- Tytuł:
- New analogue of cyclolinopeptide B modified by amphiphilic residue of α-hydroxymethylmethionine.
- Autorzy:
-
Witkowska, Renata
Donigiewicz, Anna
Zimecki, Michał
Zabrocki, Janusz - Powiązania:
- https://bibliotekanauki.pl/articles/1043319.pdf
- Data publikacji:
- 2004
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
α-hydroksymethylmethionine
analogue of cyclolinopeptide B
α-hydroksymethylamino acids - Opis:
- In order to evaluate the role and influence of the methionine residue on the biological activity of cyclolinopeptide B, an analogue with methionine residue in position 7 replaced by the amphiphilic (S)-a-hydroxymethylmethionine residue was synthesized. This peptide exhibits high immunosuppressive activity in the cellular, and to a lesser degree in the humoral immune response, comparable to that of CsA. In addition, the peptide was devoid of toxicity, even at high doses.
- Źródło:
-
Acta Biochimica Polonica; 2004, 51, 1; 67-72
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł