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Tytuł:
Preparation of scutellarin loaded TPGS polymeric micelles and evaluation of its pharmacokinetics and pharmacodynamics effects in rats
Autorzy:
Zou, Liu
Xiong, Shujuan
Deng, Xiangping
Liu, Juan
Xiong, Runde
Wang, Zhe
Cao, Xuan
Chen, Yanming
Guo, Yu
Tang, Guotao
Powiązania:
https://bibliotekanauki.pl/articles/895637.pdf
Data publikacji:
2018-12-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
scutellarin
TPGS
polymeric micelles
antithrombotic drugs
Opis:
To improve the clinical effect of scutellarin by extending the action time in vivo, scutellarin loaded polymeric micelles were developed by D-alpha tocopherol polyethylene glycol 1000 succinate (Scu/TPGS). Scu/TPGS were prepared using film solvent diffusion methods and characterized on the basis of their particle size, zeta potential, and drug encapsulation efficiency. Dynamic dialysis was used to study the release behavior of the polymeric micelles in vitro. Its pharmacokinetic characteristics and antithrombotic efficacy were studied by intravenous injection in rats. The results showed that Scu/TPGS were spherical, 20.09±2.62 nm in size and a slow release in vitro. The pharmacokinetic parameter T1/2 of Scu/TPGS was 762.12±46.56 min compared with commercial injection of 59.30±10.67 min (p<0.05). At the 1 mg/kg dose, the thrombolysis effect of micellar group was stronger than that of the commercial group (p<0.05). In conclusion, TPGS polymer micelles provided a valid strategy in chemotherapy for cerebrovascular diseases with poor water solubility and poor lipid solubility drugs such as scutellarin.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1305-1312
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Telomerase enhances osteogenic ifferentiation of sheep bone marrow mesenchymal stem cells (BMSCs) by up-regulating PI3K/Akt pathway in vitro
Autorzy:
Zhu, X.
Zhou, L.
Liu, Z.
Chen, X.
Wei, L.
Zhang, Z.
Liu, Y.
Zhu, Y.
Wang, Y.
Yang, X.
Han, Y.
Powiązania:
https://bibliotekanauki.pl/articles/2087304.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bone marrow mesenchymal stem cells
telomerase
proliferation
osteogenic differentiation
PI3K/Akt signalling pathway
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 3; 359-372
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sound Absorption Behavior of Polyurethane Foam Composites with Different Ethylene Propylene Diene Monomer Particles
Autorzy:
Zhu, W.
Chen, S.
Wang, Y.
Zhu, T.
Jiang, Y.
Powiązania:
https://bibliotekanauki.pl/articles/178030.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
polyurethane foam composites
EPDM
Ethylene Propylene Diene Monomer
contents of EPDM
hardness of EPDM
sound absorption coefficient
Opis:
Considering the environmental pollution caused by waste rubber, some measures should be taken to improve the utilization rate of waste rubber. In this study, the effect of Ethylene Propylene Diene Monomer (EPDM) particles in the polyurethane (PU) foams on sound absorption behavior is investigated for improving sound environment within vehicles and reducing the environment pollution. EPDM particles of different contents and hardness are used as fillers for producing foams with different pore morphologies and sound absorption properties. The results show that adding EPDM to foam would produce smaller pores, higher density and bigger air-flow resistivity. Simultaneously, there are better sound absorption properties of the PU foam composites in the medium frequency region, and the better value can be obtained at the lower frequency with the content of EPDM increasing. The hardness of EPDM also shows better influence on sound absorption properties, especially in the medium frequency region. It means the foam pore morphologies have influence on sound absorption properties.
Źródło:
Archives of Acoustics; 2018, 43, 3; 403-411
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cloning and partial characterization of a gene in Bombyx mori homologous to a human adiponectin receptor
Autorzy:
Zhu, Minfeng
Chen, Keping
Wang, Yong
Guo, Zhongjian
Yin, Huijuan
Yao, Qin
Chen, Huiqin
Powiązania:
https://bibliotekanauki.pl/articles/1040735.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
BmAdipoR
bioinformatics study
subcellular localization
real-time quantitative PCR
BmNPV
Opis:
In this study, we report the cloning and characteristics of an adiponectin-like receptor gene from Bombyx mori (BmAdipoR) with highly conserved deduced amino-acid sequences and similar structure to the human adiponectin receptor (AdipoR). Structural analysis of the translated cDNA suggested it encoded a membrane protein with seven transmembrane domains. BmAdipoR was found to be expressed in multiple tissues and highly expressed in Malpighian tubules, fat body and testis. BmNPV (Bombyx mori nucleopolyhedrovirus) bacmid system combined with confocal microscopy revealed that BmAdipoR was targeted to the cell membrane. We also found that infection with BmNPV did not have an effect on BmAdipoR mRNA quantity in the midgut of susceptible Bombyx mori strain (306) at 48 h, but BmAdipoR mRNA quantity increased significantly at 72 h. We concluded that BmAdipoR gene was a membrane protein ubiquitously expressed in Bombyx mori tissues and that its expression was altered by treating with BmNPV.
Źródło:
Acta Biochimica Polonica; 2008, 55, 2; 241-249
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dispersion-compensating en/decoder for a time-spreading/wavelength-hopping optical code-division multiplexing (OCDM) system
Autorzy:
Zheng, J.
Wang, R.
Pu, T.
Lu, L.
Fang, T.
Su, Y.
Li, L.
Yang, Q.
Chen, X.
Powiązania:
https://bibliotekanauki.pl/articles/174365.pdf
Data publikacji:
2013
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
optical code-division multiplexing (OCDM)
fiber Bragg grating (FBG)
dispersion
Opis:
A novel dispersion-compensating fiber Bragg grating (FBG)-based en/decoder is proposed to compensate both the out-band and in-band dispersion in a time-spreading/wavelength-hopping (TS/WH) optical code-division multiplexing (OCDM) system. The experimental realization of such en/decoders only needs a uniform-pitch phase mask and a sub-micrometer precision moving stage. Such an en/decoder pair with the ability of compensating the dispersion of transmission in 20-km single mode fiber (SMF) is simulated and experimentally fabricated. Both the simulation and experimental results show that the decoded pulse can be recovered without any distortion owing to the elimination of dispersion.
Źródło:
Optica Applicata; 2013, 43, 3; 485-495
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Non-contact harmonic detection of ferromagnetic material defects based on SQGSR and OPLTF
Autorzy:
Zhao, Yizhen
Wang, Xinhua
Chen, Yingchun
Ju, Haiyang
Shuai, Yi
Powiązania:
https://bibliotekanauki.pl/articles/1848986.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
harmonic detection
ferromagnetic materials defects
focusing vector array
signal extraction algorithm
Opis:
In order to find the defects in ferromagnetic materials, a non-contact harmonic detection method is proposed. According to the principle of frequency modulated carrier wave, a tunnel magneto resistance harmonic focusing vector array detector was designed which radiates lower and higher frequency electromagnetic waves through the coil array to the detection targets. We use bistable stochastic resonance to enhance the energy of collected weak target signal and apply quantum computation and a Sobol low deviation sequence to improve genetic algorithm performance. Then we use the orthogonal phase-locked loop to eliminate the intrinsic background excitation field and tensor calculations to fuse the vector array signal. The finite element model of array detector and the magnetic dipole harmonic numerical model were also established. The simulation results show that the target signal can be identified effectively, its focusing performance is improved by 2 times, and the average signal-to-noise ratio is improved by 9.6 times after the algorithm processing. For the experiments, we take Q235 steel pipeline as the object to realize the recognition of three defects. Compared with the traditional methods, the proposed method is more effective for ferromagnetic materials defects detection.
Źródło:
Metrology and Measurement Systems; 2021, 28, 1; 55-72
0860-8229
Pojawia się w:
Metrology and Measurement Systems
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pharmacokinetics of the recombinant ovine interferon-tau in lambs
Autorzy:
Zhao, J.
Yu, H.Y.
Zhao, Y.
Li, S.Q.
Fu, X.L.
Zhou, W.
Xia, B.B.
Wang, M.L.
Chen, J.
Powiązania:
https://bibliotekanauki.pl/articles/2087588.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bioavailability
ovine interferon-τ
cytopathic effect inhibition assay
pharmacokinetic study
Źródło:
Polish Journal of Veterinary Sciences; 2019, 1; 75-82
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Grid-side current harmonic suppression based on Butterworth filter and quasi-proportional resonance controller
Autorzy:
Zhao, Feng
Zhang, Jianing
Chen, Xiaoqiang
Wang, Ying
Powiązania:
https://bibliotekanauki.pl/articles/2172801.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
Butterworth filter
current harmonic suppression
high-speed electric multiple units
quasi-PR controller
traction drive system
Opis:
In order to meet the lightweight requirements of high-speed trains, the inductancecapacitance (LC) resonance circuits are cancelled in the traction drive system of some high-speed electric multiple units (EMUs) in China, which will lead to large low-order current harmonics on the grid side in the traction drive system of EMUs, seriously affecting the power quality. Therefore, the low-order harmonic current of the traction drive system of an EMU is studied in this paper. Firstly, the working principle of a four-quadrant pulse rectifier in a traction drive system is analyzed, and then the generation mechanism of loworder current harmonics on the grid side is studied deeply. Secondly, the voltage outer loop and current inner loop control of a four-quadrant pulse rectifier are optimized respectively. In the voltage outer loop control, a Butterworth filter is designed to suppress the beat frequency voltage of the DC side voltage, so as to indirectly suppress the low-order current harmonics. In the current inner loop, a quasi-proportional resonance (PR) controller with harmonic compensation is used to suppress low-order current harmonics, and a novel loworder current harmonics suppression strategy based on the Butterworth filter and quasi-PR controller is proposed. Finally, the results of the simulated validation of the proposed control strategy show that compared with the existing method of the notch filter ₊ PR controller, the proposed optimal control strategy has a better effect on low-order current harmonic suppression, and improves the dynamic performance of the control system, further showing the correctness and effectiveness of the optimal control strategy.
Źródło:
Archives of Electrical Engineering; 2022, 71, 4; 909--929
1427-4221
2300-2506
Pojawia się w:
Archives of Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of chromatographic plate theory on the weathered crust elution-deposited rare earth ore with carboxylate
Autorzy:
Zhang, Zhenyue
Wang, Guangshuai
Li, Chunhua
Chi, Ruan
Long, Fei
Chen, Zhuo
Chi, Xiao Wang
Liu, Defeng
Powiązania:
https://bibliotekanauki.pl/articles/1446022.pdf
Data publikacji:
2021
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
weathered crust elution-deposited rare earth ore
carboxylate ammonium
mass transfer
theory plate
rare earth
Opis:
To improve the leaching process of rare earth and reduce the impurities in the leachate, the carboxylate ammonium, such as ammonium acetate, ammonium citrate and ammonium tartrate, were selected as lixiviant to compare the effects of concentration, flow rate, pH and temperature on leaching mass process of rare earth and aluminum. Meanwhile, the leaching behaviors of rare earth and aluminum leached by three kinds of carboxylate ammonium were analyzed by chromatographic plate theory. The relationship between the flow rate and height equivalent (HETP) could fit well with the Van Deemter equation and there was an optimal flow rate (uopt) for the leaching of the rare earth and aluminum. Besides, the conditions of carboxylate ammonium lixiviant were optimized. The optimum concentrations of ammonium acetate, ammonium tartrate and ammonium citrate were 15 g/L, 25 g/L and 5 g/L respectively, the leaching flow rate was 0.50 mL/min, the pH value was approximatively 7.00 and the leaching temperature was 293 K to 303 K. At these conditions, the mass transfer efficiencies of three ammonium carboxylates for rare earth and aluminum was in the order of ammonium acetate > ammonium tartrate > ammonium citrate. Moreover, the ammonium acetate could commendably inhibit aluminum ions entering the lixivium.
Źródło:
Physicochemical Problems of Mineral Processing; 2021, 57, 4; 48-62
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Flotation separation of scheelite from calcite using sodium polyacrylate as depressant
Autorzy:
Zhang, Y.
Chen, R.
Li, Y.
Wang, Y.
Luo, X.
Powiązania:
https://bibliotekanauki.pl/articles/110896.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
scheelite
calcite
flotation
sodium polyacrylate
selective depression
Opis:
The depressing properties of sodium polyacrylate (PA-Na) for calcite from scheelite were studied by microflotation experiments, zeta potentials, X-ray photoelectron spectroscopy (XPS) and density functional theory (DFT) calculation. Flotation results revealed that the selective depression effect of PA-Na was better than that of sodium silicate (Na2SiO3), and PA-Na can depress calcite more effectively than scheelite. The flotation recovery of scheelite and calcite kept at about 75% and 15% respectively at the pulp pH 9.3~9.6 and PA-Na concentration from 37.5 mg/dm3 to 50 mg/dm3. The zeta potentials of the minerals were significantly altered and the zeta potential of calcite became more negative than scheelite. XPS analysis deduced the occurrence of chemisorption between PA-Na and mineral surfaces, and the chemisorption of PA-Na on calcite was stronger than on scheelite. The results from DFT calculation demonstrated that the absolute value of the adsorption energy in the presence of PA-Na on the surface of calcite {104} was larger than on the surface of scheelite {111}. With the combination of the analysis, it could be concluded that calcite was more easily depressed than scheelite, and this finding remarkably matched with the microflotation experimental results. Furthermore, by using PA-Na as depressant, the flotation separation of scheelite from calcite can be achieved by controlling the flotation pH and PA-Na dosage.
Źródło:
Physicochemical Problems of Mineral Processing; 2018, 54, 2; 505-516
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wave propagation in piezoelectric rings with rectangular cross-sections
Autorzy:
Zhang, X.
Wang, Y.
Chen, H.
Powiązania:
https://bibliotekanauki.pl/articles/279995.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
Tematy:
piezoelectric rings
orthogonal polynomial
guided wave
dispersion curves
Opis:
The ring ultrasonic transducers are widely used in the ocean engineering and medical fields. This paper employs an extended orthogonal polynomial approach to solve the guided wave propagation in two-dimensional structures, i.e. piezoelectric rings with rectangular cross- -sections. The extended polynomial approach can overcome the drawbacks of the conven- tional orthogonal polynomial approach which can be used to solve wave propagation in one-dimensional structures. Through numerical comparison with the available results for a rectangular aluminum bar, the validity of the present approach is illustrated. The dispersion curves and displacement and electric potential distributions of various rectangular piezo- electric rings are calculated, and the effects of different radius to thickness ratios, width to height ratios and polarizing directions on the dispersion curves are illustrated.
Źródło:
Journal of Theoretical and Applied Mechanics; 2015, 53, 3; 673-682
1429-2955
Pojawia się w:
Journal of Theoretical and Applied Mechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Geomagnetic detection method for pipeline defects based on ceemdan and WEP-TEO
Autorzy:
Zhang, Tao
Wang, Xinhua
Chen, Yingchun
Shuai, Yi
Ullah, Zia
Ju, Haiyang
Zhao, Yizhen
Powiązania:
https://bibliotekanauki.pl/articles/220762.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
geomagnetic detection
pipeline defects
magnetic field
filtering
data processing
Opis:
This paper presents a geomagnetic detection method for pipeline defects using complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN) and wavelet energy product (WEP) - Teager energy operator (TEO), which improves detection accuracy and defect identification ability as encountering strong inference noise. The measured signal is first subtly decomposed via CEEMDAN into a series of intrinsic mode functions (IMFs), which are then distinguished by the Hurst exponent to reconstruct the filtered signal. Subsequently, the scale signals are obtained by using gradient calculation and discrete wavelet transform and are then fused by using WEP. Finally, TEO is implemented to enhance defect signal amplitude, completing geomagnetic detection of pipeline defects. The simulation results created by magnetic dipole in a noisy environment, indoor experiment results and field testing results certify that the proposed method outperforms ensemble empirical mode decomposition (EEMD)-gradient, EEMD-WEP-TEO, CEEMDAN-gradient in terms of detection deviation, peak side-lobe ratio (PSLR) and integrated side-lobe ratio (ISLR).
Źródło:
Metrology and Measurement Systems; 2019, 26, 2; 345-361
0860-8229
Pojawia się w:
Metrology and Measurement Systems
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI.
Autorzy:
Zhang, Jiayi
Dai, Jianliang
Zhao, Enpeng
Lin, Yun
Zeng, Li
Chen, Jinzhong
Zheng, Huari
Wang, Yu
Li, Xin
Ying, Kang
Xie, Yi
Mao, YuMin
Powiązania:
https://bibliotekanauki.pl/articles/1041522.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
ovary
ePAD
peptidylarginine deiminase
hPADVI
Opis:
Peptidylarginine deiminase (PAD) catalyzes the post-translational modification of protein through the conversion of arginine to citrulline in the presence of calcium ions. Human, similar to rodents, has four isoforms of PAD (type I, II, III and IV/V), each of which is distinct in substrate specificity and tissue specific expression. In our large-scale sequencing project, we identified a new human PAD cDNA from a human fetal brain cDNA library. The putative protein encoded by this cDNA is designated hPADVI. Expression analysis of hPADVI showed that it is mainly expressed in adult human ovary and peripheral blood leukocytes. We conclude that hPADVI may be orthologous to mouse ePAD, basing on sequence comparison, chromosome localization and exon-intron structure analysis. PAD-mediated deimination of epithelial cell keratin resulting in cytoskeletal remodeling suggests a possible role for hPADVI in cytoskeletal reorganization in the egg and in early embryo development. This study describes a new important member of the human PAD family.
Źródło:
Acta Biochimica Polonica; 2004, 51, 4; 1051-1058
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multiscale water drop contact angles at selected silica surfaces
Autorzy:
Zhang, Chen
Wang, Xuming
Li, Lixia
Jin, Jiaqi
Polson, Randy
Miller, Jan D.
Powiązania:
https://bibliotekanauki.pl/articles/2146924.pdf
Data publikacji:
2022
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
contact angle
atomic force microscopy
hollow tip
submicron-drop
wettability
MD simulation
Opis:
In this study, multiscale advancing contact angles for glycerol/water drops at silica surfaces are reported for millidrops, submicron-drops, and nanodrops. Selected silica surfaces were muscovite, silicon, and talc. The contact angles for millidrops (1–2 mm) were determined by the traditional sessile drop technique. For submicron-drops (0.1–1.0 μm), a hollow tip Atomic Force Microscope (AFM) procedure was used. The contact angles for nanodrops (~7 nm) were examined from Molecular Dynamics (MD) simulation. The results were compared to evaluate the effect of drop size on the contact angle. In the case of the hydrophobic talc surface, the 75° advancing contact angle did not vary significantly with drop size. For the hydrophilic muscovite surface, the water drop wet the surface and an advancing contact angle of about 10° was found for the millidrops and submicron-drops. However, for the MD simulated nanodrops, attachment and spreading of the ~7 nm drop created a 2D film of molecular dimensions, the contact angle of which was difficult to define and varied from 0° to 17°. Perhaps of equal interest from the MD simulation results was that the spreading of the glycerol/water nanodrop at the muscovite surface resulted in crystallographic directional transport of water molecules to the extremities of the 2D film. Such separation and segregation left the center of the film with an increased concentration of glycerol. Based on these results, the line tension, which has been found in other investigations to account for contact angle decrease with a decrease in drop size, does not seem to be a significant factor in this study.
Źródło:
Physicochemical Problems of Mineral Processing; 2022, 58, 5; art. no. 152154
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Opportunistic maintenance strategy of a Heave Compensation System for expected performance degradation
Autorzy:
Zhang, Chao
Qian, Yujie
Dui, Hongyan
Wang, Shaoping
Chen, Rentong
Tomovic, Mileta M.
Powiązania:
https://bibliotekanauki.pl/articles/2038156.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Polskie Naukowo-Techniczne Towarzystwo Eksploatacyjne PAN
Tematy:
opportunistic maintenance
importance measure
heave compensation
hydraulic system
Monte Carlo
Opis:
In the marine industry, heave compensation systems are applied to marine equipment to compensate for the adverse effects of waves and the hydraulic system is usually used as the power system of heave compensation systems. This article introduces importance theory to the opportunistic maintenance (OM) strategy to provide guidance for the maintenance of heave compensation systems. The working principle of a semi-active heave compensation system and the specific working states of its hydraulic components are also first explained. Opportunistic maintenance is applied to the semi-active heave compensation system. Moreover, the joint integrated importance measure (JIIM) between different components at different moments is analyzed and used as the basis for the selection of components on which to perform PM, with the ultimate goal of delaying the degradation of the expected performance of the system. Finally, compared with conditional marginal reliability importance (CMRI)based OM, the effectiveness of JIIM-based OM is verified by the Monte Carlo method.
Źródło:
Eksploatacja i Niezawodność; 2021, 23, 3; 512-521
1507-2711
Pojawia się w:
Eksploatacja i Niezawodność
Dostawca treści:
Biblioteka Nauki
Artykuł

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