect of sodium stearate and lead nanoparticles, potassium stearate, and lead nanoparticles had the character of additive action and potentiation according to most indicators of lipid peroxidation and antioxidant protection. According to the change of the circulating immune complexes indicator in the blood, it had the character of antagonistic action. Conclusions. The studies have shown that, in most indicators of lipid peroxidation and antioxidant system, the combined action of lead nanoparticles and stearates had the character of potentiation.
Wprowadzenie. Celem pracy było określenie wpływu skojarzonego działania nanocząstek stearynianów i ołowiu na stan peroksydacji lipidów, obronę antyoksydacyjną oraz poziom krążących kompleksów immunologicznych u doświadczalnych szczurów. Materiał i metody. Badania przeprowadzono na czterech grupach białych szczurów. Pierwsza (kontrolna) i druga grupa zwierząt spożywały odchlorowaną wodę z wodociągu miejskiego. Trzecia i czwarta grupa zwierząt spożywały wodę, odpowiednio z zawartością stearynianu sodu i stearynianu potasu w dawce wynoszącej 1/250 LD50. Po 40 dniach picia wskazanych wód, zwierzętom z grupy drugiej, trzeciej i czwartej podano doustnie przez wstrzyknięcie nanocząstki ołowiu w dawce odpowiadającej 1/250 LD50. Wyniki. Zgodnie z większością wskaźników peroksydacji lipidów i ochrony antyoksydacyjnej, skojarzone działanie stearynianu sodu i nanocząstek ołowiu, a także stearynianu potasu i nanocząstek ołowiu, miało charakter efektu addytywnego i potęgowania. Zgodnie ze zmianą wskaźnika krążących kompleksów immunologicznych we krwi, miało to charakter działania antagonistycznego. Wnioski. Badania wykazały, że w większości wskaźników peroksydacji lipidów i układu antyoksydacyjnego skojarzone działanie nanocząstek ołowiu i stearynianów miało charakter potencjalizacji.
Źródło:
Health Problems of Civilization; 2023, 17, 2; 137-144
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of luteolin on spermatological parameters, apoptosis, oxidative stress rate in freezing rabbit semen
Autorzy:
Akarsu, S.A.
Acısu, T.C.
Güngör, İ.H.
Çakır Cihangiroğlu, A.
Koca, R.H.
Türk, G.
Sönmez, M.
Gür, S.
Fırat, F.
Esmer Duruel, H.E.
Powiązania:
https://bibliotekanauki.pl/articles/16647483.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
rabbit
semen
cryopreservation
luteolin
oxidative stress
apoptosis
Opis:
The aim of the present study was to determine the effects of Luteolin (LUT) on semen quality, oxidative stress, apoptosis, acrosomal integrity, mitochondrial membrane potential and dead sperm ratio in rabbits. Ejaculates from six New Zealand rabbits were collected, evaluated and pooled. The pooling was divided into five groups as control (no additive) LUT 25 μM, LUT 50 μM, LUT 100 μM and LUT 200 μM and LUT added. It was then filled into a falcon tube with Tris-based extender at a final concentration of approximately 35 x 106 spermatozoa. Diluated rabbit semen samples were drawn into frozen and thawed. Frozen semen straws were thawed at 37°C in 30 seconds. According to our findings, no statistical difference was found between all doses of luteolin and the control group in the CASA (computer assisted sperm analysis) analysis performed at 4°C. However, total motility, progressive motility and rapid sperm percentage were found to be higher in the frozen and thawed rabbit semen at a dose of LUT 50 μM compared to the other groups (p<0.05). While amplitude of lateral head displacement (ALH) and beat cross-frequency (BCF) values were found at the lowest dose of LUT 200 μM, a statistically significant difference was observed between the other groups. When the flow cytometry results were examined, no statistical difference was found between the rate of dead sperm, acrosomal integrity, mitochondrial membrane potential and apoptosis rate. Morever, the H2O2 percentage was found to be lower in all experimental groups compared to the control group (p<0.001). In conclusion, the addition of LUT in long-term storage of rabbit semen provided a protective effect for spermatozoa with its antioxidative properties against damage caused by cryopreservation.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 1; 91-98
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of dietary nitrates and acrylamide intake on systemic redox status in healthy young adults
Autorzy:
Piwowar, Agnieszka
Żurawska-Płaksej, Ewa
Bizoń, Anna
Sawicka, Ewa
