Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "Wilk, Michał" wg kryterium: Autor

  Lista filtrów

Dostawca treści

Podbaza

Wyrównaj
Wyświetlanie 1-15 z 33
Tytuł:
Association of XRCC6 C1310G and LIG4 T9I polymorphisms of NHEJ DNA repair pathway with risk of colorectal cancer in the Polish population
Autorzy:
Balinska, Kinga
Wilk, Damian
Filipek, Beata
Mik, Michal
Zelga, Piotr
Skubel, Pawel
Dziki, Łukasz
Dziki, Adam
Mucha, Bartosz
Kabziński, Jacek
Majsterek, Ireneusz
Powiązania:
https://bibliotekanauki.pl/articles/1391955.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
Colorectal Neoplasms/genetics
DNA-Binding Proteins/genetics
Genetic Predisposition to Disease/genetics
Genotype
Polymorphism
Single Nucleotide
Opis:
Introduction: Colorectal cancer is the second most common cancer worldwide. DNA double strand breaks (DSBs) are the most dangerous lesions which can lead to carcinogenesis. Nonhomologous end joining (NHEJ) is an important pathway, that allows for recovering DNA by direct end joining. The XRCC6 and LIG4 genes encode respectively Ku70 protein and human ATP-dependent DNA ligase, which are the components of the NHEJ repair pathway. The aim of our study was to evaluate the influence of XRCC6 C1310G and LIG4 T9I genes polymorphisms on colorectal cancer risk among Polish population. Materials and method: Genotyping was performed using TaqMan probes based on analysis of PCR products amplified in Real Time PCR. The research has been carried out on the material obtained from 100 patients with colorectal cancer and 100 cancer-free individuals who were age and sex-matched as a control group. The results were developed using the chi – squer test and odds ratio (OR). Results: Odd ratio analysis indicates reduced risk of colorectal cancer for LIG4 T9I polymorphism in heterozygotus model C/T (OR= 0.2717 95% CI= 0.1247-0,5918) and homozygous model T/T (OR= 0.3593 95% CI= 0.1394-0.9266). Similar situation we observed for XRCC6 C1310G gene polymorphism, which indicated on heterozygotus variant C/G (OR= 0.1181 95% CI= 0.0145-0.964) and homozygotus variant G/G (OR= 0.0972 95% CI= 0.0097-0.9713) to decrease the risk of colorectal cancer. Conslusions: Our research revealed XRCC6 C1310G and LIG4 T9I polymorphisms are associated with diminished risk of colorectal cancer. However, to confirm obtained results, a further investigations should be carried out.
Źródło:
Polish Journal of Surgery; 2019, 91, 3; 15-20
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Związek polimorfizmów XRCC6 C1310G i LIG4 T9I genów naprawy DNA szlaku NHEJ z ryzykiem występowania raka jelita grubego w populacji polskiej
Autorzy:
Balinska, Kinga
Wilk, Damian
Filipek, Beata
Mik, Michal
Zelga, Piotr
Skubel, Pawel
Dziki, Łukasz
Dziki, Adam
Mucha, Bartosz
Kabziński, Jacek
Majsterek, Ireneusz
Powiązania:
https://bibliotekanauki.pl/articles/1391985.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
genotypowanie
polimorfizm pojedynczego nukleotydu
rak jelita grubego
Opis:
WSTĘP: Rak jelita grubego (RJG) zajmuje na świecie drugie miejsce wśród przyczyn zgonów na nowotwory złośliwe. Utrata integralności genomu spowodowana jest uszkodzeniami DNA generowanymi przy użyciu czynników środowiskowych. Szczególnie niebezpieczny rodzaj uszkodzeń stanowią pęknięcia dwuniciowe DNA. W celu obrony przed ich skutkami, komórki wyewoluowały molekularne mechanizmy naprawy. Wiodącym szlakiem naprawy pęknięć dwuniciowych w komórkach ludzkich jest łączenie niehomologicznych końców DNA (ang. non-homologous end-joining, NHEJ). Geny XRCC6 i LIG4 kodują odpowiednio białko Ku70 i ludzką ATP- zależną ligazę DNA, będące składowymi szlaku naprawy NHEJ. Celem naszych badań była ocena wpływu polimorfizmów genów XRCC6 w pozycji C1310G i LIG4 w pozycji T9I na ryzyko występowania raka jelita grubego w populacji Polskiej. MATERIAŁY I METODY: Genotypowanie