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Wyświetlanie 1-11 z 11
Tytuł:
Mechanizmy molekularne przekazywania sygnału aktywacji przez wybrane receptory błonowe płytek krwi
Molecular mechanisms of signal transduction in selected receptor systems of blood platelets
Autorzy:
Golański, Jacek
Watała, Cezary
Powiązania:
https://bibliotekanauki.pl/articles/944984.pdf
Data publikacji:
2001
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Opis:
This review paper concerns molecular mechanisms of signal transduction by various receptor systems and the role of various agonists in the activation of blood platelets. Authors present the physiological pathways leading to platelet activation and release reaction, as well as those responsible for the natural feedback inhibition of platelet activation. The significance of the conformational changes in platelet receptor glycoproteins, the reorganisation of platelet cytoskeleton, the mobilisation of calcium, processes of phosphorylation/déphosphorylation, and lipid bilayer fluidity in the modulation of the triggering of platelet signal transduction is discussed.
Źródło:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica; 2001, 15
0208-614X
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modulacja aktywacji płytek krwi - antagoniści receptora tromboksanu i modulatory receptorów eikozanoidowych
Modulation of blood platelet activation - thromboxane receptor antagonists and prostanoid analogs
Autorzy:
Więcławska, Bogusława
Watała, Cezary
Powiązania:
https://bibliotekanauki.pl/articles/945052.pdf
Data publikacji:
1999
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Źródło:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica; 1999, 14
0208-614X
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Regulation of cell function by isoforms of C-reactive protein: A comparative analysis
Autorzy:
Boncler, Magdalena
Watała, Cezary
Powiązania:
https://bibliotekanauki.pl/articles/1040607.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
inflammation
native CRP
atherosclerosis
modified CRP
C-reactive protein
Opis:
Despite the emerging evidence suggesting a proatherogenic role of C-reactive protein (CRP) in atherosclerosis, the contribution of CRP in pathogenesis of atherosclerosis and atherothrombosis has not been unequivocally defined. The role of CRP in pathophysiology/pathology seems to largely depend on its structure. Two CRP isoforms, the native pentameric and the modified monomeric one, differ substantially in their physiological functions, which is thought to origin from the considerable structural heterogeneity of the CRP molecule. The present review provides an overview of the experimental evidence with relevance to the clinical role(s) of various CRP isoforms. The biological role of the protein, its structure and distribution are discussed with particular emphasis on the diverse properties of the pentameric and monomeric forms of CRP. Some methodological aspects, related to experimental models and techniques of CRP preparation, are also critically reviewed.
Źródło:
Acta Biochimica Polonica; 2009, 56, 1; 17-31
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In vitro effect of insulin on the osmotic fragility of human diabetic erythrocytes
Wpływ insuliny in vitro na wrażliwość osmotyczną erytrocytów ludzi chorych na cukrzycę
Autorzy:
Bryszewska, Maria
Watała, Cezary
Leyko, Wanda
Powiązania:
https://bibliotekanauki.pl/articles/945032.pdf
Data publikacji:
1986
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Źródło:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica; 1986, 4
0208-614X
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Decreased erythrocyte ghost membrane fluidity as a result of lipid composition changes in plasma of adult Insulin-dependent diabetics
Obniżona płynność błon arytrocytarnych jako wynik zmian ilościowych lipidów osocza w cukrzycy insulnozależnej u ludzi dorosłych
Autorzy:
Watała, Cezary
Bryszewska, Maria
Leyko, Wanda
Powiązania:
https://bibliotekanauki.pl/articles/945083.pdf
Data publikacji:
1986
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Źródło:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica; 1986, 5
0208-614X
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adenosine diphosphate receptors on blood platelets - potential new targets for antiplatelet therapy
Autorzy:
Rozalski, Marcin
Nocun, Marek
Watala, Cezary
Powiązania:
https://bibliotekanauki.pl/articles/1041421.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
P2Y12
ADP antagonists
ADP receptors
P2Y1
platelet
antiplatelet therapy
Opis:
Platelets play a key role not only in physiological haemostasis, but also under pathological conditions such as thrombosis. Platelet activation may be initiated by a variety of agonists including thrombin, collagen, thromboxane or adenosine diphosphate (ADP). Although ADP is regarded as a weak agonist of blood platelets, it remains an important mediator of platelet activation evoked by other agonists, which induce massive ADP release from dense granules, where it occurs in molar concentrations. Thus, ADP action underlies a positive feedback that facilitates further platelet aggregation and leads to platelet plug formation. Additionally, ADP acts synergistically to other, even weak, agonists such as serotonin, adrenaline or chemokines. Blood platelets express two types of P2Y ADP receptors: P2Y_1 and P2Y_12. ADP-dependent platelet aggregation is initiated by the P2Y1 receptor, whereas P2Y_12 receptor augments the activating signal and promotes platelet release reaction. Stimulation of P2Y_12 is also essential for ADP-mediated complete activation of GPIIb-IIIa and GPIa-IIa, and further stabilization of platelet aggregates. The crucial role in blood platelet biology makes P2_Y12 an ideal candidate for pharmacological approaches for anti-platelet therapy.
Źródło:
Acta Biochimica Polonica; 2005, 52, 2; 411-415
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przegląd krajowych gatunków rodziny Cicindelidae (Coleoptera)
Synopsis of Polish spedes of the family Cicindelidae (Coleoptera)
Autorzy:
Burakowski, Bolesław
Jadwiszczak, Andrzej
Watała, Cezary
Powiązania:
https://bibliotekanauki.pl/articles/1038153.pdf
Data publikacji:
1994
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
Cicindela
morfologia larw
Opis:
Ten species of tiger-beetles (Coleoptera, Cicindelidae) occuring in Central Europe are described and figured. Keys to the adults and known larvae, with brief notes on their distribution and bionomics, are provided.
Źródło:
Acta Universitatis Lodziensis. Folia Zoologica; 1994, 2
1230-0527
Pojawia się w:
Acta Universitatis Lodziensis. Folia Zoologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Znaczenie uwarunkowań genetycznych w dysfunkcjach układu hemostazy w cukrzycy - potencjalne czynniki ryzyka powikłań naczyniowych
Significance of genetic po lymorphisms in haemostatic dysfunctions in diabetes mellitus - potential risk factors of vascular complications
Autorzy:
Watała, Cezary
Boncler, Magdalena
Różalski, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/945055.pdf
Data publikacji:
1999
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Opis:
The unambiguous determination of etiopathogenetic factors underlying the increased risk of vascular disease in diabetic patients remains to be established. Evidence accumulated hitherto points that such an increased risk might be a constellation of metabolic disorders and genetic background. Thus, the impairments in coagulation and fibrinolysis, which are believed to partly result from metabolic disorders encountered in diabetes, and genetic factors might be compounding in predisposing a diabetic individual to develop the late diabetic sequelae sooner. The role of the latter seems superior with respect to some dysfunctions in haemostasis. Hence, the monitoring of the frequency and distribution of genetic polymorphisms of selected haemostatic proteins might be promising in an attempt to define the reasons of altered haemostatic imbalance in patients with diabetes mellitus. Based on such a knowledge one could discriminate the groups of patients with high risk for the development of vascular disease, in whom pharmacological strategy to attenuate haemostatic impairments would be desirable.
Źródło:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica; 1999, 14
0208-614X
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of 1-methylnicotinamide and its metabolite N-methyl-2-pyridone-5-carboxamide on streptozotocin-induced toxicity in murine insulinoma MIN6 cell line
Autorzy:
Przygodzki, Tomasz
Slominska, Ewa
Polakowska, Ewa
Mlynarski, Wojciech
Watala, Cezary
Powiązania:
https://bibliotekanauki.pl/articles/1039953.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
nucleotide pool
streptozotocine
1-methylnicotinamide
N-methyl-2-pyridone-5-carboxamide
Opis:
1-methylnicotinamide (MNA) is a primary metabolite of nicotinamide. In recent years several activities of MNA have been described, such as anti-inflammatory activity in skin diseases, induction of prostacyclin synthesis via COX-2, aortal endothelium protection in diabetes and hypertriglyceridaemia and increased survival rate of diabetic rats. 1-methylnicotinamide was also suggested to protect pancreatic cells from streptozotocin in vivo. Streptozotocin toxicity is known to be mediated by poly-ADP-ribose polymerase. Nicotinamide and its derivatives have been shown to ameliorate poly-ADP-ribose polymerase-dependent nucleotide pool reduction. We aimed to verify if 1-methylnicotinamide and its metabolite, N-methyl-2-pyridone-5-carboxamide, can protect insulinoma cells from streptozotocin-induced toxicity. We found that N-methyl-2-pyridone-5-carboxamide, but not 1-methylnicotinamide, restores the pool of ATP and NAD+ in streptozotocin-treated cells, but neither compound improved the cell viability. We conclude that inhibition of poly-ADP-ribose polymerase-dependent nucleotide pool reduction may not be sufficient to protect cells from streptozotocin toxicity.
Źródło:
Acta Biochimica Polonica; 2011, 58, 1; 75-77
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inhibition of collagen-induced platelet reactivity by DGEA peptide.
Autorzy:
Luzak, Boguslawa
Golanski, Jacek
Rozalski, Marcin
Boncler, Magdalena
Watala, Cezary
Powiązania:
https://bibliotekanauki.pl/articles/1043398.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
collagen
platelet receptor antagonists
collagen receptors
GPIaIIa
DGEA
platelet reactivity
Opis:
Direct interactions between collagen, the most thrombogenic component of the extracellular matrix, and platelet surface membrane receptors mediate platelet adhesion and induce platelet activation and aggregation. In this process two glycoproteins are crucial: integrin α2β1, an adhesive receptor, and GPVI, which is especially responsible for signal transduction. Specific antagonists of the collagen receptors are useful tools for investigating the complexity of platelet-collagen interactions. In this work we assessed the usefulness of DGEA peptide (Asp-Gly-Glu-Ala), the shortest collagen type I-derived motif recognised by the collagen-binding integrin α2β1, as a potential antagonist of collagen receptors. We examined platelet function using several methods including platelet adhesion under static conditions, platelet function analyser PFA-100TM, whole blood electric impedance aggregometry (WBEA) and flow cytometry. We found that DGEA significantly inhibited adhesion, aggregation and release reaction of collagen activated blood platelets. The inhibitory effect of DGEA on static platelet adhesion reached sub-maximal values at millimolar inhibitor concentrations, whereas the specific blocker of α2β1 - monoclonal antibodies Gi9, when used at saturating concentrations, had only a moderate inhibitory effect on platelet adhesion. Considering that 25-30% of total collagen binding to α2β1 is specific, we conclude that DGEA is a strong antagonist interfering with a variety of collagen-platelet interactions, and it can be recognised not only by the primary platelet adhesion receptor α2β1 but also by other collagen receptors.
Źródło:
Acta Biochimica Polonica; 2003, 50, 4; 1119-1128
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Answer to Comments to the article “Five years of difficult experiences with the Act on the protection of animals used for scientific or educational purposes dated of January 15, 2015”
Odpowiedź na polemikę z artykułem Pięć lat trudnych doświadczeń z Ustawą o ochronie zwierząt wykorzystywanych do celów naukowych lub edukacyjnych z dnia 15 stycznia 2015 r.
Autorzy:
Gajewska, Marta
Gromadzka-Ostrowska, Joanna
Konopacki, Jan
Turlejski, Krzysztof
Watała, Cezary W.
Wąsowicz, Krzysztof
Wesołowska, Anna
Wieczorek, Marek
Wlaź, Piotr
Zabielski, Romuald
Powiązania:
https://bibliotekanauki.pl/articles/2121408.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
laboratory animals’ regulations
implementation of EU Directive
local ethics committee function
Opis:
This is response of the authors of the article published in the “Nauka” (3/2020) to the polemic note published in the issue 1/2021. In the response, authors signal- ed the progressive difficulties in conducting research on animals, attributed to the practices of applying the “Act on the protection of animals used for scientific or educational purposes” of January 15, 2015. The use of animals for research in accordance with the provisions of the Act of 2015 was paid for by a number of ambiguities in the interpretation of the provisions of the Act, increased official reporting without any real effect on animal welfare, and increased pressure from some non-governmental organizations, whose aim is to completely block the con- duct of animal research.
Źródło:
Nauka; 2021, 3; 173-176
1231-8515
Pojawia się w:
Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-11 z 11

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