Płaczkowska, Sylwia
Prescha, Anna
Powiązania:
https://bibliotekanauki.pl/articles/23370829.pdf
Data publikacji:
2023-12-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
acrylamide
nitrates
oxidative stress
intake with food
nutritional survey
oxidative/antioxidative balance
Opis:
Objectives The nitrogen-containing xenobiotics, such as nitrates and acrylamide may potentially influence systemic redox status and contribute to the generation of oxidative stress (OS) in the human body, but there is still a lack of studies that would evaluate the various parameters assessing the oxidative-antioxidant balance. The aim of this study was to evaluate the exposure to nitrates and acrylamide derived from daily diet and to analyze the impact of these nitrate-containing xenobiotics on the parameters of systemic redox status in healthy young adults. Material and Methods To assess nitrate and acrylamide intake in the study population, a semi-quantitative food frequency questionnaire was used. Systemic redox status was evaluated by measurement of a panel of biochemical parameters: enzymatic (glutathione S-transferase, glutathione reductase, glutathione peroxidase [GPx]) and non-enzymatic (uric acid, bilirubin and albumin), thiol/disulphide homeostasis parameters (total thiol, native thiol, and disulfide) and oxidative/ antioxidant balance indicators (total antioxidant status, total oxidant status, OS index). Results The average consumption of nitrates and acrylamide in the study population was 1.24 mg/kg b.w./day and 0.23 μg/kg b.w./day, respectively, which is within the normal value range. Of 12 measured parameters, significant differences were revealed for disulfide and total thiol levels, which were increased in the subgroup with the highest daily intake of nitrates compared to the subgroup with the lowest intake; for GPx, which was highest in the subgroup of the lowest daily intake of acrylamide; and for native thiols in the subgroup with the highest daily intake. Conclusions The intake of nitrogen-containing xenobiotics within the range considered as normal does not markedly influence redox state parameters in healthy young adults. Some significant changes were revealed only for thiol/disulphide homeostasis parameters, which may be the first line of antioxidant defense, as well as for GPx activity. Compensative mechanisms in healthy young people are efficient enough to neutralize OS induced by slightly increased exposure to nitrogen-containing xenobiotics delivered with food.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2023, 36, 6; 773-787
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of ginger and curcumin on diabetic nephropathy induced by streptozotocin in rats
Autorzy:
Taha, Alaa
Ashour, Hanaa K.
Reffat, Manar
Elkhawaga, Omali Y.
Powiązania:
https://bibliotekanauki.pl/articles/24987713.pdf
Data publikacji:
2023-11-28
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
Oxidative stress
Anti-inflammatory
diabetic nephropathy
Ginger
Cunrcumin
Opis:
Background: Diabetes mellitus is a global health concern affecting 173 million adults annually that requires effective treatment. Medicinal plants such as ginger and curcumin are rich in bioactive compounds that have therapeutic potential. The aim of this study was to evaluate the therapeutic potential of ginger and curcumin extracts in diabetic nephropathy in the rat model. Material and methods: High-performance liquid chromatography was used to examine ginger and curcumin extracts. Fifty male Sprague Dawley rats were divided into five groups: control, untreated diabetic, ginger-treated diabetic, curcumin-treated diabetic and a ginger + curcumin combination group. Diabetes was induced with a single intraperitoneal dose of streptozotocin. Rats received daily oral doses of ginger, curcumin or the combination of both. After sixteen weeks, rats were anesthetized and various tests were conducted to evaluate treatment outcomes. Results: The rats treated with combined ginger and curcumin extracts had superior outcome in terms of more antioxidant activity, better glycemia management and less DN-related kidney damage (reduced albuminuria and less histological changes). Conclusions: Our findings indicate that ginger and curcumin extracts have therapeutic potential in mitigating functional and structural alterations in the kidneys of diabetic rats, possibly due to their anti-diabetic and anti-inflammatory properties.
Źródło:
European Journal of Translational and Clinical Medicine; 2023, 6, 2; 51-65
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association of base excision repair pathway genes OGG1, XRCC1 and MUTYH polymorphisms and the level of 8-oxo-guanine with increased risk of colorectal cancer occurrence
Autorzy:
Kabziński, Jacek
Majsterek, Ireneusz
Powiązania:
https://bibliotekanauki.pl/articles/2152985.pdf
Data publikacji:
2022
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
XRCC1
DNA repair
OGG1
MUTYH
oxidative stress
cancer
Opis:
Objectives Reduced efficiency of DNA repair systems has long been a suspected factor in increasing the risk of cancer. In this work authors investigate influence of selected polymorphisms of DNA repair genes (XRCC1, OGG1 and MUTYH) and level of oxidative damage (measured as level of 8-oxo-guanine, 8-oG) on modulation of the risk of colorectal cancer. Material and Methods In group of 324 patients with colorectal cancer the occurrence of polymorphic variants in Ser326Cys of OGG1, Arg399Gln of XRCC1 and Gln324His of MUTYH were studied with TaqMan technique. In addition level of 8-oG in isolated DNA was determined. Results Studied polymorphisms of OGG1, XRCC1 and MUTYH genes influence the risk of CRC: OGG1 Ser326Cys (OR = 1.259, 95% CI: 1.058–1.499, p = 0.007), XRCC1 Arg399Gln (OR = 2.481, 95% CI: 1.745–3.529, p < 0.0001) and MUTYH Gln324His (OR = 1.421, 95% CI: 1.017–1.984, p = 0.039) increase the risk. At the same time, studies examined level of 8-oG for each of the genotypes in both the patient and control group, and have shown that OGG1 Ser326Cys and XRCC1 Arg399Gln are associated with elevated 8-oG level, while MUTYH Gln324His is not, suggesting, that in case of OGG1 Ser326Cys and XRCC1 Arg399Gln CRC risk modulation is connected to mechanisms associated with 8-oG levels. Conclusions This work shows that patients with CRC not only have an increased level of 8-oG and that the studied polymorphisms modulate risk of cancer, but also indicate a relationship between these 2 phenomena, which may contribute to a better understanding of the mechanism of neoplastic process in case of reduced effectiveness of DNA repair mechanisms.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 5; 625-633
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cell response of Antarctic strain Penicillium griseofulvum against low temperature stress
Autorzy:
Krumova, Ekaterina Ts.
Koeva, Ekaterina K.
Stoitsova, Stoyanka R.
Paunova-Krasteva, Tsvetelina S.
Stoyancheva, Galina D.
Angelova, Maria B.
Powiązania:
https://bibliotekanauki.pl/articles/16538465.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
Antarctic
filamentous fungi
oxidative stress
biomarkers
antioxidant enzymes
Opis:
During the evolution organisms are subjected to the continuous impact of environmental factors. In recent years an increasing number of studies have focused on the physicochemical limits of life on Earth such as temperature, pressure, drought, salt content, pH, heavy metals, etc. Extreme environmental conditions disrupt the most important interactions that support the function and structure of biomolecules. For this reason, organisms inhabiting extreme habitats have recently become of particularly great interest. Although filamentous fungi are an important part of the polar ecosystem, information about their distribution and diversity, as well as their adaptation mechanisms, is insufficient. In the present study, the fungal strain Penicillium griseofulvum isolated from an Antarctic soil sample was used as a study model. The fungal cellular response against short term exposure to low temperature was observed. Our results clearly showed that short-term low temperature exposure caused oxidative stress in fungal cells and resulted in enhanced level of oxidative damaged proteins, accumulation of reserve carbohydrates and increased activity of the antioxidant enzyme defence. Ultrastructural changes in cell morphology were analysed. Different pattern of cell pathology provoked by the application of two stress temperatures was detected. Overall, this study aimed to observe the survival strategy of filamentous fungi in extremely cold habitats, and to acquire new knowledge about the relationship between low temperature and oxidative stress.
