Autor: Zagórska-Dziok, Martyna - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Tlenek węgla – trucizna czy potencjalny terapeutyk?
Carbon monoxide – poison or potential therapeutic agent?
Autorzy:: Furman-Toczek, Dominika
Zagórska-Dziok, Martyna
Kruszewski, Marcin
Kapka-Skrzypczak, Lucyna
Powiązania:: https://bibliotekanauki.pl/articles/1035502.pdf
Data publikacji:: 2016
Wydawca:: Instytut Medycyny Wsi
Tematy:: "cytoprotekcja"
"oksygenaza hemowa"
"potencjał terapeutyczny"
"sygnalizacja komórkowa"
"tlenek węgla"
Opis:: Carbon monoxide, a low molecular gaseous mediator with pleiotropic activity, arises as a result of heme degradation in reaction catalyzed by heme oxygenase. There are a variety of scientific reports confirming the participation of carbon monoxide and heme oxygenase in protection against cellular stress. It has been shown that inbiological systems, CO can display anti-inflammatory, anti-proliferative and anti-apoptotic effect. A better understanding of the function of this molecule has led to its use as a potential therapeutic agent in diseases associated with neurological, immune and vascular systems and transplantology. The aim of this study was to present the role of carbon monoxide in modulation of cellular processes, with particular consideration of potential application in pharmacotherapy.
Tlenek węgla (CO), niskocząsteczkowy, gazowy mediator o wielokierunkowej aktywności, powstaje w komórce w reakcji rozpadu cząsteczki hemu na skutek aktywności oksygenazy hemowej. Istnieje wiele doniesień naukowych potwierdzających udział tlenku węgla oraz oksygenazy hemowej w zintegrowanym systemie ochrony przed stresem komórkowym. Wykazano, że w układach biologicznych CO wykazuje działanie przeciwzapalne, anty-proliferacyjne oraz anty-apoptotyczne. Dokładniejsze poznanie funkcji tej cząsteczki doprowadziło do stopniowego wykorzystywania jej, jako potencjalnego terapeutyku w chorobach układu nerwowego, immunologicznego, krwionośnego a także w transplantologii. Celem niniejszej pracy, było przedstawienie roli tlenku węgla w modulacji procesów komórkowych, ze szczególnym uwzględnieniem potencjalnego zastosowania tej cząsteczki w farmakoterapii.
Źródło:: Medycyna Środowiskowa - Environmental Medicine; 2016, 19, 4; 59-69
1505-7054
2084-6312
Pojawia się w:: Medycyna Środowiskowa - Environmental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Encapsulation of genistein in glycidylated G3 polyamidoamine dendrimers enables diffusion of genistein through biological membranes and anti-nematode activity of the encapsulate
Autorzy:: Filipowicz-Rachwał, Aleksandra
Drozdowska, Joanna
Zagórska-Dziok, Martyna
Uram, Łukasz
Wołowiec, Stanisław
Powiązania:: https://bibliotekanauki.pl/articles/40556674.pdf
Data publikacji:: 2024-06-30
Wydawca:: Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:: C. elegans
fibroblast BJ toxicity
genistein
keratinocyte HaCaT toxicity
PAMAM dendrimer
Opis:: Introduction and aim. Poorly soluble isoflavonoid genistein is known as an anti-nematode agent and also it decreases the risk of certain types of cancer. The biological activity of genistein is limited mostly by its low solubility. Therefore many attempts to increase genistein solubility in water were reported. We applied a polyamidoamine dendrimer, modified its surface by glycidylation, and used this macromolecule as a guest for genistein. Material and methods. Polyamidoamine dendrimer 3rd generation was substituted with 64 glycidol residues to obtain a macromolecule host for genistein. The stoichiometry of this host-guest complex was determined. The complex was tested for skin model permeability, toxicity on fibroblast (BJ) and keratinocyte (HaCaT) cell lines in vitro and anthelmintic activity on the Caenorhabditis elegans nematode. Results. The partition coefficient of genistein between octanol and water was determined (KO/W). The 1:1 host-guest complex was isolated and used as drug delivery system for genistein delivery. PAMAM G3 glycidyled dendrimer containing genistein indicated an anthelmintic activity at 50 μM concentration. Conclusion. The solubility of genistein in water increases 640 times in presence of an equimolar concentration of the dendrimer. One molecule of host dendrimer encapsulates 3 molecules of genistein. The encapsulate is an efficient anti-nematode formulation.
Źródło:: European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 292-299
2544-2406
2544-1361
Pojawia się w:: European Journal of Clinical and Experimental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: A review of selected natural phytochemicals in preventing and treating malignant skin neoplasms
Autorzy:: Fruman-Toczek, Dominika
Zagórska-Dziok, Martyna
Dudra-Jastrzębska, Monika
Kruszewski, Marcin
Kapka-Skrzypczak, Lucyna
Powiązania:: https://bibliotekanauki.pl/articles/972368.pdf
Data publikacji:: 2016
Wydawca:: Instytut Medycyny Wsi
Tematy:: nonmelanoma skin cancer
malignant melanoma
phytochemicals
carotenoids
terpenoids
flavonoids
Opis:: Malignant skin neoplasms are one of the most common human malignancies. The incidence of nonmelanoma skin cancers and malignant melanoma is constantly increasing. The current therapies, especially for malignant melanoma, have relatively low success rates. Therefore, there is an urgent need to develop new remedies that are both safe and effective. Natural substances have always been an important source for the discovery of new therapies. In turn, a number of studies have indicated that some phytocheicals could have an anti-tumour effect. In vitro and in vivo testing of malignant skin neoplasm models revealed different anti-tumour actions, including antioxidation, carcinogen inactivation, anti-proliferation, cell cycle arrest, induction of apoptosis, inhibition of angiogenesis, or a combination of them. The aim of this paper is to describe anti-tumour compounds derived from natural sources that might be used in the therapy of malignant skin neoplasm. The phytochemicals discussed below include carotenoids, terpenoids and flavonoids.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2016, 10, 2; 127-130
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Evaluation of clinical effectiveness of Aloe vera - a review
Autorzy:: Zagórska-Dziok, Martyna
Furman-Toczek, Dominika
Dudra-Jastrzębska, Monika
Zygo, Karol
Stanisławek, Andrzej
Kapka-Skrzypczak, Lucyna
Powiązania:: https://bibliotekanauki.pl/articles/972712.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: wound healing
periodontal health
antidiabetic activity
Aloe vera
Opis:: Naturally occurring products have gained popularity in recent decades, especially due to their less adverse effects on human health. Various Aloe species are widespread all over the world. Aloe vera is one of the plants exhibiting multiple benefits and has gained considerable importance in clinical research. Historically, it has been used for a variety of medicinal purposes. It has attracted the attention of many researchers because of its different properties. More than 200 different biologically active substances were found in this plant that contributed to the fact it has been used to treat various types of diseases. The healthy effect of Aloe vera is primarily attributed to the polysaccharides contained in the gel of the leaves. It has been traditionally used to treat various conditions, including psoriasis, sunburn or radiation-related dermatitis, mucositis, oesophagitis or lichen planus. Aloe vera has also found application in wound healing, treatment of burns, protection against skin damage caused by X-ray, intestinal problems, reduction of plaque and gingivitis, regulating the levels of plasma lipoproteins, reduction of blood sugar levels and improving the immune system. Other biological activities of aloe, such as antifungal, antibacterial, antiviral, anti-inflammatory, anticancer and immunomodulatory have also been documented in numerous studies. This review examines the possible applications of Aloe vera in clinical trials.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 1; 86-93
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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