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Wyszukujesz frazę "Zielenkiewicz, Piotr" wg kryterium: Autor

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    Wyświetlanie 1-10 z 10
    Tytuł:
    FEDMA - a simple algorithm for theoretical modeling of linear metabolic pathways: from fuzzy data sets to prediction and experiment.
    Autorzy:
    Pawlowski, Piotr
    Zielenkiewicz, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1041464.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    linear metabolic pathway
    chemical kinetics
    algorithm
    theoretical modeling
    Opis:
    A theoretical model of a chain of irreversible Michaelis-Menten reactions proceeding inside a living cell, taking cell growth, division and subcellular compartmentation into account, was proposed. It became a basis for the construction of a "fuzzy" enzymatic data-modeling algorithm (FEDMA) - a procedure allowing the estimation of missing parameter values for the modeled system, in accordance both with the derived theoretical rules and the available experimental data. The obtained tool was tested to model the heme biosynthesis pathway in Saccharomyces cerevisiae, where about 40% of parameters remain unknown. The missing parameters estimated by means of FEDMA fall in the range of expected values.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 1; 71-86
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Biochemical kinetics in changing volumes.
    Autorzy:
    Pawłowski, Piotr
    Zielenkiewicz, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1043352.pdf
    Data publikacji:
    2004
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    glycolytic oscillations
    chemical kinetics
    cyclin oscillations
    varying volume
    Opis:
    The need of taking into account the change of compartment volume when developing chemical kinetics analysis inside the living cell is discussed. Literature models of a single enzymatic Michaelis-Menten process, glycolytic oscillations, and mitotic cyclin oscillations were tested with appropriate theoretical extension in the direction of volume modification allowance. Linear and exponential type of volume increase regimes were compared. Due to the above, in a growing cell damping of the amplitude, phase shift, and time pattern deformation of the metabolic rhythms considered were detected, depending on the volume change character. The perfomed computer simulations allow us to conclude that evolution of the cell volume can be an essential factor of the chemical kinetics in a growing cell. The phenomenon of additional metabolite oscillations caused by the periodic cell growth and division was theoretically predicted and mathematically described. Also, the hypothesis of the periodized state in the growing cell as the generalization of the steady-state was formulated.
    Źródło:
    Acta Biochimica Polonica; 2004, 51, 1; 231-243
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mammalian DNA methyltransferases
    Autorzy:
    Siedlecki, Pawel
    Zielenkiewicz, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1041231.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    DNA methyltransferases
    DNA methylation
    Opis:
    DNA methylation is an epigenetic process affecting gene expression and chromatin organization. It can heritably silence or activate transcription of genes without any change in their nucleotide sequences, and for a long time was not recognized as an important regulatory mechanism. However, during the recent years it has been shown that improper methylation, especially hypermethylation of promoter regions, is observed in nearly all steps of tumorigenesis. Aberrant methylation is also the cause of several major pathologies including developmental disorders involving chromosome instabilities and mental retardation. A great progress has been made in our understanding of the enzymatic machinery involved in establishing and maintaining methylation patterns. This allowed for the development of new diagnostic tools and epigenetic treatment therapies. The new approaches hold a great potential; several inhibitors of DNA methyltransferases have already shown very promising therapeutic effects.
    Źródło:
    Acta Biochimica Polonica; 2006, 53, 2; 245-256
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Theoretical model explaining the relationship between the molecular mass and the activation energy of the enzyme revealed by a large-scale analysis of bioinformatics data
    Autorzy:
    Pawlowski, Piotr
    Zielenkiewicz, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1039585.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    statistics
    catalysis
    turnover
    enzyme
    molecular mass
    Opis:
    A general dependence of the enzyme catalytic rate on its mass was revealed when a statistical analysis of 17065 records from the EMP database was performed. The estimated activation energy of the catalytic process decreases asymptotically with the enzyme molecular mass increase. The proposed theoretical model postulates the existence of an intermediate complex of the enzyme and the departing product. It allows for the explanation of the discovered mass-energy relationship, as an effect of the global enzyme-product interactions during complex dissociation. Fitted parameters of the model seem to be in agreement with those widely accepted for the van der Waals energy of molecular interactions. Their values also agree with the picture of the hydrogen bonding in the catalytic process and suggest that surface walk can be the favorable way of the product departure.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 2; 239-247
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Energy minimization of globular proteins with solvent effects included. Comparison of empirical solvation energy terms and explicit water treatment
    Autorzy:
    Kierzek, Andrzej
    Zielenkiewicz, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1044926.pdf
    Data publikacji:
    1997
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Źródło:
    Acta Biochimica Polonica; 1997, 44, 3; 549-556
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    MOFOID - not only the protein modeling server.
