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Wyświetlanie 1-15 z 20
Tytuł:
Effect of oligochitosans on expression of inos gene in ehrlich ascites tumour in vitro
Autorzy:
Ignacak, Jan
Wiśniewska-Wrona, Maria
Dulińska-Litewka, Joanna
Pałka, Iwona
Zagajewski, Jacek
Niekraszewicz, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/1035407.pdf
Data publikacji:
2012
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan oligomers
histone H1
iNOS (inducible nitric oxide synthase)
nitric oxide
Opis:
Oligochitosans obtained through degradation of macromolecules of chitosan with a high degree of deacetylation turned out to be biologically active, contributing to an increase of nitric oxide levels in Ehrlich ascites tumor (EAT) cells through inducing expression of the isoform of inducible nitric oxide synthase (iNOS) gene. An increase of NO levels in EAT cells in the presence of the investigated oligochitosans might contribute to nitrosylation of L-cysteine – an allosteric effector of the M2 isoenzyme of pyruvate kinase (PK), which switches the PK kinase activity, responsible for ATP synthesis, to the histone kinase activity that may participate in histone H1 phosphorylation. Lack of the histone activity of the PK M2 isoenzyme may contribute to decreased histone H1 phosphorylation and thus inhibit EAT cells proliferation.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 141-148
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inhibition of ehrlich ascites tumour (eat) cells proliferation through chitosan-mediated regulation of activity of the akt pathway
Autorzy:
Ignacak, Jan
Wiśniewska-Wrona, Maria
Dulińska-Litewka, Joanna
Pałka, Iwona
Kucharska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1035195.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
Akt kinase - PKB
EAT cells proliferation
M2 pyruvate kinase
chitosan
Opis:
Isoenzyme M2 pyruvate kinase, which is a marker of cancer transformation, can take both tetramer (cytosol) and dimer (nucleus) forms. The former is responsible for ATP synthesis, and the latter demonstrates histone H1 kinase activity. Regulation of the expression of pyruvate kinase through which Akt controls the expression of genes involved in Ehrlich ascites tumour (EAT) cell proliferation, migration and death, also involves cross-talk with the other signalling pathways, transcription factors and co-regulatory proteins such as β-catenin and c-Myc. Treatment of EAT cells with chitosans significantly reduced their proliferation (by 45-60%), expression of nuclear β-catenin, c-Myc as well as cell migration. After 48–72 hours of treatment of the cell with oligochitosans, lower levels of p-Akt were detected. Simultaneously, decreased expression of isoenzyme M2 PK protein levels was observed. The dimeric form (nucleus) can participate in H1 histone phosphorylation, which contributes to increased EAT cell proliferation.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 33-40
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of chitosan oligomers in regulation of ehrlich ascites tumor cells proliferation in vitro
Autorzy:
Ignacak, Jan
Wiśniewska-Wrona, Maria
Pałka, Iwona
Zagajewski, Jacek
Niekraszewicz, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/1035427.pdf
Data publikacji:
2011
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
EAT cells proliferation
L-S-nitrosocysteine.
chitosan oligomers
pyruvate kinase M2 isoenzyme
Opis:
Preliminary studies of proliferation of Ehrlich ascites tumor (EAT) cells and normal mammary gland epithelial cells have demonstrated the process to be inhibited by degradation products of microcrystalline chitosan, i.e. oligomers. Inhibition of proliferation has been also accompanied by a decreased activity of the M2 pyruvate kinase (PK) isoenzyme in nucleoplasm, what may indicate the role of this enzyme in regulation of tumor cell proliferation. Determinations of nitrogen oxide in tumor and normal cells point to a higher level of this endogenous effector in normal cells. An increase of nitrogen oxide levels in Ehrlich ascites tumor cells effected by chitosan oligomers may indicate increased nitrosylation, and particularly an increased amount of compounds containing sulfhydryl groups and their participation in regulation of nucleoplasm M2 PK isoenzyme activity. Chitosan oligomers have smaller molecules as compared to microcrystalline chitosan and for this reason appear to be more effective than the latter in acting upon the negatively charged cell membrane surfaces, thus contributing to proliferation inhibition.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2011, 16; 89-98
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of oligochitosans in regulation of cellular activity and location of pyruvate kinase (pk) isoenzyme m2 that affects proliferation of ehrlich ascites tumor cells (eat)
Autorzy:
Ignacak, Jan
Wiśniewska-Wrona, Maria
Pałka, Iwona
Niekraszewicz, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/1035231.pdf
Data publikacji:
2013
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
isoenzyme M1 and M2 pyruvate kinase
nucleus
oligochitosans
ε-methyl-L-lysyne
Opis:
The pyruvate kinase isoenzyme M2 originating from the nucleoplasm and cytoplasm of tumor cells, with its highest affinity to the 2-phosphoenolpyruvate (2-PEP) and sensitivity to L-cysteine, contributes to an increased generation of energy as ATP, necessary for tumor cell proliferation. In the presence of L-cysteine, the isoenzyme M2 PK demonstrates the activity of histone kinase, transferring the phosphoryl group from 2-PEP to the ε-amine residue of the H1 histone lysine. Oligochitosans induce expression of the inducible nitric oxide synthase gene (iNOS), what results in an increased synthesis of nitric oxide, which reacts with L-cysteine and produces L-S-nitrosocysteine. Lack of L-cysteine contributes to inhibition of kinase activity of the H1 histone, an M2 PK isoenzyme. Decreased phosphorylation of the H1 histone contributes to inhibition of EAT cell proliferation. No effect on proliferation of normal cells that include the PK M1 isoenzyme has been observed in the presence of oligochitosans.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 67-76
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of oligochitosans in regulation of cellular activity and location of pyruvate kinase (pk) isoenzyme m2 that affects proliferation of ehrlich ascites tumor cells (eat)
Autorzy:
Ignacak, Jan
Wiśniewska-Wrona, Maria
Pałka, Iwona
Niekraszewicz, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/1035209.pdf
Data publikacji:
2013
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
isoenzyme M1 and M2 pyruvate kinase
nucleus
oligochitosans
ε-methyl-L-lysyne
Opis:
The pyruvate kinase isoenzyme M2 originating from the nucleoplasm and cytoplasm of tumor cells, with its highest affinity to the 2-phosphoenolpyruvate (2-PEP) and sensitivity to L-cysteine, contributes to an increased generation of energy as ATP, necessary for tumor cell proliferation. In the presence of L-cysteine, the isoenzyme M2 PK demonstrates the activity of histone kinase, transferring the phosphoryl group from 2-PEP to the ε-amine residue of the H1 histone lysine. Oligochitosans induce expression of the inducible nitric oxide synthase gene (iNOS), what results in an increased synthesis of nitric oxide, which reacts with L-cysteine and produces L-S-nitrosocysteine. Lack of L-cysteine contributes to inhibition of kinase activity of the H1 histone, an M2 PK isoenzyme. Decreased phosphorylation of the H1 histone contributes to inhibition of EAT cell proliferation. No effect on proliferation of normal cells that include the PK M1 isoenzyme has been observed in the presence of oligochitosans.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 67-76
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of chitosan on the synthesis of l-s-nitrosocysteine that participates in the regulation of the m2 pyruvate kinase isoenzyme activity associated with ehrlich ascites cells proliferation in vitro
Autorzy:
Ignacak, Jan
Zagajewski, Jacek
Pałka, Iwona
Wiśniewska-Wrona, Maria
Niekraszewicz, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/1035527.pdf
Data publikacji:
2010
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
L-S-nitrosocysteine
L-cysteine
inhibition of EAT cell proliferation
microcrystalline chitosan
pyruvate kinase M2 isoenzyme
Opis:
L-S-nitrosocysteine formation in EAT tumor cells and normal CRL-1636 cells incubated with microcrystalline chitosan was confirmed by RP-HPLC. The metabolite was identified based on UV-VIS spectra. The formation of L-S-nitrosocysteine in EAT tumor cells contributes to decreasing the level of L-cysteine in these cells. L-cysteine as an effector of the bifunctional M2 isoenzyme of pyruvate kinase (PK) initiates its histone kinase activity, which is responsible for histone H1 phosphorylation. A decrease of L-cysteine level in EAT tumor cells contributes to lack of histone H1 phosphorylation by the M2 PK isoenzyme and by the same token to inhibition of EAT cell proliferation.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2010, 15; 149-158
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of chitosan in akt kinase regulation activity
Autorzy:
Ignacak, Jan
Wiśniewska-Wrona, Maria
Dulińska-Litewka, Joanna
Pałka, Iwona
Kucharska, Magdalena
Kazimierski, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1034695.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
Akt kinase (PKB)
M2 pyruvate kinase
cells migration
metalloproteinases
Opis:
A decrease in migration of tumor cells incubated with the investigated chitosan preparations was correlated with a decreased activity of MMP-2 and MMP-9 metalloproteinases, what significantly affected inhibition of tumor cell proliferation. In the investigations of the effects of various chitosan preparations on expression of PCNA, Akt and β-catenin in the normal human 184A1 cells and in breast carcinoma MCF7 cells evaluated at the protein level, significant differences in inhibition of expression of selected genes were noted in the tumor cells. Similarly as in the case of human cells, in mouse cells, the differences in expression of the investigated genes involved solely the Ehrlich carcinoma cells. In the presence of the investigated chitosan preparations, there was observed inhibition of expression of the N-cadherin, β-catenin, Akt and PCNA genes. In case of p21 protein, its level increased, similarly as in the human breast carcinoma cells, what may also be related to phosphorylation of the protein, its capture by the cytosol and prolonging its half-life as compared to the non-phosphorylated form. In case of the normal human 181A1 cells and mouse CRL 1636 cells, no significant alterations were noted in expression of the investigated genes in presence of the employed chitosan preparations.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 73-82
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of oligochitosans in akt kinase regulation
Autorzy:
Ignacak, Jan
Wiśniewska-Wrona, Maria
Dulińska-Litewka, Joanna
Pałka, Iwona
Kucharska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1034912.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
Akt kinase – PKB
EAT cells proliferation
HIF-1 factor.
M2 pyruvate kinase
Opis:
Among characteristic properties of cancers, there is their increased glycolytic activity.Contrary to normal cells, neoplastic cells use anaerobic glycolysis, even when a sufficient amount of oxygen is available. The intensity of the process is associated with a considerable demand for energy in the form of ATP. Akt, which - acting through the mTOR pathway - activates the HIF-1 factor, which in turn activates hexokinase that participates in glucose phosphorylation, stimulates the transport of glucose to cells via increasing glucose transporters (GLUT) and activates lactate dehydrogenase (which transforms pyruvate to lactate). Chitosan, as well as products of its degradation - oligochitosans - contribute to inhibiting the activity of the Akt kinase, and thus contribute to inhibiting excessive glycolytic activity of Ehrlich ascites tumor (EAT) cells and to decreasing proliferation of these cells.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 73-81
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
POTENTIAL USE OF CHITOSAN – BASED MATERIALE IN MEDICINE
Autorzy:
Kucharska, Magdalena
Ciechańska, Danuta
Niekraszewicz, Antoni
Wiśniewska-Wrona, Maria
Kardas, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1035560.pdf
Data publikacji:
2010
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
biomaterials
medicine
polysaccharides
Opis:
Polysaccharides are macromolecular polymers that manifest ability toward the forming of fibres, film and coatings. Some of their specific properties like biodegradability and biocompatibility make them suitable for medical application. Chitin, chitosan and alginates are basic polymers mostly used in the preparation of medical biomaterials. In the Institute of Biopolymers and Chemical Fibres (IBWCh) multidirectional investigations are in full swing concerned with the use medical of polysaccharides and their various useful forms. The research includes amongst: multifunctional dressing materials, implants and other polysaccharide biomaterials.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2010, 15; 169-176
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Association between uridin diphosphate glucuronosylotransferase 1A1 (UGT1A1) gene polymorphism and neonatal hyperbilirubinemia
Autorzy:
Mazur-Kominek, Katarzyna
Romanowski, Tomasz
Bielawski, Krzysztof
Kiełbratowska, Bogumiła
Preis, Krzysztof
Domżalska-Popadiuk, Iwona
Słomińska-Frączek, Magdalena
Sznurkowska, Katarzyna
Renke, Joanna
Plata-Nazar, Katarzyna
Śledzińska, Karolina
Sikorska-Wiśniewska, Grażyna
Góra-Gębka, Magdalena
Liberek, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1038662.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
UGT1A1 gene
polymorphism
hyperbilirubinemia
neonates
Opis:
Objective: To assess the prevalence of UGT1A1*28 and UGT1A1*60 polymorphisms of UGT1A1 gene and their association with hyperbilirubinemia. Study design: The study was performed at a single centre - at the Department of Obstetrics of the Medical University of Gdansk in Poland. DNA was isolated from Guthrie cards of 171 infants. Only full term newborns (gestational age 38-42 weeks) were included in the study. Fluorescent molecular probes were used for UGT1A1 promoter variation analysis. The presence of UGT1A1*28 polymorphism was detected with a dual-probe system, and UGT1A1*60 with a SimpleProbe™. Result: Homozygous UGT1A1*28 and UGT1A1*60 genotypes were detected in 14.6% and 20.5% of the newborns, respectively. Homozygous (G/G) genotypes of UGT1A1*60 polymorphism were found in all of the UGT1A1*28 (i.e. (TA)7/(TA)7) homozygotes. More than 80% (55/66) of the children with "wild" type UGT1A1*28 genotype (where no polymorphism was detected) (i.e. (TA)6/(TA)6) carried the "wild" (T/T) genotype of UGT1A1*60 as well. The UGT1A1*28 polymorphism was detected more often among neonates with elevated bilirubin. Hyperbilirubinemia was diagnosed more frequently in boys. Conclusion: Polymorphisms of the UGT1A1 gene frequently co-exist in neonates. The presence of UGT1A1*28 polymorphism and male gender seem to predispose to neonatal hyperbilirubinemia.
