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Wyświetlanie 1-15 z 295
Tytuł:
Elevated CO2 attenuates oxidative stress caused by drought and elevated temperature in four C3 plant species
Autorzy:
Abd Elgawad, H.
Asard, H.
Powiązania:
https://bibliotekanauki.pl/articles/80040.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
oxidative stress
carbon dioxide
reactive oxygen species
plant species
drought stress
lipid peroxidation
hydrogen peroxide
NADPH oxidase
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of liver antioxidant status and mitochondrial membrane composition of Plasmodium berghei-infected mice treated with selected antimalarials
Autorzy:
Adisa, Rahmat
Sulaimon, Lateef
Powiązania:
https://bibliotekanauki.pl/articles/1038594.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Plasmodium berghei
Artecxin
Lonart
P-Alaxin
Chloroquine
oxidative stress
mitochondrial membrane fluidity
Opis:
The present study was aimed at determining and comparing the effects of Artecxin (ART), P - Alaxin (P-ALA), Lonart (LON) and Chloroquine (CQ) on oxidative stress parameters and mitochondrial membrane composition in the course of malaria infection. Six groups of five mice each categorized as healthy control (non-parasitized non-treated group), parasitized-non-treated (PnT), parasitized-chloroquine-treated (positive control), parasitized-Artecxin, -Lonart and -P-Alaxin-treated groups were used for the study. Hepatic antioxidant status was assessed with levels of malondialdehyde (MDA) and reduced glutathione (GSH) as well as activity of superoxide dismutase (SOD) and catalase (CAT) in the post mitochondrial and mitochondrial fractions. Mitochondrial membrane integrity was also evaluated with activity of succinate dehydrogenase and levels of phospholipids, cholesterol and proteins in the liver mitochondria. Results revealed that treatment of parasitized mice with the antimalarial drugs significantly (p<0.05) decreased hepatic malondialdehyde (MDA) and mitochondrial membrane phospholipids compared to parasitized untreated group. On the other hand, significantly (p<0.05) elevated succinate dehydrogenase (SDH) activity, mitochondrial membrane cholesterol level, GSH concentration, catalase (CAT) and superoxide dismutase (SOD) activity in the post mitochondrial fraction were obtained. Thus, antimalarial drugs distort mitochondrial membrane integrity and electron transfer but reduce the malaria-induced oxidative stress on the host.
Źródło:
Acta Biochimica Polonica; 2017, 64, 3; 485-491
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of luteolin on spermatological parameters, apoptosis, oxidative stress rate in freezing rabbit semen
Autorzy:
Akarsu, S.A.
Acısu, T.C.
Güngör, İ.H.
Çakır Cihangiroğlu, A.
Koca, R.H.
Türk, G.
Sönmez, M.
Gür, S.
Fırat, F.
Esmer Duruel, H.E.
Powiązania:
https://bibliotekanauki.pl/articles/16647483.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
rabbit
semen
cryopreservation
luteolin
oxidative stress
apoptosis
Opis:
The aim of the present study was to determine the effects of Luteolin (LUT) on semen quality, oxidative stress, apoptosis, acrosomal integrity, mitochondrial membrane potential and dead sperm ratio in rabbits. Ejaculates from six New Zealand rabbits were collected, evaluated and pooled. The pooling was divided into five groups as control (no additive) LUT 25 μM, LUT 50 μM, LUT 100 μM and LUT 200 μM and LUT added. It was then filled into a falcon tube with Tris-based extender at a final concentration of approximately 35 x 106 spermatozoa. Diluated rabbit semen samples were drawn into frozen and thawed. Frozen semen straws were thawed at 37°C in 30 seconds. According to our findings, no statistical difference was found between all doses of luteolin and the control group in the CASA (computer assisted sperm analysis) analysis performed at 4°C. However, total motility, progressive motility and rapid sperm percentage were found to be higher in the frozen and thawed rabbit semen at a dose of LUT 50 μM compared to the other groups (p<0.05). While amplitude of lateral head displacement (ALH) and beat cross-frequency (BCF) values were found at the lowest dose of LUT 200 μM, a statistically significant difference was observed between the other groups. When the flow cytometry results were examined, no statistical difference was found between the rate of dead sperm, acrosomal integrity, mitochondrial membrane potential and apoptosis rate. Morever, the H2O2 percentage was found to be lower in all experimental groups compared to the control group (p<0.001). In conclusion, the addition of LUT in long-term storage of rabbit semen provided a protective effect for spermatozoa with its antioxidative properties against damage caused by cryopreservation.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 1; 91-98
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DYn-2 is an excellent chemical reporter for the Arabidopsis sulfenome
Autorzy:
Akter, M.
Wahni, K.
Martinez-Acedo, P.
Carroll, K.
van Breusegem, F.
Messens, J.
Powiązania:
https://bibliotekanauki.pl/articles/80760.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
oxidative stress
redox signal
Arabidopsis thaliana
DYn-2 reporter
purification
sulphenome
stress tolerance
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Induction of hemolysis and eryptosis by occupational pollutant nickel chloride is mediated through calcium influx and p38 MAP kinase signaling
Autorzy:
Alfhili, Mohammad A.
Alamri, Hassan S.
Alsughayyir, Jawaher
Basudan, Ahmed M.
Powiązania:
https://bibliotekanauki.pl/articles/2085691.pdf
Data publikacji:
2022-02-15
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
calcium
p38 MAPK
oxidative stress
hemolysis
nickel
eryptosis
Opis:
ObjectivesNickel (Ni) is an abundant environmental hazard and an occupational pollutant. Exposure to Ni compounds is prevalent in electroplating workers and in the printing industry, among others. The toxicity of Ni manifests as dermatological, gastrointestinal, respiratory, allergic, and cardiovascular symptoms. In particular, hyperbilirubinemia and reticulocytosis have been detected in intoxicated subjects; an observation possibly implicating selective red blood cell (RBC) toxicity. Herein, the interaction of nickel chloride (NiCl2) with human RBCs and associated molecular mechanisms are described.Material and MethodsCells from healthy donors were incubated for 24 h at 37°C in the presence or absence of 0.5‒10 mM of NiCl2, and cytotoxicity was determined through hemoglobin leakage by colorimetry under different experimental conditions. Eryptotic markers were also identified by flow cytofluorometry using Annexin-V-FITC tagging for phosphatidylserine (PS) exposure, light scatter properties for cellular dimensions, Fluo4/AM labeling for intracellular calcium, and H2DCFDA staining for reactive oxygen species (ROS). Additionally, small molecule inhibitors were used to probe the signaling pathways involved.ResultsIt was found that NiCl2 at 10 mM caused profound intracellular calcium overload and significant calcium-dependent hemolysis. Also, NiCl2 reduced forward scatter and increased side scatter, Annexin-positive cells, and ROS levels. Importantly, NiCl2-induced hemolysis was significantly attenuated by the exclusion of extracellular calcium, and in the presence of p38 MAP kinase (MAPK) inhibitor SB203580.ConclusionsIt is concluded that NiCl2 induces p38 MAPK-dependent hemolysis, and stimulates the canonical features of premature eryptosis. This report presents the first description of the molecular mechanisms underlying the hemolytic and eryptotic potential of NiCl2 and, thus, may explain changes in hematological parameters observed in poisoning victims.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 1; 1-11
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimers disease
Autorzy:
Aly, Hanan
Metwally, Fateheya
Ahmed, Hanaa
Powiązania:
https://bibliotekanauki.pl/articles/1039841.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
dehydroepiandrosterone
Alzheimer's disease
apoptosis
oxidative stress
Opis:
The current study was undertaken to elucidate a possible neuroprotective role of dehydroepiandrosterone (DHEA) against the development of Alzheimer's disease in experimental rat model. Alzheimer's disease was produced in young female ovariectomized rats by intraperitoneal administration of AlCl3 (4.2 mg/kg body weight) daily for 12 weeks. Half of these animals also received orally DHEA (250 mg/kg body weight, three times weekly) for 18 weeks. Control groups of animals received either DHAE alone, or no DHEA, or were not ovariectomized. After such treatment the animals were analyzed for oxidative stress biomarkers such as hydrogen peroxide, nitric oxide and malondialdehyde, total antioxidant capacity, reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase activities, antiapoptotic marker Bcl-2 and brain derived neurotrophic factor. Also brain cholinergic markers (acetylcholinesterase and acetylcholine) were determined. The results revealed significant increase in oxidative stress parameters associated with significant decrease in the antioxidant enzyme activities in Al-intoxicated ovariectomized rats. Significant depletion in brain Bcl-2 and brain-derived neurotrophic factor levels were also detected. Moreover, significant elevations in brain acetylcholinesterase activity accompanied with significant reduction in acetylcholine level were recorded. Significant amelioration in all investigated parameters was detected as a result of treatment of Al-intoxicated ovariectomized rats with DHEA. These results were confirmed by histological examination of brain sections. These results clearly indicate a neuroprotective effect of DHEA against Alzheimer's disease.
Źródło:
Acta Biochimica Polonica; 2011, 58, 4; 513-520
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Single-electron reduction of quinone and nitroaromatic xenobiotics by recombinant rat neuronal nitric oxide synthase
Autorzy:
Anusevičius, Žilvinas
Nivinskas, Henrikas
Šarlauskas, Jonas
Sari, Marie-Agnes
Boucher, Jean-Luc
Čėnas, Narimantas
Powiązania:
https://bibliotekanauki.pl/articles/1039577.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
antitumour agents
nitroaromatic compounds
electron transfer mechanism
oxidative stress
quinones
Neuronal nitric oxide synthase (nNOS)
Opis:
We examined the kinetics of single-electron reduction of a large number of structurally diverse quinones and nitroaromatic compounds, including a number of antitumour and antiparasitic drugs, and nitroaromatic explosives by recombinant rat neuronal nitric oxide synthase (nNOS, EC 1.14.13.39), aiming to characterize the role of nNOS in the oxidative stress-type cytotoxicity of the above compounds. The steady-state second-order rate constants (kcat/Km) of reduction of the quinones and nitroaromatics varied from 102 M-1s-1 to 106 M-1s-1, and increased with an increase in their single-electron reduction potentials (E17). The presence of Ca2+/calmodulin enhanced the reactivity of nNOS. These reactions were consistent with an 'outer sphere' electron-transfer mechanism, considering the FMNH./FMNH2 couple of nNOS as the most reactive reduced enzyme form. An analysis of the reactions of nNOS within the 'outer sphere' electron-transfer mechanism gave the approximate values of the distance of electron transfer, 0.39-0.47 nm, which are consistent with the crystal structure of the reductase domain of nNOS. On the other hand, at low oxygen concentrations ([O2] = 40-50 μM), nNOS performs a net two-electron reduction of quinones and nitroaromatics. This implies that NOS may in part be responsible for the bioreductive alkylation by two-electron reduced forms of antitumour aziridinyl-substituted quinones under a modest hypoxia.
Źródło:
Acta Biochimica Polonica; 2013, 60, 2; 217-222
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Content of reduced glutathione form as a biomarker of oxidative stress in spinach plants growing in soil contaminated with zinc
Autorzy:
Arasimowicz, M.
Wiśniowska-Kielian, B.
Niemiec, M
Powiązania:
https://bibliotekanauki.pl/articles/124867.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:
environmental stress
glutathione
biomarkers of oxidative stress
soil pollution
zinc
Opis:
The aim of the paper is the assessment of the efficiency of anti-oxidative system in spinach plants growing in the substratum polluted with zinc. The assessment was conducted on the basis of changes of reduced glutathione (GSH) form concentration in the plant aboveground organs. Spinach plants, ‘Matador’ c.v., were cultivated in soils contaminated with zinc in two pot experiments conducted in 2010 and 2011. The experimental substratum was light, slightly soil with granulometric composition of sandy silt loam. Zinc in the acetate form, was supplied to the soil in four doses corresponded to this metal critical concentrations in soil with 0, I, II and III degrees of pollution with this element according to IUNG classification. Simultaneously, the control with natural Zn content in soil was maintained. Zn concentrations in spinach ranged from 412.8 to 1722 mg kg-1 d.m. and increased with growing degree of substratum pollution with this element. Over the course of the vegetation period the content of Zn in plants was generally greater. GSH content in spinach grown in both years of experiments fluctuated from 31.70 to 238 μg g-1 f.m. The biggest content of this compound in spinach was stated in the initial phase of plants growth. The plants tolerated only the first two Zn doses supplied to the substratum. Spinach growing in the objects where zinc additions to the soil equalled II and III degree of substratum pollution died shortly after germination. The plants from these objects in the initial growth phase contained significantly less GSH than spinach from the objects with two first degrees (0 and I) of substratum pollution with zinc or from the control. The content of reduced glutathione form in spinach is a good biomarker of oxidative stress caused by zinc presence in plants. Synthesis of a bigger amount of GSH conditions spinach plant resistance to over the norm zinc content in soil. The efficiency of antioxidative system in spinach is bigger in the initial phase of this plant growth.
Źródło:
Journal of Ecological Engineering; 2014, 15, 1; 61-66
2299-8993
Pojawia się w:
Journal of Ecological Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hydrogen peroxide induced by the fungicide prothioconazole triggers deoxynivalenol (DON) production by Fusarium graminearum.
Autorzy:
Audenaert, Kris
Callewaert, Elien
Höfte, Monica
De Saeger, Sarah
Haesaert, Geert
Powiązania:
https://bibliotekanauki.pl/articles/2199594.pdf
Data publikacji:
2020-06-21
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
fungicide
oxidative stress
deoxynivalenol production
Fusarium graminearum
Opis:
Fusarium head blight is a very important disease of small grain cereals with F. graminearum as one of the most important causal agents. It not only causes reduction in yield and quality but from a human and animal healthcare point of view, it produces mycotoxins such as deoxynivalenol (DON) which can accumulate to toxic levels. Little is known about external triggers influencing DON production. In the present work, a combined in vivo/in vitro approach was used to test the effect of sub lethal fungicide treatments on DON production. Using a dilution series of prothioconazole, azoxystrobin and prothioconazole + fluoxastrobin, we demonstrated that sub lethal doses of prothioconazole coincide with an increase in DON production 48 h after fungicide treatment. In an artificial infection trial using wheat plants, the in vitro results of increased DON levels upon sub lethal prothioconazole application were confirmed illustrating the significance of these results from a practical point of view. In addition, further in vitro experiments revealed a timely hyperinduction of H2O2 production as fast as 4h after amending cultures with prothioconazole. When applying H2O2 directly to germinating conidia, a similar induction of DON-production by F. graminearum was observed. The effect of sub lethal prothioconazole concentrations on DON production completely disappeared when applying catalase together with the fungicide. These cumulative results suggest that H2O2 induced by sub lethal doses of the triazole fungicide prothioconazole acts as a trigger of DON biosynthesis. In a broader framework, this work clearly shows that DON production by the plant pathogen F. graminearum is the result of the interaction of fungal genomics and external environmental triggers.
Źródło:
Plant Breeding and Seed Science; 2011, 63; 3-22
1429-3862
2083-599X
Pojawia się w:
Plant Breeding and Seed Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Does the increased SOD activity reflects drought resistance of barley?
Autorzy:
Baczek-Kwinta, R.
Borek, M.
Koscielniak, J.
Zmuda, K.
Powiązania:
https://bibliotekanauki.pl/articles/80302.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
oxidative stress
barley
drought resistance
superoxide dismutase activity
reactive oxygen species
chlorophyll a
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Thyroid dysfunctions due to lithium treatment in bipolar disorder: changes in oxidative stress, trace elements, and hemorheological parameters
Autorzy:
Bahtiyar, N.
Serinkan Cinemre, F.
Cinemre, H.
Kiziler, A.
Atagun, M.
Gulyasar, T.
Aydemir, B.
Powiązania:
https://bibliotekanauki.pl/articles/1192380.pdf
Data publikacji:
2020
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
bipolar disorder
lithium treatment
thyroid dysfunction
oxidative stress
trace
elements
hemorheology
Opis:
Lithium is one of the most widely used medications for the treatment of bipolar disorder (BD). It also has some side effects on thyroid functions. We aimed to investigate the role of oxidative stress, trace elements, and hemorheological parameters on the pathophysiology of thyroid dysfunctions developed by lithium treatment in patients with BD. Patients with BD were divided into three groups: patients that non-lithium-treated, lithium-treated patients for 4-6 weeks, and lithium-treated patients for 40-68 weeks. Blood samples for analysis were taken before and after the treatment period. After analysis, patients were divided into six groups: non-treatment BD group (Group 1); short-term lithium-treatment group that did not develop thyroid dysfunctions (Group 2); short-term lithium-treatment group that developed hyperthyroidism (Group 3); longterm lithium treatment group that developed hypothyroidism (Group 4), long-term lithium-treatment group that developed hyperthyroidism (Group 5), and long-term lithium-treatment group that did not develop thyroid dysfunctions (Group 6). Plasma and whole blood viscosity levels were significantly increased in Groups 4 and 6 compared to Groups 1, 2, and 3. Hemoglobin levels were lower in Group 4 than in Groups 1, 2, and 5. Fibrinogen values were higher in Groups 4 and 5 than Group 1. Plasma and erythrocyte malondialdehyde levels were higher in Group 4 than In Groups 1, 2, 3, and 5. Also, they were increased in Group 6 in comparison with Groups 2 and 3. Erythrocyte glutathione levels were lower in Groups 4 and 6 than Groups 1, 2, 3 and 5. Plasma protein carbonyls levels were higher in Group 4 than in Group 1, or in Group 5 than in Groups 1, 2, and 3, as well as in Group 6 than Groups 1, and 2. Serum zinc levels were higher in Groups 2, 3 and 6 than in Group1. Serum copper levels increased in Groups 2, 4 and 6 in comparison with Group1. The results of this study indicate that oxidative stress increased with treatment time in lithium-induced thyroid dysfunctions. Also, whole blood viscosity, plasma viscosity, fibrinogen, zinc, and copper levels were affected by lithium treatment and treatment duration induced thyroid dysfunctions.
Źródło:
Journal of Elementology; 2020, 25, 3; 863-878
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress development in the leaves of Amaranthus cruentus L. containing amaranthine under conditions of nighttime low temperatures, soil hypoxia and the combined effects of both stress factors
Autorzy:
Balakhnina, T.
Gins, M.
Fomina, I.