Źródło:
Polish Polar Research; 2022, 43, 2; 125-143
0138-0338
2081-8262
Pojawia się w:
Polish Polar Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of pre-treatment with inulin on the kidney in lipopolysaccharide-induced endotoxemia in rats
Autorzy:
Kandil, A.
Powiązania:
https://bibliotekanauki.pl/articles/16539091.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
acute kidney injury
endotoxemia
inulin
oxidative stress
Opis:
This study was aimed to evaluate the effects of inulin used as prebiotic on the kidney in lipopolysaccharide (LPS)-induced endotoxemia model. Wistar Albino rats were divided into four groups: Control group, LPS (endotoxemia) group, Inulin + LPS group in which LPS (1.5 mg/kg, E. coli, Serotype 0111: B4) was treated after inulin (500 mg/kg) given by gavage for 21 days and Inulin group. The animals were sacrificed 24 h after the last LPS injection. Kidney samples were taken for biochemical and immunohistochemical analyses. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), malondialdehyde (MDA) and myeloperoxidase (MPO) values were determined. In addition, kidney sections were stained for inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α and interleukine-6 (IL-6) expression, and leukocyte infiltration. LPS caused oxidative stress and inflammation. Inulin administration could prevent oxidative stress and lipid peroxidation. Moreover, inulin decreased iNOS, TNF-α and IL-6 expression. However, it did not change the distribution of leukocytes in kidney tissues. These results suggest to promising benefits of inulin as prebiotic in reducing the effects of endotoxemia. Further studies should be conducted to evaluate the capacity of prebiotics in endotoxemia.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 1; 103-108
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exogenous seed treatment with proline and its consequences to Norway spruce (Picea abies (L.) H. Karst) seedling establishment
Autorzy:
Kijowska-Oberc, J.
Wawrzyniak, M.K.
Staszak, A.M.
Ratajczak, E.
Powiązania:
https://bibliotekanauki.pl/articles/2130182.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Instytut Dendrologii PAN
Tematy:
proline
seed treatment
Norway spruce
seedlings development
tree seeds
oxidative stress
Opis:
Accumulation of proline is a defense mechanism against external stress conditions, preventing damage to the structure and function of cells and improving plant development processes, such as germination. The purpose of this study was to investigate proline treatment as a means of improving the germination and development of Norway spruce seedlings. The effect of exogenous proline has been studied in three stages of initial plant development. The collected seeds were soaked in water or 8 mM proline solution and placed on the germinators. The germination capacity and the mean germination time were determined. Seedlings with radicles >10 mm were transferred to the sand-peat substrate at a constant temperature of 20 °C. Seedlings at 3 subsequent developmental stages (S1 – germinated seeds with radicles > 3 mm; S2 – seedlings with radicles >10 mm; S3 – established seedlings grown for 90 days) were examined for the oxygen consumption rate, total antioxidant capacity, hydrogen peroxide level, malondialdehyde level and intracellular proline content. Proline treatment was conducive to lowering the levels of hydrogen peroxide and malondialdehyde at stage S1. At the subsequent stages of development, the levels of hydrogen peroxide and malondialdehyde increased, and at the S3 stage, there was also a marked increase in total antioxidant capacity. At stage S3, the seedlings of the proline treatment were characterized by a lower total mass, and the response to exogenous proline was stronger in the root tissues than in the leaves. The oxygen consumption rate was higher for the proline treatment at all stages of development. Seedlings at the analyzed stages of establishment differed in response to proline treatment. Exogenous proline had some beneficial effects during the first phase of germination by reducing the level of hydrogen peroxide and improving the condition of lipid membranes. In the subsequent stages of seedling development, in response to the same concentration of proline solution, undesirable effects, such as an increase in hydrogen peroxide levels and damage to cytoplasmic membranes, were observed. Optimal concentrations of exogenous proline should be determined prior to commercial use of proline treatment to improve plant stress tolerance.
Źródło:
Dendrobiology; 2022, 87; 149-162
1641-1307
Pojawia się w:
Dendrobiology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 295

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