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Tytuł:
The effect of selected environmental Fusarium mycotoxins on the ovaries in the female wild boar (Sus scrofa)
Autorzy:
Zielonka, L.
Gajecka, M.
Zmudzki, J.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/31466.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The contamination of agricultural crops with Fusarium mycotoxins poses one of the greatest problems in food production. Wild boars live in specific habitats and are physiologically sensitive to Fusarium mycotoxins, therefore, they are an interesting model for studies investigating the effects of the discussed toxin, in particular under low-dose exposure. The objective of this study was to determine potential effects of Fusarium mycotoxins ingested with naturally contaminated food on reproductive function based on the proliferation and apoptotic indices of ovarian follicles in female wild boars. The experiment was conducted on 40 wild boars inhabiting north-eastern Poland. The effect of seasonal variations in the quantity and quality of ingested food on the concentrations of Fusarium mycotoxins and their metabolites in the blood of wild boars was analyzed. The observed differences in toxin levels were accompanied by changes in proliferation and apoptotic indices. Proliferation processes were most intense in autumn-winter and were least advanced in winter-spring. The intensity of apoptotic processes was inversely correlated with proliferation.
Źródło:
Polish Journal of Veterinary Sciences; 2015, 18, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effects of dietary deoxynivalenol (DON) on selected blood biochemical and hematological parameters in pre-pubertal gilts
Autorzy:
Zielonka, L.
Gajecka, M.
Tarasiuk, M.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087992.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The aim of this study was to determine whether exposure to low doses of DON leads to changes in serum hematological and biochemical profiles. In the experiment, pre-pubertal gilts (with body weight of up to 25 kg) were administered DON per os at a daily dose of 12 |ig/kg BW (group E, n=18) or a placebo (group C, n=21) over a period of 42 days. Blood for analysis was sampled seven times at weekly intervals. Minor, but statistically significant changes were observed in selected indicators, particularly in weeks 2 and 3 in values of biochemical parameters such AlAT, AspAT, Pin and Fe, and in values of hematological parameters such as RBC, MCV, MCHC, PLT, MPV, WBC, neutrophil, eosinophil, lymphocyte and monocyte counts. In group E, a decreasing trend of the values was observed in most cases, except for RBC, PLT, eosinophil, lymphocyte and monocyte counts. Similar results were obtained in the last two weeks of the experiment. Initially, exposure to DON has a stimulating effect, which is eliminated when adaptive mechanisms are triggered. The results of the study indicate that the intensity of biotransformation processes varies subjected to the body's energy resources.
Źródło:
Polish Journal of Veterinary Sciences; 2015, 18, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multi-mycotoxicosis
Autorzy:
Gajęcki, M.
Zielonka, Ł.
Obremski, K.
Jakimiuk, E.
Gajęcka, M.
Powiązania:
https://bibliotekanauki.pl/articles/363270.pdf
Data publikacji:
2007
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:
antagonizm
pasza
mykotoksyna
synergizm
antagonism
feed materials
mycotoxicosis
synergism
Opis:
Contamination of food and feeds with mycotoxins is a major problem of human and animal's health concern, and it is also extremely detrimental to economy. Mycotoxin-producing moulds may produce the most known mycotoxins, such as aflatoxins, ochratoxin, trichothecenes, zearalenone and fumonisin. Although toxicological, environmental and epidemiological studies have addressed the problem of these toxins one by one, more than one mycotoxin is found usually in the same contaminated commodities. That raises the incommensurable problem of multi-mycotoxicosis in which the respective metabolites are also involved. These mycotoxins bear potential toxicity leading to acute and chronic effects in humans and animals, depending on species. The mechanisms that lead to toxic effects, such as immune toxicity and carcinogenicity, are complex. The risk assessment for humans potentially exposed to multi-mycotoxins suffers very much from the lack of adequate food consumption data. Furthermore, for a given mycotoxin additive, synergism and antagonism with other mycotoxins found in the same food commodities are usually not taken into account.
Źródło:
Environmental Biotechnology; 2007, 3, 1; 25-29
1734-4964
Pojawia się w:
Environmental Biotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical evaluation of apoptosis and proliferation in the mucous membrane of selected uterine regions in pre - pubertal bitches exposed to low doses of zearalenone
Autorzy:
Stopa, E.
Babinska, I.
Zielonka, L.
Gajecki, M.
Gajecka, M.
Powiązania:
https://bibliotekanauki.pl/articles/30158.pdf
Data publikacji:
2016
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Mycotoxins are toxic secondary metabolites produced by fungi. Those biologically active compounds occur naturally and they include zearalenone (ZEN), a mycotoxin that contaminates plant material, including the ingredients used in the production of commercial dog food. The influence of monotonic, low-dose and long-term exposure to ZEN on pre-pubertal bitches has not been fully explored to date. This paper describes a 42-day experiment performed on clinically healthy female dogs aged approximately 70 days, with estimated body weight of 8 kg. The animals were randomly divided into two experimental groups (EI and EII) and a control group (C) of 10 animals each. Group EI received 50 μg ZEN/kg (of body weight) per os, group EII received 75 μg ZEN/kg BW per os, and the control group was administered placebo. The bitches were ovariohysterectomized at the end of the experiment (at around 112 days of age), and selected sections of the uterine wall were subjected to immunohistochemical analyses (TUNEL and PCNA). A shift towards higher apoptotic (AI) and proliferative index (PI) was observed, in particular in group EI. Higher AI and PI values were noted in the epithelium of all uterine regions analysed and in the uterine glands in the uterine horn proximal to the body of the uterus.
Źródło:
Polish Journal of Veterinary Sciences; 2016, 19, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of exogenous proteases on selected hematological and serum biochemical parameters in boars
Autorzy:
Zielonka, L
Przewoski, W.
Gajecka, M.
Jakimiuk, E.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/32369.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
boar
farm animal
pig
enzymatic complex
enzymatic growth promoter
hematological parameter
serum
biochemical parameter
proteolytic enzyme
physiological norm
nitrogen metabolism
Opis:
The increasing interest in enzymatic growth promoters prompted this investigation of the effect of an enzymatic stimulating complex on selected hematological and serum biochemical parameters in boars. The enzymatic complex [five proteases (proteinases-endopeptidases) and two peptidases (exopeptidases) obtained by fermentation from Streptomyces fradiae] was added to diets for three months, at initial doses of 90 (group El) and 120 (group E2) g/ton feed for the first seven days followed by 40 and 60 g/ton, respectively, in the subsequent weeks. The evaluation was based on selected hematological (RBC, WBC, HCT (Ht), HGB (Hb), MCV, MCH, and MCHC) and biochemical (AST, ALT, AP, Ca, Mg, urea, cholesterol, creatinine, inorganic phosphorus, and oxyglucose) parameters determined before and after the experimental period. The reported values were within physiological norms. Statistical differences were found between experimental groups with respect to WBC, HCT (Ht), MCV, MCH, AP, Ca, Mg, creatinine, and inorganic phosphorus. The study results indicate that the complex of proteolytic enzymes administered to boars caused no negative changes in their metabolic profiles. The statistically different hematological and serum biochemical parameters, while within normal limits, point to an early stage of microcytic anemia and heightened agitation that could be the result of intensified nitrogen metabolism.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 1; 151-156
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of deoxynivalenol on the levels of toll-like receptors 2 and 9 and their mRNA expression in enterocytes in the porcine large intestine: a preliminary study
Autorzy:
Dabrowski, M.
Jakimiuk, E.
Gajecka, M.
Gajecki, M.T.
Zielonka, L.
Powiązania:
https://bibliotekanauki.pl/articles/32154.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
Deoxynivalenol (DON), one of the most prevalent mycotoxins in the world, and is capable of inducing immune disorders in humans and animals. The aim of this study was to determine the effect of feed contaminated with DON on the number of TLR2- and TLR9-positive cells and their mRNA expression in the porcine large intestine. The experiment was conducted on two equal groups of pigs (n=4). The experimental group (E) was administered feed contaminated with DON (1008 μg/kg of feed) for 6 weeks, and the control group (C) was administered non-contaminated feed over the same period of time. A decrease in the expression of TLR2 mRNA was noted in the cecum. The percentage of TLR9-positive enterocytes increased in the ascending colon and decreased in the cecum. The results of this study indicate that DON can modify the local immune response by changing the expression of TLRs.
Źródło:
Polish Journal of Veterinary Sciences; 2017, 20, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cecal enzyme activity in gilts following experimentally induced Fusarium mycotoxicosis
Autorzy:
Slizewska, K.
Nowak, A.
Piotrowska, M.
Zakowska, Z.
Gajecka, M.
Zielonka, L.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087975.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The objective of the presented study was to examine the influence of Fusarium mycotoxins (zearalenone - ZEN and deoxynivalenol - DON), administered separately and in combination, on the activity of cecal enzymes (ß-glucosidase and ß-glucuronidase) in gilts which were fed fodder contaminated with these mycotoxins. The activity of ß-glucosidase and ß-glucuronidase varied in the range of 0.170-1.236 μmol • h-1 • mg-1 and 8.701-96.704 μmol • h-1 • mg-1, respectively. In the first two weeks, the toxins had no significant effect on the activity of ß-glucosidase and ß-glucuronidase in the ascending and descending colon. After week 3 and later on, ZEN and DON administered as a mixture led to the highest increase in the activity of both enzymes. Administered separately, DON affected the activity of enzymes more than ZEN. From the third week of the experiment, an increase in the activity of CW ß-glucosidase and ß-glucuronidase was observed.
Źródło:
Polish Journal of Veterinary Sciences; 2015, 18, 1
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of T-2 toxin on percentages of CD4plus, CD8plus, CD4plusCD8plus and CD21plus lymphocytes, and mRNA expression levels of selected cytokines in porcine ileal Peyer’s patches
Autorzy:
Obremski, K.
Podlasz, P.
Zmigrodzka, M.
Winnicka, A.
Wozny, M.
Brzuzan, P.
Jakimiuk, E.
Wojtacha, P.
Gajecka, M.
Zielonka, L.
Gajecki, M.
Powiązania:
https://bibliotekanauki.pl/articles/30985.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Opis:
The immune system is one of the main toxicity targets of the T-2 toxin. In view of scant research data demonstrating the effect of T-2 on cellular and humoral responses in gut-associated lymphoid tissue (GALT), this study set out to investigate the effects of chronic exposure to low doses of the T-2 toxin (200 μg T-2 toxin kg⁻¹ feed) on percentages of CD4⁺ and CD8⁺ T lymphocytes, CD4⁺/CD8⁺ double-positive T lymphocytes, CD21⁺ B cells, and IL-2, IFN-γ, IL-4 and IL-10 mRNA expression levels in porcine ileal Peyer’s patches. The investigated material comprised ileum sections sampled from piglets (aged 8-10 weeks, body weight of 15-18 kg) on days 14, 28 and 42 of the experiment. After 42 days of exposure to T-2, a significant drop in the quantity of the IL-10 product was observed (R=0.94; S.E. 0.49-0.79; p<0.001). A gradual decrease in the amount of IL-4 and IFN-γ cytokine transcripts was found throughout the experiment, but the reported trend was not significant. On experimental days 14 and 42, a significant increase in the percentage of CD8⁺ T lymphocytes was observed in comparison with the control (p=0.04 and p=0.05, respectively), whereas on day 28, a significant decrease in the percentage of the above subpopulation was noted (p=0.00). The percentage of CD21⁺ B cells in the experimental group decreased steadily in comparison with the control, and the observed drop was significant on days 28 and 42 (p=0.06 and p=0.00, respectively). On days 14 and 28, the percentages of CD4⁺ and CD8⁺ T lymphocytes were lower in the experimental animals than in the control group, and the drop reported on day 28 was statistically significant (p=0.03).
Źródło:
Polish Journal of Veterinary Sciences; 2013, 16, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dynamic loads exerted on legs of seated passengers during frontal collision of a bus with an obstacle
Autorzy:
Prochowski, L.
Zielonka, K.
Powiązania:
https://bibliotekanauki.pl/articles/247439.pdf
Data publikacji:
2010
Wydawca:
Instytut Techniczny Wojsk Lotniczych
Tematy:
transport
road transport
security on buses
buses
Opis:
The dynamic loads exerted on legs of seated bus passengers during a frontal traffic collision were studied. Passengers are being displaced as a result o f a bus collision with an obstacle and the nature of such displacement depends on the design of seats and personal protections applied (2- or 3-point safety belt or no belt). The study describes the dynamic loading of thighs as afunction of time and the relationship between the operation of personal protections and leg injuries. Most injuries result from hitting components of seats faced by passengers. The results were recorded using sensors placed in the dummies' thighs and filmed with a Photosonics camera. The video was used for studying the kinematics of the dummies' legs of the dummy secured with a 3-point belt, secured with a 2-point belt and unsecured, including possible combination of extreme forces with a specific type of leg displacement. Knee movement trajectories and consequences of dummy hips rotation on the bus seat were also presented. Problem of rotation of the hips of the dummy secured with a 3-point belt has also direct influence onto the dynamic loads affecting legs. The research demonstrates the existing design of 3-point safety belts is unsuitable for protection of seated passengers and the clearances between seat rows are insufficient. The need for applying new energy-absorbing materials or modification of seat design is obvious.
Źródło:
Journal of KONES; 2010, 17, 3; 377-384
1231-4005
2354-0133
Pojawia się w:
Journal of KONES
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of the risk of double-deck bus rollover at the avoidance of an obstacle (analytical approach and computer simulation)
Analiza zagrożenia przewróceniem się autobusu piętrowego podczas omijania przeszkody (ujęcie analityczne i symulacja komputerowa)
Autorzy:
Prochowski, L.
Zielonka, K.
Powiązania:
https://bibliotekanauki.pl/articles/1366036.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
road traffic safety
double-deck buses
bus rollover
bus driver training
bezpieczeństwo ruchu drogowego
autobusy piętrowe
przewracanie się autobusów (bus rollover)
szkolenie kierowców autobusów
Opis:
When critical traffic situations are analysed, particular attention should be paid to the behaviour of double-deck buses in curvilinear motion. Due to the high location of the centre of mass of such vehicles, even relatively low values of vehicle speed result in a considerable risk of bus rollover under the impact of lateral forces.The paper presents an analytical approach to the bus motion along a road bend and a computer simulation of the process of avoiding an obstacle having suddenly sprung up. At the first stage, the hazards encountered during motion along a curve with constant radius were analysed; the motion along a curvilinear path with dynamically varying radius was explored at the second stage. The analysis of the risk of bus rollover at the avoidance of an obstacle is based on a model of bus motion dynamics with 12 degrees of freedom. The calculations were carried out with the use of a computational program specially built for this purpose where a double-deck bus model and a bus driver model, adapted to the traffic situation analysed, were applied.
Podczas analizy krytycznych sytuacji w ruchu drogowym szczególną uwagę warto skierować na zachowanie się autobusów piętrowych (double deck) w ruchu krzywoliniowym. Pojazdy te, wobec wysoko położonego środka masy, są zagrożone przewróceniem się pod działaniem sił bocznych już przy stosunkowo niskich wartościach prędkości jazdy. W pracy przedstawiono ujęcie analityczne w odniesieniu do ruchu autobusu na łuku drogi oraz symulację komputerową procesu omijania nagle pojawiającej się przeszkody. W pierwszym etapie analizie poddano zagrożenia podczas ruchu krzywoliniowego o stałym promieniu, a w drugim rozważa się ruch krzywoliniowy z dynamicznie zmiennym promieniem. Analiza zagrożenia przewróceniem się podczas gwałtownego omijania przeszkody jest oparta na modelu dynamiki autobusu o 12 stopniach swobody. Obliczenia przeprowadzono przy wykorzystaniu zbudowanego w tym celu programu obliczeniowego, w którym aplikowano model autobusu piętrowego i model kierowcy, dostosowany do analizowanej sytuacji drogowej.
Źródło:
Eksploatacja i Niezawodność; 2014, 16, 4; 507-517
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 21

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