Powiązania:
https://bibliotekanauki.pl/articles/2082639.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Instytut Agrofizyki PAN
Tematy:
Amaranthus cruentus L.
night hypothermia
oxidative stress
peroxide processes
soil flooding
Opis:
The investigation of the effect of night chilling up to 4±2oC, soil flooding at the optimal day and night temperature, and the combined effect of these stress factors on the adaptive potential of Amaranthus cruentus L. cv “Krepysh” containing amaranthine showed that changes in the intensity of the peroxide oxidation of lipids and superoxide dismutase activity, varied in antiphase to each other, both in the control and in experimental plants. Due to night chilling, unlike hypoxia, the content of amaranthine decreased shaply at the beginning of the stress period and then increased and significantly exceeded the control level until the end of the experiment. It has been suggested that lowering the temperature induces amaranthine synthesis, whereas with the development of hypoxic stress due to the reactions of reactive oxygen species neutralization, constitutive amaranthine is used. The suppression of plant growth during periods of hypothermia was more pronounced than it was due to soil hypoxia, this phenomenon may be associated with a decrease in the overall level of metabolism under conditions of hypothermia and is another example of the adaptive reactions of plants. It was found that the negative effects of the combined activity of soil hypothermia and soil hypoxia on plants, were greater than the negative effects of each stressor applied separately.
Źródło:
International Agrophysics; 2019, 33, 4; 511-516
0236-8722
Pojawia się w:
International Agrophysics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of temperature on oxidative stress induced by lead in the leaves of Plantago major L.
Autorzy:
Balakhnina, T.I.
Borkowska, A.
Nosalewicz, M.
Nosalewicz, A.
Wlodarczyk, T.M.
Kosobryukhov, A.A.
Fomina, I.R.
Powiązania:
https://bibliotekanauki.pl/articles/24178.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Instytut Agrofizyki PAN
Tematy:
temperature effect
oxidative stress
lead
heat stress
oxidative destruction
leaf
Plantago major
ascorbate peroxidase
glutathione reductase
Źródło:
International Agrophysics; 2016, 30, 3
0236-8722
Pojawia się w:
International Agrophysics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cadmium acts as a silent killer of liver by inducing oxidative stress and hepatocellular injury and a possible amelioration by vitamin B12 and folic acid in rat model
Autorzy:
Banerjee, A.
Nandi, P.
Bhattacharya, C.
Kabir, Z.
Mukherjee, S.
Maji, B.K.
Powiązania:
https://bibliotekanauki.pl/articles/1918855.pdf
Data publikacji:
2019-08-26
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Cadmium
liver
hepatocellular injury
oxidative stress
Opis:
Purpose: To investigate the involvement of oxidative stress in Cadmium (Cd) induced alteration in the functional status of the liver. And to assess the efficacy of folic acid and vitamin B12 in preventing Cd-induced damage in the same. Materials and methods: The experiment was carried out for four weeks. For the experiment, 25 healthy male adult Wistar albino rats were randomly selected and were divided into five equal groups and treated as control, treated with Cd, supplemented with vitamin B12 and folic acid and in the combination of these two. After 28 days the liver function enzymes and oxidative stress parameters were measured. Results: Cd is the silent killer of the hepatic system through the induction of oxidative stress in male rats. From this investigation, it is evident that the folic acid+vitamin B12 possess significant hepatoprotective and antioxidant activity against Cd-induced hepatotoxicity in the rat model. In addition, results revealed that the folic acid alone and or in combination with vitamin B12 blunted the hepatotoxic effect significantly. Conclusions: Based on results obtained, it can be concluded that folic acid and vitamin B12 offer a protective effect in Cd-induced oxidative stress associated with hepatocellular injury. Folic acid and vitamin B12 can be considered as a potent natural antioxidant which has the capacity to provide protection against Cd-induced oxidative stress in the liver in rats. However, to elucidate the exact mechanism of this modulatory effect and to examine its potential therapeutic effects further studies are essential.
Źródło:
Progress in Health Sciences; 2019, 1; 105-117
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serum and milk concentrations of oxidant and anti-oxidant markers in dairy cows affected with bloody milk
Autorzy:
Bani Ismail, Z.
Abutarbush, S.M.
Al-Qudah, K.
Omoush, F.
Powiązania:
https://bibliotekanauki.pl/articles/2087303.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
dairy cows
oxidative stress
anti-oxidants
dietary supplements
bloody milk
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 3; 341-347
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
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