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Wyświetlanie 1-15 z 23
Tytuł:
Chemical Information of Chitosan-Based Complex Extracted from Coincidence Doppler Broadening Spectra
Autorzy:
Cao, Xingzhong
Xia, Rui
Yang, Jing
Zeng, Minfeng
Wang, Baoyi
Yu, Runsheng
Wei, Long
Powiązania:
https://bibliotekanauki.pl/articles/1033908.pdf
Data publikacji:
2017-11
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
78.70.Bj
64.70.km
82.30.Gg
Opis:
In recent years, coincidence Doppler broadening (CDB) of annihilation radiation measurement on polymeric system has been attracting special attention because of its unique elemental sensitivities in comparison to the traditional Doppler broadening measurement. In the present study, chitosan-Fe₃O₄ nanocomposite (CS-Fe₃O₄) and copper-chitosan (Cu-CS) complexes were prepared through a simple casting method from aqueous solution. The inclusion of Fe₃O₄ nanoparticles in the chitosan matrix is confirmed by X-ray diffraction. In order to obtain data about atomic composition of the annihilation site in the CS composites, CDB measurements were carried out. The normalized CDB ratio curve, which is related to the ratio between the momentum density distribution for the studied samples and pure CS, was displayed to illustrate the variation of ion cores of different elements present in the chitosan matrix. Our result confirms a contribution of active group available in chitosan molecules to the features in the high-momentum region of the CDB ratio curve. The findings show that the local chemical environment of the annihilation site in chitosan-based complexes could be estimated by such positron annihilation spectroscopic investigation.
Źródło:
Acta Physica Polonica A; 2017, 132, 5; 1535-1537
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tubular biofilter treatment of isobutanol emissions under various organic loading rates
Autorzy:
Chen, Hong
Peng, Liang
Wei, Yanxiao
Yu, Lie
Jiang, Bo
Wang, Hong
Yu, Guanlong
Zhang, Guijin
Powiązania:
https://bibliotekanauki.pl/articles/207774.pdf
Data publikacji:
2020
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
biofiltration
pollutants removal
volatile compounds
biofiltracja
usuwanie zanieczyszczeń
związki lotne
Opis:
Isobutanol in waste gas streams was treated by a tubular biofilter (TBF) which continuously operated for 364 days under various organic loading rate (OLR) from 11 g·m–3·h–1 to 66 g·m–3·h–1. Results show that within 60 days, the TBF successfully started up even after changing the OLR from 31.3 to 15.6 g·m–3·h–1. The average removal efficiencies (REs) were totally higher than 90% when OLRs ranged from 12.14 to 66.45 g·m–3·h–1. Two distinct performance deterioration periods were observed at days 186–253 and days 280–334, both of which recovered without additional measurement. During these periods, the larvae and adult moth flies, been identified as Psychodinae infested the TBF, greatly affected the TBF performance. When the number of adult Psychodinae decreased, TBF performance recovered. The elimination capacity (EC) was 60.42 g·m–3·h–1 at the inlet OLR of 66.45 g·m–3·h–1, with the critical EC being around 50 g·m–3·h–1. Even under a low gas empty bed residence time of 15 s, the preferable REs and ECs under middle or low OLRs were still obtained by the TBF.
