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    Wyświetlanie 1-4 z 4
    Tytuł:
    Myocardial remodeling in rats with metabolic syndrome: role of Rho-kinase mediated insulin resistance
    Autorzy:
    Li, Chuan-Bao
    Li, Xiao-Xing
    Chen, Yu-Guo
    Gao, Hai-Qing
    Bao, Cheng-Mei
    Liu, Xiang-Qun
    Bu, Pei-Li
    Zhang, Juan
    Zhang, Yun
    Ji, Xiao-Ping
    Powiązania:
    https://bibliotekanauki.pl/articles/1039743.pdf
    Data publikacji:
    2012
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Rat
    Metabolism
    Myocardium
    Phosphorylation
    Insulin resistance
    Opis:
    Insulin resistance (IR) plays a critical role in metabolic syndrome (MS). Previous studies have demonstrated that activated ROCK is increased in MS patients. However, the effect of Rho-kinase (ROCK) on IR has not been definitely determined. Thus, the aims of the present study were to determine whether ROCK activation induces IR or affects myocardial structure and function, as well as the possible mechanisms underlying this process. Wistar rats fed high fat, high glucose and high salt diet sewed as model of MS and we used transmission electron microscopy, echocardiogram technology, and terminal deoxynucleotidyl transferase-mediated DNA nick-end labeling staining to identify any myocardial damage. The protein levels of MYPT-1 (characteristic of ROCK activation), IRS-1 and AKT were analyzed by immunohistochemistry and Western blotting. In hearts from MS rats, we found increased protein levels of phospho-MYPT-1 and phospho-IRS-1 (Ser307) and decreased phospho-AKT compared to levels in normal rats. In conclusion, the results suggest that ROCK-mediated IR is involved in the development of myocardial impairments in MS rats and that this effect is mediated probably via the IRS-1/PI3-kinase/AKT pathway.
    Źródło:
    Acta Biochimica Polonica; 2012, 59, 2; 249-254
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The elastic anisotropic and thermodynamic properties of I4mm-B₃C
    Autorzy:
    Fan, Qingyang
    Wei, Qun
    Chai, Changchun
    Yang, Yintang
    Yu, Xinhai
    Liu, Yang
    Zheng, Junping
    Zhou, Peikun
    Zhang, Dongyun
    Powiązania:
    https://bibliotekanauki.pl/articles/1075538.pdf
    Data publikacji:
    2016-01
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    71.15.Mb
    65.40.De
    62.20.de
    Opis:
    The structural, elastic anisotropy and thermodynamic properties of the I4mm-B₃C are investigated using first-principles calculations and the quasi-harmonic Debye model. The calculated elastic anisotropic suggest that I4mm-B₃C is elastically anisotropic with its Poisson ratio, shear modulus, the Young modulus, the universal anisotropic index, shear anisotropic factors, and the percentage of elastic anisotropy for bulk modulus and shear modulus. The quasi-harmonic Debye model, using a set of total energy versus molar volume obtained with the first-principles calculations, is applied to the study of the thermal and vibrational effects. The thermal expansions, heat capacities, the Grüneisen parameters and the Debye temperatures dependence on the temperature and pressure are obtained in the whole pressure range from 0 to 90 GPa and temperature range from 0 to 2000 K.
    Źródło:
    Acta Physica Polonica A; 2016, 129, 1; 103-107
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Study on hydrodynamic configuration parameters of vertical-axis tidal turbine
    Autorzy:
    Li, Guangnian
    Chen, Qingren
    Liu, Yue
    Zhu, Shanqiang
    Yu, Qun
    Powiązania:
    https://bibliotekanauki.pl/articles/259704.pdf
    Data publikacji:
    2020
    Wydawca:
    Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
    Tematy:
    vertical-axis turbine
    configuration parameters
    structure strength
    tidal energy
    efficiency
    Opis:
    In this paper, a numerical code for predicting the hydrodynamic performance of vertical-axis tidal turbine array is developed. The effect of the tip speed ratio, solidity, and preset angle on the hydrodynamic performance are discussed using a series of calculations. The load principle of the rotor and the variation principle of the turbine power coefficient are studied. All these results can be considered as a reference for the design of vertical-axis tidal turbines.
    Źródło:
    Polish Maritime Research; 2020, 1; 116-125
    1233-2585
    Pojawia się w:
    Polish Maritime Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Dynamic performance and stability analysis of an active inerter-based suspension with time-delayed acceleration feedback control
    Autorzy:
    Wang, Yong
    Jin, Xian-Yu
    Zhang, Yun-Shun
    Ding, Hu
    Chen, Li-Qun
    Powiązania:
    https://bibliotekanauki.pl/articles/2173651.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    active inerter-based suspension
    acceleration feedback control
    dynamic performance
    stability analysis
    time delay
    kontrola sprzężenia zwrotnego przyspieszenia
    wydajność dynamiczna
    aktywne zawieszenie na bazie inertera
    analiza stabilności
    opóźnienie
    Opis:
    An active inerter-based suspension with acceleration feedback control is proposed in this paper, the time delay generated in the controllers and actuators is considered, which constitutes the time-delayed active inerter-based (TDA-IB) suspension. The dynamic equation of the TDA-IB suspension is established and is a neutral type of delay differential equation (NDDE) in which the time delay exists in the highestorder derivative. The stability analysis is conducted by calculating the number of unstable characteristic roots based on the definite integral stability method, the stable and unstable regions are determined. The effect of time delay and feedback gain on the dynamic performance of the TDA-IB suspension under harmonic, random, and shock excitations is studied in detail and compared with the parallel-connected inerterbased (PC-IB) and traditional suspensions. The results show that the TDA-IB suspension is asymptotically stable for smaller feedback gain and time delay, through increasing the feedback gain, the stable regions shrink, and a smaller time delay could cause the system to become unstable. Furthermore, the time delay could regulate the resonance peak around the unsprung mass natural frequency and generate multiple high-frequency resonance peaks. If the time delay is chosen appropriately and falls into the stable range, the TDA-IB suspension could improve the dynamic performance for the suspension stroke and dynamic tire load while having a deterioration for the vehicle body acceleration compared with the PC-IB and traditional suspensions.
    Źródło:
    Bulletin of the Polish Academy of Sciences. Technical Sciences; 2022, 70, 2; art. no. e140687
    0239-7528
    Pojawia się w:
    Bulletin of the Polish Academy of Sciences. Technical Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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