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Wyszukujesz frazę "Witkowska-Zimny, M." wg kryterium: Autor

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    Wyświetlanie 1-3 z 3
    Tytuł:
    Tissue engineering of bone: the role of osteoblasts in osteogenesis and peri-implant bone healing
    Autorzy:
    Wróbel, E.
    Witkowska-Zimny, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/284980.pdf
    Data publikacji:
    2013
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    bone tissue engineering
    osteoblasts
    human bone-derived cells
    peri-implant bone healing
    osteogenesis
    cell culture
    Opis:
    Osteoblasts are cells of mesenchymal origin, which rebuild resorbed bone by synthesizing bone matrix proteins and by inducing bone matrix mineralization. Osteoblasts play a crucial role in creating and maintenance of healthy bone architecture, bone repair, and peri-implant bone healing (osseointegration). These bone-forming cells are also involved in regulation of osteoclasts function, and hence bone resorption in osteoclastogenesis process. We have presented our own studies on the subsequent stages of differentiation of Human Bone-Derived Cells (HBDCs) that could be a good candidate as an autogenous source for reconstruction and rebuilding of own patient's bone using tissue engineering methods. In this review we discussed the biology of osteoblasts, compared with the HBDCs cultures, under the influence of growth factors (FGF-2, TGF-ß, IGF, PDGF) and hormones (PTH, 1,25-dihydroxyvitamin D3, leptin). Our review is also focused on the participation of intercellular adhesion proteins (cadherins, claudins, connexin, 'OsteoMacs'), transcription factors (Cbfal, Msx-2, Osx, ATF4), and others molecules (RANKL, OPG, BMP2, lactofferin, PPARY) in modulating osteoblasts functions on the basis of current reports, throwing new light on the involvement of osteoblasts during osteogenesis and peri-implant bone healing.
    Źródło:
    Engineering of Biomaterials; 2013, 16, 119; 2-7
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Non-nutritional use of breast milk for umbilical cord stump care: a case report
    Autorzy:
    Jędral, B.
    Kaminska-El-Hassan, E.
    Witkowska-Zimny, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/2087923.pdf
    Data publikacji:
    2020
    Wydawca:
    Uniwersytet Opolski. Instytut Nauk o Zdrowiu
    Tematy:
    breast milk
    colostrum
    umbilical cord care
    separation time
    milk therapy
    Opis:
    Background: Human milk, in addition to nutrients, contains many biologically active substances including immunoglobulins, growth factors, cytokines, and a diverse population of somatic cells. Breast milk involves no risk of allergy, contains antibodies, and contains factors such as epidermal growth factor (EGF) and erythropoietin, which may promote the growth and repair of skin cells. The discovery of stem cells and the HAMLET complex in breast milk has led to increased interest in human milk as a natural medicine. Aim of the study: The aim of the study was to identify the effect of topical application of breast milk on the separation time of the umbilical cord stump in newborns. Case report: This paper presents the case of a patient who decided to treat her child’s umbilical cord stump with colostrum/breast milk because her two older children had experienced long umbilical stump separation times. As a result of this treatment, separation of the stump occurred 90 hours after labor. There were no abnormalities in the construction of the navel, complications, or separation disorders of the umbilical cord stump. Conclusions: This research demonstrates that colostrum/mother’s milk was used as an easy, cheap, effective, and natural method of umbilical cord care.
    Źródło:
    Medical Science Pulse; 2020, 14, 2; 55-59
    2544-1558
    2544-1620
    Pojawia się w:
    Medical Science Pulse
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Integrin αv signaling influences phenotype and maturation of primary human osteoblasts on alumina surface
    Autorzy:
    Wróbel, E.
    Witkowska-Zimny, M.
    Mrówka, P.
    Głodkowska-Mrówka, E.
    Powiązania:
    https://bibliotekanauki.pl/articles/284664.pdf
    Data publikacji:
    2014
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    integrin
    human bone-derived cells
    osteogenic differentiation
    cell adhesion
    biomaterial
    Opis:
    Due to the growing interest in stem cells application in tissue engineering the better understanding of primary human osteoblasts behavior in vitro, on biomaterial surface, is required. Among other molecules integrins may be taken into account as being involved in these phenomena. Integrins are a family of cell adhesion receptors, which may regulate many cellular functions e.g., adhesion, motility, phenotype and cell maturation. The aim of this study was to determine the effect of the biomaterial surfaces and αv integrin signaling pathway on the behavior, phenotype and maturation of human osteoblasts in vitro. Human bone derived cells (HBDCs) obtained from adult femoral bone fragments were cultured on both alumina disks and tissue culture polystyrene (TCPS) dishes. After 7, 14, and 21 days of culture, localization and mRNA expression level of αv integrin subunits and BGLAP (osteocalcin) on polystyrene were analyzed in addition, we treated the cell cultures with monoclonal antibodies against human αv integrin to block its ligand-binding activity, on both alumina and TCPS substrates. We found that the αv integrin was present in focal contacts and cell cytoplasm at subsequent stages of cell maturation and the level of αv integrin mRNA was the highest in mature osteoblasts. Blocking αv integrin transduction pathway caused changes in cell activity and morphology, decreased cells proliferation on TCPS and reduced expression of alkaline phosphatase (ALP) on both materials. The results suggest that αv integrin is involved as an important receptor facilitating osteogenic differentiation.
    Źródło:
    Engineering of Biomaterials; 2014, 17, 127; 33-39
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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