- Tytuł:
- Retroviral targeting of proliferating endothelial cells
- Autorzy:
-
Gornikiewicz, Alexander
Zommer, Anna
Jakesz, Raimund
Gnant, Michael
Brostjan, Christine - Powiązania:
- https://bibliotekanauki.pl/articles/1041388.pdf
- Data publikacji:
- 2005
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
targeting
endothelial cell
envelope glycoprotein
angiogenin
retrovirus - Opis:
- Tumor growth requires the formation of new blood vessels by endothelial cells. Thus, surface molecules - such as angiogenin receptors - that are selectively expressed on growing endothelium represent an attractive target for directed delivery of compounds to tumor tissue. We attempted to obtain genetically engineered retroviral vectors targeted to the endothelium by inserting the human angiogenin sequence into Moloney murine leukemia virus envelope glycoprotein. Abundant expression of the chimeric protein could be verified. However, while being selective for proliferating human endothelial cells, the recombinant retroviral particles displayed low transduction efficiencies and thus have to be further improved.
- Źródło:
-
Acta Biochimica Polonica; 2005, 52, 3; 731-735
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł