- Tytuł:
- Selective arylation of phenol proteted propygyl bromide via pd-catalysed Suzuki coupling reaction: synthesis, mechanistic studies by DFT calculations and Their Pharmacological Aspects
- Autorzy:
-
farooq, hira
rasool, nasir
Ansari, Muhammad T.
rizwan, komal
mahmood, tariq
israr, hira
Ayub, Khurshid
rasheed, tahir
Zareen, Seema
Akhtar, muhammad N.
iqbal, sarosh - Powiązania:
- https://bibliotekanauki.pl/articles/895304.pdf
- Data publikacji:
- 2018-08-31
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
biofilm
phenol
DFT
Suzuki coupling
organoboron
Biaryl - Opis:
- Biaryls are the potential source of synthetic drugs. The present study describes the synthesis of a series of functionalized biphenyl derivatives (3a-3g) using Pd-catalyzed Suzuki coupling reaction. The experimental results revealed the facile synthesis of biphenyl derivatives (3a-3g) with notably high yield (80-88 %). Density functional theory (DFT) studies were performed by Gaussian 09 software in order to rationalize the selectivity of coupling at C-Br bond instead of C-Cl bond. In addition of synthesis, the biological activities (biofilm inhibition, hemolytic and anti-thrombolytic) of these novel compounds were investigated. These results exhibited good biofilm inhibition (5.86-65.8 %), hemolytic (1.32-30.1 %) and anti-thrombolytic activities (9.64-42.5 %), indicating the potential use of these compounds for pharmaceutical applications.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 911-919
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł