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Tytuł:
SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death
Autorzy:
Cheng, Yanhao
Dai, Chao
Zhang, Jian
Powiązania:
https://bibliotekanauki.pl/articles/1038661.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
linalool
glioma
apoptotic cell death
SIRT3
SOD2
Opis:
Glioma is the most prevalent type of adult primary brain tumor and chemotherapy of glioma was limited by drug-resistance. Linalool is an acyclic monoterpene alcohol possessing various pharmacological activities. The present study was conducted to evaluate the effect of linalool on glioma cell growth. The effect of linalool on cell viability in U87-MG cells was investigated and the results showed that linalool significantly reduced cell viability in a concentration- and time-dependent manner. In addition, exposure of the cells to linalool resulted in a concentration-dependent increase of TUNEL-stained cells, indicating the occurrence of apoptotic cell death. Linalool decreased mitochondrial oxygen consumption rate, increased the expression of Bax and Bak, reduced the expression of Bcl-2 and Bcl-xl, and increased the activities of caspase 3 and caspase 9, leading to increase of apoptosis. Linalool resulted in a concentration-dependent decrease of SOD activity but had no significant effect on mRNA and protein expression of SOD2. Moreover, linalool resulted in a significant increase of the expression of acetylated SOD2. The mRNA and protein expression of SIRT3 was significantly inhibited by linalool. Immunoblot analysis showed that there was an evident protein/protein interaction between SOD2 and SIRT3 under normal condition. Linalool treatment significantly decreased the interaction between SOD2 and SIRT3. Overexpression of SIRT3 significantly inhibited linalool-induced increase of mitochondrial ROS production and apoptotic cell death, and decrease of cell viability. In summary, the data demonstrated that linalool exhibited inhibitory effect on glioma cells through regulation of SIRT3-SOD2-ROS signaling.
Źródło:
Acta Biochimica Polonica; 2017, 64, 2; 343-350
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Radiation Amplification near an Autoionizing State
Autorzy:
Lambropoulos, P.
Zhang, Jian
Van Enk, S. J.
Powiązania:
https://bibliotekanauki.pl/articles/1931394.pdf
Data publikacji:
1994-07
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
32.80.Rm
32.80.Wr
32.70.Jz
Opis:
We present an internally consistent theory of amplification near the minimum of autoionizing states with quantitative application to calcium. We have included a completely specified three-photon pumping and we find certain unusual aspects of the system. We find conditions under which the system remains in a steady state, although being coupled to the continuum. For incoherent pumping we obtain quantitative results for the gain. Our results and their extensions are also discussed in the context of present-day experimental possibilities.
Źródło:
Acta Physica Polonica A; 1994, 86, 1; 61-69
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anonymous traffic classification based on three-dimensional Markov image and deep learning
Autorzy:
Tang, Xin
Li, Huanzhou
Zhang, Jian
Tang, Zhangguo
Wang, Han
Cai, Cheng
Powiązania:
https://bibliotekanauki.pl/articles/27311448.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
anonymous network
traffic classification
three-dimensional Markov image
output self-attention
deep learning
sieć anonimowa
klasyfikacja ruchu
trójwymiarowy obraz Markowa
samouwaga wyjściowa
uczenie głębokie
Opis:
Illegal elements use the characteristics of an anonymous network hidden service mechanism to build a dark network and conduct various illegal activities, which brings a serious challenge to network security. The existing anonymous traffic classification methods suffer from cumbersome feature selection and difficult feature information extraction, resulting in low accuracy of classification. To solve this problem, a classification method based on three-dimensional Markov images and output self-attention convolutional neural network is proposed. This method first divides and cleans anonymous traffic data packets according to sessions, then converts the cleaned traffic data into three-dimensional Markov images according to the transition probability matrix of bytes, and finally inputs the images to the output self-attention convolution neural network to train the model and perform classification. The experimental results show that the classification accuracy and F1-score of the proposed method for Tor, I2P, Freenet, and ZeroNet can exceed 98.5%, and the average classification accuracy and F1-score for 8 kinds of user behaviors of each type of anonymous traffic can reach 93.7%. The proposed method significantly improves the classification effect of anonymous traffic compared with the existing methods.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2023, 71, 4; art. no. e145676
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Simulation of the migration path of the maximum pollutants’ concentration. Case study of the tailing pond, southwest China
Autorzy:
Zhang, Jing
Ma, Yong
Xing, Bing
Zhang, Jian-Min
Ren, Yu-Feng
Liang, Yue
Powiązania:
https://bibliotekanauki.pl/articles/2086910.pdf
Data publikacji:
2022
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
groundwaters
tailing pond
zinc mine
lead mine
ground contaminants
wody gruntowe
staw osadowy
kopalnia cynku
kopalnia ołowiu
zanieczyszczenie gruntu
Opis:
Following China's economic development, lots of tailing deposits have become potential pollution sources, and their leaching would release the trace elements into the natural environment. The leakage rate model and the solute transport models of groundwater are coupled to investigate the effects of the tailing ponds on groundwater. It indicates that the anti-seepage layer is a necessary and important component of the tailing ponds, which could protect the soil or groundwater to be polluted by wastewater. Under three scenarios (scenario A - ideal conditions, scenario B - the worst conditions, and scenario C), the proportions of maximum concentration to source concentration are 1.2, 94.6, and 19.1%, respectively. Under the worst states of anti-seepage layers, the pollution areas after 730, 1800, 3807 and 7300 days were 130 500, 313 200, 523 800, and 729 000 m2, respectively. Compared with Scenario B, the pollution areas of Scenario C after 1800, 3807, and 7300 days were cut by 52.97, 74.55, and 81.73, respectively. Given important anti-seepage layers, the tracking monitor system is necessary and important to discover whether the groundwater was contaminated in time.
Źródło:
Environment Protection Engineering; 2022, 48, 2; 59--72
0324-8828
Pojawia się w:
Environment Protection Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Research on new process for separation of silicon wafers and glass from decommissioned photovoltaic module
Autorzy:
Zhang, Jian wen
Wang, Hai dong
Zhang, Sheng guang
Liang, Han
Guo, Hui
Tao, Si-yao
Powiązania:
https://bibliotekanauki.pl/articles/2175425.pdf
Data publikacji:
2022
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
crystalline silicon photovoltaic modules
decommissioned photovoltaic modules
silicon
solar cell
tempered glass
vibration separation
Opis:
In view of the disadvantages of the existing electrostatic separation process of decommissioned photovoltaic modules, which can only achieve the separation of fine silicon wafers and glass and has high energy consumption, a new process to solve the efficient dry separation of coarse silicon wafers and glass in decommissioned photovoltaic modules is proposed- the vibration separation method. Based on the theoretical analysis of the vibration separation of flaky silicon wafer and polyhedral glass particles, the effects of feed size, feed amount, vibration voltage, vibration frequency, horizontal inclination angle and longitudinal inclination angle on the product indexes of wafer and glass separation were investigated by single factor experiment. The optimal experimental conditions were obtained as follows: feed particle size +0.83mm, feed amount 0.15 t/h, vibration voltage 190 V, vibration frequency 48 Hz, horizontal inclination Angle 8°, longitudinal inclination Angle 3°. Under this optimized condition, the content of metal Si in the obtained silicon wafer product is 84.47%, the recovery rate of is 83.73%, the content of impurity SiO2 is 1.09%, and the content of SiO2 in the obtained glass product is 65.69%, and the recovery rate is 98.95%, the impurity metal Si content is 0.56%. This study provides a research idea for the industrial separation of silicon wafers and glass from decommissioned photovoltaic modules.
Źródło:
Physicochemical Problems of Mineral Processing; 2022, 58, 6; art. no. 151679
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
VSC-HVDC transmission line fault location based on transient characteristics
Autorzy:
Zhang, Yanxia
Bi, Anlu
Wang, Jian
Zhang, Fuhe
Lu, Jingyi
Powiązania:
https://bibliotekanauki.pl/articles/1841298.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
characteristic roots
fault location
identification of fault stages
Prony algorithm
VSC-HVDC
Opis:
Accurate and reliable fault location is necessary for ensuring the safe and reliable operation of the VSC-HVDC transmission system. This paper proposed a single-terminal fault location method based on the fault transient characteristics of the two-terminal VSCH-VDC transmission system. The pole-to-pole transient fault process was divided into three stages, the time-domain expression of the DC current during the diode freewheel stage was used to locate the fault point, and a criterion for judging whether the fault evolves to the diode freewheel stage was proposed. Taking into account the enhancing effect of the opposite system to the fault current, the DC side pole-to-ground fault networkwas equated to a fourth-order circuit model, the relationship of fault distance with the characteristic roots of fault current differential equationwas derived, and the Prony algorithmwas utilized for datafitting to extract characteristic roots to realize fault location. A two-terminal VSC-HVDC transmission system was modelled in PSCAD/EMTDC. The simulation result verifies that the proposed principle can accurately locate the fault point on the VSC-HVDC transmission lines.
Źródło:
Archives of Electrical Engineering; 2021, 70, 2; 381-398
1427-4221
2300-2506
Pojawia się w:
Archives of Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Thermodynamic analysis of hybrid ceramic bearings with metal inner rings
Autorzy:
Sun, Jian
Zhang, Gungxiang
Tian, Junxing
Zhu, Yusheng
Powiązania:
https://bibliotekanauki.pl/articles/27312210.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
hybrid ceramic bearing
silicon nitride
inner ring metal
bearing temperature rise
Opis:
For the sake of exploring the thermodynamic characteristics of hybrid ceramic bearings with metal inner rings in the application process, we established the mathematical model of bearings with metal inner rings based on the thermodynamics of bearings. The heat of the bearings, inner and outer raceway, and the deformation of bearings were calculated by the thermodynamic model. We used the bearing life testing machine to test the bearing load and speed. The consequences indicate that the temperature stability time of a hybrid ceramic bearing with the metal inner ring is about 6 hours after loading, and its temperature is about 1–2◦C higher than that of a metal bearing. Under the condition of a certain speed, the stable temperature of bearing operation improves with the enlargement of the load. Under the condition of a certain load, the bearing temperature also improves with the enlargement of bearing speed. The overall temperature trend of the bearing outer ring is unanimous with the overall temperature value calculated by the model. The maximum error is between 2.2 and 2.4◦C. The thermodynamic analysis of hybrid bearings with metal inner rings is conducive to a better study of the effect of bearing material characteristics on bearing performance.
Źródło:
Archives of Thermodynamics; 2023, 44, 3; 83--98
1231-0956
2083-6023
Pojawia się w:
Archives of Thermodynamics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Subcutaneous administration of infliximab-attenuated silica-induced lung fibrosis
Autorzy:
Zhang, Hua
Sui, Jun-Na
Gao, Lei
Guo, Jian
Powiązania:
https://bibliotekanauki.pl/articles/2162006.pdf
Data publikacji:
2018-07-04
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
infliximab
silicosis
TNF-α
rat model
NF-κB
iNOS
Opis:
Objectives To investigate the influence of the anti-tumor necrosis factor-α infliximab (IFX) in the case of rats with silicosis. Material and Methods Forty-eight Wistar rats were randomly divided into 3 groups. The study group (N = 16) – silicosis was induced by intratracheal instillation of 50 mg silica on day 1, and IFX was subcutaneously administered at a dose of 15 mg/kg of body weight from day 2 to day 6, the vehicle group (N = 16) – silica used as the study group but without IFX, the sham group (N = 16) – 1 ml of saline was intratracheal-used. Eight rats in each group were euthanized on day 7 and on day 14, respectively. Lung tissue sections were stained with hematoxylin and eosin or Masson’s trichromedye. The nuclear factor-κB p65 (NF-κB p65) positioning in the lung tissues were determined by immunohistochemical staining. Levels of tumor necrosis factor α (TNF-α) in rat serum and bronchoalveolar lavage fluid were measured with enzyme linked immunosorbent assay. The inducible nitric oxide synthase (iNOS) mRNA in the lung tissues was measured by quantitative real-time polymerase chain reaction, as well as inhibitor protein-κB (I-κB) and NF-κB p65 expression were measured quantitatively by western blotting. Results Silica installation increased the lung tissues inflammation reaction, oxidative stress and pulmonary fibrosis. Infliximab treatment significantly improved silica-induced lung pathological changes (inflammatory cells, collagen deposition), decreased the TNF-α inhibited NF-κB signaling (I-κB, NF-κB p65) as well as oxidant status (iNOS). Conclusions Infliximab may improve silica-induced pulmonary inflammation by decreasing the TNF-α, inhibiting NF-κB signaling (I-κB, NF-κB p65) as well as oxidant status (iNOS), which suggest that IFX has potential role in the treatment of silica-induced lung damage. Int J Occup Med Environ Health 2018;31(4):503–515
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 4; 503-515
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
On the Estimation of Fatigue Crack Initiation Life of H62 Brass
Autorzy:
Zheng, M.
Zhang, S.
Peng, Xiao Jian
Wang, Yi
Powiązania:
https://bibliotekanauki.pl/articles/2048866.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
strain energy density
fatigue damage strain
theoretical strain fatigue limit
fatigue crack initiation
life prediction
Opis:
In the present paper, the excavation of the energetic approach that estimates the fatigue crack initiation life of metal is conducted for H62 brass. The benefit of the energetic approach is the division of the actual applied strain range Δε into two parts, that is, a damage strain range Δεd that induces fatigue damage within the metal, and an undamaged strain range Δεc, which does not produce fatigue damage of the metal and corresponds to theoretical strain fatigue limit. The brightness of this approach is that the undamaged strain range Δεc can be estimated by the fundamental conventional parameters of metal in tensile test. The result indicated that the fatigue crack initiation life of H62 brass can be estimated by this approach successfully.
Źródło:
Archives of Metallurgy and Materials; 2022, 67, 1; 31-35
1733-3490
Pojawia się w:
Archives of Metallurgy and Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An alternating current calibration method for Helmholtz coil constant based on orthogonal calculation principle
Autorzy:
Zhang, Kuankuan
Cao, Mingxing
He, Jian
Gong, Wenjie
Huang, Yunhua
Powiązania:
https://bibliotekanauki.pl/articles/27311758.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
Helmholtz coils constant
alternating current method
induction voltage
orthogonal calculations
Opis:
The Helmholtz coil constant (ℎ) is a crucial standard in magnetic moment measurement devices for permanent magnet materials. To overcome the problem of low accuracy of the direct-current (DC) calibration method, this study used a constant sinusoidal current in the Helmholtz coil and measured the induced voltage of the detection coil with known coil turns and coil area. Subsequently, the ℎ was calculated. The noise signal deduction rate in the induction voltage of the detection coil was greater than 99%, its influence on the induction voltage is less than 0.005%, and the repeatability of the calibration results is 0.003% (1). The results reveal that the alternating current (AC) method and orthogonal calculation (OC) can accurately measure the valid values of the voltage signal under the influence of the spatial stray field during the calibration of ℎ.
Źródło:
Metrology and Measurement Systems; 2023, 30, 3; 549--561
0860-8229
Pojawia się w:
Metrology and Measurement Systems
Dostawca treści:
Biblioteka Nauki
Artykuł
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