Źródło:
Environment Protection Engineering; 2020, 46, 1; 15-29
0324-8828
Pojawia się w:
Environment Protection Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stigmasterol blocks cartilage degradation in rabbit model of osteoarthritis
Autorzy:
Chen, Wei-Ping
Yu, Chong
Hu, Peng-Fei
Bao, Jia-Peng
Tang, Jing-Li
Wu, Li-Dong
Powiązania:
https://bibliotekanauki.pl/articles/1039645.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
matrix metalloproteinases
stigmasterol
osteoarthritis
Opis:
Stigmasterol has been shown exihbit anti-osteoarthritic properties in vitro studies. However, the in vivo effects of stigmasterol on cartilage are still unclear. This study investigated the anti-osteoarthritic properties of stigmasterol on cartilage degradation in a rabbit model of osteoarthritis (OA). Twenty rabbits underwent bilateral anterior cruciate ligament transection (ACLT) to induce OA. Five rabbits were used as normal control. Two weeks after operation, the rabbits were randomly divided into two groups. Each group of 10 rabbits received intra-articular injection with 0.3 ml of stigmasterol in left knees and vehicle in right knees, once weekly. Group 1 was killed 6 weeks after ACLT and 2 were sacrificed 9 weeks after ACLT. The knee joints were assessed by gross morphology, histology and gene expression analysis. We found that expression of genes encoding matrix metalloproteinases (MMPs) was significantly higher while tissue inhibitors of metalloproteinase (TIMP)-1 was significantly lower in the both joints of the two OA groups compared to normal contrals. Stigmasterol reduced the cartilage degradation as assessed by histological analysis and markedly suppressed MMPs expression both in group 1 and group 2. Our results suggest that stigmasterol may be considered as a possible therapeutical agent in the treatment of OA.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 537-541
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The elastic anisotropic and thermodynamic properties of I4mm-B₃C
Autorzy:
Fan, Qingyang
Wei, Qun
Chai, Changchun
Yang, Yintang
Yu, Xinhai
Liu, Yang
Zheng, Junping
Zhou, Peikun
Zhang, Dongyun
Powiązania:
https://bibliotekanauki.pl/articles/1075538.pdf
Data publikacji:
2016-01
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
71.15.Mb
65.40.De
62.20.de
Opis:
The structural, elastic anisotropy and thermodynamic properties of the I4mm-B₃C are investigated using first-principles calculations and the quasi-harmonic Debye model. The calculated elastic anisotropic suggest that I4mm-B₃C is elastically anisotropic with its Poisson ratio, shear modulus, the Young modulus, the universal anisotropic index, shear anisotropic factors, and the percentage of elastic anisotropy for bulk modulus and shear modulus. The quasi-harmonic Debye model, using a set of total energy versus molar volume obtained with the first-principles calculations, is applied to the study of the thermal and vibrational effects. The thermal expansions, heat capacities, the Grüneisen parameters and the Debye temperatures dependence on the temperature and pressure are obtained in the whole pressure range from 0 to 90 GPa and temperature range from 0 to 2000 K.
Źródło:
Acta Physica Polonica A; 2016, 129, 1; 103-107
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Removal of chromium and strontium from aqueous solutions by adsorption on laterite
Autorzy:
He, Yong
Chen, Yong-Gui
Zhang, Ke-Neng
Ye, Wei-Min
Wu, Dong-Yu
Powiązania:
https://bibliotekanauki.pl/articles/204768.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
adsorption
isotherms
chromium
strontium
laterite
Opis:
To investigate the adsorptive properties of a local laterite deposited in Chenzhou, Hunan province, China, the adsorptive properties of the natural laterite were investigated by batch technique in this study. The effects of contact time, pH, ionic strength, temperature, and the concentration on adsorption properties were also analyzed. The obtained experimental results show that the main mineral composition of laterite is kaolinite and montmorillonite. The adsorption process achieved equilibrium within 60 minutes and 90 minutes for Sr(II) and Cr(VI), respectively. The adsorption capacities for Cr(VI) and Sr(II) by the laterite were about 7.25 mg·g-1 and 8.35 mg·g-1 under the given experimental conditions, respectively. The equilibrium adsorption data were fitted to the second-order kinetic equation. The adsorption capacity for Sr(II) onto the laterite increased with increasing pH from 3–11 but decreased with increasing ionic strength from 0.001 to 1.0 M NaCl. The Sr(II) adsorption reaction on laterite was endothermic and the process of adsorption was favored at high temperature. Similarly, the adsorption capacity for Cr(VI) onto the laterite increased with increasing pH from 3–11, however, the ionic strength and temperature had an insignificant effect on Cr(VI) adsorption. The adsorption of Cr(VI) and Sr(II) was dominated by ion exchange and surface complexation in this work. Furthermore, the Langmuir and Freundlich adsorption isotherm model was used for the description of the adsorption process. The results suggest that the studied laterite samples can be effectively used for the treatment of contaminated wastewaters.
Źródło:
Archives of Environmental Protection; 2019, 45, 3; 11-20
2083-4772
2083-4810
Pojawia się w:
Archives of Environmental Protection
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Design and test study of a new mixed control method for magnetorheological semi-active suspension based on electromechanical analogy theory
Autorzy:
Jiang, Yu
Wang, Ruochen
Ding, Renkai
Sun, Dong
Liu, Wei
Powiązania:
https://bibliotekanauki.pl/articles/1839706.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:
semi-active suspension
electromechanical analogy
mixed control
hardware-in-the-loop
Opis:
For pursuing high performance, the development of semi-active suspension control tends to be complicated and ignores practicability. A new mixed control method effectively suppressing vibration of the vehicle body in the whole frequency band is proposed based on electromechanical analogy theory. Simulation results show that in comparison with passive suspension, on a long slope bumpy road, the mixed control reduces body acceleration by 21.49% and the maximum amplitude by 22.40%. On a C class road, the mixed control reduces body acceleration by 9.78%. Finally, an ECU hardware-in-the-loop test is conducted, which verifies the effectiveness and feasibility of the new mixed control method.
Źródło:
Journal of Theoretical and Applied Mechanics; 2021, 59, 2; 189-201
1429-2955
Pojawia się w:
Journal of Theoretical and Applied Mechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of pollution accumulation on coating aging of UHV line insulators with different suspension height in coal-ash polluted area
Autorzy:
Lan, Lei
Mu, Lin
Wang, Yu
Yuan, Xiaoqing
Wang, Wei
Li, Zhenghui
Powiązania:
https://bibliotekanauki.pl/articles/140717.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
aging
pollution component
pollution degree
RTV coating
Opis:
Room temperature vulcanized (RTV) silicone rubber is widely used to prevent pollution flashover with its excellent hydrophobicity and hydrophobicity transfer. However, RTV coatings are at the risk of deterioration and failure in heavily polluted operating environment. In this paper, RTV coated insulators with different suspension heights operating in coal ash polluted areas were sampled. Pollution degree, pollution composition and aging degree of coatings were tested. The result shows that the insoluble pollution contains Al(OH)3 filler precipitated from RTV coating, which indicates the aging of the RTV coating. The top surface coating is more affected by ultraviolet and rainwater than the bottom surface resulting in more serious degradation. As the pollution degree of the lower phase insulator is heavier than that of the upper phase insulator, the erosion effect of pollution on the RTV coating is more intense. The fillers and rubber molecules of RTV continuously precipitate into the pollution layer, leading to further aging. Therefore, the overall aging degree of the lower insulator coating is more serious than that of the upper insulator coating.
Źródło:
Archives of Electrical Engineering; 2020, 69, 1; 39-56
1427-4221
2300-2506
Pojawia się w:
Archives of Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study on dynamic response of offshore wind turbine structure under typhoon
Autorzy:
Li, Junlai
Wu, Weiguo
Wei, Yu
Shu, Yu
Lu, Zhiqiang
Lai, Wenbin
Jia, Panpan
Zhao, Cheng
Xie, Yonghe
Powiązania:
https://bibliotekanauki.pl/articles/32891255.pdf
Data publikacji:
2022
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
floating offshore wind turbine
structural dynamic response
typhoon
physical model test
Opis:
Floating offshore wind turbines are easily affected by typhoons in the deep sea, which may cause serious damage to their structure. Therefore, it is necessary to study further the dynamic response of wind turbine structures under typhoons. This paper took the 5MW floating offshore wind turbine developed by the National Renewable Energy Laboratory (NREL) as the research object. Based on the motion theory of platforms in waves, a physical model with a scale ratio of 1:120 was established, and a hydraulic cradle was used to simulate the effect of waves on the turbines. The dynamic response characteristics of offshore wind turbines under typhoons are systematically studied. The research results clarified that the turbine structure is mainly affected by wave loads under typhoons, and its motion response reaches its maximum value under the action of extreme wave loads. The research results of this paper can provide reference value for the design of offshore wind turbine structures under typhoons.
Źródło:
Polish Maritime Research; 2022, 1; 34-42
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Examining the success factors of smart watch : a behavioral perspective on consumers
Badanie czynników sukcesu inteligentnego zegarka : behawioralna perspektywa konsumentów
Autorzy:
Lin, Chih Wei
Yang, Chin-Cheng
Sia, Wei Yeng
Tang, Kai-Yu
Powiązania:
https://bibliotekanauki.pl/articles/404795.pdf
Data publikacji:
2019
Wydawca:
Politechnika Częstochowska
Tematy:
perceived playfulness
compatibility
technology acceptance model
innovation diffusion theory
postrzegana użyteczność
kompatybilność
model akceptacji technologii
teoria dyfuzji innowacji
Opis:
The purpose of this study was to investigate factors influencing consumers’ intention to use Apple Watch by applying Decomposed Theory of Planned Behavior (DTPB). The subject of the study was the Apple Watch users in Taiwan. The researcher used purposive and snowball sampling as the sampling method, a total of 350 surveys were issued, 327 valid surveys were collected and the effective response rate was 93.43%. The collected data were analyzed by confirmatory factor analysis and structural equation model. The results are illustrated as follow. First, the overall behavior model of Apple Watch users constructed by Decomposed Theory of Planned Behavior in this study fitted well. Second, the research model has well explanatory power to wearable device users, which is R² of attitudes, subjective norms and perceived behavioral control on behavior intentions have reached 63%. Third, perceived usefulness and perceived playfulness are the most two important influencing factors on attitudes. Interpersonal influence is the most important influencing factor to subjective norm. The most influencing factor of perceived behavioral control is facilitating condition.
Celem tego badania było zbadanie czynników wpływających na zamiar korzystania przez Apple z zegarka przez zastosowanie dekompozycji teorii planowanego zachowania (DTPB). Przedmiotem badania byli użytkownicy Apple Watch na Tajwanie. Badacz zastosował celowe i śnieżkowe pobieranie próbek jako metodę pobierania próbek, wykonano w sumie 350 badań, zebrano 327 ważnych badań, a efektywny odsetek odpowiedzi wyniósł 93,43%. Zebrane dane przeanalizowano za pomocą potwierdzającej analizy czynnikowej i modelu równań strukturalnych. Wyniki zostały zilustrowane w następujący sposób. Po pierwsze, ogólny model zachowania użytkowników Apple Watch skonstruowany przez Dekomponowaną Teorię Planowanego Zachowania (DTPB) w tym badaniu dobrze skonstruowany. Po drugie, model badawczy wyjaśnia użytkownikom tych urządzeń, subiektywnych norm i postrzeganej kontroli behawioralnej nad zamiarami zachowań osiągnął 63%. Po trzecie, postrzegana użyteczność i postrzegana zabawa to dwa najważniejsze czynniki wpływające na postawy użytkowników.
Źródło:
Polish Journal of Management Studies; 2019, 20, 2; 368-378
2081-7452
Pojawia się w:
Polish Journal of Management Studies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Autoimmune diseases and their various manifestations in the oral cavity – a systematic review
Autorzy:
Lin, Shin-Yi
Huang, Yu-Wei
Błochowiak, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/29519509.pdf
Data publikacji:
2023-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
autoimmune diseases
Behcet’s disease
lichen planus
lupus erythematous
rheumatoid arthritis
Sjögren’s syndrome
Opis:
Introduction and aim. Oral manifestation of the disorder is the leading cause of common initial features of most autoimmune diseases. Therefore, this study aimed to present different oral manifestations of selected autoimmune diseases. Material and methods. We systematically reviewed the etiology, signs and symptoms, oral manifestations, epidemiology, diagnosis, treatment plan, and prognosis. We searched the articles on PubMed, Google Scholar and Web of Science for the following search term: Behcet’s disease, lichen planus, mucous membrane pemphigoid and bullous pemphigoid, pemphigus vulgarisms and paraneoplastic pemphigus, rheumatoid arthritis, Sjögren’s syndrome, IgG4-related disease, systemic lupus erythematous, and granulomatosis with polyangitis. Analysis of the literature. We conducted that the disorder’s oral manifestation causes most autoimmune illnesses’ earliest symptoms. Conclusion. Clinical-pathological is a piece of requisite knowledge for the dentist to recognize and diagnose in the early phase of the symptoms.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 3; 627-638
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A Single-Photon Router in Quantum Fluctuation of Field
Autorzy:
Liu, Li-Wei
Shi, Yu-Qing
Qiong, Chen
Powiązania:
https://bibliotekanauki.pl/articles/1032595.pdf
Data publikacji:
2017-10
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
single-photon quantum router
Bose-Einstein condensate
cavity optomechanical
Opis:
We investigate a single-photon quantum router in quantum fluctuation of fields. The optomechanical system composed of a cigar-shaped Bose-Einstein condensate trapped in an ultrahigh-finesse Fabry-Pérot cavity. We show how an analog of electromagnetically induced transparency in an optomechanical system can be used to produce a switch for a quantum fluctuation field using very low pumping field strength. The numerical results show that the output photon is completely different by turning the pump off and turning the pump on. We also show that the quantum noise sources are very small. This optomechanical system can serve as a single-photon quantum router.
Źródło:
Acta Physica Polonica A; 2017, 132, 4; 1358-1362
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fast bearing fault diagnosis of rolling element using Lévy Moth-Flame optimization algorithm and Naive Bayes
Autorzy:
Sun, Shuang
Przystupa, Krzysztof
Wei, Ming
Yu, Han
Ye, Zhiwei
Kochan, Orest
Powiązania:
https://bibliotekanauki.pl/articles/1841936.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
malfunction diagnostics
naive Bayes
moth-flame optimization algorithm
ensemble empirical mode decomposition
Opis:
Fault diagnosis is part of the maintenance system, which can reduce maintenance costs, increase productivity, and ensure the reliability of the machine system. In the fault diagnosis system, the analysis and extraction of fault signal characteristics are very important, which directly affects the accuracy of fault diagnosis. In the paper, a fast bearing fault diagnosis method based on the ensemble empirical mode decomposition (EEMD), the moth-flame optimization algorithm based on Lévy flight (LMFO) and the naive Bayes (NB) is proposed, which combines traditional pattern recognition methods meta-heuristic search can overcome the difficulty of selecting classifier parameters while solving small sample classification under reasonable time cost. The article uses a typical rolling bearing system to test the actual performance of the method. Meanwhile, in comparison with the known algorithms and methods was also displayed in detail. The results manifest the efficiency and accuracy of signal sparse representation and fault type classification has been enhanced.
Źródło:
Eksploatacja i Niezawodność; 2020, 22, 4; 730-740
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of abnormal vibrations of crude oil efflux pumps using Ansys
Autorzy:
Wang, Tianqi
Xie, Lei
Yu, Hongsheng
Wei, Xiuliang
Dong, Pengmin
Zhao, Tianyi
Powiązania:
https://bibliotekanauki.pl/articles/2200858.pdf
Data publikacji:
2023
Wydawca:
Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:
abnormal vibrations
internal flow field
Ansys
Opis:
In this study, abnormal vibrations of 1 pump fluid in a crude oil efflux station in the Changqing Oilfield was investigated. Kinetic simulation was applied to flow fields in the crude oil efflux pump using Ansys to determine trends of the impeller static pressure, speed, total pressure, wall pressure of the impeller, outlet pressure and pressure on the pump shell and to identify the reasons behind the abnormal vibrations. The results indicated that the axial vibration amplitude of the pump could be reduced from 1.3mm down to 0.68mm if the operation parameters of the external control oil pump were set as 2500-2550r/min and 325-335m3/h, respectively.
Źródło:
Journal of Theoretical and Applied Mechanics; 2023, 61, 1; 23--36
1429-2955
Pojawia się w:
Journal of Theoretical and Applied Mechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vehicle emission computation through microscopic traffic simulation calibrated using genetic algorithm
Autorzy:
Wei, Yun
Yu, Ying
Xu, Lifeng
Huang, Wei
Guo, Jianhua
Wan, Ying
Cao, Jinde
Powiązania:
https://bibliotekanauki.pl/articles/91529.pdf
Data publikacji:
2019
Wydawca:
Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
Tematy:
environment protection
microscopic traffic simulation
genetic algorithm
IVE model
emission evaluation
Opis:
Vehicle emission calculation is critical for evaluating motor vehicle related environmental protection policies. Currently, many studies calculate vehicle emissions from integrating the microscopic traffic simulation model and the vehicle emission model. However, conventionally vehicle emission models are presented as a stand-alone software, requiring a laborious processing of the simulated second-by-second vehicle activity data. This is inefficient, in particular, when multiple runs of vehicle emission calculations are needed. Therefore, an integrated vehicle emission computation system is proposed around a microscopic traffic simulation model. In doing so, the relational database technique is used to store the simulated traffic activity data, and these data are used in emission computation through a built-in emission computation module developed based on the IVE model. In order to ensure the validity of the simulated vehicle activity data, the simulation model is calibrated using the genetic algorithm. The proposed system was implemented for a central urban region of Nanjing city. Hourly vehicle emissions of three types of vehicles were computed using the proposed system for the afternoon peak period, and the results were compared with those computed directly from the IVE software with a trivial difference in the results from the proposed system and the IVE software, indicating the validity of the proposed system. In addition, it was found for the study region that passenger cars are critical for controlling CO, buses are critical for controlling CO and VOC, and trucks are critical for controlling NOx and CO2. Future work is to test the proposed system in more traffic management and control strategies, and more vehicle emission models are to be incorporated in the system.
Źródło:
Journal of Artificial Intelligence and Soft Computing Research; 2019, 9, 1; 67-80
2083-2567
2449-6499
Pojawia się w:
Journal of Artificial Intelligence and Soft Computing Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers
Autorzy:
Wu, Fen
Liu, Jing
Qiu, Yu-Lan
Wang, Wei
Zhu, Shou-Min
Sun, Pin
Miao, Wen-Bin
Li, Yong-Liang
Brandt-Rauf, Paul W.
Xia, Zhao-Lin
Powiązania:
https://bibliotekanauki.pl/articles/2179802.pdf
Data publikacji:
2013-03-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
vinyl chloride monomer
chromosome damage
MGMT
hMLH1
DNA methylation
Opis:
Objective: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM). Materials and Methods: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation-specifi c PCR. Chromosome damage in peripheral blood lymphocytes was measured by the cytokinesis-block micronucleus assay. The subjects were divided into chromosome damaged and non-damaged groups based on the normal reference value of micronuclei frequencies determined for two control groups. Results: MGMT promoter methylation was detectable in 5 out of 49 chromosome damaged subjects, but not in the chromosome non-damaged subjects; there was a signifi cant difference in MGMT methylation between the two groups (p < 0.05). Conclusions: We detected aberrant promoter methylation of MGMT in a small number of chromosome damaged VCM-exposed workers, but not in the chromosome non-damaged subjects. This preliminary observation warrants further investigation in a larger study.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2013, 26, 1; 173-182
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
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