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Tytuł:
Review and future perspectives on the integration characteristics for equine lentivirus in the host genome
Autorzy:
Yu, Y.-Y.
Xu, M.-S.
Liang, H.
Wang, H.-Y.
Yu, C.-Q.
Liu, Q.
Powiązania:
https://bibliotekanauki.pl/articles/16647532.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
lentivirus
equine infectious anemia virus
integration
long interspersed elements
Opis:
Despite over 40 years of research on the human immunodeficiency virus type 1 (HIV-1) vaccine, we still lack a considerable progress. Equine infectious anemia virus (EIAV) is a lentivirus in the Retroviridae family, akin to HIV-1 in genome structure and antigenicity. EIA is an important infectious disease in equids, characterized by anemia, persistent infection, and repeated fevers. The EIAV attenuated vaccine in China is the only lentiviral vaccine used on a large scale. Elucidating the mechanism of waning and induction of protective immunity from this attenuated vaccine strain will provide a critical theoretical basis and reference point for vaccine research, particularly in the development of lentivirus vaccines, with far-reaching scientific value and social significance. In this paper, we summarize the information related to EIAV integration site selection, particularly for the Chinese EIAV attenuated vaccine strains on the equine genome. This may improve our mechanistic understanding of EIAV virulence reduction at the host genome level. The obtained data may help elucidate the biological characteristics of EIAV, particularly the Chinese attenuated EIAV vaccine strain, and provide valuable information regarding retroviral infections, particularly lentiviral infection and associated therapeutic vectors.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 1; 163-172
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative analysis of CpG islands in two genotypes of African swine fever virus
Autorzy:
Yu, Y.-Y.
X, M.-S.
Liu, Q.
Powiązania:
https://bibliotekanauki.pl/articles/16539329.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
African Swine Fever Virus (ASFV)
genotype
DNA methylation
CpG island
Opis:
African swine fever (ASF) is an acute, hemorrhagic, and devastating viral infectious disease that causes important economic losses to the swine industry. Currently, there are no effective vaccines or drugs available. Epigenetic mechanisms, especially cytosine methylation of cytosine-phosphate-guanine (CpG) islands, have a significant impact on the life cycle of several viruses. Hence, drugs targeting DNA methylation may potentially be used for the treatment of ASF. Here, we selected the inner core, core shell, inner membrane, capsid, and external envelope membrane, to analyze the characteristics of CpG islands in the ASF virus (ASFV) genomes. Furthermore, we analyzed the promoters and CpG islands in the upstream regions of these genes. Results showed that the CpG islands of seven genes were conserved in the genomes of two genotype of ASFV strains, whereas the CpG islands of other genes were relatively conserved (ASFV strains differed mainly in the quantity of CpG islands). The different distribution of CpG islands in the genomes of different ASFV strains may affect their methylation status, which may in turn affect the regulation of viral gene expression, leading to different clinical outcomes. In addition, the predicted promoter regions based on the upstream sequences of most genes overlapped with CpG island positions. Methylation of the binding sites of the promoter regions inhibits the binding of the transcription factors to the promoters, thus inhibiting the activation of the promoters and limiting the synthesis of viral proteins. The results of this study provide a basis for exploring new antiviral therapeutic strategies from an epigenetic perspective.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 3; 455-462
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in various types of cells in thymic tissues
Autorzy:
Liu, Q.
Yu, Y.-Y.
Wang, H.-Y.
Powiązania:
https://bibliotekanauki.pl/articles/16539177.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
pig
thymus
highly pathogenic porcine reproductive and respiratory syndromevirus
immunofluorescence double labeling method
target cells
Opis:
Thymus, an important central immune organ in pigs, is the site of T lymphocyte development and maturation and an important target organ for infection and replication of various pathogens. Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection results in severe thymic atrophy in piglets. This study aimed to explore the effects of HP-PRRSV on the thymic structure of piglets to elucidate the pathogenesis of thymic atrophy induced by HP-PRRSV. In this study, histopathological techniques and immunofluorescence double staining techniques were used to analyze thymic tissues infected by HP-PRRSV to explore the structural changes of thymus caused by the viral infection and its target cell types. An antibody of cluster of differentiation (CD) 3 (CD3), CD20, CD80, or calgranulin + calprotectin was applied to identify T cells, B cells, dendritic cells (DCs), and macrophages, respectively. The results indicated that a variety of cell components in the thymic tissue were diffusely damaged after viral infection. In the infected thymic tissue, CD80- or calgranulin + calprotectin- -labeled cells supported the HP-PRRSV infection, whereas CD3-labeled T cells and CD20- -labeled B cells did not support the viral infection. The results showed that HP-PRRSV caused the reduction of visible cell components in the thymic tissue, and the virus attacked CD80- and calgranulin + calprotectin-positive cells (such as DCs and macrophages) in the thymic tissue, which played an important role in the pathogenesis of thymus atrophy. These results lay the foundation for elucidating the immunosuppression of piglets after infection with HP-PRRSV.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 2; 287-294
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
17 beta-estradiol affects proliferation and apoptosis of canine bone marrow mesenchymal stem cells in vitro
Autorzy:
Zhou, Z.-H.