zostało przeprowadzone z użyciem sond TaqMan w oparciu o analizę produktu PCR w czasie rzeczywistym - real-time PCR. Próbę badaną stanowiło DNA wyizolowane od 100 pacjentów z rakiem jelita grubego, potwierdzonym w badaniu histopatologicznym, z kolei do grupy kontrolnej włączono taką samą liczbę osób bez chorób nowotworowych, dopasowanych pod względem płci i wieku. Analiza statystyczna obejmowała ocenę rozkładu genotypów w kontekście zgodności z modelem Hardy’ego - Weinberga na podstawie Chi-kwadrat, dodatkowo został obliczony iloraz szans z przedziałem ufności 95%. WYNIKI: Analiza statystyczna przeprowadzona dla polimorfizmu T9I genu LIG4 wykazała, że genotyp heterozygotyczny C/T (OR= 0.2717 95% CI= 0.1247-0,5918) oraz homozygotyczny T/T (OR= 0.3593 95% CI= 0.1394-0.9266) wiąże się ze zmniejszonym ryzykiem występowania raka jelita grubego. Podobną zależność w kontekście zredukowanego ryzyka raka jelita grubego wykazano w rozkładzie genotypów dla polimorfizmu C1310G genu XRCC6 w modelu C/G (OR= 0.1181 95% CI= 0.0145-0.964) i G/G (OR= 0.0972 95% CI= 0.0097-0.9713). WNIOSKI: Badanie potwierdziło znaczenie polimorfizmów XRCC6 C1310G i LIG4 T9I na zmniejszenie ryzyka występowania RJG, jednakże konieczne są dalsze badania w celu potwierdzenia uzyskanych wyników na większej grupie respondentów.
Źródło:
Polish Journal of Surgery; 2019, 91, 3; 15-20
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Delimitation of Bipolar Metropolitan Area Within the Kujawsko-Pomorskie Region
Autorzy:
Biczkowski, Mirosław
Müller-Frączek, Iwona
Muszyńska, Joanna
Pietrzak, Michał Bernard
Wilk, Justyna
Powiązania:
https://bibliotekanauki.pl/articles/489004.pdf
Data publikacji:
2014
Wydawca:
Instytut Badań Gospodarczych
Tematy:
delimitation
metropolitan area
synthetic measure of development
Opis:
The objective of the article was to re-define the bipolar metropolitan area within the area of the Kujawsko-Pomorskie region (NUTS 2). Concentration of metropolitan features, as well as socio-economic situations of its communes (NUTS 5) in 2011, and also the dynamics of communes’ development in the period 2009-2011 were considered in the procedure of delimitation. Bydgoszcz and Toruń, as the economically strongest cities in the region, were established as the dual core of the bipolar metropolitan area. It was assumed that the determined metropolitan area would cover the best developed and the fastest developing communes which met the following criteria of a metropolitan area: neighbourhood, continuity, compactness, maximum distance and population. The development levels of the communes were determined with the use of syn-thetic measure. Its values were calculated considering the economic (e.g. the amount of income) and also social (e.g. unemployment) aspects of regional devel-opment, as well as features typical of metropolitan areas, such as: well-developed sectors of R&D, knowledge-based economy and serving superior services. In the research, linear arrangement methods classifying as taxonomic tools of multivari-ate data analysis was applied. The metropolitan area resulting from the research (BipOM) slightly differs from the Bydgoszcz-Toruń Metropolitan Area (B-TOM) which was formally ap-pointed in 2005 and composed all of the communes located within the area of the Bydgoski and Toruński districts (NUTS 4). Chełmża and Koronowo, as the less developed communes of the districts, were excluded from the new metropolitan area, while the communes of Ciechocinek, Nakło and Unisław, belonging to the neighbouring districts of the region, were included in the BipOM due to their significant level of regional development and its dynamics. Furthermore the Inowrocław district (bordered on the BipOM) was identified as the prospective candidate for the BipOM, due to the fact that its communes demonstrate a high potential for regional development.
Źródło:
Oeconomia Copernicana; 2014, 5, 2; 101-122
2083-1277
Pojawia się w:
Oeconomia Copernicana
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in Motor Skills of Children who Train Sports Swimming at the Initial Stage of School Education (in an Annual Training Cycle)
Autorzy:
Eider, Paweł
Wilk, Krzysztof
Tarnowski, Michał
Terczyński, Robert
Powiązania:
https://bibliotekanauki.pl/articles/1055109.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
analysis
girls
motor skills
selection
swimming
Opis:
This paper presents an empirical approach to the changes in motor skills of children who train sports swimming at the initial stage of school education in an annual training cycle. Swimming belongs to the disciplines in which training starts at the age of 6-7. The proper selection of candidates to train certain disciplines is a complex process as they should be chosen from a large population of children, both girls and boys, having specific somatic and motor characteristics which, developed in the long-term, will enable them to achieve sports mastery. The aim of the research was to define which changes in motor skills occur in girls who train sports Aim: swimming in an annual training cycle. The Subject group consisted of 85 girls aged 7 who attended four elementary schools in Szczecin, Poland. 36 of them belonged to the Swimmers group and they were all members of the Municipal Swimming Club (MKP) in Szczecin. The Control group consisted of 49 girls who attended the same elementary schools. All subjects took part in two examinations (carried out in the school year 2009/2010. Physical ability tests were conducted in gyms. Motor skills were assessed with EUROFIT Test Battery which is the most reliable and accurate tool according to scientific research. The research revealed changes in both groups (Sw, C) in terms of all eight tests. Examination II proved statistically significant improvement of results in both groups (Sw, C) in comparison to Examination I. Changes between Examination I and Examination II results were most visible in the Swimmers groups in terms of balance, agility, static strength, functional strength and agility run. Changes between Examination I and Examination II were similar in both groups (Sw, C) in terms of speed of limb movement, explosive strength and torso strength. Progressive changes in motor skill of subjects are a positive phenomenon in the physical development of a child. Swimming training resulted significantly in positive changes in terms of motor skills of subject who were at the initial stage of swimming trainings, compared to their non-training peers. Participation in organized, regular sports classes results in the development of motor (physical) skills of children.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2017, 20, 4; 93-105
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Middle Palaeozoic chondrichthyans and the associated ichthyofauna from southern Poland : a review
Autorzy:
Ginter, Michał
Wilk, Olga
Powiązania:
https://bibliotekanauki.pl/articles/1835970.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Geologiczne
Tematy:
Chondrichthyes
Osteichthyes
Devonian
Carboniferous
Polska
Opis:
During the last sixty years, large collections of ichthyofauna, mainly isolated, microscopic, skeletal remains (ichthyoliths), from the Middle–Upper Devonian and Lower Carboniferous rocks of southern Poland have accumulated in the hands of Polish palaeontologists and in palaeontological institutions. Some parts of these collections were described in unpublished dissertations and others were published in dispersed papers, dealing mostly with selected regions or taxa. This review summarises the available data from the following regions: the Holy Cross Mountains, the Cracow Upland, the Sudetes and the Lublin Coal Basin (in the latter two cases, single localities). Altogether, 29 chondrichthyan species were identified and a few more still require classification. Of the Sarcopterygii, three species of onychodontiforms and one of the actinistians were found, in addition to a collection of dipnoans that was described much earlier. A few morphological types were distinguished among actinopterygian scales; otherwise the actinopterygian fossils are not referred to any lower-level taxon, and the same applies to the acanthodians. There were several attempts in the past to apply Polish ichthyoliths in biostratigraphy and palaeoecology, but after all these years, it appears that such propositions have only limited significance.
Źródło:
Annales Societatis Geologorum Poloniae; 2021, 91, 3; 253-286
0208-9068
Pojawia się w:
Annales Societatis Geologorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in Bar Velocity and Muscular Activity During the Bench Press in Relation to the Load Lifted
Autorzy:
Gołaś, Artur
Maszczyk, Adam
Wilk, Michał
Statsny, Petr
Petr, Miroslav
Wróbel, Grzegorz
Król, Henryk
Powiązania:
https://bibliotekanauki.pl/articles/1054723.pdf
Data publikacji:
2015
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
EMG
bar velocity
sticking region
Opis:
The purpose of the study was to determine velocity changes in relation to the load lifted along with their muscular activity. Twenty athletes representing different sport disciplines, familiar with the flat bench press took part in the research project. The ANOVA analysis revealed a significantly higher effect on range of mean velocity (F = 128.34; η2 = 1.22 with p = 0.001) and maximal velocity (F = 7 3.31; η 2 = 0 .81 w ith p = 0 .001) t o m easured l oads ( 70÷100% 1-RM) i n a scending p hase. Tukey’s p ost-hoc t ests revealed a statistically significant difference between 70% and 100% 1-RM loads, in mean velocity with p = 0.001 and maximal velocity with p = 0.001. Similarly the results revealed a statistically significant difference between 80% and 100% 1-RM loads in mean velocity (p = 0,012) and maximal velocity (p = 0,021) during the ascending phase. Relationship between velocity and the muscles activity indicates that the anterior deltoid and latissimus dorsi muscles show synergy and a significant relationship for loads 90 and 100% 1-RM. The triceps brachii muscle shows a higher relationship with velocity of the barbell for loads 70% and 80%, then the relationship of the pectoralis major muscle with velocity only for 90% 1-RM.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2015, 11, 3; 95-101
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hugona ze Świętego Wiktora traktacik De verbo Dei
Hugh of Saint Victor’s Treatise De verbo Dei
Autorzy:
Libowski, Łukasz
Buraczewski, Michał
Wilk, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/595730.pdf
Data publikacji:
2020
Wydawca:
Uniwersytet Opolski. Redakcja Wydawnictw Wydziału Teologicznego
Tematy:
Hugon ze św. Wiktora
De verbo Dei
wiktoryni
filozofia XII wieku
List do Hebrajczyków
Hugh of St. Victor
Victorine school
12th century philosophy
Letter to the Hebrews
Opis:
This article presents the translation of the treatise De verbo Dei, one of the several minor works of Hugh of Saint Victor (c. 1096–1141), which are known under the joint title Sex opuscula spiritualia. Hugh was a philosopher, a theologian, and a mystic, one of the main representatives of the Parisian Victorine School, an author increasingly present in Polish specialist literature. Hugh’s opuscle is an excellent exemplum of the twelfth-century monastic method of Scriptural interpretation. It is an exegesis of a short New Testament fragment, just a few verses of the Letter to the Hebrews (4:12–5:2).
W niniejszym artykule przedkłada się tłumaczenie jednego spośród kilku pomniejszych, znanych pod wspólnym tytułem Sex opuscula spiritualia, dziełek Hugona ze Świętego Wiktora (ok. 1096–1141) – filozofa i teologa oraz mistyka, jednego z głównych przedstawicieli paryskiej szkoły wiktoryńskiej, autora coraz bardziej w polskim piśmiennictwie specjalistycznym obecnego – tłumaczenie mianowicie traktatu De verbo Dei. Utwór ten jest znakomitym exemplum dwunastowiecznej, monastycznej metody interpretacji Biblii. Stanowi go egzegeza króciutkiego fragmentu nowotestamentalnego, kilku zaledwie wersetów Listu do Hebrajczyków (4,12–5,2).
Źródło:
Studia Teologiczno-Historyczne Śląska Opolskiego; 2020, 40, 1; 267-281
0137-3420
Pojawia się w:
Studia Teologiczno-Historyczne Śląska Opolskiego
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Severe aortic stenosis in a patient with breast cancer
Autorzy:
Mańczak, Rafał
Wilk, Michał
Walaszkowska-Czyż, Anna
Florczyk, Michał
Szmit, Sebastian
Powiązania:
https://bibliotekanauki.pl/articles/1064894.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
anthracyclines
aortic stenosis
aortic valve replacement
breast cancer
echocardiography
Opis:
We present a case of 68-year-old female with severe symptomatic aortic stenosis and locally advanced breast cancer disqualified from mastectomy due to heart failure and from aortic valve replacement due to malignant neoplasm. The patient received neoadjuvant chemotherapy without anthracyclines. The aortic valve replacement was performed and then mastectomy and lymphadenectomy were made without hemodynamic complications. Adjuvant hormonotherapy was started. During 42 months of follow-up the patient remained free of recurrent cancer disease as well as no progression of heart failure was observed.
Źródło:
OncoReview; 2016, 6, 2; A49-56
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ekonomiczno-Społeczne Uwarunkowania Migracji Wewnętrznych W Polsce W Świetle Metody Drzew Klasyfikacyjnych
Economic and Social Determinants of Internal Migration in Poland in the Light of the Classification Trees Method
Autorzy:
Matusik, Stanisław
Pietrzak, Michał Bernard
Wilk, Justyna
Powiązania:
https://bibliotekanauki.pl/articles/418320.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
classification trees method
internal migration
economic and social factors
Opis:
This paper analyses socio-economic determinants of migration flows between Polish sub-regions in the years 2008-2010 by using the classification trees (CART) method. Six explanatory variables are selected to determine migration, including GDP per capita, number of economic entities (firms) per 100 inhabitants, investment assets and tangible assets per capita, registered unemployment rate, as well as average monthly salary. The CART method is then used to build models explaining the classification of migration flows into four quartile-based categories. The results confirm that the classification of internal migration flows is strongly determined by socio-economic features, in particular the number of economic entities, investment assets per capita and the unemployment rate. The suburbanisation from cities to neighbouring sub-regions is clearly demonstrated. Better developed regions, especially the largest Polish cities, have the highest migration outflows as well as inflows, yet retain positive net migration. We argue that the proposed analytical approach enables to determine the multidimensional relationships between explanatory social-economic variables and the migration coefficients under study.
Źródło:
Studia Demograficzne; 2012, 162, 2; 3-28
0039-3134
Pojawia się w:
Studia Demograficzne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Practical aspects of testing superconducting electromagnets by the capacitor discharge method taking into account the non-linearity of circuit parameters
Autorzy:
Michna, Michał
Wilk, Andrzej
Wołoszyk, Marek
Ziółko, Michał
Galla, Stanisław
Szwangruber, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/24202739.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
diagnostic
discharge method
superconducting electromagnets
Opis:
The article presents selected issues related to the development and testing of the diagnostics systems dedicated for superconducting electromagnets. The systems were con- structed to assess the production quality of superconducting electromagnets of the SIS100 synchrotron, a new accelerator being built as part of the Facility of Antiproton and Ion Re- search (FAIR). One of the systems is used for automatic checking of electrical connection parameters and the continuity of electric circuits. The role of the second device is to assess the quality of winding insulation and to estimate circuit parameters of electromagnet coils using the capacitor discharge method. The work presents measurements and analysis of current and voltage waveforms acquired during discharges on a magnet coil simulator and on the SIS100 main dipole electromagnet.
Źródło:
Archives of Electrical Engineering; 2023, 72, 2; 323--338
1427-4221
2300-2506
Pojawia się w:
Archives of Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 33

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies