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    Wyświetlanie 1-13 z 13
    Tytuł:
    Annual report inquiry letters, disclosure of key audit matters and audit fees: Evidence from Chinese A-share listed companies
    Autorzy:
    Li, Xiaoyu
    Gou, Hongyao
    Wang, Miao
    Powiązania:
    https://bibliotekanauki.pl/articles/39830171.pdf
    Data publikacji:
    2023
    Wydawca:
    Instytut Badań Gospodarczych
    Tematy:
    annual report inquiry letter
    key audit matters
    audit fees
    audit quality
    Opis:
    Research background: Issuing an annual report inquiry letter is a powerful means by which securities exchanges regulate the information of listed companies, which can convey information, reveal risks, and sustain the orderly development of capital markets. However, research on the economic consequences is limited. Purpose of the article: This study analyses the relationships and mechanisms between annual report inquiry letters, key audit matters (KAMs), and audit fees. Methods: We collected data from Chinese A-share companies listed on the Shanghai and Shenzhen Stock Exchanges between 2017 and 2022, totalling 9,903 observations. We used Stata to conduct mediation effects and heterogeneity tests on the data. We also conducted further research on the relationship between audit fees and the purchase of audit opinions. Findings & value added: The results indicate that (1) companies that receive annual report inquiry letters have higher audit fees. Furthermore, (2) companies that receive annual report inquiry letters are more likely to increase the number of disclosed KAMs, leading to higher audit fees. Finally, (3) the above relationship is more significant amongst companies audited by non-Big-Four accounting firms than amongst those audited by Big-Four accounting firms. Further, the increase in audit fees for the sample companies is not due to the purchase of audit opinions and is combined with robustness tests, further validating the conclusions of this study. These findings contribute to research on the economic impact of implementing the annual report inquiry system and new auditing standards, providing empirical evidence for the effectiveness of government oversight of capital markets.
    Źródło:
    Oeconomia Copernicana; 2023, 14, 4; 1303-1339
    2083-1277
    Pojawia się w:
    Oeconomia Copernicana
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Research on a mining area risk management system based on internal control theory
    Badania systemu zarządzania ryzykiem obszaru górniczego w oparciu o teorię kontroli wewnętrznej
    Autorzy:
    Mu, Hailong
    Meng, Shangjiu
    Wang, Miao
    Zhang, Shengjun
    Powiązania:
    https://bibliotekanauki.pl/articles/27311626.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Instytut Gospodarki Surowcami Mineralnymi i Energią PAN
    Tematy:
    internal control
    mining area
    risk management system
    kontrola wewnętrzna
    obszar górniczy
    system zarządzania ryzykiem
    Opis:
    Based on China’s resource endowment and coal mine disaster statistics, it has been found that there are many deficiencies in the management of disasters and risks in mining areas in China. Therefore, to scientifically and effectively manage mining areas, based on the theory of internal control, this paper systematically analyzes the risks of mining areas in the context of various factors and relevant suggestions. From the occurrence of mine risk to the occurrence of damage, the importance of risk management is highlighted. In accordance with the five selection principles of evaluation indicators (goal principle, comprehensiveness principle, scientificity principle, timeliness principle and focus principle) as well as the five elements of internal control (control environment, risk assessment, control activities, information and communication and supervision), a mining area risk management framework of human-machine-environment-management – disturbance is constructed, and twenty-seven secondary risk indicators are divided. The criteria for determining the risk level and the risk response process have been established, and a more systematic and accurate mine risk management system under the theory of internal control has been formed. Finally, based on four key technologies, a dual prevention and control mechanism is formed around the system risk and job risk management system. This provides new methods and ideas for the prevention and control of coal mine safety risks and the containment of disasters and accidents.
    Na podstawie chińskich zasobów i statystyk dotyczących katastrof w kopalniach węgla stwierdzono, że istnieje wiele niedociągnięć w zarządzaniu katastrofami i ryzykiem na obszarach górniczych w Chinach. Dlatego, aby naukowo i efektywnie zarządzać obszarami górniczymi, w oparciu o teorię kontroli wewnętrznej, w artykule systematycznie analizuje się ryzyko obszarów górniczych pod kątem różnych czynników i odpowiednich sugestii. Od wystąpienia ryzyka górniczego do wystąpienia szkód podkreśla się znaczenie zarządzania ryzykiem. Zgodnie z pięcioma zasadami wyboru wskaźników oceny: zasadą celu, zasadą kompleksowości, zasadą naukowości, zasadą terminowości i zasadą ukierunkowania, a także pięcioma elementami kontroli wewnętrznej: środowiskiem kontroli, oceną ryzyka, działaniami kontrolnymi, informacją i komunikacją oraz nadzorem, skonstruowano ramy zarządzania ryzykiem w obszarze górniczym w zakresie zakłóceń w zarządzaniu ludźmi, maszynami i środowiskiem oraz podzielono 27 drugorzędnych wskaźników ryzyka. Ustalono kryteria określania poziomu ryzyka i proces reagowania na ryzyko, a także stworzono bardziej systematyczny i dokładny system zarządzania ryzykiem kopalnianym w ramach teorii kontroli wewnętrznej. Wreszcie, w oparciu o cztery kluczowe technologie, stworzono podwójny mechanizm zapobiegania i kontroli ryzyka systemowego i systemu zarządzania ryzykiem zawodowym. Zapewnia to nowe metody i pomysły w zakresie zapobiegania i kontroli zagrożeń bezpieczeństwa w kopalniach węgla oraz ograniczania katastrof i wypadków.
    Źródło:
    Gospodarka Surowcami Mineralnymi; 2023, 39, 4; 49--66
    0860-0953
    Pojawia się w:
    Gospodarka Surowcami Mineralnymi
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Collocation method based on barycentric interpolation iteration for analysis of nonlinear microbeams
    Autorzy:
    Zhuang, M.
    Miao, C.
    Wang, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/279890.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
    Tematy:
    nonlinear microbeams
    barycentric Lagrange interpolation
    collocation method
    linearization method
    iteration method
    Opis:
    A powerful computational methodology, named the barycentric Lagrange interpolation iteration collocation method (BLIICM), for solving nonlinear bending problems of a doubly clamped microbeam under electrostatic loads is presented. The nonlinear governing equation of the microbeam is converted into a linear differential equation by assuming the initial function. The barycentric Lagrange interpolation collocation method (BLICM) is used to solve the linear differential equation. The direct linearization formulations and Newton linearization calculation formulations for the nonlinear differential equation have been given. The calculation method and formulation of the nonlinear integral term have been discussed in details. By applying a barycentric Lagrange interpolation differential matrix, a matrix-vector calculation formula of BLIICM has been established. Numerical results of calculation examples show that the advantages of the proposed methodology are efficient, simple and of high precision.
    Źródło:
    Journal of Theoretical and Applied Mechanics; 2018, 56, 3; 741-749
    1429-2955
    Pojawia się w:
    Journal of Theoretical and Applied Mechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Design and fabrication of 125I seeds for brachytherapy using capillary-based microfluidic technique
    Autorzy:
    Wang, Yuan
    Zhang, Miao
    Song, Tong
    Chang, Zhenqi
    Powiązania:
    https://bibliotekanauki.pl/articles/2055673.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    125I seeds
    brachytherapy source
    microfluidic
    Monte Carlo calculation
    core-shell
    Opis:
    A new kind of 125I seeds with a core-shell structure were synthesized by an easy assembling–disassembling coaxial capillaries microfluidic device. The dose distribution of a 125I brachytherapy source fabricated by arranging six 125I seeds collinearly within a cylindrical titanium capsule was simulated by modelling the source in a water phantom using Monte Carlo N-Particle Transport code. The infl uence of the motion and the core size of the 125I seeds on the dose distribution was also studied in this work.
    Źródło:
    Nukleonika; 2021, 66, 2; 55--60
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Optimization of sealing parameters of double-sealing pipeline repair clamp
    Autorzy:
    Zhao, Bingjie
    Zhang, Shuli
    Gao, Qijun
    Miao, Canliang
    Wang, Tongyu
    Powiązania:
    https://bibliotekanauki.pl/articles/2086977.pdf
    Data publikacji:
    2022
    Wydawca:
    Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
    Tematy:
    seal
    rubber
    pressure
    the orthogonal experimental design
    Opis:
    Considering the key equipment of the pipeline clamp repair technology, this paper analyzes design of the pipeline repair clamp. Based on the damaged pipeline repair requirements, the design of a double-sealing pipeline repair clamp is established. The subsea pipeline in the Bohai Bay is considered as an example to develop a finite element model of a double sealing structure and calculate the sealing capacity, targeting a sealing pressure of 6MPa. The parameters affecting the sealing capacity are studied. For circumferential sealing, the effects of distance between the rubber and the pipeline, distance between the ring and the pipeline, and the contact friction coefficient on the sealing capacity are analyzed. The design parameters of circumferential sealing are optimized by an orthogonal experimental design method. Further, the effect of the friction coefficient on the axial sealing capacity is studied, and design suggestions are put forward based on the analysis. The results of this study can provide guidance for the design and application of subsea pipeline repair clamps.
    Źródło:
    Journal of Theoretical and Applied Mechanics; 2022, 60, 3; 333--346
    1429-2955
    Pojawia się w:
    Journal of Theoretical and Applied Mechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Indoor and outdoor 222Rn and 220Rn and their progeny levels surrounding Bayan Obo mine, China
    Autorzy:
    Wang, Nanping
    Hu, Miao
    Zeng, Weihua
    Yu, Cong
    Jia, Binlin
    Yang, Zhijie
    Powiązania:
    https://bibliotekanauki.pl/articles/146589.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    radon
    thoron
    thoron progeny
    equilibrium equivalent thoron concentration
    Rn equilibrium factor
    Bayan Obo
    Opis:
    More than half of the total natural ionizing radiation dose received by the human population is caused by radon and thoron (Rn and Tn) and their progeny. To estimate the level of radiation due to radon and thoron and their progeny, an investigation was conducted in a residential area near the world’s largest open-pit mine of Bayan Obo in Inner Mongolia, China. The concentration of Rn, Tn, and their decay products in air and soil were studied by using AlphaGUARD, RAD7, and ERS-RDM-2S for a discrete period of time in three different locations. The average indoor concentration of radon and thoron was 62.6 ± 44.6 Bq/m3 and 108.3 ± 94.5 Bq/m3 respectively, and the outdoor concentration was 12.9 ± 6.3 Bq/m3 and 55.8 ± 18.5 Bq/m3 , respectively. Relatively high concentrations were recorded in the area near to the mine, with a significant increasing trend observed in indoor thoron concentration. A prominent hotspot in thoron concentration was found in a single-story house with values 747 ± 150 Bq/m3 . The equilibrium equivalent thoron concentration (EECTn) varies from 0.48 Bq/m3 to 2.36 Bq/m3 with an arithmetic mean of 1.37 ± 0.64 Bq/m3 , and comparatively higher than EECRn. Concluding that the mining activity at Bayan Obo mine is significantly increasing the level of indoor thoron and its progeny in surroundings. It is suggested to further systematically investigate the indoor Rn and Tn progeny concentrations in the residential dwellings of the Bayan Obo mining area, and 232Th content of the building materials, to provide a basis for calculating the radiation dose.
    Źródło:
    Nukleonika; 2020, 65, 2; 145-148
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Low atmospheric density measurement based on Rayleigh scattering of an ultraviolet laser
    Autorzy:
    Wang, R
    Yao, J.
    Zhong, K.
    Miao, Y.
    Cui, H.
    Zhao, X.
    Zhang, C.
    Powiązania:
    https://bibliotekanauki.pl/articles/174910.pdf
    Data publikacji:
    2013
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    atmospheric density measurement
    Rayleigh scattering
    ultraviolet laser
    Opis:
    The qualitative measurement of low atmospheric density in the air flow field has been investigated in this paper. The supersonic flow field with Mach number of 1.5 around the NACA0006 aerofoil has been numerically simulated and the transient slight pressure and low density atmosphere have been experimentally determined based on Rayleigh scattering of a 266 nm ultraviolet laser. The scattering patterns have been effectively captured under different atmospheric pressure of 4.5, 92, 470 and 710 Pa with laser energy of only 0.5 mJ. It has been demonstrated that in the pressure range from 4.5 to 1100 Pa, corresponding to the atmospheric density from 4.8105×10–5 kg/m3 to 1.279×10–2 kg/m3, the scattering intensity of an ultraviolet laser is linear to the pressure and density with the slope coefficient of 0.00968 a.u./Pa and 0.83226 a.u./(kg/m3×10–3). It has been proved that Rayleigh scattering is a promising technology for observation of instantaneous and multidimensional distribution of a supersonic flow field.
    Źródło:
    Optica Applicata; 2013, 43, 3; 597-605
    0078-5466
    1899-7015
    Pojawia się w:
    Optica Applicata
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Semi-quantitative analysis study of the impact of microwave treatment on fly ash
    Autorzy:
    Ma, Xian Yun
    Nie, Yi Miao
    Guo, Jia Le
    Chen, Yang
    Chang, Zhen Jia
    Wang, Ling
    Liu, Shu Xian
    Wang, Long
    Powiązania:
    https://bibliotekanauki.pl/articles/27323647.pdf
    Data publikacji:
    2023
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    microwave
    fly ash
    semi-quantitative analysis
    adsorption
    XRD refinement
    infrared fitting
    NMR
    Opis:
    Pre-processing provides an effective way for fly ash's high value-added utilization. However, the shortcomings of pre-processing methods such as grinding and flotation are apparent with many disadvantages that make it more challenging to use efficiently. Microwave heating helps the SiO2-Al.2O3 bond break, not only can make the structural change of the material can also promote the chemical reaction process. In the article, XRD, SEM, FT-IR, ammonia nitrogen adsorption, and other methods were used to analyze the changes in the properties of fly ash before and after microwave pre-treatment, the change in adsorption performance of fly ash before and after microwave treatment was analyzed. The study found that under microwave conditions of 600 W and 15 min, the adsorption rate of ammonia nitrogen by fly ash reached a maximum of 29.67%. The intensity of mullite and amorphous diffraction peaks decreased after 20 min at 600 W. The Si-O-(Si, Al) and Si-O-(Si) bonds showed significant changes at 15 min and 20 min under 600 W conditions. Based on the results, the microwave conditions were selected at 600 W for different periods, and semi-quantitative analysis was carried out by XRD-Rietveld, infrared peak fitting, and nuclear magnetic resonance. The XRD-Rietveld analysis showed that the amorphous phase content reached 46.18% at 15 min. In the infrared peak fitting, the fitting area at 1300-900 cm-1 and 600-400 cm-1 peaks at 56.92% at 25 min and 17.5% at 15 min, respectively. The silicon-oxygen network's degree of connection and polymerization was reduced after 15 min of microwave treatment for the nuclear magnetic resonance analysis. By combining specific surface area measurements, it was discovered that the maximum specific surface area attained a value of 3.122 m2/g at 15 min.
    Źródło:
    Physicochemical Problems of Mineral Processing; 2023, 59, 6; art. no. 174897
    1643-1049
    2084-4735
    Pojawia się w:
    Physicochemical Problems of Mineral Processing
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Non-histone nuclear protein HMGN2 differently regulates the urothelium barrier function by altering expression of antimicrobial peptides and tight junction protein genes in UPEC J96-infected bladder epithelial cell monolayer
    Autorzy:
    Tian, Hanwen
    Miao, Junming
    Zhang, Fumei
    Xiong, Feng
    Zhu, Feimei
    Li, Jinyu
    Wang, Xiaoying
    Chen, Shanzhe
    Chen, Junli
    Huang, Ning
    Wang, Yi
    Powiązania:
    https://bibliotekanauki.pl/articles/1038529.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    HMGN2
    UPEC
    BECs 5637
    bladder epithelium
    tight junction
    antimicrobial peptides
    Opis:
    The urinary tract is vulnerable to frequent challenges from environmental microflora. Uropathogenic Escherichia coli (UPEC) makes a major contribution to urinary tract infection (UTI). Previous studies have characterized positive roles of non-histone nuclear protein HMGN2 in lung epithelial innate immune response. In the study presented here, we found HMGN2 expression was up-regulated in UPEC J96-infected urothelium. Surprisingly, over-expression of HMGN2 promoted disruption of BECs 5637 cells' intercellular junctions by down-regulating tight junction (TJs) components' expression and physical structure under J96 infection. Further investigation showed that BECs 5637 monolayer, in which HMGN2 was over-expressed, had significantly increased permeability to J96. Our study systemically explored the regulatory roles of HMGN2 in BECs barrier function during UPEC infection and suggested different modulations of intracellular and paracellular routes through which UPEC invades the bladder epithelium.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 1; 93-100
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Kinetics of simultaneous recovering of Au and Ag from CTs by chloridizing volatilization methods
    Autorzy:
    Weiwei, Wang
    Zhengyao, Li
    Shanshan, Yang
    Kai, Ma
    Xin, Gao
    Shaoqi, Han
    Shaochun, Hou
    Hecheng, Miao
    Powiązania:
    https://bibliotekanauki.pl/articles/27323663.pdf
    Data publikacji:
    2023
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    cyanide tailings
    chloridizing volatilization
    gold
    silver
    kinetics
    Opis:
    Cyanide Tailings (CTs) are known as hazardous resources that accumulate hundreds of millions of tons, threatening the ecological environment. This work proposes an eco-friendly and efficient way to recover gold and silver from CTs. The effects of calcium chloride dosage, silicon dioxide dosage, pellet moisture content, roasting temperature, and roasting time on Au and Ag chloridizing volatilization were studied. The kinetics of simultaneously recovering of gold and silver from cyanide Tailings by chlorination roasting was investigated. It was determined that the chloridizing volatilization rates increased with increasing calcium chloride dosage, temperature and decreasing silicon dioxide dosage, pellet moisture content. The chloridizing volatilization kinetics followed a shrinking core model, with inter-diffusion through gangue layer as the rate determining step. This finding is in accordance with the apparent activation energy (Ea) of 24.01 kJ•mol-1 (Au) and 24.62 kJ•mol-1 (Ag). The orders of reaction with respect to moisture content, temperature, calcium chloride dosage and silicon dioxide dosage were also achieved. The rate of reaction based on diffusion-controlled process can be expressed by semi-empirical equations. The control steps of the gold and silver recovery process were investigated by the kinetic study, which provided theoretical guidance for the optimization of the method.
    Źródło:
    Physicochemical Problems of Mineral Processing; 2023, 59, 6; art. no. 172522
    1643-1049
    2084-4735
    Pojawia się w:
    Physicochemical Problems of Mineral Processing
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Vibration transients of reservoir-pipe-valve system caused by water hammer
    Autorzy:
    Miao, Yang
    Jiang, Yuncheng
    Qiu, Zaihui
    Pan, Jun
    Wang, Lu
    Han, Zhenrong
    Li, Kun
    Zhang, Li
    Zhang, Xiaolu
    Powiązania:
    https://bibliotekanauki.pl/articles/1839616.pdf
    Data publikacji:
    2020
    Wydawca:
    Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
    Tematy:
    reservoir-pipe-valve system (RPV system)
    water hammer
    vibration
    transients
    Opis:
    A severe oscillation, accompanied with an abnormal “click” sound, of a fuel feeding pipe system during valve closing, when the feeding flowrate reaches a certain value, is observed experimentally. A fluctuation model in which stiffness and damping coefficients of the vibration system are time varying is proposed. Each coefficient is composed of two parts, one of which is constant and the other is time varying. Based on this model, simulation transients of the vibration displacement, velocity and pressure in the pipe are presented. Simulations of the pressure transients are compared with experimental data detected by pressure transducer, which shows that both have fluctuations in the transient process at a large flowrate.
    Źródło:
    Journal of Theoretical and Applied Mechanics; 2020, 58, 4; 1037-1048
    1429-2955
    Pojawia się w:
    Journal of Theoretical and Applied Mechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Error analysis of the three-phase electrical energy calculation method in the case of voltage-loss failure
    Autorzy:
    Cheng, Han-miao
    Wang, Zhong-dong
    Cai, Qi-xin
    Lu, Xiao-quan
    Gao, Yu-xiang
    Song, Rui-peng
    Tian, Zheng-qi
    Mu, Xiao-xing
    Powiązania:
    https://bibliotekanauki.pl/articles/221096.pdf
    Data publikacji:
    2019
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    three-phase electrical energy meter
    voltage-loss failure
    voltage substitution
    three-phase voltage unbalance
    calculation error
    Opis:
    The single-phase voltage loss is a common fault. Once the voltage-loss failure occurs, the amount of electrical energy will not be measured, but it is to be calculated so as to protect the interest of the power supplier. Two automatic calculation methods, the power substitution and the voltage substitution, are introduced in this paper. Considering the lack of quantitative analysis of the calculation error of the voltage substitution method, the grid traversal method and MATLAB tool are applied to solve the problem. The theoretical analysis indicates that the calculation error is closely related to the voltage unbalance factor and the power factor, and the maximum calculation error is about 6% when the power system operates normally. To verify the theoretical analysis, two three-phase electrical energy metering devices have been developed, and verification tests have been carried out in both the lab and field conditions. The lab testing results are consistent with the theoretical ones, and the field testing results show that the calculation errors are generally below 0.2%, that is correct in most cases.
    Źródło:
    Metrology and Measurement Systems; 2019, 26, 3; 505-516
    0860-8229
    Pojawia się w:
    Metrology and Measurement Systems
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Correlation of chromosome damage and promoter methylation status of the DNA repair genes MGMT and hMLH1 in Chinese vinyl chloride monomer (VCM)-exposed workers
    Autorzy:
    Wu, Fen
    Liu, Jing
    Qiu, Yu-Lan
    Wang, Wei
    Zhu, Shou-Min
    Sun, Pin
    Miao, Wen-Bin
    Li, Yong-Liang
    Brandt-Rauf, Paul W.
    Xia, Zhao-Lin
    Powiązania:
    https://bibliotekanauki.pl/articles/2179802.pdf
    Data publikacji:
    2013-03-01
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    vinyl chloride monomer
    chromosome damage
    MGMT
    hMLH1
    DNA methylation
    Opis:
    Objective: To explore the association of the methylation status of MGMT and hMLH1 with chromosome damage induced by vinyl chloride monomer (VCM). Materials and Methods: Methylation of MGMT and hMLH1 was measured in 101 VCM-exposed workers by methylation-specifi c PCR. Chromosome damage in peripheral blood lymphocytes was measured by the cytokinesis-block micronucleus assay. The subjects were divided into chromosome damaged and non-damaged groups based on the normal reference value of micronuclei frequencies determined for two control groups. Results: MGMT promoter methylation was detectable in 5 out of 49 chromosome damaged subjects, but not in the chromosome non-damaged subjects; there was a signifi cant difference in MGMT methylation between the two groups (p < 0.05). Conclusions: We detected aberrant promoter methylation of MGMT in a small number of chromosome damaged VCM-exposed workers, but not in the chromosome non-damaged subjects. This preliminary observation warrants further investigation in a larger study.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2013, 26, 1; 173-182
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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