Gu, C.-W.
Li, J.
Huang, X.-Y.
Deng, J.-Q.
Shen, L.-H.
Cao, S.-Z.
Deng, J.-L.
Zuo, Z.-C.
Wang, Y.
Ma, X.-P.
Ren, Z.-H.
Yu, S.-M.
Powiązania:
https://bibliotekanauki.pl/articles/2087308.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
apoptosis
bone marrow mesenchymal stem cells (BMSCs)
canine
proliferation
17 beta-estradiol (E2)
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 2; 235-245
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Factors regulating the compositions and distributions of dissolved organic matter in the estuaries of Jiaozhou Bay in North China
Autorzy:
Hu, J.
Zou, L.
Wang, J.
Ren, Q.
Xia, B.
Yu, G.
Powiązania:
https://bibliotekanauki.pl/articles/48070.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Instytut Oceanologii PAN
Tematy:
organic matter
chromophoric dissolved organic matter
dissolved organic matter
particulate organic matter
total carbohydrate
amino acid
biogeochemical process
coastal environment
chlorophyll a
North China
Źródło:
Oceanologia; 2020, 62, 1
0078-3234
Pojawia się w:
Oceanologia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
An expert elicitation analysis for vessel allision risk near the offshore wind farm by using fuzzy rule-based bayesian network
Autorzy:
Yu, Q.
Liu, K.
Powiązania:
https://bibliotekanauki.pl/articles/117215.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Morski w Gdyni. Wydział Nawigacyjny
Tematy:
offshore wind farms
expert elicitation analysis
Bayesian network model
fuzzy rule-based bayesian network
Failure Modes and Effects Analyses (FMEA)
Bayesian Networks
vessel allision risk
risk analysis
Opis:
This paper develops an expert based framework for analysing and synthesising the ship allision risk near the offshore wind farm (OWF) on the basis of a generic Fuzzy Bayesian network and FMEA analysis. This framework is specifically intended to overcome the difficulty of using traditional risk assessment methods in OWF allision. Under the introduced framework, subjective belief degrees are assigned to model the incompleteness encountered in establishing the knowledge base. The fuzzy transformation technology is then used to introduce all judgements results under various situations. Fully, a Bayesian network is established to aggregate all relevant attributes to the conclusion and to prioritise potential allision risk level of each ship categories. A series of case studies of different ship categories are studied to illustrate the application of the proposed framework. Results show that the fishing vessel and the service vessel have a higher allision risk than the merchant vessel due to insufficient risk detection. The collision consequence of the tanker is significantly higher than other types of vessel. The framework facilitates subjective risk assessment when historical failure data is not available in their practice, which provides support to OWF-safeguarding and decision-making.
Źródło:
TransNav : International Journal on Marine Navigation and Safety of Sea Transportation; 2019, 13, 4; 831-837
2083-6473
2083-6481
Pojawia się w:
TransNav : International Journal on Marine Navigation and Safety of Sea Transportation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative analysis of the empirical seismic vulnerability of typical structures in multiple intensity zones
Autorzy:
Li, S. Q.
Yu, T. L.
Chen, Y. S.
Powiązania:
https://bibliotekanauki.pl/articles/230122.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
sejsmiczność
porównanie podatności
analiza podatności
dane empiryczne
baza danych sejsmicznych
MDI
struktura typowa
seismicity
vulnerability comparison
vulnerability analysis
empirical data
seismic database
typical structure
Opis:
To study the difference in seismic vulnerability of multiple typical structures in multiple intensity zones, the seismic damage of 7099 buildings of Dujiangyan masonry structure (MS), reinforced concrete structure (RC) and bottom frame seismic wall masonry (BFM) in the 2008 Wenchuan earthquake in China is summarized and analysed. First, a statistical analysis of the data is carried out, the empirical seismic vulnerability matrix and model curves are established by considering the number of storeys, the age and the fortification factors.The vulnerability curves of the cumulative exceeding probability of the empirical seismic damage and the grade of the seismic damage in multiple intensity zones are shown. The mean damage index vulnerability matrix model is proposed and verified using the empirical seismic damage matrix of typical structures.
Źródło:
Archives of Civil Engineering; 2019, 65, 3; 167-183
1230-2945
Pojawia się w:
Archives of Civil Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pharmacokinetics of the recombinant ovine interferon-tau in lambs
Autorzy:
Zhao, J.
Yu, H.Y.
Zhao, Y.
Li, S.Q.
Fu, X.L.
Zhou, W.
Xia, B.B.
Wang, M.L.
Chen, J.
Powiązania:
https://bibliotekanauki.pl/articles/2087588.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bioavailability
ovine interferon-τ
cytopathic effect inhibition assay
pharmacokinetic study
Źródło:
Polish Journal of Veterinary Sciences; 2019, 1; 75-82
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The response of cyclonic eddies to typhoons based on satellite remote sensing data for 2001-2014 from the South China Sea
Autorzy:
Yu, F.
Yang, Q.
Chen, G.
Li, Q.
Powiązania:
https://bibliotekanauki.pl/articles/48316.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Instytut Oceanologii PAN
Tematy:
satellite remote sensing
tropical cyclone
kinetic energy
typhoon
spatial distribution
quantitative analysis
South China Sea
Źródło:
Oceanologia; 2019, 61, 2
0078-3234
Pojawia się w:
Oceanologia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Image encryption combining discrete fractional angular transform with Arnold transform in image bit planes
Autorzy:
Zhou, Z.
Yu, J.
Liao, Q.
Gong, L.
Powiązania:
https://bibliotekanauki.pl/articles/173704.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
Arnold transform
bit plane
discrete fractional angular transform
image encryption algorithm
Opis:
A new image encryption algorithm by using a discrete fractional angular transform and Arnold transform in image bit planes is investigated. In the image encryption algorithm, the original image is encrypted by the Arnold transform in image bit planes firstly, and then the resulting image is encrypted by the discrete fractional angular transform further. The key of the image encryption algorithm includes the parameters of the Arnold transform and the order of the discrete fractional angular transform. It is shown that the proposed image encryption algorithm is of high security and strong enough to counteract some conventional image attack manners.
Źródło:
Optica Applicata; 2018, 48, 2; 225-236
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optimal expression and purification of sapelovirus A structural protein VP1, and its immunogenicity in mice
Autorzy:
Zhao, T.T.
Cui, L.
Chen, L.
Li, J.J.
Liang, Q.L.
Wu, P.J.
Yu, X.Q.
Zhang, Z.H.
Hua, X.G.
Powiązania:
https://bibliotekanauki.pl/articles/2087686.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
sapelovirus A
prokaryotic expression
purification
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 3; 573-579
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Plantar pressure analysis of above-knee amputee with a developed microprocessor-controlled prosthetic knee
Autorzy:
Cao, W.
Yu, H.
Meng, Q.
Li, S.
Powiązania:
https://bibliotekanauki.pl/articles/306983.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
ciśnienie podeszwowe
proteza stawu kolanowego
analiza chodu
plantar pressure
above-knee amputee
microprocessor-controlled
prosthetic knee
gait analysis
Opis:
Human gait motion analysis was one useful method for lower limb prosthesis study. The most often measured parameters were plantar pressure, kinetic and kinematic parameters. It was indispensable for prosthetic knee design and performance assessment. The aim of this study was to analysis the plantar pressure in traumatic above-knee amputee equipped with a developed microprocessor-controlled prosthetic knee. Methods: The maximum force of forefoot and rearfoot, the average vertical reaction force and pressure and the centre of pressure (COP) offset trajectories of ten above-knee amputees under different walking speeds were obtained. Results: Both forefoot and rearfoot force were bigger in intact leg than prosthetic leg. As the speed increased, the pressure increased in both sides. Forefoot bore more pressure than rearfoot in both legs. The average vertical pressure and force both increased along with the increase of speed. The force and pressure of intact side were always bigger than the prosthetic side. The trend of COP and gait line of the prosthetic and intact side had no significant difference. The length of the gait line of prosthetic side was greater than the intact side. Conclusions: The results of this study exhibited reduced plantar pressure in the prosthetic side. The typical butterfly diagrams were produced during different walking speeds. It indicated that the stability of the microprocessor-controlled prosthetic knee could be guaranteed.
Źródło:
Acta of Bioengineering and Biomechanics; 2018, 20, 4; 33-40
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A Novel Through Capacity Model for One-way Channel Based on Characteristics of the Vessel Traffic Flow
Autorzy:
Nie, Y.
Liu, K.
Xin, X.
Yu, Q.
Powiązania:
https://bibliotekanauki.pl/articles/115997.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Morski w Gdyni. Wydział Nawigacyjny
Tematy:
maritime traffic
vessel traffic service (VTS)
vessel traffic flow
one-way channel
mathematical model
Automatic Identification System (AIS)
Opis:
Vessel traffic flow is a key parameter for channel-through capacity and is of great significance to vessel traffic management, channel and port design and navigational risk evaluation. Based on the study of parameters of characteristics of vessel traffic flow related to channel-through capacity, this paper puts forward a brand-new mathematical model for one-way channel-through capacity in which parameters of channel length, vessel arrival rate and velocity difference in different vessels are involved and a theoretical calculating mechanism for the channel-through capacity is provided. In order to verify availability and reliability of the model, extensive simulation studies have been carried out and based on the historical AIS data, an analytical case study on the Xiazhimen Channel validating the proposed model is presented. Both simulation studies and the case study show that the proposed model is valid and all relative parameters can be readjusted and optimized to further improve the channel-through capacity. Thus, all studies demonstrate that the model is valuable for channel design and vessel management.
Źródło:
TransNav : International Journal on Marine Navigation and Safety of Sea Transportation; 2017, 11, 3; 495-502
2083-6473
2083-6481
Pojawia się w:
TransNav : International Journal on Marine Navigation and Safety of Sea Transportation
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Calibration of backward-in-time model using drifting buoys in the East China Sea
Autorzy:
Yu, F.
Li, J.
Zhao, Y.
Li, Q.
Chen, G.
Powiązania:
https://bibliotekanauki.pl/articles/47533.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Instytut Oceanologii PAN
Tematy:
crude oil
marine environment
marine pollution
oil spill
China Sea
random walk
wind field
calibration
Opis:
In the process of oil exploitation and transportation, large amounts of crude oil are often spilled, resulting in serious pollution of the marine environment. Forecasting oil spill reverse trajectories to determine the exact oil spill sources is crucial for taking proactive and effective emergency measures. In this study, the backward-in-time model (BTM) is proposed for identifying sources of oil spills in the East China Sea. The wind, current and random walk are three major factors in the simulation of oil spill sources. The wind drag coefficient varies along with the uncertainty of the wind field, and the random walk is sensitive to various traits of different regions, these factors are taken as constants in most of the state-of-the-art studies. In this paper, a self-adaptive modification mechanism for drift factors is proposed, which depends on a data set derived from the drifter buoys deployed over the East China Sea shelf. It can be well adapted to the regional characteristics of different sea areas. The correlation factor between predicted positions and actual locations of the drifters is used to estimate optimal coefficients of the BTM. A comparison between the BTM and the traditional method is also made in this study. The results presented in this paper indicate that our method can be used to predict the actual specific spillage locations.
Źródło:
Oceanologia; 2017, 59, 3
0078-3234
Pojawia się w:
Oceanologia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
General concerns life-cycle design of economical ice-resistant structures in the Bohai Sea
Autorzy:
Zhang, D.
Yu, S.
Yue, Q.
Powiązania:
https://bibliotekanauki.pl/articles/258458.pdf
Data publikacji:
2017
Wydawca:
Politechnika Gdańska. Wydział Inżynierii Mechanicznej i Okrętownictwa
Tematy:
ice zone
economical ice-resistant structure
life-cycle design
performance-based design
cost-effective code
Opis:
In China, the oil and natural gas resources of Bohai Bay are mainly marginal oil fields. It is necessary to build both iceresistant and economical offshore platforms. However, there are many risks during the life cycle of offshore platforms due to the imperfect preliminary design for the Bohai Sea economical ice-resistant structures. As a result, the whole life-cycle design should be considered, including plan, design, construction, management and maintenance design. Based on the demand of existing codes and research of the basic design, structural ice-resistant performance and the reasonable management and maintenance, the life-cycle design theory is discussed. It was concluded that the life-cycle cost-effective optimum design proposed will lead to a minimum risk.
Źródło:
Polish Maritime Research; 2017, S 2; 164-191
1233-2585
Pojawia się w:
Polish Maritime Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 23

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