Źródło:
Acta Biochimica Polonica; 2017, 64, 2; 351-356
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of the Electrolyte Type on the Adsorption and Electrokinetic Properties of the Ionic Polyamino Acids – Cr2O3 system
Autorzy:
Ostolska, Iwona
Wiśniewska, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/951402.pdf
Data publikacji:
2013
Wydawca:
Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
Tematy:
Polyamino acid
polyaspartic acid
polylysine
chromium (III) oxide
polymer adsorption
potentiometric titration
zeta potential
Opis:
The influence of a kind of support electrolyte on the ionic polyamino acids adsorption at the chromium (III) oxide – polymer solution interface was investigated. The NaCl and CaCl2 were used as the background electrolytes. In order to determine the effect of the electrolyte, the same value of ionic strength of the test solutions were taken. It was proved that formation of intermolecular and intramolecular complexes in the presence of divalent calcium ions is responsible for essential changes in polymer adsorption. Related to the ionic character of polyamino acid two different adsorption behaviours can be observed. The increase of the ASP adsorption amount in the presence of calcium ions may be explained by formation of complexes between the dissociated carboxylic groups and Ca2+ ions. The opposite situation takes place in the case of polylysine – the application of CaCl2 results in the dramatic decrease in the polymer adsorption caused by blocking the active sites available for LYS macromolecules. In order to make a comprehensive analysis, the zeta potential and surface charge density measurements were performed taking into account the kind of the background electrolyte. The above-mentioned tests were carried out in the absence and presence of the polyamino acid at two different concentrations – 10 and 100 ppm respectively.
Źródło:
Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia; 2013, 68, 1-2
2083-358X
Pojawia się w:
Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular probes for detection of wheat chromosomal fragments in rye.
Autorzy:
Rafalski, Andrzej
Wiśniewska, Iwona
Sikora, Teresa
Łapiński, Bogusław
Powiązania:
https://bibliotekanauki.pl/articles/2198780.pdf
Data publikacji:
2000-12-20
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
introgression
PCR
rye
Southern blotting
Triticum durum probe
wheat
wheat specific probes
Opis:
Twelve DNA fragments amplified on templates of Triticum urartu, Aegilops speltoides and Aegilops squarrosa were separated, reamplified and used as digoxigenin-labelled probes. The species and genome specificity of probes was evaluated by Southern dot-blot hybridisation to Triticum durum, the donors of wheat genomes, rye and rye with introgressed wheat chromosome fragments. In comparison to labelled genomic DNA of T. durum, the probes obtained by labelling PCR-amplified fragments exhibited higher specificity to wheat genomes. Under the applied hybridisation conditions all probes showed different degree of cross-hybridisation to rye DNA. Some probes indicated quantitative difference in their specificity to wheat genomes, but generally the intensity of hybridisation to the genomes A, S and D was independent of the origin of an amplified fragment. Selected probes, used in dot-blot hybridisation system together with genomic DNA of T. durum, may increase the sensitivity of screening wheat chromosomal fragments introgressed to rye.
Źródło:
Plant Breeding and Seed Science; 2000, 44; 27-37
1429-3862
2083-599X
Pojawia się w:
Plant Breeding and Seed Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wyspa na uwięzi : Kaliningrad między Moskwą a UE
Autorzy:
Rogoża, Jagoda.
Wierzbowska-Miazga, Agata.
Wiśniewska, Iwona (1975- ).
Współwytwórcy:
Duchnowicz, Ilona. Tłumaczenie
Todd, Jim. Tłumaczenie
Data publikacji:
2012
Wydawca:
Warszawa : Ośrodek Studiów Wschodnich im. Marka Karpia
Tematy:
Unia Europejska (UE)
Polityka
Opis:
Współwyd. w kierunku przeciwnym: A captive island : Kaliningrad between Moscow and the EU / Jadwiga Rogoża, Agata Wierzbowska-Miazga, Iwona Wiśniewska ; [transl. Ilona Duchnowicz, coop. Jim Todd].
Dostawca treści:
Bibliografia CBW
Książka
Tytuł:
Integracja euroazjatycka : rosyjska próba ekonomicznego scalenia obszaru poradzieckiego
Autorzy:
Wiśniewska, Iwona.
Fischer, Ewa.
Współwytwórcy:
Ośrodek Studiów Wschodnich im. Marka Karpia ; Warszawa
Data publikacji:
2013
Wydawca:
Warszawa : Ośr. Studiów Wschodnich im. Marka Karpia
Tematy:
Integracja gospodarcza
Polityka
Opis:
Współwyd. w kierunku przeciwnym: Eurasian integration : Russia's attempt at the economic unification of the post-soviet area / Iwona Wiśniewska ; coop. Ewa Fisher [et al.].
Dostawca treści:
Bibliografia CBW
Książka
Wyświetlanie 1-15 z 20

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