    Autorzy:
    Szczesny, Pawel
    Wieczorek, Grzegorz
    Zielenkiewicz, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1041488.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    protein structure prediction
    homology modeling
    Opis:
    MOFOID is a new server developed mainly for automated modeling of protein structures by their homology to the structures deposited in the PDB database. Selection of a template and calculation of the alignment is performed with the Smith-Waterman or Needleman-Wunsch algorithms implemented in the EMBOSS package. The final model is built and optimised with programs from the JACKAL package. The wide spectrum of options in the web-based interface and the possibility of uploading user's own alignment make MOFOID a suitable platform for testing new approaches in the alignment building. The server is available at https:// valis.ibb.waw.pl/mofoid/.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 1; 267-269
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mechanisms of plasmid stable maintenance with special focus on plasmid addiction systems.
    Autorzy:
    Zielenkiewicz, Urszula
    Cegłowski, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1044043.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    partition; multimer resolution
    post-segregational killing
    plasmid addiction
    Opis:
    The stable inheritance of bacterial plasmids is achieved by a number of different mechanisms. Among them are resolution of plasmid oligomers into monomers, active plasmid partitioning into dividing cells and selective killing of plasmid-free segregants. A special focus is given to the last mechanism. It involves a stable toxin and an unstable antidote. The antidotes neutralize their cognate toxins or prevent their synthesis. The different decay rates of the toxins and the antidotes underlie molecular mechanisms of toxin activation in plasmid-free cells. By eliminating of plasmid-free cells from the population of plasmid-bearing ones the toxin-antidote couples therefore act as plasmid addiction systems.
    Źródło:
    Acta Biochimica Polonica; 2001, 48, 4; 1003-1023
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mechanizmy stabilnego dziedziczenia plazmidów
    Mechanisms of plasmid stable inheritance
    Autorzy:
    Zielenkiewicz, Urszula
    Cegłowski, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1201666.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Przyrodników im. Kopernika
    Opis:
    The stable inheritance of bacterial plasmids is achieved by a number of different mechanisms. Among them are: resolution of plasmid multimers into monomers, selective killing of plasmid-free segregants and active plasmid partitioning into dividing cells. The first two mechanisms are discussed in this article. The multimer resolution systems (mrs) consist of a site specific recombinase (resolvase) and the defined nucleotide sequence res located on the plasmid. By specific recombination between repeated res sequences the recombinase resolves plasmid oligomers to monomers. This maximizes the number of plasmid units prior to cell division and considerably contributes to stable maintenance of plasmid in bacterial cells. The post-segregational killing systems involve a stable poison and an unstable antidote. The antidotes nautralize their cognate poisons or prevent their synthesis. The different decay rates of the poisons and the antidotes underlie the molecular mechanisms of poison activation in plasmid-free cells. By killing and eliminating plasmid-free cells from the population of plasmidbearing ones the poison-antidote couples act therefore as plasmid addiction systems. While the mrs maximize the random plasmid distribution into the dividing cells addiction systems assure better-than-random plasmid distribution.
    Źródło:
    Kosmos; 2002, 51, 3; 297-304
    0023-4249
    Pojawia się w:
    Kosmos
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Characterization of Bacillus subtilis clones surviving overproduction of Zeta, a pSM19035 plasmid-encoded toxin.
    Autorzy:
    Nowakowska, Beata
    Kern-Zdanowicz, Izabela
    Zielenkiewicz, Urszula
    Cegłowski, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1041467.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    toxin
    Gram positive bacteria
    postsegregational killing
    plasmid stable maintenance
    Opis:
    The postsegregational killing system of pSM19035 plasmid consists of the proteins Zeta and Epsilon, a toxin and an antidote, respectively. Zeta mutants were isolated with the use of Bacillus subtilis strain with the ζ gene under control of an inducible promoter integrated into the chromosome. Results of mutant analysis point to the amino terminal part of the Zeta protein as being responsible for the toxicity.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 1; 99-107
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-10 z 10

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