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    Wyświetlanie 1-5 z 5
    Tytuł:
    The influence of silver nanoparticles on the process of epithelial transition in the context of cancer metastases
    Autorzy:
    Matysiak-Kucharek, Magdalena
    Sawicki, Krzysztof
    Kurzepa, Jacek
    Wojtyła-Buciora, Paulina
    Kapka-Skrzypczak, Lucyna
    Powiązania:
    https://bibliotekanauki.pl/articles/28411038.pdf
    Data publikacji:
    2023-12-29
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    breast cancer
    metastasis
    silver nanoparticles
    nanotoxicology
    epithelial-mesenchymal transition
    MDA-MB-436
    Opis:
    Background Exposure to nanoparticles (NPs) can occur in a variety of occupational situations. Ultrafine particles of natural and anthropological origin toxicity has been described in epidemiological studies. Meanwhile, the risks associated with NPs exposure are not comprehensively assessed. A wide spectrum of NPs toxicity has been demonstrated, mainly through the induction of oxidative stress and inflammatory mediators. Among the newly described mechanisms of NPs toxicity is the induction of fibrosis via the epithelial-mesenchymal transition (EMT), which is also a key mechanism of cancer metastasis. The effect of NPs on EMT in the context of metastasis has not been sufficiently described so far, and the results of studies do not allow for the formulation of unambiguous conclusions. Therefore, the aim of the work was to determine the biological activity of silver NPs against MDA-MB-436 triple-negative breast cancer cells. Material and Methods Reverse transcription real-time polymerase chain reaction was used to examine mRNA expression of EMT markers. The QCM Chemotaxis Cell Migration Assay and QCM ECMatrix Cell Invasion Assay were used to assess the level of cell migration and invasion. The tumor growth factor beta 1 (TGF-beta 1) secretion was determined by the immunoenzymatic method using the Human TGF-beta 1 ELISA Kit. Results Silver nanoparticles (AgNPs) cause a statistically significant increase in relative expression of all tested mesenchymal EMT markers – cadherin 2, vimentin, matrix metalloproteinase 2 and matrix metalloproteinase 9. At the same time, reduction of epithelial cadherin 1 expression was observed. The level of MDA-MB-436 migration and TGF-beta 1 secretion was slighty increased in AgNPs-treated cells, with no influence on invasion potential. Conclusions Potentially prometastatic effect of AgNPs encourages further work on the safety of nanomaterials.
    Źródło:
    Medycyna Pracy. Workers’ Health and Safety; 2023, 74, 6; 541-548
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy. Workers’ Health and Safety
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The awareness of caregivers about their children’s exposure to ionizing radiation accompanying medical procedures: the assessment study
    Autorzy:
    Jończyk-Potoczna, Katarzyna
    Pucher, Beata
    Strzelczuk-Judka, Lidia
    Buraczyńska-Andrzejewska, Beata
    Więckowska, Barbara
    Krauss, Hanna
    Biliński, Przemysław
    Wojtyła-Buciora, Paulina
    Powiązania:
    https://bibliotekanauki.pl/articles/2161993.pdf
    Data publikacji:
    2019-02-27
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    children
    CT examination
    parents
    radiation protection
    ionizing radiation
    radiation dose
    Opis:
    Objectives The aim of the study was a survey-based assessment concerning parents of children undergoing CT examinations and their knowledge of detailed information about procedures involved in imaging diagnostics. Material and Methods A statistical analysis of 108 surveys of parents of children undergoing CT studies in the Department of Pediatric Radiology in Poznań, Poland was done, with the use of Statistica software. Results In result of the evaluation of all subsections of the substantive question number, the majority of answers were incorrect (68–98%). No correlation between the number of CT examinations conducted for a child and the number of correct answers to substantive questions was observed. No correlation between the number of CT examinations conducted for a child and the fact of noting the examination with the use of ionizing radiation down in a child’s health certificate was stated. The statistical analysis showed that children of parents who declared that the aim of the CT examination had been explained to them better underwent more of them. Conclusions Parents are poorly informed about a radiation dose and risk related to a CT examination procedure. Int J Occup Med Environ Health. 2019;32(1):65–73
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2019, 32, 1; 65-73
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Authors’ response (December 7, 2017) to the letter to the Editor concerning the paper “Trends in smoking among secondary school and high school students in Poland, 2009 and 2011”
    Autorzy:
    Wojtyła-Buciora, Paulina
    Stawińska-Witoszyńska, Barbara
    Żukiewicz-Sobczak, Wiola
    Wojtyła, Cezary
    Biliński, Piotr
    Urbaniak, Monika
    Wojtyła, Andrzej
    Marcinkowski, Jerzy T.
    Wojciechowska, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/2160042.pdf
    Data publikacji:
    2018-07-04
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    health education
    cigarette smoking
    tobacco epidemiology
    smoking initiation
    secondary school students
    high school students
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2018, 31, 4; 541-542
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Trends in smoking among secondary school and high school students in Poland, 2009 and 2011
    Autorzy:
    Wojtyła-Buciora, Paulina
    Stawińska-Witoszyńska, Barbara
    Żukiewicz-Sobczak, Wiola
    Wojtyła, Cezary
    Biliński, Piotr
    Urbaniak, Monika
    Wojtyła, Andrzej
    Marcinkowski, Jerzy T.
    Wojciechowska, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/2161891.pdf
    Data publikacji:
    2017-07-14
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    health education
    cigarette smoking
    high school students
    tobacco epidemiology
    smoking initation
    secondary school students
    Opis:
    Objectives To determine the age and the most common circumstances for smoking initiation along with smoking rates and to evaluate smoking trends for secondary and high school students in Poland during 2009 and 2011. Material and Methods In 2009, a pilot study was conducted in districts of Poland on high school students and their parents. For statistical analysis, correctly completed questionnaires from 999 students and 667 parents were qualified for use. After the pilot study, a nationwide study of secondary school students and their parents was also conducted in 2009. For statistical analysis, correctly completed questionnaires were used from 9360 students and 6951 from their parents. The research tool was a questionnaire developed by the Chief Sanitary Inspectorate. These studies were then compared to the nationwide research study from 2011. Questionnaires were obtained from a survey of 3548 students from secondary schools and 4423 of those from high schools. Results Smoking initiation usually begins at ages 12–15 years. Rates of secondary school student smoking at least once in their lifetime were about the same level in the surveyed years (2009 – 9%, 2011 – 11%), whereas rates of high school student smoking increased (2009 – 15%, 2011 – 24%). Moreover, 34% of secondary school student smoked less than once a week, whereas in 2009, only 8% of students had done so. For high school students, a 1/2 smoked every day; similar to 2009. Students usually smoked in parks, on streets or any other open space areas. Conclusions From analyzing the smoking trends over the survey period it can be concluded that the problem of smoking increases with respondent age. Int J Occup Med Environ Health 2017;30(5):763–773
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2017, 30, 5; 763-773
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Monitoring risk behaviour in adolescent pupils regarding consumption of psychoactive substances
    Autorzy:
    Wojtyła-Buciora, Paulina
    Klimberg, Aneta
    Kapka-Skrzypczak, Lucyna Kapka-Skrzypczak
    Diatczyk, Jarosław
    Urbaniak, Monika
    Ulatowska-Szostak, Ewa
    Bołdowski, Tomasz
    Wojtyła, Andrzej
    Marcinkowski, Jerzy T.
    Powiązania:
    https://bibliotekanauki.pl/articles/989849.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    drugs/narcotics
    designer drugs (dds)/legal highs
    adolescents/youth
    Opis:
    Introduction. Taking psychoactive substances constitutes a significant problem for Public Health, particularly in preventing drug abuse and addiction. Objectives. To estimate the amount and incidence of drug consumption in middle and high school pupils, including the circumstances in which drug taking first started, and to determine pupils’ knowledge about the consequences of taking psychoactive substances and designer drugs (DDs). Materials and methods. A randomised study was conducted throughout Poland on 9,360 pupils attending middle school (junior high school) in 2009 and 7,971 pupils from middle and high school pupils in 2011. The survey consisted of a questionnaire devised by the Chief Sanitary Inspectorate (GIS) and the replies obtained were subject to the relevant statistical analyses. Results. Drug taking was found to have increased between 2009–2011, especially among those attending high school; proportionally rising from 4% – 11%. The numbers who had ever taken designer drugs were 3% for middle school pupils and 4% from high school. Conclusions. 1) Adolescent drug consumption has increased, particularly in those of older age and in boys. 2) Despite the only brief interval for which designer drugs were legal, they have gained high popularity among the young. 3) Adolescents have insufficient knowledge about the dangers of using DDs. 4) Faced with the growing threat of a dynamic designer drug market, appropriate counter-measures in education and prevention are therefore necessary.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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